scholarly journals Local Natural Product Development in the Era of Covid 19 Pandemic

2021 ◽  
Vol 2 (2) ◽  
pp. 133-140
Author(s):  
N Noval ◽  
Dyan Fitri Nugraha ◽  
Kunti Nastiti ◽  
Dahlia Syahrina ◽  
N Novia
Keyword(s):  
High School ◽  
Side Effects ◽  
Product Development ◽  
Natural Product ◽  
Respiratory System ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Betel Leaf ◽  
Local Resources ◽  
Lime Peel

Covid-19 is a pandemic disease that infects the respiratory system by cough and sneeze. Covid 19 infection rate in Indonesia is high. On March 2nd 2020, there was reported 2 confirmed cases of Covid-19 infection. Natural ingredients contain a secondary metabolite compound has the potential as an antimicrobial that can be used to kill microorganism as a source of the disease. Natural ingredients that are commonly used as antimicrobials such as bundung, betel leaf and lime peel. Pharmaceutical formulations from natural ingredients need to be made to obtain preparations that are beneficial to the community because they are safer and have minimal side effects. Based on this description, it is necessary to conduct training on the manufacture of pharmaceutical products from natural ingredients or local resources that are easy to make so it can be useful and beneficial for the community during the Covid-19 pandemic. The activities were carried out virtually, followed by the teacher council and students from High School 1 Kahayan Hilir. The activities carried out by providing information related to the efficacy of natural ingredients from local resources, training or workshops on the manufacture of pharmaceutical products and education regarding storing and how to use drugs correctly. This activity is expected to be useful and make a big contribution to the community during the Covid-19 pandemic.

Pharmaceutical Polymers - A Review

2019 ◽  
Vol 9 (01) ◽  
pp. 27-33
Author(s):  
Naveen Kumar ◽  
Sonia Pahuja ◽  
Ranjit Sharma
Keyword(s):  
Drug Release ◽  
Industrial Revolution ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Water Soluble ◽  
Taste Masking ◽  
Natural Polymers ◽  
Pharmaceutical Dosage Forms ◽  
Pharmaceutical Applications ◽  
Pharmaceutical Industries

Humans have taken advantage of the adaptability of polymers for centuries in the form of resins, gums tars, and oils. However, it was not until the industrial revolution that the modern polymer industry began to develop. Polymers represent an important constituent of pharmaceutical dosage forms. Polymers have played vital roles in the formulation of pharmaceutical products. Polymers have been used as a major tool to manage the drug release rate from the formulations. Synthetic and natural-based polymers have found their way into the biomedical and pharmaceutical industries. Synthetic and Natural polymers can be produced with a broad range of strength, heat resistance, density, stiffness and even price. By constant research into the science and applications of polymers, they are playing an ever-increasing role in society. Diverse applications of polymers in the present pharmaceutical field are for controlled drug release. Based on solubility pharmaceutical polymers can be classified as water-soluble and water-insoluble. In general, the desirable polymer properties in pharmaceutical applications are film forming, adhesion, gelling, thickening, pH-dependent solubility and taste masking. General pharmaceutical applications of polymers in various pharmaceutical formulations are also discussed

scholarly journals A Novel Marine Natural Product Derived Pyrroloiminoquinone with Potent Activity against Skin Cancer Cells

Marine Drugs ◽  
2019 ◽  
Vol 17 (8) ◽  
pp. 443 ◽  
Author(s):  
Jaden Cowan ◽  
Mohammad Shadab ◽  
Dwayaja H. Nadkarni ◽  
Kailash KC ◽  
Sadanandan E. Velu ◽  
...  
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Skin Cancer ◽  
Cancer Cells ◽  
Natural Product ◽  
The United States ◽  
Marine Natural Product ◽  
Migration And Invasion ◽  
Migration Assay ◽  
Lead Compounds

Non-melanoma skin cancer is one of the major ailments in the United States. Effective drugs that can cure skin cancers are limited. Moreover, the available drugs have toxic side effects. Therefore, skin cancer drugs with less toxic side effects are urgently needed. To achieve this goal, we focused our work on identifying potent lead compounds from marine natural products. Five lead compounds identified from a class of pyrroloiminoquinone natural products were evaluated for their ability to selectively kill squamous cell carcinoma (SCC13) skin cancer cells using an MTT assay. The toxicity of these compounds was also evaluated against the normal human keratinocyte HaCaT cell line. The most potent compound identified from these studies, C278 was further evaluated for its ability to inhibit cancer cell migration and invasion using a wound-healing assay and a trans-well migration assay, respectively. To investigate the molecular mechanism of cell death, the expression of apoptotic and autophagy proteins was studied in C278 treated cells compared to untreated cells using western blot. Our results showed that all five compounds effectively killed the SCC13 cells, with compound C278 being the most effective. Compound C278 was more effective in killing the SCC13 cells compared to HaCaT cells with a two-fold selectivity. The migration and the invasion of the SCC13 cells were also inhibited upon treatment with compound C278. The expression of pro-apoptotic and autophagy proteins with concomitant downregulation in the expression of survival proteins were observed in C278 treated cells. In summary, the marine natural product analog compound C278 showed promising anticancer activity against human skin cancer cells and holds potential to be developed as an effective anticancer agent to combat skin cancer.

scholarly journals Validation of the Antifactor Xa and Antifactor IIa Assays for the Potency Assessment of Nadroparin in Pharmaceutical Formulations

2006 ◽  
Vol 89 (1) ◽  
pp. 58-64 ◽  
Author(s):  
Sérgio Luiz Dalmora ◽  
Maximiliano da Silva Sangoi ◽  
Thiago Barth ◽  
Liberato Brum ◽  
Silvana Ferreira Vaccari
Keyword(s):  
Molecular Weight ◽  
Arterial Thrombosis ◽  
Low Molecular Weight Heparin ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Low Molecular Weight ◽  
Nadroparin Calcium ◽  
Prevention And Treatment ◽  
Antifactor Xa ◽  
Routine Quality Control

Abstract The low-molecular weight heparin nadroparin calcium is used clinically for the prevention and treatment of venous and arterial thrombosis. The antifactor Xa and antifactor IIa assays were validated by investigating the parameters of range, linearity (r2 0.9905 and r2 0.9914, respectively) precision, accuracy, and robustness. The 2 methods incorporated a chromogenic endpoint and detection at 405 nm, yielding good results with detection limits of 0.004 and 0.01 IU/mL and quantitation limits of 0.01 and 0.03 IU/mL, respectively, for the antifactor Xa and antifactor IIa assays. Nadroparin calcium pharmaceutical products were evaluated by the antifactor Xa assay and the antifactor IIa assay, giving potencies between 93.86 and 109.88%, with an antifactor Xa/antifactor IIa ratio between 3.2 and 3.7. The results demonstrated the validity of the assays that are useful methodologies for the routine quality control of nadroparin in pharmaceutical formulations.

scholarly journals Chemical Impurities: An Epistemological Riddle with Serious Side Effects

2020 ◽  
Vol 17 (3) ◽  
pp. 1030
Author(s):  
Ahmad Yaman Abdin ◽  
Prince Yeboah ◽  
Claus Jacob
Keyword(s):  
Side Effects ◽  
Large Scale ◽  
Biological Activities ◽  
Pharmaceutical Research ◽  
Pharmaceutical Products ◽  
Regulatory Agencies ◽  
Chemical Structures ◽  
Chemical Impurities ◽  
Large Scale Manufacture ◽  
Modern Analytical

Chemical synthesis is a science and an art. Rooted in laboratory or large-scale manufacture, it results in certain side products, eventually compromising the integrity of the final products. Such “impurities” occur in small amounts and, within chemistry itself, are of little concern. In pharmacy, in contrast, impurities increase the potential for toxicity, side effects, and serious implications for human health and the environment. The pharmaceutical regulatory agencies have therefore developed regulatory and strategic systems to minimize the chemical presence or biological impact of such substances. Here, pharmaceuticals are turned from impure into more defined materials as part of a complex socio-technological system revolving around and constantly evolving its specific rules and regulations. Whilst modern analytical methods indicate the presence of impurities, the interpretations of corresponding results are gated by risk management and agreed thresholds. Ironically, this allows for entities with no identified chemical structures, and hence epistemologically outside chemistry, to be regulated in pharmaceutical products. We will refer to such substances which are not, epistemologically speaking, “chemicals” as Xpurities, in order to distinguish them from recognized and identified impurities. The presence of such Xpurities is surprisingly common and constitutes a major issue in pharmaceutical research and practice. We propose a Space of Information to deal with such impurities based on values regarding the presence, chemical identities, and biological activities. It is anticipated that this may enable pharmacists to handle such Xpurities more efficiently.

ChemInform Abstract: Glycosyltransferases: Mechanisms and Applications in Natural Product Development

ChemInform ◽  
2015 ◽  
Vol 46 (50) ◽  
pp. no-no
Author(s):  
Dong-Mei Liang ◽  
Jia-Heng Liu ◽  
Hao Wu ◽  
Bin-Bin Wang ◽  
Hong-Ji Zhu ◽  
...  
Keyword(s):  
Product Development ◽  
Natural Product

Abstract P5-15-10: A combination natural product therapy attenuates common side effects associated with chemotherapy

2015 ◽  
Author(s):  
Coy D Heldermon ◽  
Ben G Griffith ◽  
Matt Bloom ◽  
Jennifer Owen ◽  
Regina J Martuscello ◽  
...  
Keyword(s):  
Side Effects ◽  
Natural Product

scholarly journals Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

2019 ◽  
Vol 20 (2) ◽  
pp. 341 ◽  
Author(s):  
Dik-Lung Ma ◽  
Chun Wu ◽  
Sha-Sha Cheng ◽  
Fu-Wa Lee ◽  
Quan-Bin Han ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Metal Complexes ◽  
Natural Product ◽  
Cancer Care ◽  
Cancer Therapies ◽  
The Future ◽  
Therapy Development ◽  
Enhanced Selectivity

Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.

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