Irritable Bowel Syndrome: The Most Common Presentation, Severity Ranking and Therapeutic Regimens among Patients Attending Outpatient

Background: Irritable bowel syndrome (IBS) is one of the most common GI disorders in people under 50 years of age.Objective: To Formulate an overview about demographics of IBS and patterns of presentation, to determine IBS patients severity ranking, and to recognize the main regimens with their patient satisfaction.Methods: This is a cross sectional clinical study that is conducted in Outpatient Consultant Internal Medicine Clinic in Al-Kindy Teaching Hospital from 11/12/2017 to 24/12/2017. The patients suffering from IBS are diagnosed by a consultant according to the symptom-based Rome criteria for functional GI disorders, by implementing a questionnaire collecting thorough information. 77 cases of IBS patients were collected (24 male and 53 female).Results: This study revealed that majority of patients were female (68.8%). Most of the patients were married, employees and housewives, aged between (20-30 yrs). Most patients use anxiolytics, muscle relaxants and proton pump inhibitor. There is a high IBS prevalence among low educational level (high school graduates and non-school graduates).Most patients in our study had constipation.Aggravating factors Psychological factors (stress) are intrinsically associated with IBS and symptoms in a large percentage of patients.Antispasmodics usage in our study show high effectiveness for IBS patients especially those with crampy abdominal pain and diarrhea.Conclusions: Diagnosing and managing IBS can be a big challenge since many drugs used to reduce symptoms and severity, but also, they could be unnecessary medication that could aggravate bowel symptoms and have adverse effects on the long term.

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Understanding of Irritable Bowel Syndrome among General practitioners in the Periphery of Lahore

10.53350/pjmhs211571776 ◽

2021 ◽

Vol 15 (7) ◽

pp. 1776-1778

Author(s):

Atif Masood ◽

Faisal Amin Baig ◽

Tahir Ullah Khan ◽

Naseeb ur Rehman Shah ◽

Maida Nazir ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Key Words ◽

General Practitioners ◽

Final Diagnosis ◽

Cross Sectional Study ◽

Sectional Study ◽

Rome Criteria ◽

Cross Sectional ◽

Irritable Bowel ◽

Patient’S History

Objective: To determine the understanding of irritable bowel syndrome among general practitioners in Lahore in terms of diagnosis and treatment. Study Design: Observational, cross sectional study. Place and Duration of Study: Department of Medicine, University of Lahore Teaching Hospital, Lahore from 1st October 2020 to 31st March 2021. Methodology: Two hundred and ninety eight patients from both urban and rural territory in Lahore were enrolled. Manning and Rome criteria were applied to establish diagnosis of irritable syndrome. Patient’s history, investigations and final diagnosis were recorded. After three months, patients were reassessed for final diagnosis and any alternative diagnosis if under consideration. Results: There were 180 (60.4%) females and 118 (39.6%) males with mean age of 34 years. About 70 patients presented with GIT complains were functional and 45 with organic problems. Out of 70 functional patients, 45 have irritable bowel syndrome. The condition was functional or organic quite inadequate and amounted to 56%. Conclusion: Majority of irritable bowel syndrome patients were either wrongly diagnosed by the general practitioners or inadequately treated. Key words: Irritable bowel syndrome (IBS), Functional and organic diarrhea

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Blastocystis sp. Carriage and Irritable Bowel Syndrome: Is the Association Already Established?

Biology ◽

10.3390/biology10040340 ◽

2021 ◽

Vol 10 (4) ◽

pp. 340

Author(s):

Fernando Salvador ◽

Beatriz Lobo ◽

Lidia Goterris ◽

Carmen Alonso-Cotoner ◽

Javier Santos ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Microscopic Examination ◽

Parasitic Infection ◽

Diagnostic Technique ◽

Control Group ◽

Cross Sectional ◽

Significant Difference ◽

Blastocystis Sp ◽

Irritable Bowel ◽

Asymptomatic Subjects

Background: The aim of the present study is to describe the occurrence of Blastocystis sp. detection among asymptomatic subjects and patients with irritable bowel syndrome in order to evaluate the potential association between irritable bowel syndrome and the parasitic infection. Methods: Cross-sectional study where adult patients with irritable bowel syndrome diagnosed according to Rome IV criteria were included. A control group was formed by asymptomatic subjects older than 18 years. Exclusion criteria were: immunosuppressive condition or having received any drug with demonstrated activity against Blastocystis sp. within the last 6 months before study inclusion. Epidemiological and clinical information was collected from all included participants. Two stool samples were obtained from all participants: one sample for microscopic examination and one sample for Blastocystis sp. PCR detection. Blastocystis sp. infection was defined by the positivity of any of the diagnostic techniques. Results: Seventy-two participants were included (36 asymptomatic subjects and 36 patients with irritable bowel syndrome). Thirty-five (48.6%) were men, and median age of participants was 34 (IQR 29–49) years. The overall rate of Blastocystis sp. carriage was 27.8% (20/72). The prevalence assessed through microscopic examination was 22.2% (16/72), while the prevalence measured by PCR was 15.3% (11/72). When comparing the presence of Blastocystis sp. between asymptomatic subjects and IBS patients, we did not find any statistically significant difference (36.1% vs. 19.4% respectively, p = 0.114). Conclusions: regarding the occurrence of Blastocystis sp., no differences were found between asymptomatic participants and patients with irritable bowel disease irrespective of the diagnostic technique performed.

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Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

Journal of Personalized Medicine ◽

10.3390/jpm11010035 ◽

2021 ◽

Vol 11 (1) ◽

pp. 35

Author(s):

Zahra A. Barandouzi ◽

Joochul Lee ◽

Kendra Maas ◽

Angela R. Starkweather ◽

Xiaomei S. Cong

Keyword(s):

Irritable Bowel Syndrome ◽

Gut Microbiota ◽

Alpha Diversity ◽

Diversity Indices ◽

Cross Sectional Study ◽

Caffeine Intake ◽

Caffeine Consumption ◽

Cross Sectional ◽

Food Components ◽

Irritable Bowel

The interplay between diet and gut microbiota has gained interest as a potential contributor in pathophysiology of irritable bowel syndrome (IBS). The purpose of this study was to compare food components and gut microbiota patterns between IBS patients and healthy controls (HC) as well as to explore the associations of food components and microbiota profiles. A cross-sectional study was conducted with 80 young adults with IBS and 21 HC recruited. The food frequency questionnaire was used to measure food components. Fecal samples were collected and profiled by 16S rRNA Illumina sequencing. Food components were similar in both IBS and HC groups, except in caffeine consumption. Higher alpha diversity indices and altered gut microbiota were observed in IBS compared to the HC. A negative correlation existed between total observed species and caffeine intake in the HC, and a positive correlation between alpha diversity indices and dietary fiber in the IBS group. Higher alpha diversity and gut microbiota alteration were found in IBS people who consumed caffeine more than 400 mg/d. Moreover, high microbial diversity and alteration of gut microbiota composition in IBS people with high caffeine consumption may be a clue toward the effects of caffeine on the gut microbiome pattern, which warrants further study.

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Risks of Major Mental Disorders and Irritable Bowel Syndrome among the Offspring of Parents with Irritable Bowel Syndrome: A Nationwide Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094679 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4679

Author(s):

Ta-Chuan Yeh ◽

Ya-Mei Bai ◽

Shih-Jen Tsai ◽

Tzeng-Ji Chen ◽

Chih-Sung Liang ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Mental Disorders ◽

Autism Spectrum ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Logistic Regression Models ◽

Early Implementation ◽

Increased Risk ◽

Nationally Representative ◽

Irritable Bowel

Irritable bowel syndrome (IBS) is a functional bowel disorder that is highly comorbid with mental disorders. However, few studies have examined the risk of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder, major depressive disorder (MDD), and schizophrenia in the offspring of parents with IBS. We used nationally representative cross-sectional survey data to analyze cross-generational transmission patterns of both IBS and major mental disorders. Odds ratio (OR) was calculated by using logistic regression models with adjustment for potential confounding factors. Offspring of parents with IBS were more likely to develop IBS themselves (OR = 2.41, 95% confidence interval (CI), 2.09–2.78), ADHD (OR = 1.33, 95% CI, 1.08–1.62), and MDD (OR = 1.32, 95% CI, 1.04–1.68) than the controls. Data stratification by parental sex revealed that paternal IBS increased risk of ADHD (OR = 1.34, 95% CI, 1.01–1.77) in the offspring, while maternal IBS increased the risk of MDD (OR = 1.51, 95% CI, 1.11–2.06). This is the first study to reveal parental IBS is associated with IBS, ADHD, and MDD among offspring, suggesting the necessity for early implementation of prevention strategies for at-risk children.

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