Pattern of tooth mobility in smokers and non-smokers with chronic periodontitis

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Athanasia Giannakoura ◽  
Eudoxie Pepelassi ◽  
Sotirios Kotsovilis ◽  
Georgios Nikolopoulos ◽  
Ioannis Vrotsos

2011 ◽  
Vol 12 (1) ◽  
pp. 52-59 ◽  
Author(s):  
AU Chaudhari ◽  
GN Byakod ◽  
PF Waghmare ◽  
VM Karhadkar

ABSTRACT Aim Background and objectives: IL-1β is a potent stimulator of bone resorption and has been implicated in the pathogenesis of periodontal destruction. Therefore, this study was designed to compare the levels of IL-1β of chronic periodontitis patients with the healthy subjects. Another objective of this study was to correlate IL-1β levels with the clinical parameters of the periodontal disease progression. Methods For this study, total 60 subjects were chosen (30- healthy and 30-chronic periodontitis). Simplified oral hygiene index (OHI-S), gingival index (GI), periodontal disease index (PDI), probing depth (PD), tooth mobility, bleeding on probing (BOP) were recorded for all the subject. Gingival crevicular fluid (GCF) was collected and subjected for ELISA for estimation of IL-1β Results At the periodontal diseased sites, the IL-1β levels increased at least 2-fold as compared with healthy subjects. This increase was highly significant (p = 0.0000). Within the test group, IL-1β levels correlated positively and significantly with PDI, PD, BOP and tooth mobility. The correlations of IL-1β with PD (p = 0.000) and IL-1β with BOP (p = 0.0004) were highly significant. Interpretation and conclusion These data suggest that amount of GCF IL-1β is closely associated with periodontal status. This relationship may be valuable in monitoring periodontal disease activity. Clinical significance It could be stated from this study on IL- 1β that there seem to be a strong correlation between periodontal tissue destruction and IL-1β. Furthermore IL-1β level could also differentiate between active and inactive periodontal lesions. How to cite this article Chaudhari AU, Byakod GN, Waghmare PF, Karhadkar VM. Correlation of Levels of Interleukin-1β in Gingival Crevicular Fluid to the Clinical Parameters of Chronic Periodontitis. J Contemp Dent Pract 2011;12(1):52-59.


Author(s):  
Wiworo Haryani ◽  

One of the non-communicable diseases that is becoming a very serious health problem today is hypertension which is known as the silent killer. Periodontal disease is an inflammatory disease associated with a small number of gram-negative anaerobic bacteria. These gram-negative anaerobic bacteria have the opportunity to become systemic diseases, including diabetes mellitus, cardiovascular disease and blood clotting problems. Cardiovascular diseases include coronary heart disease and hypertension. This study aims to analysis the relationship between tooth mobility due to chronic periodontitis and hypertension. Methods: analytic observational research with cross sectional design. The study was carried out on patients at the Dental Polyclinic of Dr. Moewardi Hospital Surakarta. The research sample was taken by purposive sampling technique, as many as 84 people. The independent variable in this study was tooth mobility due to chronic periodontitis, while the dependent variable was hypertension. Collecting data using a questionnaire, the OHI-S index examination sheet and the Community Periodontal Index (CPI). Data analysis using Kendall’s tau test. Results: the relationship between tooth mobility due to chronic periodontitis and hypertension showed that the p-value was 0.011 (p <0.05) Conclusion: there was a significant relationship between tooth mobility due to chronic periodontitis and hypertension.


2018 ◽  
Author(s):  
Yuko Kurushima ◽  
Pei-Chien Tsai ◽  
Juan Castillo Fernandez ◽  
Alexessander Couto Alves ◽  
Julia Sarah El-Sayed Moustafa ◽  
...  

ABSTRACTBackgroundGenetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms are malleable regulators of gene function that can change in response to genetic and environmental stimuli, thereby providing a potential mechanism for mediating risk effects in periodontitis. The aim of this study is to identify epigenetic changes across tissues that are associated with periodontal disease.MethodsSelf-reported gingival bleeding and history of gum disease, or tooth mobility, were used as indicators of periodontal disease. DNA methylation profiles were generated using the Infinium HumanMethylation450 BeadChip in whole blood, buccal, and adipose tissue samples from predominantly older female twins (mean age 58) from the TwinsUK cohort. Epigenome-wide association scans (EWAS) of gingival bleeding and tooth mobility were conducted in whole blood in 528 and 492 twins, respectively. Subsequently, targeted candidate gene analysis at 28 genomic regions was carried out testing for phenotype-methylation associations in 41 (tooth mobility) and 43 (gingival bleeding) buccal, and 501 (tooth mobility) and 556 (gingival bleeding) adipose DNA samples.ResultsEpigenome-wide analyses in blood identified one CpG-site (cg21245277 inZNF804A) associated with gingival bleeding (FDR=0.03, nominal p-value=7.17e-8), and 58 sites associated with tooth mobility (FDR<0.05) with the top signals inIQCEandXKR6. Epigenetic variation at 28 candidate regions (256 CpG-sites) for chronic periodontitis showed a strong enrichment for association with periodontal traits, and signals in eight genes (VDR, IL6ST, TMCO6, IL1RN, CD44, IL1B, WHAMM, andCXCL1) were significant in both traits. The methylation-phenotype association signals validated in buccal samples, and a subset (25%) also validated in adipose tissue.ConclusionsEpigenome-wide analyses in adult female twins identified specific DNA methylation changes linked to self-reported periodontal disease. Future work will explore the environmental basis and functional impact of these results to infer potential for strategic personalized treatments and prevention of chronic periodontitis.


2016 ◽  
Vol 1 (3) ◽  
pp. 190 ◽  
Author(s):  
Dewi L. Ichwana

Patients with periodontal disease can lead to severe tooth mobility so often complains of pain when eating, decreased chewing ability and functional occlusion. Tooth mobility is a movement in a horizontal or vertical direction and one of the most unpleased effects from periodontal disease. Basically, tooth mobility is not a disease that requires treatment, but it is a symptom of periodontal tissue morphology changes, so it became a challenge for dentists in making decisions to maintain proper care of the teeth. Recent studies improved the use of periodontal splint with fiber reinforced composite (FRC) or fiber composite may lead to a long-term prognosis of teeth mobility due to periodontal disase. The case report describes treatment of chronic periodontitis patients with splinting fiber composites as a method for stabilization of the lower anterior teeth providing aesthetics, comfort, improved functionality occlusion, mastication and a good prognosis.


2015 ◽  
Vol 19 (3) ◽  
pp. 145-149
Author(s):  
Diana-Cristala Nitescu ◽  
Sorina Solomon ◽  
Irina Ursarescu ◽  
Ioana Martu ◽  
Cristian Martu ◽  
...  

SummaryBackground and Aim: Substantial evidence supports an association between chronic infections/inflammation, and cancer. The aim of this study was to assess the effect of chronic periodontitis on head and neck squamous-cell carcinoma (HNSCC).Materials and Methods: The study population consisted of 46 patients, divided into two groups. Cases were patients diagnosed with primary HNSCC (n=26). Controls were all patients seen during the same period of time but negative for malignancy (n=20). The severity of periodontitis was assessed through clinical determination of the bleeding index, periodontal index, tooth mobility degree and alveolar bone loss (ABL) on standardized panoramic radiographs. All patients were asked to fill in a questionnaire regarding aspects of quality of life before the diagnostic was established.Results: Each millimetre of ABL was associated with >4-fold increased risk for HNSCC. The strength of the association was greatest in the oral cavity, followed by the oropharynx and larynx. The association persisted in subjects who never used tobacco and alcohol. Patients with periodontitis, whose bleeding and periodontal indices and tooth mobility values were higher, were more likely to have poorly differentiated oral cavity SCC than those without periodontitis (32.8% versus 11.5%; P = 0.038). The patients in the study group had higher values regarding the questionnaire points compared to those in the control group.Conclusions: This study suggests that chronic periodontitis is a risk factor for the development of HNSCC. These results have implications for practical and improved strategies for prevention, diagnosis, and treatment of HNSCC.


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