scholarly journals SUSTAINED RELEASE MATRIX DRUG DELIVERY SYSTEM: AN OVERVIEW

2021 ◽  
Vol 6 (9) ◽  
pp. 79-87
Author(s):  
Bagmar Anjali ◽  
Tikariya Komal
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Patient Compliance ◽  
Oral Delivery ◽  
Extended Release ◽  
Evaluation Studies ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Hydrophobic Polymers

Oral delivery of drugs is the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in formulation, etc. Sustained release constitutes are the dosage form that provides medication over an extended time or denotes that the system is able to provide some actual therapeutic control whether this is of a temporal nature, spatial nature or both. The objective of the study was to explore the necessity, advantages and various techniques of extended release matrix tablet to get a constant drug delivery rate and reproducible kinetics for advance delivery. Matrix tablets are the type of controlled drug delivery systems, which release the drug in continuous manner by dissolution controlled as well as diffusion controlled mechanisms. To control the release of the drugs, which are having different solubility properties, the drug is dispersed in swellable hydrophilic substances, an insoluble matrix of rigid non swellable hydrophobic materials or plastic materials. Matrix tablets can be formulated by either direct compression or wet granulation method by using a variety of hydrophilic or hydrophobic polymers. The extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases. This review highlights the types of matrices, mechanisms involved and evaluation studies.

scholarly journals A COMPREHENSIVE REVIEW ON SUSTAINED RELEASE MATRIX TABLETS: A PROMISING DOSAGE FORM

2019 ◽  
Author(s):  
Agarwal Prakhar ◽  
Akhtar Semimul
Keyword(s):  
Drug Delivery ◽  
Dosage Form ◽  
Extended Release ◽  
Evaluation Studies ◽  
Porous Matrix ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Hydrophobic Polymers

Oral ingestion is most convenient and commonly employed route of drug delivery due to its ease of administration, least aseptic and flexibility in the design of dosage form. The objective of the study was to explore the necessity, advantages and various techniques of extended release matrix tablet to get a constant drug delivery rate and reproducible kinetics for advance delivery. Different types of extended release matrix tablet have been explained briefly along with the various formulation which mainly by wet granulation or direct compression method or by dispersion of solid particle within a porous matrix formed by using different polymers. Matrix controls the free rate of drug. Matrix tablets can be formulated by either direct compression or wet granulation method by using a variety of hydrophilic or hydrophobic polymers. The extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases. This review highlights the types of matrices, mechanisms involved and evaluation studies.

scholarly journals The Effect of Manufacturing Methods and Different Shapes on the Release Pattern of Diclofenac Sodium Matrix Tablet

1970 ◽  
Vol 2 (2) ◽  
pp. 76-80
Author(s):  
Tajnin Ahmed ◽  
Muhammad Shahidul Islam ◽  
Tasnuva Haque ◽  
Mohammad Abusyed
Keyword(s):  
Sustained Release ◽  
Release Rate ◽  
Diclofenac Sodium ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Compression Method ◽  
Release Pattern ◽  
Peg 600

In the present study sustained release diclofenac sodium matrix tablets were prepared using Kollidon SR polymer. Hydroxypropyl methylcellulose (HPMC 15 cps) and poly ethylene glycol (PEG-600) polymers respectively were used in formulating tablets prepared by direct compression and wet granulation methods. The polymers were used to explore the release pattern of the drug into the dissolution media. The tablets were also prepared in various shapes (caplet oval, round oval and flat oval). A comparatively higher release rate of drug was obtained from the polymer HPMC 15 cps at 10% concentration for directly compressed matrix tablet than those containing 20% of HPMC after a definite period of time. In wet granulation process, 10% PEG-600 containing tablets showed a better release than those containing 20% PEG. The drug release was also found to be sustained in case of wet granulation method than that of the direct compression method. Again the caplet shaped tablets in case of direct compression method showed better release rate of drug than those of the round oval and flat oval shaped tablets. Thus the result of this study shows that the proper selection of the percentage of polymer and the suitable shape of tablet and proper manufacturing method can provide a greater opportunity in designing sustained release dosage forms. Key words: Matrix tablet; release pattern; direct compression; wet granulation; PEG 600; Kollidon SR.DOI: 10.3329/sjps.v2i2.5828Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 76-80

scholarly journals Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets: Influence of Some Hydrophillic Polymers on the Release

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Amitava Roy ◽  
Kalpana Roy ◽  
Sarbani Roy ◽  
Jyotirmoy Deb ◽  
Amitava Ghosh ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Hydroxypropyl Methylcellulose ◽  
Dissolution Kinetics ◽  
Matrix Tablets ◽  
Metformin Hydrochloride ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Response Surface Optimization

The aim of the present work was designed to develop a model-sustained release matrix tablet formulation for Metformin hydrochloride using wet granulation technique. In the present study the formulation design was employed to statistically optimize different parameters of Metformin hydrochloride tablets at different drug-to-polymer ratios employing polymers Hydroxypropyl methylcellulose of two grades K4M and K100M as two independent variables whereas the dependent variables studied were X60, X120, T50, T90, n, and b values obtained from dissolution kinetics data. The in vitro drug release studies were carried out at simulated intestinal fluids, and the release showed a non-Fickian anomalous transport mechanism. The drug release was found to reveal zero order kinetics. The granules and the tablets were tested for their normal physical, morphological, and analytical parameters and were found to be within the satisfactory levels. There were no significant drug-polymer interactions as revealed by infrared spectra. It has been found out that on an optimum increased Hydroxypropyl methylcellulose K100M concentration and decreased Hydroxypropyl methylcellulose K4M concentration the formulations were elegant in terms of their release profiles and were found to be statistically significant and generable.

scholarly journals Formulation and Evaluation of Gabapentin Sustained Release Matrix Tablet Using Hibiscus rosa sinensis Leaves Mucilage as Release Retardant

2021 ◽  
pp. 564-572
Author(s):  
P. Amsa ◽  
G. K. Mathan ◽  
S. Magibalan ◽  
E. K. Velliyangiri ◽  
T. Kalaivani ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Magnesium Stearate ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Hibiscus Rosa Sinensis

The major goal of this study was to develop and evaluate Sustained release matrix tablets of Gabapentin with Hibiscus rosa - sinensis leaves mucilage prepared by using wet granulation technique with microcrystalline cellulose as a diluents and magnesium stearate as a lubricant. Pre-compression and post-compression evaluation of physicochemical parameters were carried out and to be within acceptable limits. Drug and polymer compatibility were validated by FTIR measurements. Further, tablets were evaluated for in vitro release study. To get the sustained release of Gabapentin, the concentration of Hibiscus rosa- sinensis mucilage was tuned with a gas-generating agent. The % drug release of all formulation from F1 to F5 showed 91.24%, 80.24%, 70.53%, 62.12% and 49.83% respectively. All the dosage form release kinetics was computed using zero order, first order, Higuchi, and Korsmeyer–Peppas methods. From the above results, it is concluded that the n value of formulation F5 showed 0.78 suggesting anomalous (non-fickian) behavior of the drug. Mucilage from the leaves of Hibiscus rosa-sinensis has a great retarding effect in drug release from sustained release tablets.

scholarly journals FORMULATION AND EVALUATION OF NIFEDIPINE SUSTAINED RELEASE TABLETS BY USING DIFFERENT POLYMERS

2019 ◽  
Vol 8 (5) ◽  
Author(s):  
Shraddha Pawan Pareek ◽  
Sunil Kumawat ◽  
Vijay Sharma ◽  
Devender Sharma ◽  
Devendra Singh Rathore
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Oral Delivery ◽  
Oral Drug Delivery ◽  
Pharmaceutical Products ◽  
Matrix Tablets ◽  
Oral Drug ◽  
Release Formulation ◽  
Therapeutic Benefits ◽  
Sustained Release Tablets

Oral drug delivery has been known for many years because the most generally utilized route of administration among all the routes that are explored for the general delivery of medication via various pharmaceutical products of different dosage forms.  The reason that the oral route achieved such quality could also be partly attributed to its simple administration moreover because the ancient belief that by oral administration the drug is well absorbed because the food stuffs that area unit eaten daily. In fact the event of a pharmaceutical product for oral delivery, no matter its physical kind involves variable extents of optimization of dose kind characteristics at intervals the inherent constraints of GI physiology.  The rationale for development of a extended release formulation of a drug is to enhance its therapeutic benefits, minimizing its side effects while improving the management of the diseased condition. The aim of the present investigation is to formulate and evaluate matrix tablets of Nifedipine using a mixture of polymers in view to sustain the drug release, reduce frequency of administration and improved patient compliance. In this research paper all evaluation parameter and stability studies also well discussed in well manner. Keyword: Matrix Tablets, Coating, Novel Drug Delivery System, Sustained Release Tablets

scholarly journals Formulation of Sustained-Release Matrix Tablet of Rotundin Sulfat

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Do Thi Ha ◽  
Nguyen Thanh Hai ◽  
Tran Thi Van Anh ◽  
Ha Thanh Hoa ◽  
Pham Thi Minh Hue
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Hydroxypropyl Methylcellulose ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Viet Nam ◽  
Pharmaceutical Sciences ◽  
Release Process ◽  
Tablet Hardness

Sustained-release matrix tablets containing rotundin sulfat are prepared by a wet granulation method. The influence of Metholose 100.000 RS,  4000 SR, Avicel PH101, lactose and tablet compression force on the ability to release rotundin from the tablets has been evaluated. Modde 8.0 software was used in the experiment. The influencing factors were evaluated by software FormRules v2.0 and the optimal formula predicted by the INForm v3.1 was optimized. The selected optimal formulation of rotundin sulfate tablets for a drug release process lasting 8 hours contained Metholose 100.000 RS 120 mg; Avicel PH101 24.0 mg; lactose 34.5 mg; and 8 kP tablet hardness. Keywords Rotundin sulfat, matrix tablet, sustained release, optimizing. References [1] Đỗ Tất Lợi, Những cây thuốc và vị thuốc Việt Nam, NXB Thời Đại (2011), 779. [2] Nguyễn Minh Chính và CS, Nghiên cứu tách chiết rotundin để sản xuất thuốc tiêm rotundin sulfat, Tạp chí Y Dược học Quân sự. 1 (1999) 55-56. [3] Nguyễn Thanh Hải, Bùi Thanh Tùng, Phạm Thị Minh Huệ (2017), Phỏng sinh học trong y dược học – Hướng nghiên cứu cần đẩy mạnh, Tạp chí khoa học ĐHQGHN, Khoa học Y Dược. 33(1) (2017) 1-4. [4] Bộ Y tế, Dược điển Việt Nam V, Nhà xuất bản Y học, 1 (2017), 842-844. [5] M. Levina, A.R. Rajabi-Siaboomi, The influence of excipients on drug release from hydroxypropyl methylcellulose matrices, Journal of Pharmaceutical Sciences. 93(11) (2004) 2746-2754. [6] Nguyễn Minh Chính, Nguyễn Thị Hồng Thắm, Nguyễn Văn Bạch, Tối ưu hóa công thức bào chế viên nén rotundin sulfat giải phóng kéo dài, Tạp chí Y Dược học Quân sự. số CĐ Dược (2016), 61-67. [7] N. Aruna, K.M. Babu, Formulation and evaluation of sustained release matrix tablets containing metformin HCl and Syzygium cumini, International Journal of Pharmaceutical and Biological Archive. 2(3) (2011), 900-905. [8] B.J. Lee, et al, Formulation and release charecteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin, Drug Development and Industrial Pharmacy. 25 (1999) 493-501.[9] A. Nokhochi, J.L. Ford, P. Rowe, et al, The e ffects of compression rate and force on the compaction properties of different viscosity grades of hydroxypropyl methylcellulose 2208, International Journal of Pharmaceutics. 129 (1996), 21-31.  

Formulation and Evaluation of Tramadol Hydrochloride Sustained Release Matrix Tablets

2018 ◽  
Vol 8 (3) ◽  
Author(s):  
B Sai Adithya ◽  
Gulshan Mohammad ◽  
Rama Rao Nadendla
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Patient Compliance ◽  
Oral Drug Delivery ◽  
The Body ◽  
Matrix Tablets ◽  
Angle Of Repose ◽  
In Vitro Dissolution ◽  
Oral Drug ◽  
Tramadol Hydrochloride

The ultimate goal of any oral drug delivery system is the successful delivery of the drug, in which almost 90% of the drugs are administered to the body for the treatment of various disorders and diseases as it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. The aim of the present study is to formulate sustained release matrix tablets of a model drug (Tramadol hydrochloride) using HPMC 100 MCR, HPC and EC 7cps as rate retarding polymers, microcrystalline cellulose as bulking agent, magnesium stearate as lubricant and aerosil as glidant. Drug and polymer interactions were evaluated by using FTIR and DSC. The FTIR spectrum and DSC thermograms stated that drug and polymer are compatible to each other. Tablets were prepared by direct compression technique. The micromeritic properties of formulation mixtures of all the formulations were carried out and they were found to be as angle of repose (31.150- 40.100), bulk density (0.310g/ml-0.337g/ml), tapped density (0.355g/ml-0.59g/ml), Carr’s index (8.11%-15.3%), Hausner’s ratio (1.08-1.18) which are within the limits. The formulated tablets were physically acceptable and exhibited acceptable weight variation, friability. In vitro dissolution studies were carried out using USP type-II dissolution apparatus and of all the formulations F6 (containing HPMC and HPC in equal proportions) exhibited prolonged drug release for about 8 hrsas per the objective of the work. The percent drug content varied between 88% to 99%. It can be concluded from the study that the sustained release tablets can be better alternative over immediate release tablets by improving patient compliance and reducing frequency.

scholarly journals Formulation and evaluation of sustain released matrix tablet of atenolol

2019 ◽  
Vol 9 (1) ◽  
pp. 183-189 ◽  
Author(s):  
Sonal Sahu ◽  
Rohit Dangi ◽  
Rohit Patidar ◽  
, Rukhsaar ◽  
Jagdish Rathi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dosage Form ◽  
Oral Route ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Natural Polymer ◽  
Flexible Design ◽  
Weight Variation

Oral route is one of the most popular routes of drug delivery due to its ease of administration, patient compliance, least sterility constraints and flexible design of dosage form. The aim of present investigation was to develop matrix tablets of atenolol using different polymers. Atenolol matrix tablets were prepared by direct compression and wet granulation method using different polymers. All the formulations were evaluated for weight variation, thickness, hardness, friability and dissolution. Tablets of atenolol were prepared utilizing natural polymer chitosan. The formulation F-2 contained chitosan which might have sustained the release since it is also known for its polymeric sustaining effect. The formulation F-2 gave 89.57±0.24% of the drug release in 12 hrs of study. Keywords: Atenolol, Sustained release Matrix tablets, Direct compression, Wet granulation method.

scholarly journals FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE SUSTAINED-RELEASE ORAL MATRIX TABLETS

2018 ◽  
Vol 11 (3) ◽  
pp. 342
Author(s):  
Padmaja Bookya ◽  
Ramakrishna Raparla ◽  
Ramakrishna Raparla ◽  
Harikishan Prasad Sriramula ◽  
Ramakrishna Raparla ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Xanthan Gum ◽  
Matrix Material ◽  
Matrix Tablets ◽  
Drug Dissolution ◽  
Metformin Hydrochloride ◽  
Wet Granulation ◽  
Content Uniformity ◽  
Matrix Tablet

 Objective: The aim of this investigation was to develop and optimize metformin hydrochloride matrix tablets for sustained release application. The sustained release matrix tablet of metformin hydrochloride was prepared by wet granulation technique using chitosan, xanthan gum, and hydroxypropyl methylcellulose at varying concentrations.Material and Methods: Extended release of metformin hydrochloride matrix tablets was prepared by wet granulation method. The influence of varying the polymer ratios was evaluated. The excipients used in this study did not alter physicochemical properties of the drug.Results: All the batches were evaluated for thickness, weight variation, hardness, and drug content uniformity. The in vitro drug dissolution study was carried out using USP apparatus Type II, paddle method, and the release mechanisms were explored. Mean dissolution time is used to characterize drug release rate from a dosage form and indicates the drug release is retarding efficiency of the polymer. This study revealed that as the concentration of matrix material increased, drug release from matrices decreased. This may be due to slower penetration of the dissolution medium into the matrices.Conclusion: Formulation with chitosan MS1 drug release was 86%, xanthan gum MS489%, and finally MS7 with hydroxypropyl methyl cellulose which exhibited the highest drug release retardation also had the lowest matrix concentration. Hence, lower concentration of polymers is suitable to prepare metformin hydrochloride tablets compared to higher concentrations.

Effects of release modifier on Carvedilol release from Kollidon SR based matrix

2012 ◽  
Vol 1 (8) ◽  
pp. 186 ◽  
Author(s):  
Urmi Das ◽  
Mohammad Salim Hossain
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Microcrystalline Cellulose ◽  
Matrix Tablets ◽  
Dissolution Time ◽  
Release Mechanism ◽  
Matrix Tablet ◽  
Weight Variation ◽  
The Matrix ◽  
Tablet Formulations

<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 186-192</p>

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