Glycemic Control Comparative of Metformin and Glimepiride in Monotherapy of Type 2 Diabetes Mellitus Patient at Islamic Jemursari Hospital Surabaya in 2018

2021 ◽  
Vol 71 (1) ◽  
pp. 24-29
Author(s):  
Rachma Putri Nariswari ◽  
Gwenny Ichsan Prabowo ◽  
Hermina Novida ◽  
Nurina Hasanatuludhhiyah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Adult Population ◽  
Secondary Data ◽  
Diabetes Mellitus Patient ◽  
Significant Difference ◽  
Tissue Sensitivity

Introduction: Type 2 diabetes mellitus is caused by decreased tissue sensitivity to insulin. The prevalence of diabetes in the world has almost doubled since 1980, from 4.7% to 8.5% in adult population. Early diagnosis and treatment aimed at normalizing glycemic control are very important. The objective of this study was to evaluate and compare glycemic control of metformin and glimepiride in monotherapy of type 2 diabetes mellitus patients at Islamic Jemursari Hospital Surabaya. Method: This was a retrospective observational study using secondary data (medical record), include glycemic control (RPG) before and two months after receiving therapy of outpatients’ type 2 diabetes mellitus with metformin or glimepiride therapy in 2018. 96 samples were found that fit the inclusion criteria. The data were analyzed by Mann-Whitney test. Result: Most patients were female, aged 50-69 years old, and dosage of metformin therapy 1500 mg/day or glimepiride therapy 2 mg/day. There was no significant difference (p>0.05) of glycemic control (RPG) of metformin compared to glimepiride therapies in type 2 diabetes mellitus patients at Islamic Jemursari Hospital Surabaya in 2018. Conclusion: Metformin and glimepiride were not significantly different in glycemic control (RPG). There were patients with RPG >200 mg/dl after two months of metformin or glimepiride therapy.  

scholarly journals Cardiovascular Responses Of Type 2 Diabetes Patients To Intermittent And Continous Aerobic Exercises

2007 ◽  
Author(s):  
Mukadas O Akindele ◽  
Phillip Kodzo ◽  
Mustapha Naimat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Aerobic Exercise ◽  
Intermittent Exercise ◽  
Cardiovascular Responses ◽  
Exercise Group ◽  
Significant Difference

Background: The use of aerobic exercise as a form of glycemic control in type 2 diabetes mellitus has been well documented in the literatures. High blood pressure has been shown to be one of the sequelae of type 2 diabetes mellitus. Determination of mode of exercises for glycemic control that will not adversely affect the cardiovascular indices of type 2 diabetes mellitus subjects is highly indicated. Objective: The purpose of this study was to determine the acute cardiovascular responses of type 2 diabetes mellitus subjects to continuous and intermittent modes of exercises. Results: There was statistical significant difference in heart rate of both groups. Continuous mode of exercise elicited no statistical difference in SBP and DBP but there was statistical significant difference in SBP in intermittent exercise group with no statistical significant in their DBP. Cross comparison of pre and post cardiovascular indices showed that there were statistical significant differences in SBP (F=0.710, P>0.05) and DBP (F=1.397, P>0.05). Conclusion: Cardiovascular responses of type 2 diabetes mellitus subjects were higher in intermittent exercise group compared with the continuous exercise group. KEYWORDS: Type 2 diabetes mellitus, Aerobic exercise, cardiovascular response.

scholarly journals The insulin resistance indices: necessity and opportunities in type 2 diabetes mellitus management

2020 ◽  
Vol 96 (7) ◽  
pp. 529-535
Author(s):  
Yu. A. Sorokina ◽  
O. V. Zanozina ◽  
A. D. Postnikova
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Clinical Practice ◽  
Glycemic Control ◽  
Metabolic Disorders ◽  
Glycosylated Hemoglobin ◽  
Tissue Sensitivity

The article provides a review of the literature on the possibilities of using various indices of insulin resistance in type 2 diabetes (T2DM) treatment. The main mechanisms of insulin resistance and its role in the formation of type 2 diabetes mellitus and other metabolic disorders are described. The main indices of insulin resistance, used in real clinical practice nowadays, are considered. Methods of their calculation are given. The effect of metformin and incretin active medications on insulin resistance is described. It was shown that the combination of these medications improves tissue sensitivity to insulin in patients with T2DM. Standard indicators for assessing glycemic control, such as fasting glucose and glycosylated hemoglobin (HbA1c), do not reflect the patient’s lipid metabolism. The use of insulin resistance assessment indices in patients with type 2 diabetes mellitus allows both, exercising glycemic control, and the metabolic disorders, often associated with carbohydrate metabolism disorders, monitoring. Using insulin resistance indices, it is possible to select the optimal treatment regimen for type 2 diabetes mellitus for a particular patient, to predict and evaluate the effectiveness of treatment in dynamics. Simple, generally available laboratory indicators and anthropometric data are used to calculate the indices of insulin resistance, and they are easy to measure. In this regard, the use of insulin resistance indices is possible in routine clinical practice.

scholarly journals KADAR PEROKSIDA LIPID DAN AKTIVITAS SUPEROKSIDA DISMUTASE SERUM DARAH PADA PENDERITA DIABETES MELITUS TIPE 2

Jurnal BIOMA ◽  
2015 ◽  
Vol 11 (1) ◽  
pp. 1
Author(s):  
HENI KRISTINA ◽  
NURMASARI SARTONO ◽  
RUSDI RUSDI
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Superoxide Dismutase ◽  
Type 2 Diabetes Mellitus ◽  
Correlation Coefficient ◽  
Diabetes Mellitus Patient ◽  
Cross Sectional ◽  
Ex Post ◽  
Significant Difference

ABSTRACT Prevalence of type 2 diabetes mellitus rapidly increase in industry and developing country. Oxidative stress was estimated has role in development of type 2 diabetes mellitus. This study was aim to measure levels of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in type 2 diabetes mellitus, and also to analyse the relationship among both. This study was conducted on July-October 2014, using Ex Post Facto method and cross sectional design. The result showed that MDA serum levels significantly higher in diabetes mellitus patient compare to normal (P=0,000). Activity of superoxide dismutase (SOD) in diabetes mellitus serum has no significant difference with normal (P=0,290).There was possitive correlation between levels of MDA and activity of SOD in type 2 diabetes mellitus but not significant (P=0,478) with rs=0,199, thus also in normal subject (P=0,194) with rs=0,355. There was no significant different between two correlation  coefficient  (P=0,6781).  In  conclusion,  there was significant different level of MDA, there was no significant different activity of SOD, there was positive correlation but not significant between levels of MDA and activity of SOD serum in type 2 diabetes mellitus and normal. And there was no significant different between two correlation coefficient.   Keywords: malondialdehyde, superoxide dismutase, type 2 diabetes mellitus

scholarly journals An evaluation of type 2 diabetes mellitus patients on different oral antidiabetic medications with regard to glycemic control and diabetic complications

2019 ◽  
Vol 6 (9) ◽  
pp. 180-185
Author(s):  
Erhan Önalan ◽  
Nevzat Gozel ◽  
Burkay Yakar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Diabetic Complications ◽  
Type 2 Dm ◽  
Oral Antidiabetic ◽  
Metformin Monotherapy ◽  
Significant Difference

Objective:  Diabetes Mellitus is a chronic and progressive disease that significantly impairs the workforce and economy due to its complications. This study aims to evaluate patients diagnosed with type 2 diabetes mellitus who use different oral antidiabetic medications with regard to glycemic control and diabetic complications. Materials and Methods: This study included 200 patients who were being followed-up for a diagnosis of Type 2 DM. Results: Of the 200 patients included in the study, 131 were on metformin monotherapy and 69 were on metformin and gliclazide combination therapy. HbA1c value of Metformin monotherapy prescribed patients was7,6%±1,5, metformin+gliclazide prescribed patients was 8,2%±1,9. There was a statistically significant difference between the two groups in terms of blood glucose levels (p<0.05). There was no significant difference between the two groups with regard to microvascular complications and body mass index. Conclusion: Our study determined that the level of glycemic control manifested by Type 2 DM patients was suboptimal despite using different types of oral antidiabetics and that their body mass indices were high. We reached the conclusion that the present situation is linked to factors such as incorrect dietary habits, inadequate exercise and walking, failure to comply with the medical treatment suggested by the physician, and lack of awareness about the severity of the disease.

scholarly journals The prevalence of type 2 diabetes mellitus in the adult population of Russia (NATION study)

2016 ◽  
Vol 19 (2) ◽  
pp. 104-112 ◽  
Author(s):  
Ivan I. Dedov ◽  
Marina V. Shestakova ◽  
Gagik R. Galstyan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Rural Areas ◽  
Urban Areas ◽  
Adult Population ◽  
Geographic Region ◽  
Haemoglobin A1c ◽  
Significant Difference

Aim. To estimate the prevalence of type 2 diabetes mellitus (T2DM) in Russian adults.Materials and methods. NATION was a national, epidemiological, observational, cross-sectional study. The sample of adults (20–79 years old) was stratified by age, sex, geographic region and settlement type to obtain a representative sample. Recruitment was performed in public areas with large number of people. T2DM was diagnosed by glycated haemoglobin A1c (HbA1c) levels (diabetes: HbA1c≥6.5%; pre-diabetes: HbA1c≥5.7% to 6.5%). Socio-demographic and anthropometric data were collected.Results. Blood samples from 26,620 subjects were available. Overall, 5.4% were diagnosed with T2DM (2.5% were previously diagnosed and 2.9% were previously undiagnosed); 19.3% were pre-diabetic. T2DM prevalence increased with age (up to 70 years), and no significant difference was revealed between females and males (5.6% vs. 5.1%). The estimated prevalence of pre-diabetes and T2DM tended to increase with increasing BMI. T2DM prevalence varied by geographic region and was higher in rural areas than in urban areas (6.7% vs. 5.0%, p 0.001).Conclusion. Approximately one in five adult Russians had pre-diabetes, 5.4% had T2DM and about half of the diabetic subjects were previously undiagnosed. These results demonstrate the need for new programs in the Russian Federation to predict, prevent and manage T2DM.

Weight Outcomes With Empagliflozin as Compared With Liraglutide in Veterans With Type 2 Diabetes Mellitus

2020 ◽  
Vol 54 (10) ◽  
pp. 981-987
Author(s):  
Ted Robert Grabarczyk ◽  
Natalie Koury Wissman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Sodium Glucose Cotransporter ◽  
Significant Difference ◽  
Weight Outcomes ◽  
Glucagon Like Peptide 1

Background: Glucagon-like peptide-1 agonists and sodium glucose cotransporter 2 inhibitors are associated with weight loss and improved cardiovascular outcomes, and are increasingly used in pharmacotherapy for type 2 diabetes mellitus (T2DM). Objectives: To compare weight loss outcomes of empagliflozin and liraglutide in patients with T2DM and overweight/obesity not yet prescribed insulin but requiring additional pharmacotherapy to improve glycemic control. Methods: This is an observational, multisite, cohort study of veterans with T2DM prescribed liraglutide or empagliflozin. Participants were prescribed either empagliflozin or liraglutide prior to November 1, 2017, had a hemoglobin A1C (A1C) ≥7.0%, had a body mass index ≥27 kg/m2, and were not treated with insulin at baseline. The primary outcome was change in weight after 1 year using multiple regression. Secondary outcomes were the proportion achieving ≥5% weight loss and change in A1C. Results: Weight loss was not significantly different between groups: −2.17 kg (95% CI: −2.91 to −1.42) in the liraglutide group (n = 298) and −2.81 kg (95% CI: −3.43 to −2.20) in the empagliflozin group (n = 247; P > 0.05). After adjusting for covariates, this effect remained nonsignificant. There was no difference in change in A1C between liraglutide (−0.83%; 95% CI: −1.05% to −0.62%) and empagliflozin (−0.71%; 95% CI: −0.89% to −0.53%; P > 0.05). Conclusions and Relevance: There was no significant difference in weight outcomes after 1 year in veterans treated with liraglutide versus empagliflozin. Because both medications did show modest weight loss, both remain good options for patients needing an additional medication to improve glycemic control that is at least weight neutral.

scholarly journals Analisis Estimasi Biaya Langsung Medis Penderita Rawat Jalan Diabetes Mellitus Tipe 2 di RSUD Dr. Abdul Aziz Singkawang Tahun 2013

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
Mursalin 1976 ◽  
Prastuti Soewondo
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Outpatient Care ◽  
Secondary Data ◽  
Medical Costs ◽  
Cost Of Care ◽  
Direct Medical Costs ◽  
Significant Difference

AbstrakDiabetes Mellitus merupakan penyakit epidemik yang menjadi ancaman global. Selain tingkat morbiditas dan mortalitas yang tinggi, juga menyebabkan sebagian besar negara di dunia mengeluarkan anggaran kesehatan yang besar. Penelitian ini bertujuan untuk menghitung besarnya biaya langsung medis dan faktor-faktor yang mempengaruhinya pada penderita rawat jalan diabetes mellitus tipe 2. Penelitian dilaksanakan pada bulan Januari – Februari 2015 di RSUD dr. Abdul Aziz Singkawang, Kalimantan Barat. Jenis penelitian ini adalah kuantitatif analitik dengan menggunakan data sekunder yang dikumpulkan secara retrospektif berdasarkan data tahun 2013 dengan jumlah sampel sebanyak 200. Hasil analisis multivariat, terdapat perbedaan yang signifikan biaya langsung medis pada setiap tipe penatalaksanaan, lama sakit dan komplikasi yang dialami penderita. Upaya promotif dan preventif perlu ditingkatkan untuk mencapai efektivitas dan efisiensi pengobatan dan meningkatkan kualitas hidup penderita. AbstractDiabetes mellitus has epidemic diseases that seriously global threated. Except, hight level of morbidity and mortality, its also caused most countries in the world spend a lot of money for health care. This study purpose to count direct medical costs and factors of influence on type 2 diabetes mellitus outpatient care. This study conduct on January to February 2015 in RSUD dr. Abdul Aziz Singkawang at West Kalimantan. Design study used cuantitative analysis by secondary data that retrospectively collected on 2013 data and number of samples are 200. Result of multivariate analysis, there were significant difference means of direct medical costs of type 2 diabetes mellitus outpatient care on type of care, diseases duration, and complication. Health promotion and prevention on type 2 diabetes mellitus intervention must be increasingly to achieve effective and efficient cost of care and to increase patient’s quality of life.

scholarly journals Correlation between glycemic control and dyslipidemia in Type 2 Diabetes Mellitus patient

2019 ◽  
Vol 8 (6) ◽  
pp. 1387
Author(s):  
Neha Yadav ◽  
Sujata Singh ◽  
Smita Gupta ◽  
Saurabh Mishra ◽  
Krishna Singh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Correlation Coefficient ◽  
Positive Correlation ◽  
Group Iii ◽  
Group I ◽  
Significant Difference

Background: India is one of the countries with highest number of diabetes patients. Patients of type 2 diabetes mellitus are usually dyslipidemic. The objective of the research was to study the pattern of dyslipidemia and to study the correlation of glycemic control with dyslipidemia in type 2 diabetes mellitus patients.Methods: A cross sectional observational study was performed on patients of type 2 diabetes mellitus over 6 months period. The study included 200 patients and the variables recorded were demographic profile, FBS, PPBS, HbA1C and lipid profile parameters. The patients were divided into 3 groups according to HbA1C level i.e. Group I (Good glycemic control HbA1C 6-7 gm%), group II (Fair glycemic control HbA1C 7.1-8.2 gm%) and group III (poor glycemic control, HbA1C >8.2 gm%).Results: The data showed that TG level was maximum in group III and was minimum in group I. Comparison between the group shows a significant difference between all the groups (P <0.001). A significant positive correlation (Correlation coefficient 0.67, P <0.001) was also observed between level of TG and HbA1C. Similarly, LDL level was also highest in group III with a significant difference with other two groups (P <0.05). Also, a positive correlation (Correlation coefficient 0.64, P <0.05) was observed between LDL and HbA1C. On the other hand, HDL was lowest in group III as compared to groups I and II (P <0.001) and a negative correlation (Correlation coefficient -0.716, P <0.001) was seen between HDL and HbA1C.Conclusions: Dyslipidemia is less prevalent in diabetics who have better glycemic control.

scholarly journals GLYCEMIC CONTROL MODIFIES THE ASSOCIATION BETWEEN MICROALBUMINURIA AND C-REACTIVE PROTEIN IN TYPE 2 DIABETES MELLITUS

2020 ◽  
pp. 4-5
Author(s):  
Krishkumar A. Jivani
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Diabetes Mellitus Patient ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Type 2 Diabetics ◽  
Group 2

BACKGROUND: HbA1c is most commonly used parameter for glycemic control in type 2 diabetes mellitus patient. AIM The aim of the study was to evaluate whether any association exists between C-reactive protein and microalbuminuria in well controlled and poorly controlled Type 2 DM patients. METHOD : In this study, we included total 90 patients of type 2 Diabetes Mellitus admitted in GKGH , Bhuj during the period from Aug. 2018 to June 2019. The subjects were divided into two groups according to glycemic control as Group 1(Poorly controlled Diabetics) and Group 2( Well controlled Diabetics ) The groups 1 and 2 (based on Glycemic control) were further divided into 3 subgroups A, B and C (based on CRP level) with 15 subjects in each of these six subgroups. RESULT: Subjects with poor glycemic control had elevated values of MAU at all comparative levels of CRP. Further, it was shown that the level of MAU increased considerably with increasing level of CRP. CONCLUSION : There is a significant positive correlation between the level of MAU and CRP status in poorly controlled Type 2 diabetics.

Sign in / Sign up

Export Citation Format

Share Document