scholarly journals KADAR PEROKSIDA LIPID DAN AKTIVITAS SUPEROKSIDA DISMUTASE SERUM DARAH PADA PENDERITA DIABETES MELITUS TIPE 2

Jurnal BIOMA ◽  
2015 ◽  
Vol 11 (1) ◽  
pp. 1
Author(s):  
HENI KRISTINA ◽  
NURMASARI SARTONO ◽  
RUSDI RUSDI
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Superoxide Dismutase ◽  
Type 2 Diabetes Mellitus ◽  
Correlation Coefficient ◽  
Diabetes Mellitus Patient ◽  
Cross Sectional ◽  
Ex Post ◽  
Significant Difference

ABSTRACT Prevalence of type 2 diabetes mellitus rapidly increase in industry and developing country. Oxidative stress was estimated has role in development of type 2 diabetes mellitus. This study was aim to measure levels of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in type 2 diabetes mellitus, and also to analyse the relationship among both. This study was conducted on July-October 2014, using Ex Post Facto method and cross sectional design. The result showed that MDA serum levels significantly higher in diabetes mellitus patient compare to normal (P=0,000). Activity of superoxide dismutase (SOD) in diabetes mellitus serum has no significant difference with normal (P=0,290).There was possitive correlation between levels of MDA and activity of SOD in type 2 diabetes mellitus but not significant (P=0,478) with rs=0,199, thus also in normal subject (P=0,194) with rs=0,355. There was no significant different between two correlation  coefficient  (P=0,6781).  In  conclusion,  there was significant different level of MDA, there was no significant different activity of SOD, there was positive correlation but not significant between levels of MDA and activity of SOD serum in type 2 diabetes mellitus and normal. And there was no significant different between two correlation coefficient.   Keywords: malondialdehyde, superoxide dismutase, type 2 diabetes mellitus

Glycemic Control Comparative of Metformin and Glimepiride in Monotherapy of Type 2 Diabetes Mellitus Patient at Islamic Jemursari Hospital Surabaya in 2018

2021 ◽  
Vol 71 (1) ◽  
pp. 24-29
Author(s):  
Rachma Putri Nariswari ◽  
Gwenny Ichsan Prabowo ◽  
Hermina Novida ◽  
Nurina Hasanatuludhhiyah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Adult Population ◽  
Secondary Data ◽  
Diabetes Mellitus Patient ◽  
Significant Difference ◽  
Tissue Sensitivity

Introduction: Type 2 diabetes mellitus is caused by decreased tissue sensitivity to insulin. The prevalence of diabetes in the world has almost doubled since 1980, from 4.7% to 8.5% in adult population. Early diagnosis and treatment aimed at normalizing glycemic control are very important. The objective of this study was to evaluate and compare glycemic control of metformin and glimepiride in monotherapy of type 2 diabetes mellitus patients at Islamic Jemursari Hospital Surabaya. Method: This was a retrospective observational study using secondary data (medical record), include glycemic control (RPG) before and two months after receiving therapy of outpatients’ type 2 diabetes mellitus with metformin or glimepiride therapy in 2018. 96 samples were found that fit the inclusion criteria. The data were analyzed by Mann-Whitney test. Result: Most patients were female, aged 50-69 years old, and dosage of metformin therapy 1500 mg/day or glimepiride therapy 2 mg/day. There was no significant difference (p>0.05) of glycemic control (RPG) of metformin compared to glimepiride therapies in type 2 diabetes mellitus patients at Islamic Jemursari Hospital Surabaya in 2018. Conclusion: Metformin and glimepiride were not significantly different in glycemic control (RPG). There were patients with RPG >200 mg/dl after two months of metformin or glimepiride therapy.  

scholarly journals Cell-Derived Microparticles in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-Analysis

2016 ◽  
Vol 39 (6) ◽  
pp. 2439-2450 ◽  
Author(s):  
Sheyu Li ◽  
Jia Wei ◽  
Chenghui Zhang ◽  
Xiaodan Li ◽  
Wentong Meng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Meta Analysis ◽  
Cross Sectional ◽  
Significant Difference ◽  
Different Types ◽  
Mean Differences

Background/Aims: The aim of this study was to assess the association between circulating cell-derived microparticles (MPs) and type 2 diabetes mellitus (T2DM). Methods: A literature search was performed systematically in PubMed and Embase to identify available case-control or cross-sectional studies that compared different types of cell-derived MPs in patients with T2DM and non-diabetic controls. Pooled standardized mean differences (SMDs) of each MP type were pooled using meta-analysis. Results: Forty-eight studies involving 2,460 patients with T2DM and 1,880 non-diabetic controls were included for systematic review and 34 of which were included for quantitative study by meta-analysis. In the overall analysis, the levels of circulating total MPs (TMPs), platelet-derived MPs (PMPs), monocyte-derived MPs (MMPs) and endothelium-derived MPs (EMPs) were significantly higher in T2DM patients than those in controls (TMPs: SMD, 0.64; 95%CI, 0.12∼1.15; P=0.02; PMPs: SMD, 1.19; 95%CI, 0.88∼1.50; P <0.00001; MMPs: SMD, 0.92; 95%CI, 0.66∼1.17; P <0.00001; EMPs: SMD, 0.73; 95%CI, 0.50∼0.96; P <0.00001). Meanwhile, no significant difference was shown in leukocyte-derived MPs (LMPs) level between diabetic and non-diabetic groups (SMD, 0.37; 95%CI, -0.15∼0.89; P=0.17). Conclusions: The counts of TMPs, PMPs, MMPs and EMPs elevated in patients with T2DM. And cell-derived MPs may play a role in the pathogenesis of T2DM.

scholarly journals The Association Between Serum Magnesium Level and Microalbuminuria in Type 2 Diabetes Mellitus Patients

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Masoud Mohebbi ◽  
Katayoun Samadi ◽  
Nazafarin Navari ◽  
Melika Ziafati-fahmideh-sani ◽  
Golshid Nourihosseini ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Magnesium ◽  
P Value ◽  
Albumin Concentration ◽  
Cross Sectional ◽  
Urine Albumin ◽  
Significant Difference

Background: Diabetic nephropathy occurs in 20 - 30% of diabetic cases globally, and microalbuminuria (MA) is the first symptom of this disorder. Some studies have suggested that there is an association between the serum magnesium (Mg) level and MA. Objectives: Therefore, we investigated the association between the serum Mg level and MA in type 2 diabetes mellitus (T2DM) patients. Methods: We conducted a cross-sectional study on 122 subjects with T2DM. We categorized them into two groups of microalbuminuria (MA) and non-microalbuminuria (NMA) according to their urine albumin-creatinine ratio (UACR). MA was considered as a UACR of 30 to 300 mg/g. Participants were excluded if they had the following conditions: The age of under 16 years, cardiac, renal, or hepatic disorders, using corticosteroids, diuretics, Mg /calcium (Ca) supplements, and antiepileptic drugs, heavy physical activity within 24 hours before the test, pregnant and breastfeeding women, febrile patients, and patients who were unwilling to participate in the study. The analysis was performed using SPSS version 15. A P-value < 0.05 was considered significant. Results: Among the patients, 50.81% were male. Also, the mean body mass index (BMI) of the NMA group was greater than the MA group (29.84 ± 5.64 vs. 27.31 ± 3.14, P-value = 0.003). Mg levels of the MA and NMA groups showed no significant differences (2.13 ± 0.42 and 2.10 ± 0.43, respectively; P-value = 0.67). Overall, data analysis provided no significant difference between Mg level and the urine albumin concentration between the MA and NMA groups (P-value = 0.21 and 0.81, respectively.). Conclusions: Serum Mg level and MA have no significant relationship. Further prospective studies are needed to assay this issue.

scholarly journals Body Composition and Basal Metabolic Rate in Women with Type 2 Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Marina de Figueiredo Ferreira ◽  
Filipe Detrano ◽  
Gabriela Morgado de Oliveira Coelho ◽  
Maria Elisa Barros ◽  
Regina Serrão Lanzillotti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Composition ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Adult Women ◽  
Cross Sectional ◽  
Significant Difference

Objective.The aim of this study was to determine which of the seven selected equations used to predict basal metabolic rate most accurately estimated the measured basal metabolic rate.Methods.Twenty-eight adult women with type 2 diabetes mellitus participated in this cross-sectional study. Anthropometric and biochemical variables were measured as well as body composition (by absorptiometry dual X-ray emission) and basal metabolic rate (by indirect calorimetry); basal metabolic rate was also estimated by prediction equations.Results.There was a significant difference between the measured and the estimated basal metabolic rate determined by the FAO/WHO/UNU(Pvalue<0.021)and Huang et al.(Pvalue≤0.005)equations.Conclusion.The calculations using Owen et al’s. equation were the closest to the measured basal metabolic rate.

scholarly journals A STUDY OF LIPID PROFILE IN DIABETES MELLITUS TYPE-2 PATIENTS

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Vipin Kumar ◽  
Maya Pensiya ◽  
V B Singh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Sugar Levels ◽  
And Control

Background: To study the lipid profile in diabetes mellitus in type 2 Diabetes mellitus patients. Methods: This is a cross sectional case control study. 100 patients of type 2 diabetes mellitus and 100 age and sex matched healthy controls were taken. Lipid profile were done in cases and controls using appropriate tests. Results: The fasting blood sugar levels in all the diabetics were significantly higher as compare to control. There was significant difference in mean HDL, Triglycerides level in diabetic and control patients. There was no significant difference in LDL, Cholesterol level in Diabetic and control patients. Conclusion: We concluded that there is a high prevalence of elevated lipid levels among the diabetic patients. Keywords: Diabetes Mellitus -2, Cholesterol, Lipid Profile

scholarly journals Prevalence and Risk Factors of Latent Tuberculosis Infection (LTBI) in Patients with Type 2 Diabetes Mellitus (T2DM)

2021 ◽  
Vol 18 (1) ◽  
pp. 305
Author(s):  
Phan Ai Ping ◽  
Rosnani Zakaria ◽  
Md Asiful Islam ◽  
Lili Husniati Yaacob ◽  
Rosediani Muhamad ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Smoking Status ◽  
Multiple Logistic Regression ◽  
Cross Sectional ◽  
Significant Difference

Type 2 diabetes mellitus (T2DM) and tuberculosis (TB) together impose a high disease burden in terms of both mortality and health economics worldwide. The objective of this study was to estimate the prevalence and risk factors of latent TB infection (LTBI) in patients with T2DM in Malaysia. A cross-sectional study was performed, and adult T2DM patients (n = 299) were included. Simple and multiple logistic regression analyses were performed to identify the LTBI-associated risk factors in patients with T2DM. Multiple logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CIs) between T2DM and LTBI and was adjusted for potential confounders. The prevalence of LTBI in patients with T2DM was 11.4% (95% CI: 8.0–15.0%). There was no significant difference in the socio-demographic characteristics between LTBI and non-LTBI subjects. No significant difference in the smoking status, the duration of smoking, and the duration of T2DM, HbA1c, or treatments was observed. Interestingly, a higher level of education was observed to be associated with a lower prevalence of LTBI in T2DM patients (aOR: 0.08, 95% CI: 0.01–0.70, p = 0.02). Although the prevalence of LTBI in T2DM was low, it is important to screen for it in T2DM patients due to the risk of developing severe active TB.

scholarly journals Gender Variation of Lipid Profiles of Type-2 Diabetes Mellitus Patients attended at a Specialized Diabetic Hospital in Dhaka

2015 ◽  
Vol 2 (2) ◽  
pp. 34-38 ◽  
Author(s):  
Roksana Yeasmin ◽  
Nazmun Nahar ◽  
MA Muttalib ◽  
Md. Nizamul Hoque Bhuiyan ◽  
ATM Zoadur Rahim Zahid ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Physiological Level ◽  
Significant Difference ◽  
The Difference

Background: The pattern of dyslipidemia varies among the patients of type 2 of diabetes mellitus. Objective: The purpose of the present study was to observe gender difference of lipid abnormalities in type-2 Diabetes Mellitus patients.Methodology: This cross sectional comparative study was conducted in the OPD of Department of medicine at BIRDEM, Dhaka from January, 2014 to July, 2014 for a period of six months. Convenient purposive sampling method was used and data assessed in a prospective manner. Blood sugar (FBS, ABF), lipid profile (TG, TC, LDLC, and HDLC) were measured. Statistical analyses were performed with the SPSS software program.Results: A total number of 400 type 2 DM patients (200 males and 200 females) attending to BIRDEM OPD were recruited in this study. Blood sugar was higher than normal in both male and female (FBS=8.79±.20, 8.64±0.22 respectively and ABF=12.15±0.27, 11.8±0.29 mmol/l respectively). TG level was also higher in two groups of study subjects with male level is slightly more than female (194.99±6.72 and 185.21±15.51 respectively) with no significant difference between the groups (P>.05). Total cholesterol and LDL-C level was within normal physiological level in both groups, where as these levels were higher in female in comparison to male (TC=184.44±3.33 &166.16±3.04 respectively, LDLC=109.68±2.59 & 88.66±2.59 respectively), showing significant difference between the groups (P=.000). HDL-C was below normal in both male (38.28± 48) and female (39.02±2.59); however HDL-C was slightly higher in female than male and the difference was insignificant (p=.330). Conclusion: In conclusion dyslipidemia were observed in a greater proportion of female diabetic patients than male diabetic patients.Journal of Current and Advance Medical Research, 2015;2(2):34-38

scholarly journals PERBANDINGAN JUMLAH TROMBOSIT PADA PASIEN DIABETES MELITUS TIPE 2 YANG MENGGUNAKAN ASPIRIN DAN TIDAK MENGGUNAKAN ASPIRIN

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Dwi P. Palimbunga ◽  
Karel Pandelaki ◽  
Arthur E. Mongan ◽  
Firginia Manoppo
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Platelet Count ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Fourfold Increase ◽  
Significant Difference ◽  
Diabetes Melitus

Abstract: Patients with type-2 diabetes mellitus are characterized by an acceleration thrombopoiesis, an increased platelet turnover and a decreased platelet survival time which affect platelet count, that cause the increasing of proportion of large and reactive platelets, and hence more thrombogenic. People with diabetes have a two- to fourfold increase in the risk of dying from the complications of cardiovascular disease. Aspirin therapy is recommended for the primary and secondary prevention of cardiovascular events in most people with diabetes. This study was an descriptive analytic method with cross sectional study design. The subjects in this study involve 112 people, 56 people treated with aspirin, and the 56 others were not who signed in endocrine metabolic department of RSUP Prof. Dr. R. D Kandou Manado. Data were taken from medical record. The Mann-Whitney test showed that there was no significant difference between the platelet count in patients with type-2 diabetes mellitus treated with aspirin and patients who were not. Conclusion: There was no significant difference between the platelet count in patients with type-2 diabetes mellitustreated with aspirin and patients who were not. Key word:Aspirin, Type-2 Diabetes Mellitus, Platelet Count  Abstrak: Pada pasien diabetes melitus tipe-2 terjadi percepatan trombopoiesis, peningkatan pergantian trombosit dan penurunan waktu hidup trombosit yang mempengaruhi jumlah trombosit, yang menyebabkan terjadinya peningkatan ukuran trombosit yang lebih besar dan reaktif, sehingga bersifat trombogenik. Risiko kematian karena komplikasi penyakit jantung meningkat dua sampai empat kali lipat. Aspirin digunakan sebagai pencegahan primer dan sekunder terhadap kejadian kardiovaskular pada pasien diabetes. Tujuan penelitian ini untuk melihat perbedaan jumlah trombosit pada pasien diabetes melitus tipe-2 yang menggunakan aspirin dan tidak menggunakan aspirin. Penelitian ini bersifat deskriptif analitik dengan rancang penelitian cross sectional. Subjek dalam penelitian ini berjumlah 112 orang, 56 orang yang menggunakan aspirin dan 56 orang lainnya tidak menggunakan aspirin yang terdaftar di Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. Data diambil dari catatan rekam medik. Hasil penelitian menggunakan uji Mann-Whitney,menunjukkan bahwa tidak terdapat perbedaan yang signifikan antara jumlah trombosit pada pasien diabetes melitus tipe-2 yang menggunakan aspirin dan tidak menggunakan aspirin (p=0,059). Simpulan: Tidak terdapat perbedaan signifikan antara jumlah trombosit pada pasien diabetes melitus tipe 2 yang menggunakan aspirin dan tidak menggunakan aspirin. Kata Kunci: Aspirin, Diabetes Melitus Tipe-2, Jumlah Trombosit

scholarly journals THE ASSOCIATION OF PERIODONTAL DISEASES WITH TYPE 2 DIABETES MELLITUS AND DIABETES LINKED DYSLIPIDEMIA IN PAKISTANI POPULATION

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S123-29
Author(s):  
Zara Khalid Khan ◽  
Muhammad Uzair Khan ◽  
Amna Khalid Khan ◽  
Rukhsana Muttee ◽  
Rubeena Khalid ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Periodontal Diseases ◽  
High Density Lipoproteins ◽  
Military Hospital ◽  
Cross Sectional ◽  
Significant Difference ◽  
Males And Females

Objective: To determine the development of dyslipidemia in type 2 diabetics with and without periodontaldiseases. Study Design: Comparative cross-sectional study. Place and Duration of Study: Fauji Foundation Hospital and Pak Emirates Military Hospital, Rawalpindi,Pakistan, from Jan 2018 to Jan 2019. Methodology: Total number of participated subjects (males and females) was 75, with age ranging from 23 to 72 years. Their tests included blood sugar, lipid profile, HbA1c and hepatitis screening. Oral health parameters were divided into two categories; type 2 diabetes mellitus with and without periodontitis. Results: Out of 75 patients, males and females were 19 (25.3%) and 56 (74.7%). Females with periodontitis 20(74.1%) and without periodontitis 36 (75%) possessed larger numbers. Mean ages [56.33 ± 10.88 years] hada higher incline, along with significantly altered total cholesterol [5.41 ± 1.70 mmol/l], triglycerides [2.55 ± 1.46mmol/l], low and high density lipoproteins [3.01 ± 1.22 mmol/l, 0.97 ± 0.48 mmol/l] in type 2 diabetes mellituswith periodontitis. Patients of diabetes without periodontitis showed mild derangements for triglycerides [1.88 ± 1.22 mmol/l]. Patients of diabetes with dyslipidemia and periodontitis 16 (59.3%) were documented highest innumber, compared to other type 2 diabetes mellitus groups. Conclusion: There was an overall significant association between type 2 diabetes mellitus related dyslipidemiaand periodontitis. Also, significant difference in age and gender of study subjects was noted that affected middle aged females more often than middle to late aged males.

POTENSI HIPOGLIKEMIA DAN HIPERGLIKEMIA PADA PASIEN DIABETES MELITUS TIPE 2 AKIBAT INTERAKSI OBAT

2020 ◽  
Vol 5 (2) ◽  
pp. 258-267
Author(s):  
Yardi Saibi ◽  
◽  
Delina Hasan ◽  
Bukhoriah Safitri ◽  
Vidia Arlaini Anwar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Drug Interaction ◽  
Medical Record ◽  
Univariate Analysis ◽  
Data Retrieval ◽  
Diabetes Mellitus Patient ◽  
Cross Sectional

The potency of drug interaction is higher because of the presence of comorbidities and polypharmacy in type 2 diabetes mellitus patient. This study aimed to know the potency of drug interaction event in type 2 diabetes mellitus patient in one of hospital in Jakarta in 2016 which have potency to cause hypoglycemia and hyperglicemia. Data was collected from medical record of type 2 diabetes mellitus patient . The design of this research was cross- sectional. Data retrieval was conducted retrospectively. The sample size in this study was 151 Diabetes mellitus type 2 patients medical record who received antidiabetes and met the inclusion and exclusion criteria. Data analysis was done statistically using univariate analysis . Results showed that female dominated the patient as much as 74,83% with hypertension as the most common comorbidities as much as 28,48%. There were 186 drug interaction event potency with 83,8% of them could cause hypoglicemia while the rest could cause hyperglicemia. Drug interaction with the potency that can cause either hypoglycemia and hyperglycemia that can effect the failure to get the therapeutic goal still be frequent found in patient prescription. Drug interaction event should get appropriate attention from clinical pharmacist in hospital

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