scholarly journals Cardiovascular Responses Of Type 2 Diabetes Patients To Intermittent And Continous Aerobic Exercises

2007 ◽  
Author(s):  
Mukadas O Akindele ◽  
Phillip Kodzo ◽  
Mustapha Naimat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Aerobic Exercise ◽  
Intermittent Exercise ◽  
Cardiovascular Responses ◽  
Exercise Group ◽  
Significant Difference

Background: The use of aerobic exercise as a form of glycemic control in type 2 diabetes mellitus has been well documented in the literatures. High blood pressure has been shown to be one of the sequelae of type 2 diabetes mellitus. Determination of mode of exercises for glycemic control that will not adversely affect the cardiovascular indices of type 2 diabetes mellitus subjects is highly indicated. Objective: The purpose of this study was to determine the acute cardiovascular responses of type 2 diabetes mellitus subjects to continuous and intermittent modes of exercises. Results: There was statistical significant difference in heart rate of both groups. Continuous mode of exercise elicited no statistical difference in SBP and DBP but there was statistical significant difference in SBP in intermittent exercise group with no statistical significant in their DBP. Cross comparison of pre and post cardiovascular indices showed that there were statistical significant differences in SBP (F=0.710, P>0.05) and DBP (F=1.397, P>0.05). Conclusion: Cardiovascular responses of type 2 diabetes mellitus subjects were higher in intermittent exercise group compared with the continuous exercise group. KEYWORDS: Type 2 diabetes mellitus, Aerobic exercise, cardiovascular response.

Glycemic Control Comparative of Metformin and Glimepiride in Monotherapy of Type 2 Diabetes Mellitus Patient at Islamic Jemursari Hospital Surabaya in 2018

2021 ◽  
Vol 71 (1) ◽  
pp. 24-29
Author(s):  
Rachma Putri Nariswari ◽  
Gwenny Ichsan Prabowo ◽  
Hermina Novida ◽  
Nurina Hasanatuludhhiyah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Adult Population ◽  
Secondary Data ◽  
Diabetes Mellitus Patient ◽  
Significant Difference ◽  
Tissue Sensitivity

Introduction: Type 2 diabetes mellitus is caused by decreased tissue sensitivity to insulin. The prevalence of diabetes in the world has almost doubled since 1980, from 4.7% to 8.5% in adult population. Early diagnosis and treatment aimed at normalizing glycemic control are very important. The objective of this study was to evaluate and compare glycemic control of metformin and glimepiride in monotherapy of type 2 diabetes mellitus patients at Islamic Jemursari Hospital Surabaya. Method: This was a retrospective observational study using secondary data (medical record), include glycemic control (RPG) before and two months after receiving therapy of outpatients’ type 2 diabetes mellitus with metformin or glimepiride therapy in 2018. 96 samples were found that fit the inclusion criteria. The data were analyzed by Mann-Whitney test. Result: Most patients were female, aged 50-69 years old, and dosage of metformin therapy 1500 mg/day or glimepiride therapy 2 mg/day. There was no significant difference (p>0.05) of glycemic control (RPG) of metformin compared to glimepiride therapies in type 2 diabetes mellitus patients at Islamic Jemursari Hospital Surabaya in 2018. Conclusion: Metformin and glimepiride were not significantly different in glycemic control (RPG). There were patients with RPG >200 mg/dl after two months of metformin or glimepiride therapy.  

scholarly journals An evaluation of type 2 diabetes mellitus patients on different oral antidiabetic medications with regard to glycemic control and diabetic complications

2019 ◽  
Vol 6 (9) ◽  
pp. 180-185
Author(s):  
Erhan Önalan ◽  
Nevzat Gozel ◽  
Burkay Yakar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Diabetic Complications ◽  
Type 2 Dm ◽  
Oral Antidiabetic ◽  
Metformin Monotherapy ◽  
Significant Difference

Objective:  Diabetes Mellitus is a chronic and progressive disease that significantly impairs the workforce and economy due to its complications. This study aims to evaluate patients diagnosed with type 2 diabetes mellitus who use different oral antidiabetic medications with regard to glycemic control and diabetic complications. Materials and Methods: This study included 200 patients who were being followed-up for a diagnosis of Type 2 DM. Results: Of the 200 patients included in the study, 131 were on metformin monotherapy and 69 were on metformin and gliclazide combination therapy. HbA1c value of Metformin monotherapy prescribed patients was7,6%±1,5, metformin+gliclazide prescribed patients was 8,2%±1,9. There was a statistically significant difference between the two groups in terms of blood glucose levels (p<0.05). There was no significant difference between the two groups with regard to microvascular complications and body mass index. Conclusion: Our study determined that the level of glycemic control manifested by Type 2 DM patients was suboptimal despite using different types of oral antidiabetics and that their body mass indices were high. We reached the conclusion that the present situation is linked to factors such as incorrect dietary habits, inadequate exercise and walking, failure to comply with the medical treatment suggested by the physician, and lack of awareness about the severity of the disease.

Impact of aerobic exercise against general mobilisation exercise on exercise tolerance among type 2 diabetes mellitus

2021 ◽  
pp. 1-4
Author(s):  
I.V. Chandrashekaran ◽  
N. Ravi ◽  
B. Srinivasagopalane
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Aerobic Exercise ◽  
Exercise Tolerance ◽  
Walk Test ◽  
Significant Difference ◽  
Group B ◽  
Minute Walk

The objective of the study was to compare general mobilisation exercises with aerobic exercises on exercise tolerance in subjects with type 2 diabetes mellitus. Thirty type 2 diabetes mellitus subjects of both the genders in age-group between 35 and 60 years were divided into 2 groups (A and B) and were subjected to a 6-minute walk test pre- and post-training exercise. Group A participants were subjected to general mobilisation exercises and group B to aerobic exercises. The six-minute walk test between the two groups (A and B) was statistically different at P=0.03. Our study showed a significant difference in improvement of exercise tolerance in Group-B subjects, who underwent aerobic exercise. In conclusion, aerobic exercise is a better health intervention in the improvement of exercise tolerance among type 2 diabetes mellitus subjects, which could improve their cardio-respiratory fitness and thereby prevent further cardiovascular complications and improve their well-being.

Effect of a 12-Week Aerobic Exercise Training on Serum Fetuin-A and Adipocytokine Levels in Type 2 Diabetes

2017 ◽  
Vol 126 (08) ◽  
pp. 487-492 ◽  
Author(s):  
Ling-Yun Zhang ◽  
Tao Liu ◽  
Ya-Qin Teng ◽  
Xiao-Yan Yao ◽  
Tian-Tian Zhao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Serum Levels ◽  
Exercise Group ◽  
Aerobic Exercise Training ◽  
Fetuin A

Abstract Objective We aimed to evaluate the effect of 12-week aerobic exercise training on fetuin-A levels in type 2 diabetes mellitus and examine the relationships between fetuin-A and adipocytokine levels and cardiovascular risk factors. Methods The study included 32 patients with type 2 diabetes mellitus who were assigned to an exercise or a control group. The exercise group underwent 12 weeks of exercise (consisting of a 5-min warm-up, 60-min aerobic bicycle training performed at 70% of the maximal heart rate, a cool-down period, 5 times/week). Adiponectin, resistin, and fetuin-A serum levels were measured using enzyme-linked immunosorbent assay. Leptin serum levels were measured by a radioimmunoassay. Results Exercise for 12 weeks significantly reduced serum fetuin-A (643.1±109.4 to 448.7±92.5 μg/mL, P<0.05), leptin (11.9±7.2 to 8.6±5.7 ng/dL, P<0.05), and resistin (3.2±1.5 to 2.2±1.4 ng/mL, P<0.05) levels, but increased adiponectin (6.9±1.9 to 8.1±1.7 µg/mL, P<0.05) levels. In the exercise group, Δfetuin-A positively correlated with differences in weight (r=0.654, P=0.046), body mass index (r=0.725, P=0.002), waist circumference (r=0.898, P=0.013), and adiponectin levels (r=0.662, P=0.035). Conclusions Aerobic exercise significantly decreased serum fetuin-A levels in type 2 diabetes mellitus, which can be attributed to weight loss and related to increased adiponectin levels.

Weight Outcomes With Empagliflozin as Compared With Liraglutide in Veterans With Type 2 Diabetes Mellitus

2020 ◽  
Vol 54 (10) ◽  
pp. 981-987
Author(s):  
Ted Robert Grabarczyk ◽  
Natalie Koury Wissman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Sodium Glucose Cotransporter ◽  
Significant Difference ◽  
Weight Outcomes ◽  
Glucagon Like Peptide 1

Background: Glucagon-like peptide-1 agonists and sodium glucose cotransporter 2 inhibitors are associated with weight loss and improved cardiovascular outcomes, and are increasingly used in pharmacotherapy for type 2 diabetes mellitus (T2DM). Objectives: To compare weight loss outcomes of empagliflozin and liraglutide in patients with T2DM and overweight/obesity not yet prescribed insulin but requiring additional pharmacotherapy to improve glycemic control. Methods: This is an observational, multisite, cohort study of veterans with T2DM prescribed liraglutide or empagliflozin. Participants were prescribed either empagliflozin or liraglutide prior to November 1, 2017, had a hemoglobin A1C (A1C) ≥7.0%, had a body mass index ≥27 kg/m2, and were not treated with insulin at baseline. The primary outcome was change in weight after 1 year using multiple regression. Secondary outcomes were the proportion achieving ≥5% weight loss and change in A1C. Results: Weight loss was not significantly different between groups: −2.17 kg (95% CI: −2.91 to −1.42) in the liraglutide group (n = 298) and −2.81 kg (95% CI: −3.43 to −2.20) in the empagliflozin group (n = 247; P > 0.05). After adjusting for covariates, this effect remained nonsignificant. There was no difference in change in A1C between liraglutide (−0.83%; 95% CI: −1.05% to −0.62%) and empagliflozin (−0.71%; 95% CI: −0.89% to −0.53%; P > 0.05). Conclusions and Relevance: There was no significant difference in weight outcomes after 1 year in veterans treated with liraglutide versus empagliflozin. Because both medications did show modest weight loss, both remain good options for patients needing an additional medication to improve glycemic control that is at least weight neutral.

Abstract P048: Effects of Aerobic Exercise on Oxidative Stress in the Kidneys of Type2 Diabetic Rats

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Daisuke Ito ◽  
Pengyu Cao ◽  
Takaaki Kakihana ◽  
Emiko Sato ◽  
Yoshikazu Muroya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Aerobic Exercise ◽  
Nadph Oxidase Activity ◽  
Beneficial Effects ◽  
Significant Difference ◽  
Zdf Rats

Objective: Aerobic exercise is known to have multiple beneficial effects including renal protection in type 2 diabetes mellitus and obesity. However, the mechanisms regulating these actions of aerobic exercise remain unclear. The present study evaluated the effects of chronic aerobic exercise on early stage of diabetic nephropathy focusing on renal oxidative stress and nitric oxide (NO), using Zucker diabetic fatty (ZDF) rats as an animal model of obese type 2 diabetes. Methods: Male ZDF rats (6 weeks old) underwent forced treadmill exercise for 8 weeks (Ex-ZDF). Sedentary ZDF (Sed-ZDF) and Zucker lean (Sed-ZL) rats served as controls. After the last exercise session, all rats were subjected to an intra-peritoneal glucose tolerance test. Result: Exercise ameliorated hyperglycemia with increased insulin secretion, and raised the values of homeostasis model assessment for β-cell function (HOMA-β) in ZDF rats. Exercise also reduced albumin excretion and normalized creatinine clearance in ZDF rats. Endothelial (e) and neuronal (n) NO synthase (NOS) protein expression, and NOS activity in the kidneys of Sed-ZDF rats were lower compared with Sed-ZL rats, while both NOS expression and NOS activity were upregulated by exercise in ZDF rats. Although there was no significant difference in plasma levels of adiponectin between the groups, plasma levels of leptin were significantly higher in the Ex-ZDF group compared with the Sed-ZL and Sed-ZDF groups. Exercise decreased plasma and urinary thiobarbituric acid-reactive substances (TBARS) as an index of lipid peroxidation in ZDF rats. Additionally, renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and expression of p47phox protein were significantly higher in the kidneys of the Sed-ZDF group compared with the Sed-ZL group, and there was no significant difference between the Ex-ZDF and Sed-ZL groups. Immunoblots for Nox4, Nox2, namely gp91phox and p22phox protein were undetected in the kidneys of the Sed-ZDF and Ex-ZDF group as well as the Sed-ZL group. In addition, expression of nitrotyrosine as an index of peroxynitrite (ONOO–) formation was significantly lower in the kidneys of the Sed-ZDF group compared with the Sed-ZL group, and was significantly higher in the Ex-ZDF group compared with the Sed-ZDF group. Further, morphometric evidence of renal damage was alleviated in response to exercise. Conclusion: Upregulated NOS activity and NOS protein, and ameliorated NADPH oxidase activity and p47phox protein in the kidneys may be potential mechanisms by which chronic aerobic exercise can reduced early diabetic nephropathy in ZDF rats. Chronic aerobic exercise does have beneficial effects and may be a novel therapeutic approach for preventing the development of renal dysfunction in patients with type 2 diabetes mellitus and obesity.

scholarly journals Impact of aerobic exercises on taste perception for sucrose in patients with type 2 diabetes mellitus; A randomized controlled trial

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Dinithi Vidanage ◽  
Shamini Prathapan ◽  
Priyadarshika Hettiarachchi ◽  
Sudharshani Wasalathanthri
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Aerobic Exercise ◽  
Intervention Group ◽  
Sweet Taste ◽  
Exercise Group ◽  
Mean Difference ◽  
Taste Perception

Abstract Background Regular exercise is a key element in the management of type 2 diabetes mellitus (T2DM). Although the importance of regular exercises on glycemic control in people with diabetes is studied extensively, evidence is lacking on its impact on sweet taste perception. Thus, the aim of this study was to determine the impact of aerobic exercises on taste perception for sucrose in people with diabetes. Methods A sample of 225 people with diabetes aged 35-60 years was assigned randomly into 3 groups; aerobic exercise, combined exercise and a control group. The outcomes of the combined exercise group is not reported. The aerobic exercise group performed brisk walking 30min/day, 4-5days/week for 6 months. The primary outcome measures were supra-threshold intensity ratings and preference for sucrose assessed at baseline, at 3 and 6 months using ‘general Labeled Magnitude Scale’ and ‘Monell 2-series-forced choice method’ respectively. Glycated haemoglobin (HbA1c) level was assessed at baseline and at 6 months to determine glycemic control. Results Aerobic exercise group showed significantly increased ratings (mm) for higher sucrose concentrations at 3 months (mean difference for 2.02M; +6.63±2.50, p=0.048 and for 0.64M; +7.26±2.76, p=0.026) and at 6 months (mean difference for 0.64M; +7.79±4.49, p= 0.044) compared to baseline and also when compared to controls (mean difference for 2.02M between baseline and 3 months; intervention: +6.63±2.50, control: -4.01±1.79, p=0.02 and between baseline and 6 months for 2.02M; intervention: +3.15±0.57, control: -7.96±0.40, p=0.022 and for 0.64M; intervention: +7.79±4.49, control: -8.98±0.99, p=0.003). A significantly reduced preference (mol/L) was seen both at 3 (mean difference; -0.03±0.02, p= 0.037) and at 6 months (mean difference; -0.05±0.12, p=0.011) compared to baseline within the intervention group. Also, a significant reduction was seen in the intervention group compared to controls at 6 months (mean difference; intervention: -0.05±0.12, control: 0.01±0.03, p=0.044). HbA1c was significantly reduced in the intervention group compared to controls at 6 months (mean difference; intervention -0.43±1.6%, control +0.33±1.8%, p=0.018). Conclusion Regular aerobic exercises increase the sweet taste sensitivity, especially for higher concentrations of sucrose and decrease sweet taste preference in people with diabetes . These alterations in sweet taste perception, are likely to contribute to a better glycemic control in people with diabetes. Trial registration This trial was registered at the Sri Lanka Clinical Trial registry on 16/12/2015. (Trial registration number- SLCTR/2015/029, https://slctr.lk/trials/slctr-2015-029).

scholarly journals Correlation between glycemic control and dyslipidemia in Type 2 Diabetes Mellitus patient

2019 ◽  
Vol 8 (6) ◽  
pp. 1387
Author(s):  
Neha Yadav ◽  
Sujata Singh ◽  
Smita Gupta ◽  
Saurabh Mishra ◽  
Krishna Singh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Correlation Coefficient ◽  
Positive Correlation ◽  
Group Iii ◽  
Group I ◽  
Significant Difference

Background: India is one of the countries with highest number of diabetes patients. Patients of type 2 diabetes mellitus are usually dyslipidemic. The objective of the research was to study the pattern of dyslipidemia and to study the correlation of glycemic control with dyslipidemia in type 2 diabetes mellitus patients.Methods: A cross sectional observational study was performed on patients of type 2 diabetes mellitus over 6 months period. The study included 200 patients and the variables recorded were demographic profile, FBS, PPBS, HbA1C and lipid profile parameters. The patients were divided into 3 groups according to HbA1C level i.e. Group I (Good glycemic control HbA1C 6-7 gm%), group II (Fair glycemic control HbA1C 7.1-8.2 gm%) and group III (poor glycemic control, HbA1C >8.2 gm%).Results: The data showed that TG level was maximum in group III and was minimum in group I. Comparison between the group shows a significant difference between all the groups (P <0.001). A significant positive correlation (Correlation coefficient 0.67, P <0.001) was also observed between level of TG and HbA1C. Similarly, LDL level was also highest in group III with a significant difference with other two groups (P <0.05). Also, a positive correlation (Correlation coefficient 0.64, P <0.05) was observed between LDL and HbA1C. On the other hand, HDL was lowest in group III as compared to groups I and II (P <0.001) and a negative correlation (Correlation coefficient -0.716, P <0.001) was seen between HDL and HbA1C.Conclusions: Dyslipidemia is less prevalent in diabetics who have better glycemic control.

scholarly journals Effect of Low Impact Aerobic Exercise on Functional Balance and Quality of Life in Type 2 Diabetes Mellitus Patients.

1970 ◽  
Vol 2 (01) ◽  
pp. 96-104
Author(s):  
Peni Hardjanti ◽  
Bayu Santoso ◽  
Nuniek Nugraheni ◽  
Agung Pranoto
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Aerobic Exercise ◽  
Exercise Group ◽  
Control Group ◽  
Functional Balance

Objectives: To determine the effect of low impact aerobic exercise on functional balance and the quality of life in type 2 Diabetes Mellitus (DM) patientsMethods: This is an experimental study. Participants were recruited from outpatient Diabetes Clinic in Dr. Soetomo General Hospital, Surabaya, Indonesia. Subjects of this study are men and women aged 30-70 years whose diagnosed with type 2 DM, with A1c less than 10%, have been using oral anti diabetic drug or subcutaneous insulin less than 30 IU daily, blood glucose level before exercise less than 250mg%, and Berg Balance Scale between 41-56. Subjects were randomized into 2 groups with 38 subjects in the exercise group and 37 in the control group. The exercise group followed 25-30 minutes diabeticaerobic low impact exercise 3 times a week for 3months, while the control group did not. Functional balance and quality of life before and after exercise were assessed using Berg Balance Scale (BBS) andthe Sickness Impact Profile (SIP) questionnaire. Difference in BBS and quality of life improvement measured by SIP questionnaire were analyzed after 3 months of exercise.Results: Mann Whitney test showed significant difference of the total score of BBS in the exercise group (p 0.02; α < 0.05). Chi Square test revealed significant improvement in four of the twelve parameters ofthe quality of life: sleep and rest (SR) (p 0.044), body care and movement (BCM) (p 0.017), ambulation (A) (p 0.001), and work (W) (p 0.000) in the exercise group.Conclusions: Low impact aerobic exercise in type 2 Diabetes Mellitus patients may improve functional balance and the SR, BCM, A, and W parameters of the quality of life.Key words: Low impact aerobic exercise, type 2 diabetic mellitus, functional balance, quality of life.

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