Future of Periodontal Regeneration

2010 ◽  
Vol 4 (Spl) ◽  
pp. 38-47 ◽  
Author(s):  
Ranjan Malhotra ◽  
Anoop Kapoor ◽  
Vishakha Grover ◽  
Nitin Verma ◽  
Jasjit Kaur Sahota
Keyword(s):  
Tissue Engineering ◽  
Gene Therapy ◽  
Rna Interference ◽  
Human Genetics ◽  
Current Knowledge ◽  
Periodontal Regeneration ◽  
Therapeutic Approaches ◽  
Polypeptide Growth Factors ◽  
Complicating Factors ◽  
Therapeutic Measures

ABSTRACT The management of periodontal defects has been an ongoing challenge in clinical periodontics. In the recent past, attention has been focused more on regenerative and reconstructive therapies i.e. bone grafts, guided tissue regeneration, root conditioning, polypeptide growth factors, rather than on respective therapies. These therapeutic measures are shown to be limited in the predictability of healing and regenerative response in the modern clinical practice because oral environment presents several complicating factors that border regeneration. The 21st century appears to represent a time in history when there is a convergence between clinical dentistry and medicine, human genetics, developmental and molecular biology, biotechnology, bioengineering, and bioinformatics, resulting in the emergence of novel regenerative therapeutic approaches viz. tissue engineering, gene therapy and RNA interference. The focus of this review paper is to furnish and update the current knowledge of periodontal tissue engineering, gene therapy and RNA interference i.e. the future of periodontal regeneration.

scholarly journals Recent Trends in Non-Surgical Periodontal Care for the General Dentist - A Review

2014 ◽  
Vol 4 (2) ◽  
pp. 78-82 ◽  
Author(s):  
R Arpita ◽  
JL Swetha ◽  
MR Babu ◽  
R Sudhir
Keyword(s):  
Human Genetics ◽  
Therapeutic Approaches ◽  
Polypeptide Growth Factors ◽  
Oral Environment ◽  
Complicating Factors ◽  
Therapeutic Measures ◽  
Recent Trends ◽  
Research And Education ◽  
Future Direction ◽  
General Dentist

The management of periodontal defects has been an ongoing challenge in clinical periodontics. In the recent past, attention has been focused more on regenerative and reconstructive therapies i.e. bone grafts, guided tissue regeneration, root conditioning, polypeptide growth factors, rather than on respective therapies. These therapeutic measures are shown to be limited in the predictability of healing and regenerative response in the modem clinical practice because oral environment presents several complicating factors that border regeneration. The 21st century appears to represent a time in history when there is a convergence between clinical dentistry and medicine, human genetics, developmental and molecular biology, biotechnology, bioengineering, and bioinformatics, resulting in the emergence of novel regenerative therapeutic approaches and focusing mainly on non surgical modalities. The purpose of this article is to provide a review of the various non surgical therapies in use today. Future direction in this ever-changing field is also discussed. Techniques currently in use are reviewed and evaluated. They include Probiotics, Ozone therapy, Photodynamic therapy, Gene therapy, RNA interference, Nanotechnology, Perioprotect, TIPS & BOST. DOI: http://dx.doi.org/10.3329/bjdre.v4i2.20254 Bangladesh Journal of Dental Research and Education Vol.4(2) 2014: 78-82

scholarly journals Gene Therapy in Periodontal Tissue Engineering

2016 ◽  
Vol 8 (1) ◽  
pp. 46-48
Keyword(s):  
Tissue Engineering ◽  
Gene Therapy ◽  
Gene Delivery ◽  
Periodontal Regeneration ◽  
Periodontal Tissue ◽  
Delivery Method ◽  
Molecular Events ◽  
Artificial Extracellular Matrix ◽  
Periodontal Healing ◽  
Primary Strategy

ABSTRACT An elaborate system of signaling molecules regulates the cellular and molecular events of periodontal healing, the primary strategy for which is functional periodontal compartment regeneration and replication of components of the natural cellular microenvironment by providing an artificial extracellular matrix and by delivering growth factors. A new, so-called gene delivery method works by converting cells into protein- producing factories, thereby bypassing the dilemma. Gene therapy can channel the cellular signals in a controlled and very systematic manner, to provide encoded proteins at every stage of tissue regeneration. The aim of this review is to highlight the applications of gene delivery and tissue engineering in periodontal regeneration. How to cite this article Lakhani N, Vandana KL. Gene Therapy in Periodontal Tissue Engineering. CODS J Dent 2016;8(1):46-48.

Prospects for Re-engineering Salivary Glands

2000 ◽  
Vol 14 (1) ◽  
pp. 84-88 ◽  
Author(s):  
B.J. Baum
Keyword(s):  
Tissue Engineering ◽  
Gene Therapy ◽  
Salivary Glands ◽  
Biomedical Research ◽  
Scientific Progress ◽  
Internal Organs ◽  
The Public ◽  
Engineering Studies ◽  
Therapeutic Measures ◽  
Clinical Conditions

In the last decade, two areas of biomedical research-gene therapy and tissue engineering-have especially captured the imagination of the public. Both areas offer the potential for the treatment of clinical conditions that now are considered impossible or extremely difficult to manage by conventional therapeutic measures. Gene therapy has made remarkable scientific progress in the laboratory, but has yet to realize its enormous clinical promise. Tissue engineering studies have led to some tangible clinical breakthroughs, but the routine replacement of whole internal organs is still well into the future. This report will examine the applications of gene therapy and tissue engineering to salivary glands, with a focus on the repair of irreversible gland damage.

scholarly journals Aspergillus Peritonitis in Chronic Peritoneal Dialysis Patients: Review of the Literature and Report of Two Cases

2015 ◽  
Vol 12 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Fatih Yilmaz ◽  
Himmet Bora Uslu ◽  
Feyza Bora ◽  
Gultekin Suleymanlar ◽  
Turkan Sanli ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Medical Literature ◽  
Current Knowledge ◽  
Chronic Peritoneal Dialysis ◽  
Review Of The Literature ◽  
Therapeutic Approaches ◽  
Dialysis Patients ◽  
Fungal Peritonitis ◽  
Therapeutic Measures ◽  
Probability Of Death

Abstract Although gram positive bacteriae are the most common causative microorganisms of chronic peritoneal dialysis (CPD) peritonitis, fungi are responsible for 1-15% of all cases. On the other hand, fungal peritonitis episodes may potentially cause serious consequences such as resistance to treatment, extended hospital stay and also a higher probability of death. Fungal peritonitis due to Aspergillus spp is relatively uncommon, but its mortality rate and severity is known to be even higher. It was our aim to conduct a review of the medical literature regarding the treatment and clinical outcome of Aspergillus related CPD peritonitis and to present two cases with Aspergillus related CPD events. Our current knowledge and the outcome of our two cases suggest that, despite the use of recommended therapeutic measures, Aspergi-llus induced fungal peritonitis in CPD patients may still be fatal. Therefore, there is a need for development of more efficient therapeutic approaches including the type, dose and route of antifungal therapy.

Muscle-Based Gene Therapy and Tissue Engineering

2001 ◽  
Vol 11 (1-3) ◽  
pp. 10 ◽  
Author(s):  
Dalip Pelinkovic ◽  
Joon Yung Lee ◽  
Nobuo Adachi ◽  
Johnny Huard
Keyword(s):  
Tissue Engineering ◽  
Gene Therapy

Regenereation in periodontics

2018 ◽  
Author(s):  
Murtaza Kaderi ◽  
Mohsin Ali ◽  
Alfiya Ali ◽  
Tasneem Kaderi
Keyword(s):  
Tissue Engineering ◽  
Clinical Practice ◽  
Periodontal Disease ◽  
Disease Progression ◽  
Tissue Regeneration ◽  
Surgical Procedures ◽  
Periodontal Regeneration ◽  
Guided Tissue Regeneration ◽  
Periodontal Tissues ◽  
Extensive Documentation

The goals of periodontal therapy are to arrest of periodontal disease progression and to attain the regeneration of the periodontal apparatus. Osseous grafting and Guided tissue regeneration (GTR) are the two techniques with the most extensive documentation of periodontal regeneration. However, these techniques offer limited potential towards regenerating the periodontal tissues. Recent surgical procedures and application of newer materials aim at greater and more predictable regeneration with the concept of tissue engineering for enhanced periodontal regeneration and functional attachment have been developed, analyzed, and employed in clinical practice

Emerging approaches for restoration of hearing and vision

2020 ◽  
Author(s):  
Sonja Kleinlogel ◽  
Christian Vogl ◽  
Marcus Jeschke ◽  
Jakob Neef ◽  
Tobias Moser
Keyword(s):  
Gene Therapy ◽  
Hearing Aids ◽  
Sensory Information ◽  
Gene Replacement ◽  
Therapeutic Approaches ◽  
Optogenetic Stimulation ◽  
Cellular Specificity ◽  
Socioeconomic Burden ◽  
Comprehensive Reference

Impairments of vision and hearing are highly prevalent conditions limiting the quality of life and presenting a major socioeconomic burden. For long, retinal and cochlear disorders have remained intractable for causal therapies, with sensory rehabilitation limited to glasses, hearing aids, and electrical cochlear or retinal implants. Recently, the application of gene therapy and optogenetics to eye and ear has generated hope for a fundamental improvement of vision and hearing restoration. To date, one gene therapy for the restoration of vision has been approved and undergoing clinical trials will broaden its application including gene replacement, genome editing, and regenerative approaches. Moreover, optogenetics, i.e. controlling the activity of cells by light, offers a more general alternative strategy. Over little more than a decade, optogenetic approaches have been developed and applied to better understand the function of biological systems, while protein engineers have identified and designed new opsin variants with desired physiological features. Considering potential clinical applications of optogenetics, the spotlight is on the sensory systems. Multiple efforts have been undertaken to restore lost or hampered function in eye and ear. Optogenetic stimulation promises to overcome fundamental shortcomings of electrical stimulation, namely poor spatial resolution and cellular specificity, and accordingly to deliver more detailed sensory information. This review aims at providing a comprehensive reference on current gene therapeutic and optogenetic research relevant to the restoration of hearing and vision. We will introduce gene-therapeutic approaches and discuss the biotechnological and optoelectronic aspects of optogenetic hearing and vision restoration.

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