Alterations in the Serum Lipid Profile in Patients with Oral Cancer, Oral Precancerous Lesions/Conditions associated with the Habit of Tobacco Consumption

ABSTRACT The changes in lipid profile have long been associated with cancer because lipids play a key role in maintenance of cell integrity. Lipids are the major cell membrane components essential for various biological functions including cell growth and division of normal and malignant tissues. Lower blood lipids have been associated with the etiology of breast and colorectal cancer, and relation has also been reported between low cholesterol and increased risk of cancer occurrence and mortality. The present study was designed to evaluate the serum lipid profile in patients with oral precancerous lesion/condition and squamous cell carcinoma to see whether there are any alterations in the lipid levels during the pathogenesis of these lesions and also to evaluate significance of lipid profile as biochemical marker, if any.

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A study of serum lipid profile in smokers and non-smokers: evaluation of role of smoking on lipid profile

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20190995 ◽

2019 ◽

Vol 7 (4) ◽

pp. 1016

Author(s):

Chandrashekar V. Kubihal ◽

Hemalatha D. Naik

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Serum Lipid ◽

Serum Triglyceride ◽

Blood Cholesterol ◽

Serum Lipid Profile ◽

Serum Triglyceride Level ◽

Cross Sectional ◽

Cholesterol Levels ◽

Increased Risk

Background: Several studies have reported elevated blood cholesterol levels among persons who regularly smoke cigarettes and lowered blood cholesterol levels among persons quitting smoking. Other studies have also shown that smoking lowers high density lipoprotein level, resulting in an increased risk of coronary heart disease. Smoking also leads to increase in LDL cholesterol and triglyceride levels. The objective was to study serum lipid profile in smokers and non-smokers.Methods: A cross sectional comparative study was carried in 100 subjects. The subjects were divided into two groups. First group consisted of 25 nonsmokers and second group of 75 smokers. The group of 75 smokers was again divided into three equal sub groups of 25 each depending upon the duration and intensity of smoking. Concentration of serum total cholesterol and HDL was determined by Zak’s method. Concentration of serum LDL and VLDL cholesterol was determined by Friedwald’s formula. Concentration of serum triglyceride level was determined by enzymatic end point peroxidase coupled method.Results: All the values of lipid profile i.e., total cholesterol, triglycerides, LDL, VLDL were found to be significantly higher among the smokers compared to the non-smokers. HDL value was significantly lower among smokers. As the degree of smoking increased from mild to heavy smokers, the values of total cholesterol, triglycerides, LDL and VLDL increased. The degree of smoking was inversely proportional to HDL values i.e., the HDL value decreased as the smoking degree increased.Conclusions: Thus, it can be said based on the present study that smoking affects and deranges the lipid profile of the person.

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Alterations in Serum Lipid Profile Patterns in Oral Squamous Cell Carcinoma Patients

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1075 ◽

2011 ◽

Vol 12 (6) ◽

pp. 451-456 ◽

Cited By ~ 5

Author(s):

Gaurav Ghosh ◽

Krithika M Jayaram ◽

Rekha V Patil ◽

Sangeeta Malik

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Lipid Profile ◽

Cell Carcinoma ◽

Total Cholesterol ◽

Squamous Cell ◽

Serum Lipid ◽

Tobacco Consumption ◽

Serum Lipid Profile ◽

The Mean

ABSTRACT Aim Altered lipid profile patterns have been associated with malignancies because lipids play a pivotal role in the maintenance of cell integrity. The present study evaluated alterations in serum lipid profile in oral squamous cell carcinoma patients as well as its association with the habit of tobacco consumption. Materials and methods The study included 30 oral squamous cell carcinoma patients, 20 patients with the habit of tobacco consumption and 20 controls. Serum lipids, including (i) total cholesterol, (ii) LDL cholesterol (LDLC), (iii) HDL cholesterol (HDLC), (iv) VLDL cholesterol (VLDLC) and (v) triglycerides, were analyzed by spectrophotometric kits. Results A significant decrease in serum total cholesterol (TC) levels, triglyceride levels (p = 0.007, p = 0.029 respectively) were observed in oral squamous cell carcinoma patients as compared to the healthy control group. The mean serum HDLC levels (p = 0.003) were significantly lowered in the tobacco habituates when compared to the healthy controls. The mean serum total cholesterol levels were significantly lower in subjects with oral squamous cell carcinoma (p = 0.000) as compared to the tobacco habituates. Likewise, LDLC levels and TC:HDLC ratios (p = 0.000 and p = 0.000 respectively) were significantly decreased in oral squamous cell carcinoma patients as compared to the tobacco habituates. Our data strengthens the evidence of an inverse relationship between serum lipid levels and oral squamous cell carcinoma. Conclusion The lower level of serum cholesterol and other lipid constituents in the patients is thought to be due to their increased usage by tumor cells for new membrane biogenesis. Clinical significance The lower serum lipid profile status serves as a useful indicator for gauging initial changes occurring in tumor cells. A detailed study of the cholesterol carrying lipoprotein transport mechanisms helps in better understanding of the underlying mechanisms of the regulation of serum cholesterol concentrations in cancer. How to cite this article Ghosh G, Jayaram KM, Patil RV, Malik S. Alterations in Serum Lipid Profile Patterns in Oral Squamous Cell Carcinoma Patients. J Contemp Dent Pract 2011;12(6): 451-456.

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