scholarly journals Study of Prolactin in Cervicovaginal Secretion in Women with Preterm Labor and Normal Pregnancy

2020 ◽  
Vol 12 (1) ◽  
pp. 34-37
Author(s):  
Urmila Singh ◽  
Vandana Solanki ◽  
Seema Mehrotra ◽  
SM Natu ◽  
Shilpi Chauhan ◽  
...  
Keyword(s):  
Preterm Labor ◽  
Normal Pregnancy ◽  
Cervicovaginal Secretion

scholarly journals Sildenafil versus Nifedipine Treatment of PRETERM LABOR: RCT

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Alkady ◽  
M H Mostafa ◽  
R K Elkattan
Keyword(s):  
Preterm Labor ◽  
Normal Pregnancy ◽  
The United States ◽  
Labor Pain ◽  
University Hospital ◽  
P Value ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Future Therapy

Abstract Background a normal pregnancy lasts 37 to 42 weeks, counting from the first day of the last menstrual period. A pregnancy that continues beyond 37 weeks is called a “term” pregnancy. Preterm labor is defined as labor that begins before 37 weeks of pregnancy. Approximately 12 percent of babies in the United States are born preterm; 80 percent of these are due to preterm labor that occurs on its own or after preterm premature rupture of the fetal membranes (or “broken bag of waters”). The remaining 20 percent are planned early deliveries that are done for maternal or fetal problems that prevent the woman from being able to safely continue with her pregnancy. Aim of the Work to assess the efficacy of sildenafil for stopping the labor for 48 hrs compared to nifedipine in women with preterm labor. Patients and Methods this prospective study was carried on pregnant women with preterm labor pain at Ain Shams University Hospital from March 2018 till September 2018. Study includes 88 patients which were distributed into two groups: Group S: received Sildenafil to stop preterm labor.Group N: received Nifedipine to stop preterm labor. Results in the present study we found that mean age in group receiving sildenafil (group S) was 26.55 years and in group receiving nifidpine (group N) was 26.75 years with insignificant differences between two groups as regard age p-value 0.798, also as regard. BMI and parity there was insignificant differences between two groups as regard BMI p-value 0.727, 0.815 respectively, Mean Gestational age at admission was 27.1 weeks in group S and in group N was 28.16 with insignificant differences between two groups p-value 0.705. Conclusion administration of Sildenafil in women with preterm labor pain seems to be a promising future therapy of preterm labor with, limiting the teratogenic influence of the drugs on the fetus.

Inflammation in Complicated Pregnancy and Its Outcome

2016 ◽  
Vol 33 (14) ◽  
pp. 1337-1356 ◽  
Author(s):  
Ram Kalagiri ◽  
Timothy Carder ◽  
Saiara Choudhury ◽  
Niraj Vora ◽  
Amie Ballard ◽  
...  
Keyword(s):  
Preterm Labor ◽  
Maternal Obesity ◽  
Normal Pregnancy ◽  
Adverse Outcomes ◽  
Therapeutic Interventions ◽  
Inflammatory Factors ◽  
Diagnostic Tools ◽  
Inflammatory Reactions ◽  
Mortality And Morbidity

Background Normal pregnancy relies on a careful balance between immune tolerance and suppression. It is known that strict regulation of maternal immune function, in addition to components of inflammation, is paramount to successful pregnancy, and any imbalance between proinflammatory and anti-inflammatory cytokines and chemokines can lead to aberrant inflammation, often seen in complicated pregnancies. Inflammation in complicated pregnancies is directly associated with increased mortality and morbidity of the mother and offspring. Aberrant inflammatory reactions in complicated pregnancies often lead to adverse outcomes, such as spontaneous abortion, preterm labor, intrauterine growth restriction, and fetal demise. The role of inflammation in different stages of normal pregnancy is reviewed, compared, and contrasted with aberrant inflammation in complicated pregnancies. The complications addressed are preterm labor, pregnancy loss, infection, preeclampsia, maternal obesity, gestational diabetes mellitus, autoimmune diseases, and inflammatory bowel disease. Aim This article examines the role of various inflammatory factors contributing to aberrant inflammation in complicated pregnancies. By understanding the aberrant inflammatory process in complicated pregnancies, novel diagnostic tools and therapeutic interventions for modulating it appropriately can be identified.

scholarly journals Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth

2020 ◽  
Vol 28 (1) ◽  
pp. 228-236
Author(s):  
Jenna M. Mennella ◽  
Lori A. Underhill ◽  
Sophia Collis ◽  
Geralyn M. Lambert-Messerlian ◽  
Richard Tucker ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Preterm Birth ◽  
Matrix Metalloproteinase ◽  
Preterm Labor ◽  
Normal Pregnancy ◽  
Matrix Metalloproteinase 2 ◽  
Collagen Vi ◽  
Screening Model ◽  
Healthy Pregnancy ◽  
Early Indicators

AbstractPreterm birth is a leading cause of infant morbidity and mortality. Decorin and biglycan are proteoglycans that play key roles in maintaining the connective tissue matrix and tensile strength of human fetal membranes and have been previously linked to PPROM. Extracellular matrix proteins, such as matrix metalloproteinase 2 (MMP-2), matrix metalloproteinase 9 (MMP-9), TIMP metallopeptidase inhibitor 1 (TIMP-1), TIMP metallopeptidase inhibitor 2 (TIMP-2), and collagen VI (COL-6), have also been linked to PPROM and may have utility in a serum-based screening model for this condition. To define the natural course of serum decorin and biglycan expression throughout the duration of healthy pregnancy, to explore patterns of serum decorin and biglycan expression in serum of asymptomatic women who go on to develop spontaneous preterm labor, and to investigate the potential role for matrix metalloproteinases, their inhibitors, and collagen VI in a serum-based screening model to predict PPROM. Serum decorin level decreases less than 1% per week, and serum biglycan decreases by 2.9% per week over the duration of healthy pregnancy. Serum decorin and biglycan concentrations do not differ in spontaneous preterm labor cases compared with those in controls. Mean concentrations of MMP-2, MMP-9, TIMP-1, TIMP-2, and COL-6 do not differ in PPROM cases compared with those in controls. We have demonstrated that serum decorin and biglycan concentrations remain stable throughout the duration of normal pregnancy and are not early indicators of preterm labor, while common MMPs, TIMPs, and collagen VI are not early indicators of PPROM.

A comparison of vaginal secretory IgA levels in normal pregnancy and pregnancy complicated by preterm labor

1997 ◽  
Vol 176 (1) ◽  
pp. S50
Author(s):  
B.M. Karpel ◽  
A. Royek ◽  
L. Kletzin ◽  
F. Rolston ◽  
C.N. Codipily ◽  
...  
Keyword(s):  
Preterm Labor ◽  
Normal Pregnancy ◽  
Secretory Iga

scholarly journals Study of changes in levels of salivary estriol and progesterone in preterm labor in comparison to normal pregnancy

2019 ◽  
Vol 8 (12) ◽  
pp. 4660
Author(s):  
Richa Yadav ◽  
Urmila Singh
Keyword(s):  
Preterm Labor ◽  
Colorimetric Method ◽  
Normal Pregnancy ◽  
Antenatal Clinic ◽  
Mean Value ◽  
Significant Rise ◽  
Biologically Active ◽  
Control Group ◽  
P Value ◽  
Study Group

Background: This prospective research was designed to evaluate changes in levels of salivary Estriol and Progesterone in preterm labor in comparison to normal pregnancy. Spontaneous onset of labor at term is produced by definite increase in estriol and fall in progesterone. This rise in free estrogen should precede the onset of labor according with the known effect of estrogen and progesterone on myometrial activity. Concentration of steroid in saliva reflect unbound unconjugated and biologically active fraction.Methods: The present study was carried for duration of one year enrolling 115 antenatal women between 28 and < 37 weeks of gestation with or without labour pains attending the antenatal clinic in KGMU, Lucknow and those admitted in Queen Mary’s Hospital Lucknow. 5 ml of saliva was collected in cryovials from each patient to estimate estriol and progesterone. The estimation of saliva progesterone and estriol was done by immunoenzymatic colorimetric method of the supernatant of sample.Results: In our study mean value of saliva progesterone levels of pregnant women with preterm delivery (study group IIA) was lower than the control group (Group l) but the difference was not significant (3814.46±751.14 pg/ml versus 3945.16±577.11 pg/ml, p = 0.351). Mean value of estriol study group who delivered preterm (3512.85±586.16 pg/ml) was higher as compared to the mean value of control group (2691.72±681.08 pg/ml) and difference was significant (p value < 0.001).Conclusions: Thus, there is significant rise in level of saliva estriol, it can be used as a predictor for detecting symptomatic and asymptomatic women at risk for preterm birth.

scholarly journals The physiologic and therapeutic role of Heparin in implantation and placentation

2014 ◽  
Author(s):  
Michela Quaranta ◽  
Offer Erez ◽  
Salvatore Andrea Mastrolia ◽  
Arie Koifman ◽  
Elad Leron ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Preterm Labor ◽  
Normal Pregnancy ◽  
Fetal Demise ◽  
Therapeutic Role ◽  
Intrauterine Growth ◽  
Treatment And Prevention ◽  
Normal Gestation

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.

scholarly journals PERBANDINGAN KADAR ZINC PADA PERSALINAN PRETERM DAN KEHAMILAN NORMAL

2018 ◽  
Vol 12 (3) ◽  
pp. 212
Author(s):  
Visti Delvina ◽  
Arni Amir ◽  
Ermawati Ermawati
Keyword(s):  
Preterm Labor ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
T Test ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Significant Difference ◽  
The Mean ◽  
Zinc Levels

<p><strong><em>The Comparative   Zinc Levels in Preterm Labor and Normal Pregnancy</em></strong></p><h1 align="center"><em>ABSTRACT</em><em></em></h1><p><em> </em></p><p><em>               </em><em>Preterm labor occurs between 20 weeks and before 37 weeks of pregnancy. It is indicated by regular contractions of the uterus and it may cause the thinning and flattening of the cervix. Preterm labor also causes the high rates of perinatal morbidity and mortality. Deficiency zinc during pregnancy can stimulate the preterm labor. The design of this reseacrh was a comparative cross sectional study. It was conducted in Rasidin District Hospital, Siti Rahmah Hospital and Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang on Februari 2017 to June 2018. There were 50 samples in this reseach. It was selected by consecutive sampling. The samples were divided into two groups: preterm labor and normal pregnancy. Zinc levels are examined by the ELISA method. Then, the data were analyzed by using the t test. The results of this reseach showed that the mean zinc level in the preterm labor group was 12.22 ± 0.41 μmol / L and 13.96 ± 0.64 μmol / L of the mean zinc level in the normal pregnancy group with P= 0.000. Moreover, statistical test inffered that there was significant difference between zinc levels in preterm labor and normal pregnancy. In short, it can be concluded that zinc levels group in the preterm labor were lower than the normal pregnancy group.</em><em></em></p><p><em> </em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em>: Zinc, Preterm Labor</em><em></em></p><p align="center"><em> </em></p><p><em> </em></p><p><em> </em></p><p><em> </em></p><p><em> </em></p><p><em> </em></p><p><strong><em>Perbandingan Kadar Zinc Pada Persalinan Preterm dan Kehamilan Normal</em></strong></p><h1 align="center"><em>ABSTRAK</em><em></em></h1><p><em> </em></p><p><em>Persalinan</em><em> </em><em>preterm adalah persalinan yang terjadi antara 20 minggu dan sebelum 37 minggu kehamilan yang ditandai</em><em> </em><em>adanya kontraksi teratur dari </em><em>uterus</em><em> </em><em>yang dapat</em><em> </em><em>menyebabkan</em><em> </em><em>penipisan dan pendataran</em><em> </em><em>serviks. Persalinan preterm menyebabkan tingginya angka morbiditas dan mortalitas perinatal. Defiseiensi zinc selama kehamilan dapat menstimulasi terjadinya persalinan preterm. Desain penelitian ini adalah cross sectional komparatif, penelitian dilakukan di RSUD Rasidin, RSI Siti Rahmah dan Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas Padang pada bulan Februari 2017 – Juni 2018. Jumlah sampel sebanyak 50 yang dipilih secara consecutive sampling, yang dibagi menjadi dua kelompok yaitu persalinan preterm dan kehamilan normal. Kadar zinc diperiksa dengan metode ELISA. Data dianalisa menggunakan uji t test. </em><em>Hasil penelitian rerata kadar zinc pada kelompok persalinan preterm 12,22 ± 0,41 µmol/L dan rerata kadar zinc pada kelompok kehamilan normal adalah 13,96 ± 0,64 µmol/L dengan nilai p 0,000. Secara statistik terdapat perbedaan yang bermakna antara kadar zinc  pada persalinan preterm dan kehamilan normal. Kesimpulan, kadar zinc pada kelompok persalinan preterm lebih rendah daripada kelompok kehamilan normal.</em><em></em></p><p><em> </em><em></em></p><p><em> </em></p><p><strong><em>Kata Kunci</em></strong><em> : Zinc, Persalinan Preterm</em></p>

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