scholarly journals Ultrasonographic Signs of Poor Pregnancy Outcome

2017 ◽  
Vol 11 (1) ◽  
pp. 44-58
Author(s):  
Lucía Serrano-González ◽  
María Martinez-Moya ◽  
María Platero-Mihi ◽  
José Bajo-Arenas ◽  
Tirso Perez-Medina
Keyword(s):  
Pregnancy Outcome ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
Normal Pregnancy ◽  
Abdominal Wall Defects ◽  
Crown Rump Length ◽  
Additional Information ◽  
Caudal Regression ◽  
3D Volume ◽  
Poor Pregnancy Outcome

ABSTRACT The frequency of spontaneous abortion, when it is considered from its very beginning, along with the theoretical knowledge of the causes of the abortion, should provide a perspective to the obstetrician that, performing a sonographic exploration finds discoveries that cannot correspond to those characterizing a normal pregnancy. The precocity of the realization of sonographic explorations in the pregnancy will allow diagnosis of many more cases of spontaneous interruptions of the development of pregnancy. New sonographic imaging techniques including three-dimensional (3D) sonography can provide additional information regarding the presence of structural anomalies via 3D volume acquisition, like craniofacial deformities, clefts, neural tube defects, abdominal wall defects, and caudal regression syndrome. It may give further details regarding the timing of embryonic/fetal demise in early pregnancy. Sufficient informational value is regularly obtained in cases having a crown-rump length >8 mm. How to cite this article Serrano-González L, Martinez-Moya M, Platero-Mihi M, Bajo-Arenas J, Perez-Medina T. Ultrasonographic Signs of Poor Pregnancy Outcome. Donald School J Ultrasound Obstet Gynecol 2017;11(1):44-58.

Three-dimensional ultrasound first trimester fetal volume measurement and its relation to pregnancy outcome

2017 ◽  
Vol 45 (9) ◽  
Author(s):  
Haitham A. Torky ◽  
Asem A. Moussa ◽  
Ali M. Ahmad ◽  
Osama Dief ◽  
Manar A. Eldesoouky ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnancy Outcome ◽  
Gestational Age ◽  
Preterm Labor ◽  
Three Dimensional ◽  
First Trimester ◽  
3D Ultrasound ◽  
Secondary Outcome ◽  
Crown Rump Length

AbstractAim of work:To determine whether fetal volume (FV) measured by three-dimensional (3D) ultrasound was able to detect fetuses at risk of low birth weight (primary outcome) and/or preterm labor (secondary outcome).Methods:One hundred pregnant women carrying a singleton living pregnancy who were sure of dates, and had a dating scan, with gestational age between 11 weeks and 13 weeks+6 days coming for routine first trimester nuchal translucency (NT) were examined by both two-dimensional (2D) and 3D ultrasound (Vocal System) for crown-rump length (CRL) and FV then followed up regularly every 4 weeks until 28 weeks then biweekly until 36 weeks then weekly until delivery both clinically and by ultrasound biometry.Findings:Eighty-seven cases had a normal outcome, while the remaining 13 cases had either preterm labor (four cases) or low-birth weight (nine cases). FV positively correlated with CRL (P=0.026), gestational age in weeks (P=0.002), neonatal body weight in grams (P=0.018) and neonatal body length at birth (P=0.04). A mean FV of 8.3 mmConclusion:3D assessment of FV in the first trimester provides an accurate method for predicting pregnancy outcome namely low birth weight and neonatal complications, however, it is a better positive predictor than a negative one.

scholarly journals Lack of nitric oxide bioavailability in early pregnancy predisposes to dyslipidemia and surges preeclampsia and fetal growth retardation

2021 ◽  
Author(s):  
Aida A. Korish
Keyword(s):  
Nitric Oxide ◽  
Lipid Profile ◽  
Pregnancy Outcome ◽  
Normal Pregnancy ◽  
High Density Lipoproteins ◽  
No Production ◽  
Blood Lipid Profile ◽  
Pregnant Rats ◽  
Nitric Oxide Synthase Inhibitor ◽  
Poor Pregnancy Outcome

Background: Hyperlipidemia has been reported in preeclampsia (PrE) and is linked to poor pregnancy outcome and long-term cardiovascular complications. This study aimed to elucidate the relationship between nitric oxide (NO) and blood lipids levels during normal pregnancy and in NG-nitro-l-arginine methyl ester (L-NAME) - induced preeclampsia before and after magnesium sulphate (MgSO4) therapy and its effect on the pregnancy outcome.Methods: Forty female Wistar rats were divided into four groups: non pregnant (NP) group - non pregnant healthy rats receiving no treatment, control pregnant (Con-P) group - control pregnant rats receiving no treatment, pregnant (PE) group - pregnant animals with untreated PrE, and the pregnant MgSO4 (PE-Mg) group - pregnant animals with PrE- treated with MgSO4. The nitric oxide synthase inhibitor L-NAME was used to induce experimental model of PrE in the PE and the PE-Mg groups. The changes in total NO production, total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL-C), high density lipoproteins (HDL), LDL-C/HDL-C ratio, soluble vascular endothelial growth factor receptor-1 (sVEGFR1) also known as sFlt-1, blood pressure, kidney functions, body weight, and pregnancy outcome were assessed.Results: Decreased NO production in the PE group was associated with elevated TC, TG, LDL-C/HDL-C ratio, hypertension, proteinuria, increased urea, creatinine, and sFlt-1 levels, and poor pregnancy outcome demonstrated by high pup mortality rate and low birth weight. Increased NO production in the PE-Mg group treated with MgSO4 therapy was associated with decreased signs of preeclampsia and hypolipidemia and increased pup viability and birth weight.Conclusions: NO bioavailability is crucial for the homeostasis of the lipid profile in normal pregnancy and the prevention of preeclampsia. Routine periodic assessments of the blood lipid profile and the NO production in the pregnant females may be a helpful tool in early prediction of preeclampsia.

scholarly journals Mean Sac Diameter Minus Crown Rump Length as a Predector of Early Pregnancy Outcome

2021 ◽  
pp. 93-104
Author(s):  
Hasnaa M. Mosbah ◽  
Mona K. Omar ◽  
Manal F. Hemisa ◽  
Elsayed F. Rakha
Keyword(s):  
Pregnancy Outcome ◽  
Early Pregnancy ◽  
Transvaginal Ultrasound ◽  
Normal Pregnancy ◽  
Accurate Estimation ◽  
P Value ◽  
Good Prediction ◽  
Crown Rump Length ◽  
Gestational Sac ◽  
The Difference

Background: Mean sac diameter (MSD) is a sonographic measurement of the gestational sac which is usually first seen at around 5 weeks, when it measures about 2-3 mm, It's the average of measurements taken in three dimensions.Crown rump length (CRL) defined as the length of the embryo or fetus from the top of it's head to bottom of torso, it's the most accurate estimation of gestational age in early pregnancy, it's determined by the average of three measurements of the longest fetal length. Aim of the study Determine efficacy of mean sac diameter minus crown rump length  (MSD-CRL) in prediction of early pregnancy outcome. Methods: The study included 80 cases at (6:9) gestational weeks with singletone pregnancy. We examined the case at the initial visit, Mean sac diameter and Crown rump length were calculated for each case. The difference between the MSD and CRL in mm was calculated. Then follow up visit after two weeks later. Pregnancy outcome was then recorded between (11:14w). During transvaginal ultrasound (TVUS) we observed location, size, number and regularity of gestational sac. Cardiac pulsation & Presence or absence of sub-chorionic hematoma. Results: 73 cases (91, 3%) continued normal pregnancy and 7 cases (8, 8%) had pregnancy failure. It was found that the age, body mass index, gravidity and history of abortion show insignificant relation with outcome (p >0.05).  Area under a curve was 0.984, p Value was <0.001, 95% CI was (0.961 – 1.000), at the cut off value (MSD-CRL) less than or equal 4, the sensitivity was 71.4%, the specificity was 97.2%, PPV was 71.4% and NPV was 97.3%, while at cut off value less than or equal 5, the sensitivity was 100.0%, specificity was 95.89, PPV was 70.0% and NPV was 100.0%. Conclusions: (MSD- CRL) is good prediction for early pregnancy outcome but, the optimum threshold for predicting pregnancy outcome needed to be established by further studies, also bigger sample size will provide more advantage.

Second trimester Doppler ultrasound screening of the uterine arteries differentiates between subsequent normal and poor outcomes of hypertensive pregnancy: two different pathophysiological entities?

2004 ◽  
Vol 106 (4) ◽  
pp. 377-382 ◽  
Author(s):  
M. W. AARDEMA ◽  
M. C. S. SARO ◽  
M. LANDER ◽  
B. T. H. M. DE WOLF ◽  
H. OOSTERHOF ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Pregnancy Outcome ◽  
Doppler Ultrasound ◽  
Early Onset ◽  
Uterine Artery ◽  
Normal Pregnancy ◽  
Striking Difference ◽  
Ultrasound Screening ◽  
Nulliparous Women ◽  
Poor Pregnancy Outcome

The ‘classical’ concept that pregnancy-induced hypertension (PIH) and pre-eclampsia (PE) primarily originate from defective placentation in early pregnancy has been challenged recently. There is growing evidence that other factors, including maternal predisposing conditions, also play a significant role in the pathophysiology of PIH and PE. The aim of the present study was to test the hypothesis that PIH and PE with an early onset and poor pregnancy outcome is associated with defective placentation, e.g. inadequate spiral artery dilatation and subsequent reduced uteroplacental perfusion, whereas PIH and PE with normal pregnancy outcome is not. Using Doppler ultrasound, we measured the uterine artery pulsatility index (PI) in a population of 531 nulliparous women in the 22nd week of gestation. Uterine artery PI was used as an index of resistance to blood flow in the uteroplacental circulation. Outcome measures were PIH/PE with or without poor pregnancy outcome, preterm birth and intra-uterine growth restriction (IUGR). The results revealed a striking difference between PI values for PIH/PE with and without poor pregnancy outcome. Uterine artery PI in the 22nd week was increased significantly in pregnancies which developed early-onset (before 35 weeks) PIH/PE with a poor pregnancy outcome. In contrast, uterine artery PI values were normal in women who developed PIH/PE, but had a good pregnancy outcome. There was a significant correlation between 22nd week uterine artery PI and subsequent preterm birth or IUGR. Our results indicate that only PIH/PE with poor pregnancy outcome is associated with defective placentation, whereas PIH/PE with good outcome is not. These findings support the concept of heterogeneous causes of hypertensive disorders of pregnancy.

Registration of Biplane Angiography and Intravascular Ultrasound for 3D Vessel Reconstruction

2004 ◽  
Vol 43 (04) ◽  
pp. 398-402 ◽  
Author(s):  
M. Wawro ◽  
H. Müller ◽  
C. Wilke ◽  
F. Weichert
Keyword(s):  
Intravascular Ultrasound ◽  
Three Dimensional ◽  
Interventional Treatment ◽  
Alignment Procedure ◽  
Additional Information ◽  
Vascular Brachytherapy ◽  
Computer Based ◽  
Stenotic Arteries ◽  
3D Volume ◽  
Biplane Angiography

Summary Abstract: If planned and applied correctly, intra-vascular brachytherapy (IVB) can significantly reduce the risk of restenosis after interventional treatment of stenotic arteries. Objectives: In order to facilitate computer-based IVB planning, a three-dimensional reconstruction of the stenotic artery based on intravascular ultrasound (IVUS) sequences is desirable. Methods: To attain a 3D reconstruction, the frames of the IVUS sequence are properly aligned in space and completed with additional intermediate frames generated by interpolation. The alignment procedure uses additional information that is obtained from biplane X-ray angiography performed simultaneously during the capturing of the IVUS sequence. After IVUS images and biplane angiography data are acquired from the patient, the vessel-wall borders and the IVUS catheter are detected by an active contour algorithm. Next, the twist between adjacent IVUS frames is determined by a sequential triangulation method combined with stochastic analysis. Results: The above procedure results in a 3D volume-model of the vessel, which also contains information from the IVUS modality. This data is sufficient for computer-based intravascular brachytherapy planning. Conclusion: The proposed methodology can be used to improve the current state-of-the-art IVB treatment planning by enabling computerized dosage computations on a highly accurate 3D model.

Mitochondrial Reconstructions Based on Serial Thick Sections and HVEM

1975 ◽  
Vol 33 ◽  
pp. 286-287
Author(s):  
Jerome J. Paulin
Keyword(s):  
Imaging Techniques ◽  
Three Dimensional ◽  
Posterior Pole ◽  
Dimensional Structure ◽  
Stereo Imaging ◽  
Thin Sections ◽  
Anatomical Features ◽  
The Past ◽  
Cellular Components ◽  
Mitochondrial Reticulum

Within the past decade it has become apparent that HVEM offers the biologist a means to explore the three-dimensional structure of cells and/or organelles. Stereo-imaging of thick sections (e.g. 0.25-10 μm) not only reveals anatomical features of cellular components, but also reduces errors of interpretation associated with overlap of structures seen in thick sections. Concomitant with stereo-imaging techniques conventional serial Sectioning methods developed with thin sections have been adopted to serial thick sections (≥ 0.25 μm). Three-dimensional reconstructions of the chondriome of several species of trypanosomatid flagellates have been made from tracings of mitochondrial profiles on cellulose acetate sheets. The sheets are flooded with acetone, gluing them together, and the model sawed from the composite and redrawn.The extensive mitochondrial reticulum can be seen in consecutive thick sections of (0.25 μm thick) Crithidia fasciculata (Figs. 1-2). Profiles of the mitochondrion are distinguishable from the anterior apex of the cell (small arrow, Fig. 1) to the posterior pole (small arrow, Fig. 2).

Image formation analysis of thick biological specimens using three-dimensional power-spectra of through focus series

1994 ◽  
Vol 52 ◽  
pp. 124-125
Author(s):  
Karen F. Han
Keyword(s):  
Inelastic Scattering ◽  
Imaging Techniques ◽  
Mass Density ◽  
Relative Proportion ◽  
Three Dimensional ◽  
Power Spectra ◽  
Image Formation ◽  
Energy Filtering ◽  
Ewald Sphere ◽  
Nonlinear Imaging

The primary focus in our laboratory is the study of higher order chromatin structure using three dimensional electron microscope tomography. Three dimensional tomography involves the deconstruction of an object by combining multiple projection views of the object at different tilt angles, image intensities are not always accurate representations of the projected object mass density, due to the effects of electron-specimen interactions and microscope lens aberrations. Therefore, an understanding of the mechanism of image formation is important for interpreting the images. The image formation for thick biological specimens has been analyzed by using both energy filtering and Ewald sphere constructions. Surprisingly, there is a significant amount of coherent transfer for our thick specimens. The relative amount of coherent transfer is correlated with the relative proportion of elastically scattered electrons using electron energy loss spectoscopy and imaging techniques.Electron-specimen interactions include single and multiple, elastic and inelastic scattering. Multiple and inelastic scattering events give rise to nonlinear imaging effects which complicates the interpretation of collected images.

EFFECT OF FEEDING ETHINYLOESTRADIOL FOR VARIOUS PERIODS BEFORE MATING ON REPRODUCTION IN THE HAMSTER

1972 ◽  
Vol 70 (3) ◽  
pp. 582-590
Author(s):  
B. K. Davis ◽  
I. Noske ◽  
M. C. Chang
Keyword(s):  
Single Dose ◽  
Pregnancy Rate ◽  
Fertility Control ◽  
Normal Pregnancy ◽  
Oestrous Cycle ◽  
The Other ◽  
Feeding Schedule ◽  
Crown Rump Length ◽  
Essentially Normal ◽  
Effect Of Feeding

ABSTRACT Ethinyloestradiol (EO) fed for various periods before mating to female hamsters affected the timing of mating and pregnancy rate. Slight effects on ovulation, foetal-crown rump length and resorption may have occurred, but effects on implantation were not apparent among pregnant hamsters. The response observed depended upon the feeding schedule adopted: hamsters fed 2.5 mg EO in a single dose, on day 3 before mating, mated normally but had a significantly lower pregnancy rate; on the other hand, animals fed 2.5 mg EO (0.21 mg/day) over three oestrous cycles, days 14–3 before mating, showed variations in the time of mating but had an essentially normal pregnancy rate; and, a group of hamsters who received the same total amount of EO (0.63 mg/day) over one oestrous cycle, days 6–3 premating, showed untowards effects by the steroid on both the timing of mating and pregnancy rate. The implications of these results are considered in relation to fertility control.

Cardiovascular Imaging for Guiding Interventional Therapy in Structural Heart Diseases

2020 ◽  
Vol 16 (2) ◽  
pp. 111-122
Author(s):  
Nora Rat ◽  
Iolanda Muntean ◽  
Diana Opincariu ◽  
Liliana Gozar ◽  
Rodica Togănel ◽  
...  
Keyword(s):  
Heart Diseases ◽  
Interventional Procedure ◽  
Imaging Techniques ◽  
Ductus Arteriosus ◽  
Three Dimensional ◽  
High Specificity ◽  
Interventional Therapy ◽  
Structural Defects ◽  
Imaging Method ◽  
Three Dimensional Echocardiography

Development of interventional methods has revolutionized the treatment of structural cardiac diseases. Given the complexity of structural interventions and the anatomical variability of various structural defects, novel imaging techniques have been implemented in the current clinical practice for guiding the interventional procedure and for selection of the device to be used. Three– dimensional echocardiography is the most used imaging method that has improved the threedimensional assessment of cardiac structures, and it has considerably reduced the cost of complications derived from malalignment of interventional devices. Assessment of cardiac structures with the use of angiography holds the advantage of providing images in real time, but it does not allow an anatomical description. Transesophageal Echocardiography (TEE) and intracardiac ultrasonography play major roles in guiding Atrial Septal Defect (ASD) or Patent Foramen Ovale (PFO) closure and device follow-up, while TEE is the procedure of choice to assess the flow in the Left Atrial Appendage (LAA) and the embolic risk associated with a decreased flow. On the other hand, contrast CT and MRI have high specificity for providing a detailed description of structure, but cannot assess the flow through the shunt or the valvular mobility. This review aims to present the role of modern imaging techniques in pre-procedural assessment and intraprocedural guiding of structural percutaneous interventions performed to close an ASD, a PFO, an LAA or a patent ductus arteriosus.

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