Epithelial Thickness and Mouth Opening Negatively Correlates with the Burning Sensation of the Oral Cavity: A Pilot Clinicopathological Study

Abstract Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition characterized by limited mouth opening, burning sensation, stiffness, and blanching of the oral mucosa induced by areca nut eating. With any of the current therapy regimens, complete regression of the illness has not been accomplished in all patients. Curcumin is a yellow pigment found in curry powder that has antioxidant, anti-inflammatory, and pro-apoptotic properties. As a result, interventional research was conducted to determine the efficacy of Collaper RTu a proprietary collagen-curcumin based product in patients with OSMF.Setting and design: Forty patients with clinically and histologically confirmed Oral Submucous Fibrosis participated in a randomized open label interventional research. Method & materials: For the research, forty patients with clinically and histologically verified Oral Submucous Fibrosis were randomly assigned to one of two groups. The first group was given a weekly intralesional injection of 4 mg Dexamethasone and 1500 I.U Hyaluronidase, whereas the second was given two Collagen-Curcumin pills (Collaper Rtu 60mg Collagen with 100 mg Curcumin) every day for three months. On a weekly basis, the improvement of burning sensation, interincisal distance, and tongue protrusion was assessed.Results: From early to late stages, the burning feeling improved in both groups. Collaper Rtu was found to eliminate the burning feeling. In groups 1 and 2, the mean increase in interincisal distance was 3.13 mm and 1.25 mm, respectively. The interincisal distance improved significantly in both groups by the end of the first month. When compared to group 2, group 1's tongue protrusion recovered faster at the conclusion of the first month. Conclusion: Collaper RTu is useful and effective in lowering the burning feeling in people with early OSMF.

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Efficacy of betamethasone, hyaluronidase and its combination on mouth opening, burning sensation and QOL in patients with OSF

Journal of Oral Biology and Craniofacial Research ◽

10.1016/j.jobcr.2020.07.007 ◽

2020 ◽

Vol 10 (4) ◽

pp. 492-497

Author(s):

Mohd Saalim ◽

Kaustubh Sansare ◽

Ibrahim K. Ali ◽

Heena Sonawane ◽

Neha Singla ◽

...

Keyword(s):

Mouth Opening ◽

Burning Sensation

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Hearing Efficiency in Oral Submucous Fibrosis: A Clinical Study

Indian Journal of Otolaryngology and Head & Neck Surgery ◽

10.1007/s12070-020-02246-5 ◽

2020 ◽

Author(s):

J. S. Shah ◽

Nutan Lunagariya

Keyword(s):

Oral Mucosa ◽

Conductive Hearing Loss ◽

Oral Submucous Fibrosis ◽

Hearing Threshold ◽

Mouth Opening ◽

Burning Sensation ◽

Areca Nut ◽

Gradual Reduction ◽

Submucous Fibrosis ◽

Conductive Hearing

Abstract Oral Submucous fibrosis (OSMF) is a chronic insidious disease of oral mucosa that occurs due to areca-nut chewing, consumption of chillies, autoimmunity and genetic predisposition. The disease starts with burning sensation and inability to tolerate spicy foods with gradual reduction in mouth opening due to fibrosis of the oral mucosa. The extension of fibrosis into the naso pharynx leads to reduction in hearing efficiency. As very few studies had been done to evaluate the hearing disability in OSMF patients, this study had been undertaken to prove the same. To evaluate hearing efficiency in patients with Oral Submucous Fibrosis of various grades of severity. Presentation includes 30 patients of osmf with various grades and evaluated for hearing efficacy by audiometry. Hearing threshold was compared in different grades of osmf. The present study revealed a significant association between OSMF and hearing deficit. Involvement of the palatal muscles with OSMF may decrease the patency of the Eustachian tube, leading to conductive hearing loss. Therefore, the protocol for managing OSMF patients should include ENT consultation and treatment for hearing deficit in order to increase the success rate of treatment.

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An Enhanced Development of 3D Intra-Oral Scanner Using Fringe-Projection Technique for Dentistry

Volume 2: Advanced Manufacturing ◽

10.1115/imece2016-66427 ◽

2016 ◽

Author(s):

Hong-Seok Park ◽

Chintal Shah ◽

Rima Shah

Keyword(s):

Oral Cavity ◽

Light Source ◽

Phase Distribution ◽

Three Dimensional ◽

Mouth Opening ◽

Vital Role ◽

Fringe Projection ◽

Mapping Algorithm ◽

Novel Approach ◽

Cad Cam

3D shape recognization technique is rapidly advancing from last decade in the fields of manufacturing, computer science, entertainment and medical technology. Due to the restriction of size and area of cavity, it’s challenging to develop such non-contact optical technologies for scanning. 3D digitization technology plays a vital role in the field of dentistry benefiting dentists and patients by eliminating long time procedures for making the prosthesis/abutments and results into ultimate comfort. In this paper, we have recounted a design of a prototype for a three-dimensional intra-oral scanner using the principle of fringe projection and active triangulation method. LED as a light source passed through the liquid crystal on silicon (LCoS) which radiates the light into three colors and strikes onto the collimating lens assembly and then passed through the optical deflectors. Once the light strikes the object through scanning window it is guided back through the flat reflectors and the fringe pattern on the object is stored into the gray encoding plate. With the help of camera all these images are stored. After the acquisition of images, firstly it will calculate the phase distribution using four-step phase shifting algorithm and unwrap the wrap phase which helps us in getting accurate images. Later, we get display of scanned oral cavity onto the computer screen. Phase-height mapping algorithm has been realized for the reconstruction of the 3D real time reconstruction of the scanned oral cavity which helps us in fast scanning with accurate data. A novel approach of LED as a light source and LCoS display for scattering light fragments into three different colors helps us to scan more effectively for registration of dental surfaces from the patient’s mouth more accurately. Apart from that, its sleek design helps to scan with less pain to the patient’s having low mouth opening. Experiment was performed on the prototype of denture and using this proposed method we have achieved the accuracy of 25μm and it took around 180 sec for the full arc scan of the lower oral cavity. The result of scanned data was checked using the CAD/CAM software for dentistry and compared with the prototype data of denture. Further this image can be used for making prosthesis/abutment directly into production using 3D printing machine or the milling machine. Thus, an abutment or prosthesis obtained with this method is of high quality and eliminates conventional long procedures which helps in reducing pain of patient’s and helps dentists to attain more patients in less time.

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Health related quality of life (HRQoL) and demographic characteristics of long term head and neck cancer survivors submitted to concomitant chemoradiation in Brazil

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.18572 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 18572-18572

Author(s):

D. V. Santos ◽

K. M. Kiyota ◽

I. Snitcovsky ◽

G. M. Leitão ◽

M. H. Federico

Keyword(s):

Head And Neck Cancer ◽

Oral Cavity ◽

Head And Neck ◽

Neck Cancer ◽

Financial Distress ◽

Mouth Opening ◽

Demographic Characteristics ◽

Emotional Function ◽

Related Quality ◽

Eortc Qlq

18572 Background: Head and neck cancer (HNC) is a stigmatizing disease. In order to identify special needs in these patients (pts), we evaluated HRQoL and the demographic characteristics of HNC pts who had survived at least one year after chemoradiation. Methods: Our survey, done in may 2005, identified 42 pts alive (from 527 admitted from May 2002 to May 2004 treated with either exclusive (n = 19) or adjuvant (n = 23) chemoradiation. These pts as well 16 normal controls, were interviewed and invited to complete EORTC-QLQ-C30 and HN35. These questionnaires had already been validated for Brazilian Portuguese. Primary site was 12 oral cavity, 14 pharynx, 13 larynx, 3 not determined. Age 60.3 ± 9.0 y, 36 male and 6 female; 39 were squamous cell carcinoma and 3 other type; 28 were stage III or IV; 40 had no evidence of disease and two had recurrent disease at the time of survey. Comparison between groups were done by using the Mann-Whitney test and differences of at least 10 points was considered of clinical significance. Simple correlations were conducted between HRQoL variables and clinical correlates and demographics. The level of significance was established at p < 0.05. This work was conducted according to Helsinki declaration and Brazilian law. Results: Scores relative to global QoL (p = 0.18) and emotional function (p = 0.59) did not differ in pts as compared to controls. Pts presented worse scores in swallowing, senses, speech, pain, dental problems, xerostomia and mouth opening (all p < 0.05). Emotional function (r = 0.316, p = 0.041) and financial worries (r = −0.509, p = 0.001) impacted on global QoL, what did not happen with marital status, income and level of education, age or previous surgery. Chronic pain was more prevalent in oral cavity tumors than in other sites such as pharynx or larynx tumors (p = 0.046 and p = 0.030, respectively). Pts with larynx tumors presented worse cough score as compared to those with pharynx tumors (p = 0.009). Conclusions: Providing continuous oral and dental care seems to be important to address survivors’ concerns. Financial distress could be ameliorated by a better social support system. Tumor site seem to affect differently some domains of HRQoL, in contrast to organ preservation. No significant financial relationships to disclose.

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Measurement of epithelial thickness within the oral cavity using optical coherence tomography (OCT)

10.1117/12.853543 ◽

2010 ◽

Cited By ~ 2

Author(s):

S. Prestin ◽

C. Betz ◽

M. Kraft

Keyword(s):

Optical Coherence Tomography ◽

Oral Cavity ◽

Optical Coherence ◽

Epithelial Thickness

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Paresthesia of mucosae membranes of an oral cavity against the background of taking inhaled hormonal drugs

Vestnik of Russian military medical Academy ◽

10.17816/brmma12291 ◽

2018 ◽

Vol 20 (4) ◽

pp. 101-105

Author(s):

L N Kazarina ◽

I M Chuvarkova

Keyword(s):

Oral Cavity ◽

Bronchial Asthma ◽

Drug Group ◽

Burning Sensation ◽

Oropharyngeal Candidiasis ◽

Long Time ◽

And Control ◽

Further Development ◽

Medium Weight ◽

Immunologic Status

Bronchial asthma draws the attention of increasing number of doctors worldwide. The prevalence of this disease is from 4 to 10%. Nowadays basic medicines for treatment and control of bronchial asthma are inhalation hormonal drugs which are taken daily and for a long time, often the whole life of a patient. According to numerous literary data, this drug group owing to a way of their introduction causes a series of complications in an oral cavity. The most frequent of them are the oropharyngeal candidiasis, a dysphonia and paresthesia of a mucosa of a mouth. Above-mentioned complications are directly bound to the existence of a dysbiosis of a mouth that contributes to the development of an immune failure and sensitivity to organism microbial antigens. It was established, that patients with bronchial asthma of medium-weight severity with various experience of intake of inhalation hormonal drugs were examined highly often complaint to dryness, a burning sensation not only in an oral cavity, but also in the field of a larynx and a pharynx, on a food faddism, pain at meal, on availability of scurf of white color on various sites of a mucosa of an oral cavity. There were not only existence of characteristic symptoms of these diseases, but also depression of the immunologic status and change of a microbial landscape of an oral cavity at the patients with bronchial asthma taking the inhalation hormonal drugs. The above confirms the fact of obligatory detailed studying of implications in an oral cavity at the patients with bronchial asthma taking the inhalation hormonal drugs and the related complications, their nature, and further development of a rational way of the etiopathogenetic scheme of treatment and also their prevention.

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EFFICACY OF ANTIOXIDANT WITH ALOE VERA GEL VERSUS INTRA-LESIONAL STEROIDS IN THE MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS - A PROSPECTIVE COMPARATIVE STUDY

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v71isuppl-3.7921 ◽

2021 ◽

Vol 71 (Suppl-3) ◽

pp. S526-29

Author(s):

Muhammad Tahir ◽

Asim Abbas ◽

Faiz Ul Hassan Nawaz ◽

Mohsin Raza ◽

Atif Rafique ◽

...

Keyword(s):

Comparative Study ◽

Lipoic Acid ◽

Oral Submucous Fibrosis ◽

Aloe Vera ◽

Mouth Opening ◽

Burning Sensation ◽

Alpha Lipoic Acid ◽

Aloe Vera Gel ◽

Prospective Comparative Study ◽

Submucous Fibrosis

Objective: To compared efficacy of alpha lipoic acid (antioxidant medication) and aloe vera gel together versus intralesional steroids (hydrocortisone) in management of oral submucous fibrosis by evaluating post treatment clinical features of mouth opening and burning sensation. Study Design: A prospective comparative study. Place and Duration of Study: Department of ENT, Combined Military Hospital, Malir Karachi, from Jul 2018 to Mar 2020. Methodology: Twenty-eight patients were involved in the research and were distributed into two groups, I and II. Alpha lipoid acid with aloe vera gel was given in group I and hydrocortisone was given in group II. Burning sensation and mouth opening were recorded both at start and at monthly interval later on for three consecutive months. The data collected were statistically analyzed by using SPSS-22. Results: A significant lessening in burning sensation (p<0.001) and improvement in mouth opening were noticed in both groups. However, comparison between alpha lipoic acid with aloe vera gel group versus hydrocortisone group showed almost similar results. Conclusion: Alpha lipoic acid and aloe vera gel can significantly improve oral submucous fibrosis clinically. So, these can be utilized as an alternative option in cases where intralesional steroid is poorly tolerated or is contraindicated.

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Burning Mouth Syndrome pada wanita Menopause dengan Hiposalivasi, Coated Tongue dan Gangguan Pengecapan serta Penatalaksanaannya

Majalah Kedokteran Gigi Indonesia ◽

10.22146/majkedgiind.15920 ◽

2012 ◽

Vol 19 (1) ◽

pp. 82

Author(s):

Sri Hadiati

Keyword(s):

Oral Cavity ◽

Postmenopausal Women ◽

Vitamin B1 ◽

Burning Mouth Syndrome ◽

Burning Sensation ◽

Chewing Gum ◽

Affected Patient ◽

Burning Mouth ◽

Oral Burning

Blackground: Burning mouth syndrome (BMS) is a disorder that is characterized by a burning sensation of the oral cavity in the absence of visible local or systemic abnormalities. Affected patient often present with multiple oral complaints, including burning, dryness and taste alterations. The exact cause of burning mouth syndrome often is difficult to pin point. Conditions that have been reported in association with burning mouth syndrome include menopause, hyposlivation, coated tongue, taste alterations and psychologic condition. Objective: To report a case of burning mouth syndrome in postmenopausal women with hyposalivation, coated tongue, taste alterations and psychologic condition and its management. Case and management: a case of burning mouth syndrome in women with menopause, hyposalivation, coated tongue, and taste alterations, was managed effectively by gabapentin 100mg, probiotic chewing gum, diazepam 2mg and vitamin B1, B6, B12. Conclusion: Oral burning appears to be most prevalent in postmenopausal women often present with multiple oral complaints, including burning, dryness and taste alterations, in this case was managed effectively by gabapentin 100mg, prebiotic chewing gum, diazepam 2mg and vitamin B1, B6, B12.

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Effectiveness of Pentoxifylline Therapy for Management of Oral Submucous Fibrosis

Journal of Nepalgunj Medical College ◽

10.3126/jngmc.v19i1.40228 ◽

2022 ◽

Vol 19 (1) ◽

pp. 51-54

Author(s):

Dwarika Prasad Bajgai ◽

Bela Agrawal ◽

Abadhesh Yadav

Keyword(s):

Oral Submucous Fibrosis ◽

Mouth Opening ◽

Burning Sensation ◽

Oral Disease ◽

Medical College ◽

Adjacent Structures ◽

Group A ◽

Submucous Fibrosis ◽

Group B

Introduction: Oral submucous fibrosis is a chronic oral disease characterized by progressive buildup of constricting collagen bands in the cheeks and adjacent structures of the mouth due to chewing of areca nut. This can severely restrict mouth opening and tongue movement causing pain and burning sensation in the mouth. Aims: This study evaluates the efficacy of pentoxifylline in the management of oral submucous fibrosis. Methods: A hospital-based study, conducted in the dental outpatient department of Nepalgunj Medical College from October 2019 to September 2020. Forty-nine patients who were diagnosed histopathologically with oral submucous fibrosis were included. The patients were divided into two groups. In group A, patients were given, 200 mg thrice daily for first 30 days, then dose hiked to 400 mg thrice daily for two more months. Group B patients received treatment with multi-vitamin capsules (B-complex one capsule before sleep daily) for three months. All patients were followed up for six months and were assessed for maximum inter-incisor opening, pain on opening of mouth and burning sensation. Results: There was no statistical difference in mouth opening at baseline and first follow up. The mouth opening was significantly more in group A compared to group B from second follow up which persisted till third follow up (p <0.05). Pain and burning sensation significantly reduced in group A compared to group B from 2nd follow up which persisted till 3rd follow up (p <0.05). Few patients had nausea, dyspepsia and vomiting during treatment in group A which resolved within a few days without the need for cessation of the drug. Conclusion: Pentoxifylline can bring about significant clinical improvements in the symptoms of oral submucous fibrosis like mouth opening, pain and burning sensation, thereby improving the quality of life of the affected individuals.

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