An Enhanced Development of 3D Intra-Oral Scanner Using Fringe-Projection Technique for Dentistry

2016 ◽  
Author(s):  
Hong-Seok Park ◽  
Chintal Shah ◽  
Rima Shah
Keyword(s):  
Oral Cavity ◽  
Light Source ◽  
Phase Distribution ◽  
Three Dimensional ◽  
Mouth Opening ◽  
Vital Role ◽  
Fringe Projection ◽  
Mapping Algorithm ◽  
Novel Approach ◽  
Cad Cam

3D shape recognization technique is rapidly advancing from last decade in the fields of manufacturing, computer science, entertainment and medical technology. Due to the restriction of size and area of cavity, it’s challenging to develop such non-contact optical technologies for scanning. 3D digitization technology plays a vital role in the field of dentistry benefiting dentists and patients by eliminating long time procedures for making the prosthesis/abutments and results into ultimate comfort. In this paper, we have recounted a design of a prototype for a three-dimensional intra-oral scanner using the principle of fringe projection and active triangulation method. LED as a light source passed through the liquid crystal on silicon (LCoS) which radiates the light into three colors and strikes onto the collimating lens assembly and then passed through the optical deflectors. Once the light strikes the object through scanning window it is guided back through the flat reflectors and the fringe pattern on the object is stored into the gray encoding plate. With the help of camera all these images are stored. After the acquisition of images, firstly it will calculate the phase distribution using four-step phase shifting algorithm and unwrap the wrap phase which helps us in getting accurate images. Later, we get display of scanned oral cavity onto the computer screen. Phase-height mapping algorithm has been realized for the reconstruction of the 3D real time reconstruction of the scanned oral cavity which helps us in fast scanning with accurate data. A novel approach of LED as a light source and LCoS display for scattering light fragments into three different colors helps us to scan more effectively for registration of dental surfaces from the patient’s mouth more accurately. Apart from that, its sleek design helps to scan with less pain to the patient’s having low mouth opening. Experiment was performed on the prototype of denture and using this proposed method we have achieved the accuracy of 25μm and it took around 180 sec for the full arc scan of the lower oral cavity. The result of scanned data was checked using the CAD/CAM software for dentistry and compared with the prototype data of denture. Further this image can be used for making prosthesis/abutment directly into production using 3D printing machine or the milling machine. Thus, an abutment or prosthesis obtained with this method is of high quality and eliminates conventional long procedures which helps in reducing pain of patient’s and helps dentists to attain more patients in less time.

scholarly journals DENTAL SCANNERS IN PROSTHODONTICS

2019 ◽  
Vol 31 (4) ◽  
pp. 845-852
Author(s):  
Blagoja Dashtevski ◽  
Aneta Mijoska ◽  
Marjan Petkov ◽  
Vanco Spirov ◽  
Oliver Dimitrovski
Keyword(s):  
Oral Cavity ◽  
Digital Technology ◽  
Three Dimensional ◽  
Spatial Layout ◽  
Dental Restoration ◽  
Digital Data ◽  
Prosthetic Devices ◽  
Scanning Process ◽  
Engineering Sciences ◽  
Cad Cam

As a digital technology enters in every area of everyday life, including the medicine, it begins to increase its influence in dental practice too. The term scanner in dentistry is called a 3-D scanner and refers to an instrument that collects data on the three-dimensional spatial layout and the shape of the tooth and dental structures in the mouth or the model and transforms them into a set of digital data. With the help of the scanner, the anatomic-morphological structures of the oral cavity are recorded or reflected and data are received in digital form.The first stage in the three-part CAD / CAM process of making a prosthetic device-scanning of the anatomic-morphological structures in this process presents the main basis of the future dental restoration. The scanning, as well as the remaining two parts of the CAD / CAM system are taken from the mechanical engineering sciences that incorporate dental doctrines for the production of a prosthetic devices. The dentists who want to use this technology often do not have enough time or sufficient knowledge to understand the current scanning process. The term scanner in dentistry is called a 3-D scanner and refers to an instrument that collects data on the three-dimensional spatial layout and the shape of the tooth and dental structures in the mouth or the model and transforms them into a set of digital data. With the help of the scanner, the anatomic and morphological structures of the oral cavity are recorded or reflected and data are received in digital form. For these reasons, we feel the need to demonstrate the development of the dental scanning process and its methodological procedures to obtain a virtual model. This makes it possible to obtain a complete picture of digital technology and to understand the necessary information about the scanning process that is today in everyday use. The paper presents the basic data that are currently available with the remark that this technology has a rapid development that will contribute to even better results in the manufacture of prosthetic devices.

scholarly journals THE USE OF CAD/CAM TECHNOLOGY IN SURGICAL TREATMENT OF CONDYLAR HEAD FRACTURE

2019 ◽  
Vol 112 (4) ◽  
pp. 23-31
Author(s):  
Tetiana Pavlychuk ◽  
Denis Chernogorskyi ◽  
Yurii Chepurnyi ◽  
Andrii Kopchak
Keyword(s):  
Surgical Treatment ◽  
Maxillofacial Surgery ◽  
Three Dimensional ◽  
Mouth Opening ◽  
Surrounding Tissue ◽  
Patient Specific ◽  
Number Of Patients ◽  
Two Component ◽  
Cad Cam ◽  
Condylar Head

Management of the condylar head fractures is still one of the most controversial issues of the maxillofacial surgery. The aim of the present study was to increase the accuracy and quality of the surgical treatment of condylar head fracture with the use of navigation surgical guide and patient specific reinforcement two-component plate and individualized fixator with the use of CAD/CAM technology. In study was included 8  patient with 10 condylar head fractured. In 5 cases was used navigation guides, in 4 cases (the biomechanical unfavorable)  was used the patient specific two-component plate and only in one case we used  individualized patient specific plate. A CT scan was done immediately after the operation. The reduction of the fragments and the location of the screws, plate and fixator were checked on the same view in the preoperative and postoperative pictures on the computer. The relation between the screw and the cortical bones was clearly shown on CT, and the sizes of the bicortical screws were suitable with no injury to the articular cartilage or surrounding tissue. The three-dimensional objects showed that the screw was in the designated position and the condyle had been replaced and fixed in the normal position. The height of the ramus on the fractured side was restored immediately postoperatively. The malocclusion was corrected and the passive mouth opening of each patient was never less than 3 cm. One  patients had transient paralysis of the temporal branch of the facial nerve postoperatively, which gradually recovered within a 2 month. Postoperative clinical examination showed good occlusion and mouth opening of at least 3 cm in all patients after 3 months without pain. All patients regained normal mandibular movements and had short and invisible scars at 6 months’ follow-up. Given the small number of patients, this issue needs further study in randomized prospective studies involving more patients and evaluating long-term postoperative outcomes

Three-Dimensional reconstruction of isolated centrosomes by automated electron tomography

1994 ◽  
Vol 52 ◽  
pp. 310-311
Author(s):  
M.B. Braunfeld ◽  
M. Moritz ◽  
B.M. Alberts ◽  
J.W. Sedat ◽  
D.A. Agard
Keyword(s):  
Electron Tomography ◽  
Three Dimensional ◽  
Vital Role ◽  
Complex Nature ◽  
Animal Cells ◽  
Microtubule Organizing Center ◽  
Nucleation Sites ◽  
Dimensional Reconstruction ◽  
Organizing Center ◽  
Resolution Model

In animal cells, the centrosome functions as the primary microtubule organizing center (MTOC). As such the centrosome plays a vital role in determining a cell's shape, migration, and perhaps most importantly, its division. Despite the obvious importance of this organelle little is known about centrosomal regulation, duplication, or how it nucleates microtubules. Furthermore, no high resolution model for centrosomal structure exists.We have used automated electron tomography, and reconstruction techniques in an attempt to better understand the complex nature of the centrosome. Additionally we hope to identify nucleation sites for microtubule growth.Centrosomes were isolated from early Drosophila embryos. Briefly, after large organelles and debris from homogenized embryos were pelleted, the resulting supernatant was separated on a sucrose velocity gradient. Fractions were collected and assayed for centrosome-mediated microtubule -nucleating activity by incubating with fluorescently-labeled tubulin subunits. The resulting microtubule asters were then spun onto coverslips and viewed by fluorescence microscopy.

Novel Approach of Improving Secondary Electron Detector in FIB System

2018 ◽  
Author(s):  
Steve Wang ◽  
Jim McGinn ◽  
Peter Tvarozek ◽  
Amir Weiss
Keyword(s):  
Integrated Circuit ◽  
Secondary Electron ◽  
Focused Ion Beam ◽  
Ion Beam ◽  
Vital Role ◽  
Electron Detector ◽  
System A ◽  
Novel Approach

Abstract Secondary electron detector (SED) plays a vital role in a focused ion beam (FIB) system. A successful circuit edit requires a good effective detector. Novel approach is presented in this paper to improve the performance of such a detector, making circuit altering for the most advanced integrated circuit (IC) possible.

scholarly journals Elastic transformation of histological slices allows precise co-registration with microCT data sets for a refined virtual histology approach

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jonas Albers ◽  
Angelika Svetlove ◽  
Justus Alves ◽  
Alexander Kraupner ◽  
Francesca di Lillo ◽  
...  
Keyword(s):  
Three Dimensional ◽  
High Specificity ◽  
Histopathological Analysis ◽  
Specific Information ◽  
Data Sets ◽  
Virtual Histology ◽  
Novel Approach ◽  
Cell Tissue ◽  
Immuno Histochemistry ◽  
3D Information

AbstractAlthough X-ray based 3D virtual histology is an emerging tool for the analysis of biological tissue, it falls short in terms of specificity when compared to conventional histology. Thus, the aim was to establish a novel approach that combines 3D information provided by microCT with high specificity that only (immuno-)histochemistry can offer. For this purpose, we developed a software frontend, which utilises an elastic transformation technique to accurately co-register various histological and immunohistochemical stainings with free propagation phase contrast synchrotron radiation microCT. We demonstrate that the precision of the overlay of both imaging modalities is significantly improved by performing our elastic registration workflow, as evidenced by calculation of the displacement index. To illustrate the need for an elastic co-registration approach we examined specimens from a mouse model of breast cancer with injected metal-based nanoparticles. Using the elastic transformation pipeline, we were able to co-localise the nanoparticles to specifically stained cells or tissue structures into their three-dimensional anatomical context. Additionally, we performed a semi-automated tissue structure and cell classification. This workflow provides new insights on histopathological analysis by combining CT specific three-dimensional information with cell/tissue specific information provided by classical histology.

scholarly journals Artificial Tumor Microenvironments in Neuroblastoma

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1629
Author(s):  
Colin H. Quinn ◽  
Andee M. Beierle ◽  
Elizabeth A. Beierle
Keyword(s):  
Extracellular Matrix ◽  
Three Dimensional ◽  
Therapeutic Interventions ◽  
3D Bioprinting ◽  
Culture Studies ◽  
In Vivo Models ◽  
Novel Treatments ◽  
Tumor Microenvironments ◽  
Novel Approach

In the quest to advance neuroblastoma therapeutics, there is a need to have a deeper understanding of the tumor microenvironment (TME). From extracellular matrix proteins to tumor associated macrophages, the TME is a robust and diverse network functioning in symbiosis with the solid tumor. Herein, we review the major components of the TME including the extracellular matrix, cytokines, immune cells, and vasculature that support a more aggressive neuroblastoma phenotype and encumber current therapeutic interventions. Contemporary treatments for neuroblastoma are the result of traditional two-dimensional culture studies and in vivo models that have been translated to clinical trials. These pre-clinical studies are costly, time consuming, and neglect the study of cofounding factors such as the contributions of the TME. Three-dimensional (3D) bioprinting has become a novel approach to studying adult cancers and is just now incorporating portions of the TME and advancing to study pediatric solid. We review the methods of 3D bioprinting, how researchers have included TME pieces into the prints, and highlight present studies using neuroblastoma. Ultimately, incorporating the elements of the TME that affect neuroblastoma responses to therapy will improve the development of innovative and novel treatments. The use of 3D bioprinting to achieve this aim will prove useful in developing optimal therapies for children with neuroblastoma.

scholarly journals Polymer cyclization for the emergence of hierarchical nanostructures

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Chaojian Chen ◽  
Manjesh Kumar Singh ◽  
Katrin Wunderlich ◽  
Sean Harvey ◽  
Colette J. Whitfield ◽  
...  
Keyword(s):  
Self Assembly ◽  
Three Dimensional ◽  
Hierarchical Structures ◽  
Structural Similarity ◽  
Vital Role ◽  
Nanomaterial Synthesis ◽  
Wide Range ◽  
Linear Poly ◽  
Polymer Folding ◽  
Dynamics Simulations

AbstractThe creation of synthetic polymer nanoobjects with well-defined hierarchical structures is important for a wide range of applications such as nanomaterial synthesis, catalysis, and therapeutics. Inspired by the programmability and precise three-dimensional architectures of biomolecules, here we demonstrate the strategy of fabricating controlled hierarchical structures through self-assembly of folded synthetic polymers. Linear poly(2-hydroxyethyl methacrylate) of different lengths are folded into cyclic polymers and their self-assembly into hierarchical structures is elucidated by various experimental techniques and molecular dynamics simulations. Based on their structural similarity, macrocyclic brush polymers with amphiphilic block side chains are synthesized, which can self-assemble into wormlike and higher-ordered structures. Our work points out the vital role of polymer folding in macromolecular self-assembly and establishes a versatile approach for constructing biomimetic hierarchical assemblies.

scholarly journals Virtual Surgical Planning, Stereolitographic Models and CAD/CAM Titanium Mesh for Three-Dimensional Reconstruction of Fibula Flap with Iliac Crest Graft and Dental Implants

2021 ◽  
Vol 10 (9) ◽  
pp. 1922
Author(s):  
Carlos Navarro Cuéllar ◽  
Manuel Tousidonis Rial ◽  
Raúl Antúnez-Conde ◽  
Santiago Ochandiano Caicoya ◽  
Ignacio Navarro Cuéllar ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Surgical Planning ◽  
Iliac Crest ◽  
Three Dimensional ◽  
Titanium Mesh ◽  
Iliac Crest Graft ◽  
Virtual Surgical Planning ◽  
Fibula Flap ◽  
Dimensional Reconstruction ◽  
Cad Cam

Mandibular reconstruction with fibula flap shows a 3D discrepancy between the fibula and the remnant mandible. Eight patients underwent three-dimensional reconstruction of the fibula flap with iliac crest graft and dental implants through virtual surgical planning (VSP), stereolitographic models (STL) and CAD/CAM titanium mesh. Vertical ridge augmentation and horizontal dimensions of the fibula, peri-implant bone resorption of the iliac crest graft, implant success rate and functional and aesthetic results were evaluated. Vertical reconstruction ranged from 13.4 mm to 10.1 mm, with an average of 12.22 mm. Iliac crest graft and titanium mesh were able to preserve the width of the fibula, which ranged from 8.9 mm to 11.7 mm, with an average of 10.1 mm. A total of 38 implants were placed in the new mandible, with an average of 4.75 ± 0.4 implants per patient and an osseointegration success rate of 94.7%. Two implants were lost during the osseointegration period (5.3%). Bone resorption was measured as peri-implant bone resorption at the mesial and distal level of each implant, with a variation between 0.5 mm and 2.4 mm, and with a mean of 1.43 mm. All patients were rehabilitated with a fixed implant prosthesis with good aesthetic and functional results.

scholarly journals Identification of the conserved long non-coding RNAs in myogenesis

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Anupam Bhattacharya ◽  
Simang Champramary ◽  
Tanya Tripathi ◽  
Debajit Thakur ◽  
Ilya Ioshikhes ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Muscle Development ◽  
Three Dimensional ◽  
C2c12 Cells ◽  
Mouse Muscle ◽  
Rna Molecules ◽  
Expression Of Genes ◽  
Novel Approach ◽  
Non Coding Rna ◽  
Topologically Associated Domains

Abstract Background Our understanding of genome regulation is ever-evolving with the continuous discovery of new modes of gene regulation, and transcriptomic studies of mammalian genomes have revealed the presence of a considerable population of non-coding RNA molecules among the transcripts expressed. One such non-coding RNA molecule is long non-coding RNA (lncRNA). However, the function of lncRNAs in gene regulation is not well understood; moreover, finding conserved lncRNA across species is a challenging task. Therefore, we propose a novel approach to identify conserved lncRNAs and functionally annotate these molecules. Results In this study, we exploited existing myogenic transcriptome data and identified conserved lncRNAs in mice and humans. We identified the lncRNAs expressing differentially between the early and later stages of muscle development. Differential expression of these lncRNAs was confirmed experimentally in cultured mouse muscle C2C12 cells. We utilized the three-dimensional architecture of the genome and identified topologically associated domains for these lncRNAs. Additionally, we correlated the expression of genes in domains for functional annotation of these trans-lncRNAs in myogenesis. Using this approach, we identified conserved lncRNAs in myogenesis and functionally annotated them. Conclusions With this novel approach, we identified the conserved lncRNAs in myogenesis in humans and mice and functionally annotated them. The method identified a large number of lncRNAs are involved in myogenesis. Further studies are required to investigate the reason for the conservation of the lncRNAs in human and mouse while their sequences are dissimilar. Our approach can be used to identify novel lncRNAs conserved in different species and functionally annotated them.

scholarly journals Three-dimensional in situ morphometrics of Mycobacterium tuberculosis infection within lesions by optical mesoscopy and novel acid-fast staining

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Robert J. Francis ◽  
Gillian Robb ◽  
Lee McCann ◽  
Bhagwati Khatri ◽  
James Keeble ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Three Dimensional ◽  
Large Field ◽  
Staining Procedure ◽  
3D Analysis ◽  
Mycobacterium Tuberculosis Infection ◽  
In Vivo Models ◽  
Novel Approach

AbstractTuberculosis (TB) preclinical testing relies on in vivo models including the mouse aerosol challenge model. The only method of determining colony morphometrics of TB infection in a tissue in situ is two-dimensional (2D) histopathology. 2D measurements consider heterogeneity within a single observable section but not above and below, which could contain critical information. Here we describe a novel approach, using optical clearing and a novel staining procedure with confocal microscopy and mesoscopy, for three-dimensional (3D) measurement of TB infection within lesions at sub-cellular resolution over a large field of view. We show TB morphometrics can be determined within lesion pathology, and differences in infection with different strains of Mycobacterium tuberculosis. Mesoscopy combined with the novel CUBIC Acid-Fast (CAF) staining procedure enables a quantitative approach to measure TB infection and allows 3D analysis of infection, providing a framework which could be used in the analysis of TB infection in situ.

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