scholarly journals Comparative Evaluation of Mixture of Calcium Hydroxide and Chlorhexidine, with Triple Antibiotic Paste and Combination of Calcium Hydroxide, Chlorhexidine, and Lycopene on Incidence of Interappointment Flare-up: An in vivo Study

2017 ◽  
Vol 1 (1) ◽  
pp. 10-14
Author(s):  
Priyanka S Bilgi ◽  
Nimisha C Shah ◽  
Jash Mehta
Keyword(s):  
Calcium Hydroxide ◽  
Comparative Evaluation ◽  
Rating Scale ◽  
Clinical Performance ◽  
Group Iii ◽  
Group I ◽  
Triple Antibiotic Paste ◽  
Significant Difference ◽  
Post Hoc

ABSTRACT Background The present study was undertaken to evaluate the most suitable intracanal medicament with the least incidence on Interappointment flare-up. Aim To clinically evaluate and compare the effect of combination of calcium hydroxide (CH) and chlorhexidine (CHX) with triple antibiotic paste and combination of CH, CHX, and lycopene on interappointment flare-up. Materials and methods A total of 36 patients requiring root canal treatment were selected according to the selection criteria and divided into three groups: Group I – CH and CHX, group II – triple antibiotic paste, and group III – CH, CHX, and lycopene. Access opening and biomechanical preparation of all samples, and intracanal medicaments were placed respectively. Subsequently, interappointment flare-up was assessed at 1, 2, 3, 7, and 14 days using verbal rating scale. Statistical analysis used One way analysis of variance test and Tukey's post hoc test. Results There was no statistically significant difference seen in the clinical performance of CH + CHX, triple antibiotic paste, and mixture of CH + CHX + lycopene at the end of 14 days in terms of interappointment flare-up. Conclusion All the intracanal medicaments were effective in reducing interappointment flare-up at the end of 14 days. How to cite this article Bilgi PS, Shah NC, Mehta J. Comparative Evaluation of Mixture of Calcium Hydroxide and Chlorhexidine, with Triple Antibiotic Paste and Combination of Calcium Hydroxide, Chlorhexidine, and Lycopene on Incidence of Interappointment Flare-up: An in vivo Study. Int J Clin Dent Res 2017;1(1):10-14.

scholarly journals Comparative Evaluation of Antibacterial Efficacy of Four Toothpastes and Mouthwashes against Streptococcus mutans and Lactobacillus: An in vivo Study

2016 ◽  
Vol 1 (2) ◽  
pp. 60-65
Author(s):  
Jonathan E Sam ◽  
Paulaian Benin ◽  
Ruth H Beaulah ◽  
Gnanaseelan LNU ◽  
Lal Krishna ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Comparative Evaluation ◽  
Antibacterial Efficacy ◽  
Time Intervals ◽  
Group Iii ◽  
Antimicrobial Substances ◽  
Group I ◽  
Intergroup Comparison ◽  
Significant Difference

ABSTRACT Background Cariogenic microorganisms are the most important cause for occurrence of dental caries. Dentifrices and mouthwashes containing antimicrobial substances are proven to be effective in the eradication of these pathogens from the oral cavity. Aim To evaluate the antimicrobial efficacy of fluoride, chlorhexidine (CHX), herbal, and xylitol containing toothpastes and mouthwashes against Streptococcus mutans (S. mutans) and Lactobacillus (LB) in subjects within the age group of 18 to 22 years at time intervals of 1, 3, and 6 months. Materials and methods One hundred subjects were randomly divided into four groups. Group I: fluoride, group II: chlorhexidine, group III: herbal, group IV: xylitol and instructed to use toothpastes and mouthwashes containing the specific agents. Salivary samples were collected to evaluate the levels of S. mutans and LB at baseline, 1, 3, and 6 months. Bacterial levels were evaluated using caries risk test (CRT) kit. Data were analyzed using analysis of variance and post hoc test. Results During intragroup comparison, S. mutans levels in group I showed statistically significant difference among the four time intervals. On intergroup comparison, S. mutans levels after 6 months for groups I, II, III, and IV were 1.12, 1.16, 1.28, and 1.4 respectively. Conclusion It can be concluded that fluoride, CHX, and xylitol showed a significant reduction in S. mutans and LB count after a time period of 6 months while herbal group did not show a significant reduction in S. mutans and LB count at any intervals. How to cite this article Sam JE, Benin P, Beaulah RH, Gnanaseelan, Krishna L, Raja J. Comparative Evaluation of Antibacterial Efficacy of Four Toothpastes and Mouthwashes against Streptococcus mutans and Lactobacillus: An in vivo Study. J Oper Dent Endod 2016;1(2):60-65.

scholarly journals Comparative Evaluation of the Interappointment Pain by Using Different Intracanal Medicaments—An In Vivo Study

2019 ◽  
Vol 07 (01) ◽  
pp. 019-022
Author(s):  
Varun Jindal ◽  
Sahil Monga ◽  
Deepti Jindal
Keyword(s):  
Calcium Hydroxide ◽  
Visual Analog Scale ◽  
Comparative Evaluation ◽  
Apical Periodontitis ◽  
In Vivo Study ◽  
Analog Scale ◽  
Cavity Preparation ◽  
Triple Antibiotic Paste

Abstract Objective The purpose of this in vivo study was to evaluate pain using different intracanal medicaments. Materials and Methods Seventy-five permanent single-rooted mandibular premolars with acute apical periodontitis were selected for this study. After access cavity preparation and cleaning and shaping of canals, patients were randomly divided into five groups with different intracanal medicaments viz calcium hydroxide paste, calcium hydroxide points, triple antibiotic paste, and Ledermix paste. Interappointment pain was recorded by the patient using visual analog scale after 6 hours, 12 hours, 18 hours, 24 hours, 2 days, 3 days, 4 days, 5 days, and 6 days of intracanal medicament dressing. Results Ledermix paste showed highly significant results in reducing the interappointment pain as compared with calcium hydroxide paste, calcium hydroxide points, and triple antibiotic paste. Conclusion Patients with Ledermix as intracanal medicament had minimum interappointment pain.

scholarly journals The Relationship Between Dental Caries and YKL-40 Levels in Saliva

2020 ◽  
Author(s):  
Gülsüm Duruk ◽  
Esra Laloglu
Keyword(s):  
Dental Caries ◽  
Group Iii ◽  
Group I ◽  
Pufa Index ◽  
Icdas Ii ◽  
Significant Difference ◽  
Group Ii ◽  
And Gender ◽  
Post Hoc ◽  
The Relationship

Abstract Objective : YKL-40, a new biomarker of localized inflammation, is secreted by macrophages and regulates inflammation and immune responses. The aim of this study was to investigate YKL-40 levels in saliva and compare the level of this mediator in healthy and unhealthy oral cavity. Methods: 85 children (46 girls, 39 boys), aged 6-15 (mean±SD: 9.15±2.16) were included in this study. The children were divided into three groups: Group-I (control, n=25, DMFT/dmft=0), Group-II (n=30, exist of localized dental caries) and Group-III (n=30, exist of localized advanced dental caries). Gingival index (GI), plaque index (PI), DMFT/dmft, DMFS/dmfs, and the number of advanced dental caries according to the ICDAS II and PUFA/pufa index were recorded. Saliva was collected and YKL-40 concentrations were measured. One-way ANOVA with Tukey post hoc, Kruskal-Wallis, multiple regression analysis, and Sperman’s correlation tests were used for statistical analysis. Results: The highest level of YKL-40 was obtained in group III , followed by groups II and I , respectively (p<0.01). In Group II, DMFT/dmft scores and the number of caries (DT/dt) were higher than in group III (p<0.01). In group III, there was a statistically significant correlation between YKL-40 levels in saliva and the number of advanced dental caries. In addition, there was no statistically significant difference in terms of age and gender (p>0.05). Conclusion: Advanced dental caries, rather than DMFT/dmft score, may play an important role in the increasing levels of YKL-40 in saliva.

scholarly journals Extrusion of Debris from Primary Molar Root Canals following Instrumentation with Traditional and New File Systems

2017 ◽  
Vol 18 (11) ◽  
pp. 1040-1044 ◽  
Author(s):  
Bhagyashree Thakur ◽  
Ajinkya M Pawar ◽  
Anda Kfir ◽  
Prasanna Neelakantan
Keyword(s):  
Primary Teeth ◽  
File Systems ◽  
Primary Molar ◽  
Group Iii ◽  
Root Canals ◽  
Group I ◽  
Significant Difference ◽  
Molar Teeth ◽  
Post Hoc ◽  
Root Canal Instrumentation

ABSTRACT Introduction To assess the amount of debris extruded apically during instrumentation of distal canals of extracted primary molars by three instrument systems [ProTaper Universal (PTU), ProTaper NEXT (PTN), and self-adjusting file (SAF)] compared with conventional stainless steel hand K-files (HF, control). Materials and methods Primary mandibular molars (n = 120) with a single distal canal were selected and randomly divided into four groups (n = 30) for root canal instrumentation using group I, HF (to size 0.30/0.02 taper), group II, PTU (to size F3), group III, PTN (to size X3), and group IV, SAF. Debris extruded during instrumentation was collected in preweighed Eppendorf tubes, stored in an incubator at 70°C for 5 days and then weighed. Statistical analysis was performed by one-way analysis of variance (ANOVA), followed by Turkey's post hoc test (p = 0.05). Results All the groups resulted in extrusion of debris. There was statistically significant difference (p < 0.001) in the debris extrusion between the three groups: HF (0.00133 ± 0.00012), PTU (0.00109 ± 0.00005), PTN (0.00052 ± 0.00008), and SAF (0.00026 ± 0.00004). Conclusion Instrumentation with SAF resulted in the least debris extrusion when used for shaping root canals of primary molar teeth. Clinical significance Debris extrusion in primary teeth poses an adverse effect on the stem cells and may also alter the permanent dental germ. Debris extrusion is rarely reported for primary teeth and it is important for the clinician to know which endodontic instrumentation leads to less extrusion of debris. How to cite this article Thakur B, Pawar AM, Kfir A, Neelakantan P. Extrusion of Debris from Primary Molar Root Canals following Instrumentation with Traditional and New File Systems. J Contemp Dent Pract 2017;18(11):1040-1044.

scholarly journals An in vitro comparative Evaluation of Fracture Strength of Roots Instrumentated with Self-adjusting File and Reciproc Reciprocating File, with and without Obturation

2017 ◽  
Vol 1 (1) ◽  
pp. 20-25
Author(s):  
Pooja Kabra
Keyword(s):  
Fracture Strength ◽  
Comparative Evaluation ◽  
Group Iv ◽  
Control Group ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

ABSTRACT Aim The purpose of this study was to evaluate the fracture strength of roots instrumented with the self-adjusting file (SAF; ReDent-Nova, Ra'anana, Israel) and the Reciproc reciprocating file and that were and were not obturated using the warm vertical lateral compaction technique. Materials and methods In total, 75 mandibular premolar teeth were sectioned at or below the cementoenamel junction to obtain roots 13 mm in length. The roots were balanced with respect to buccolingual and mesiodistal diameters and weight. They were distributed into four experimental groups and one control group (n = 15): No instrumentation (group I), instrumentation with SAF files but no obturation (group II), instrumentation with SAF files and obturated with warm vertical lateral compaction (group III), instrumentation with Reciproc File but no obturation (group IV), and instrumentation with Reciproc File and obturated with warm vertical lateral compaction (group V). AH Plus sealer (Dentsply DeTrey, Konstanz, Germany) was used along with gutta-percha points. One week later, a vertical load was applied to the specimen's canal until fracture occurred. Data were statistically analyzed using one-way analysis of variance (p = 0.05). Results The mean fracture load was 312.83 N for group I, 297.35 N for group II, 359.15 N for group III, 231.51 N for group IV, and 275.81 N for group V. Conclusion The fracture resistances exhibited a statistically significant difference between all the groups. Teeth instrumented by SAF exhibited a better fracture resistance. How to cite this article Tyagi S, Choudhary E, Kabra P, Chauhan R. An in vitro comparative Evaluation of Fracture Strength of Roots Instrumentated with Self-adjusting File and Reciproc Reciprocating File, with and without Obturation. Int J Clin Dent Res 2017;1(1):20-25.

scholarly journals Homocysteine Levels in Parkinson’s Disease: Is Entacapone Effective?

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Bilge Kocer ◽  
Hayat Guven ◽  
Selim Selcuk Comoglu
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Folic Acid ◽  
Dopamine Agonist ◽  
Dopamine Agonists ◽  
Rating Scale ◽  
Comt Inhibitors ◽  
Group Iii ◽  
Group I ◽  
Significant Difference

Plasma homocysteine (Hcy) levels may increase in levodopa-treated patients with Parkinson’s disease (PD) as a consequence of levodopa methylation via catechol-O-methyltransferase (COMT). Results from previous studies that assessed the effect of COMT inhibitors on levodopa-induced hyperhomocysteinemia are conflicting. We aimed to evaluate the effects of levodopa and entacapone on plasma Hcy levels. A hundred PD patients were enrolled to the study and divided into three treatment groups (group I: levodopa and/or dopamine agonists; group II: levodopa, entacapone, and/or a dopamine agonist; and group III: dopamine agonist alone). We measured the serum B12, folic acid, and Hcy levels in all patients. There were no statistically significant differences between groups in terms of modified Hoehn and Yahr stages, Unified Parkinson’s Disease Rating Scale II/III, Standardized Mini-Mental Test scores, and serum vitamin B12 and folic acid levels. Plasma median Hcy levels were found above the normal laboratory values in groups I and II, but they were normal in group III. However, there was no statistically significant difference in plasma Hcy levels between groups. Our results showed that levodopa treatment may cause a slight increase in the Hcy levels in PD compared with dopamine agonists and that COMT inhibitors may not have a significant effect on preventing hyperhomocysteinemia.

scholarly journals Evaluation of Anticariogenic Efficacy of Pomegranate (Punica Granatum) Pericarp Extract as Natural Mouth Rinse: An In Vitro and In Vivo Study

2018 ◽  
Vol 11 (4) ◽  
pp. 2025-2030
Author(s):  
Jyothsna Pinni ◽  
J.S. Sankar Avula ◽  
Sridhar Mukthineni ◽  
Sujatha Bandi ◽  
Thulasi Gokul
Keyword(s):  
Antimicrobial Efficacy ◽  
Mouth Rinse ◽  
Plant Materials ◽  
Group Iii ◽  
Group I ◽  
Mouth Rinses ◽  
Significant Difference ◽  
Mouth Rinsing

Plant materials were known as source of new antimicrobial agents. Many efforts have been made to develop alternative mouth rinses from natural products which are safe, easily available and substitute the standard pharmaceutical remedies. Thus, considering the therapeutic value of pomegranate fruit, the present study was designed to compare the antimicrobial efficacy of aqueous extract of Pomegranate pericarp and commercially available Chlorhexidine mouth wash against caries causative microorganisms both in vitro and in vivo. To evaluate the antimicrobial efficacy of pomegranate pericarp extract (PPE) against Streptococcus mutans (S.mutans) and to determine its usefulness as anti caries mouth rinse. In vitro antimicrobial efficacy was evaluated by disc inhibition zone method and broth dilution assay considering minimum inhibitory concentration of PPE. In vivo evaluation was done as a randomised controlled trial which included thirty children aged between 6-12 years. They were divided randomly into 3 groups of ten each and subjected to different mouth rinses - Group I: PPE mouth rinse, Group II: 0.2% Chlorhexidine mouth rinse and Group III: Distilled water (control). The salivary samples which were collected before and after (5 minutes) mouth rinsing were inoculated on Mutans Sanguis agar and the bacterial count was calculated.Statistically significant decrease in salivary S.mutans count was observed in group I and II compared to group III after mouth rinsing. However, there was no statistically significant difference between groups I and II. PPE mouthwash was effective in reducing the salivary S.mutans count and was comparable to chlorhexidine mouth rinse. Hence PPE mouth rinse may be considered as a potential anti caries mouth rinse.

scholarly journals Proliferation of odontoblast-like cells following application of a combination of calcium hydroxide and propolis

2019 ◽  
Vol 52 (4) ◽  
pp. 183
Author(s):  
Ira Widjiastuti ◽  
Sri Kunarti ◽  
Fauziah Diajeng Retnaningsih ◽  
Evri Kusumah Ningtyas ◽  
Debby Fauziah Suryani ◽  
...  
Keyword(s):  
Calcium Hydroxide ◽  
Wistar Rats ◽  
Control Group ◽  
Group V ◽  
Propolis Extract ◽  
Group Iii ◽  
Group I ◽  
Occlusal Surfaces ◽  
Significant Difference ◽  
Group Ii

Background: One purpose of operative dentistry is the maintenance of healthy pulp by reducing the need for root canal treatment and the possibility of undesirable scenarios such as tooth loss. Propolis is a plant-derived substance that contains a resin produced by honeybees belonging to the Apis mellifera species. Purpose: This study aimed to investigate the effect of a combination of calcium hydroxide (Ca(OH)2) and propolis extract on odontoblast-like cell proliferation in Wistar rats (Rattus norvegicus). Methods: This research constituted a true experimental laboratory-based investigation with post-test control group design. Thirty Wistar rats were randomly divided into six groups. The first molar pulp of each sample was perforated on occlusal surfaces using a low speed round bur. On day 3, the samples were divided into six groups (n=10): Group I: control; Group II: Ca(OH)2 + 11%; propolis extract; Group III: Ca(OH)2 + aquadest, and on day 7: Group IV: control; Group V: Ca(OH)2 + 11% propolis extract; Group VI: Ca(OH)2 + aquadest. All samples were filled with restorative material. They were subsequently sacrificed after 3 and 7 days post-pulp capping administration and the afflicted tooth extracted for hematoxylin and eosin (H&E) staining. The resulting data was subjected to statistical analysis to ascertain the proliferation of odontoblast-like cells. The significance of differences between the groups was determined by a one-way ANOVA test followed by a post hoc Tuckey HSD. A p-value <0.05 was considered to be significant. Results: On day 3, a significant difference existed between group II (Ca(OH)2–propolis) and group I (control group) and group III (Ca(OH)2–aquades), whereas Ca(OH)2–propolis revealed that the proliferation of odontoblast-like cells was higher. Meanwhile, on day 7, there was a significant difference between all groups whereas, with regard to Ca(OH)2–propolis, the proliferation of odontoblast-like cells in group V was higher. Conclusion: Application of combination of Ca(OH)2-propolis extract can increase the proliferation of odontoblast-like cells in pulp tissue on days 3 and 7.

scholarly journals Microhardness and Fracture Resistance of Radicular Dentin Treated with Different Concentrations of Calcium Hydroxide in Endodontic Regeneration Procedures

2021 ◽  
Vol 9 (D) ◽  
pp. 324-329
Author(s):  
Sara N. Hashem ◽  
Maha Adel Elhousiny
Keyword(s):  
Calcium Hydroxide ◽  
Root Canal ◽  
Fracture Resistance ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Endodontic Regeneration ◽  
And Control ◽  
Control Group Group

Purpose: to reveal the effect of different concentrations of prepared calcium hydroxide pastes (70%, 50%, and 30%) used in regenerative endodontic on microhardness and fracture resistance of radicular dentin. Material and methods: Different concentrations of calcium hydroxide (Ca(OH)2) were prepared with measured pH, then forty eight single rooted teeth were prepared and randomized into three groups according to Ca(OH)2 paste concentrations (12 samples each) and 12 samples were availed as control group. Group I: root canal contained 30% Ca(OH)2 paste. Group II: root canal contained 50% Ca(OH)2 paste. Group III: root canal contained 70% Ca(OH)2 paste. Samples were stored at 37 0C with 100% humidity for four weeks for subsequent microhardness and fracture resistance tests. Results: There was a statistically significant reduction of microhardness  and fracture resistance between test groups and control group (P≤ 0.05), group III showed a  significant reduction  in both microhardness and fracture resistance compared to group I. However, there was no significant difference in pH between different concentration of Ca(OH)2. Conclusion: Increasing concentration of Ca(OH)2 paste can negatively affect microhardness and fracture resistance of radicular dentin in revascularization procedure.

scholarly journals The Relationship Between Dental Caries and YKL-40 Levels in Saliva

2019 ◽  
Author(s):  
Gülsüm Duruk ◽  
Esra Laloglu
Keyword(s):  
Dental Caries ◽  
Group Iii ◽  
Group I ◽  
Pufa Index ◽  
Icdas Ii ◽  
Significant Difference ◽  
Group Ii ◽  
And Gender ◽  
Post Hoc ◽  
The Relationship

Abstract Objective: YKL-40, a new biomarker of localized inflammation, is secreted by macrophages and regulates inflammation and immune responses. The aim of this study was to investigate YKL-40 levels in saliva and compare the level of this mediator in oral cavity. Methods: 85 children (46 girls, 39 boys), aged 6-15 (mean±SD: 9.15±2.16) were included in this study. The children were divided into three groups: Group-I (control, n=25, DMFT/dmft=0), Group-II (n=30, exist of localized dental caries) and Group-III (n=30, exist of localized advanced dental caries). Gingival index (GI), plaque index (PI), DMFT/dmft, DMFS/dmfs, and the number of advanced dental caries according to the ICDAS II and PUFA/pufa index were recorded. Saliva was collected and YKL-40 concentrations were measured. One-way ANOVA withTukey post hoc, Kruskal-Wallis, multiple regression analysis, and Sperman’s correlation tests were used for statistical analysis. Results: The highest level of YKL-40 was obtained in group III, followed by groups II and I, respectively (p<0.01). In Group II, DMFT/dmft scores and the number of caries (DT/dt) were higher than in group III (p<0.01). In group III, there was a statistically significant correlation between YKL-40 levels in saliva and the number of advanced dental caries. In addition, there was no statistically significant difference in terms of age and gender (p>0.05). Conclusion: Advanced dental caries, rather than DMFT/dmft score, may play an important role in the increasing levels of YKL-40 in saliva.

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