scholarly journals Nevoid Trichostasis Spinulosa: Dermoscopic Point of View

2017 ◽  
Vol 1 (2) ◽  
pp. 65-66
Author(s):  
Swapnil Shah ◽  
Balachandra S Ankad ◽  
Anirudh A Mallapur
Keyword(s):  
Clinical Features ◽  
Hair Follicles ◽  
Point Of View ◽  
Trichostasis Spinulosa

ABSTRACT Trichostasis spinulosa (TS) is a common yet underdignosed condition affecting hair follicles. Diagnosis is based on the clinical features, hair mount, and dermoscopy. Here, the authors describe a case of TS in a nevoid distribution wherein dermoscopy aided the diagnosis. How to cite this article Ankad BS, Shah S, Mallapur AA. Nevoid Trichostasis Spinulosa: Dermoscopic Point of View. Int J Dermoscop 2017;1(2):65-66.

scholarly journals “Vyadhi Vyavachedatmak Nidan of Urdhvag and Adhog Amlapitta Lakshana in Lite of Doshagati”

2019 ◽  
Vol 7 (02) ◽  
Author(s):  
Pragati B. Rakh ◽  
Madhavi D. Gaikwad ◽  
Deepa J. Amle
Keyword(s):  
Gastric Juice ◽  
Clinical Features ◽  
Clinical Importance ◽  
Point Of View ◽  
Common Disease ◽  
Treatment Measures

            Vyavachedak Nidan is distinguishing of particular disease or condition from others that present with similar clinical features. Dosha-Gati is basic consideration discussed by Charakacharya which keeps great clinical importance to the diagnostic (Roga Nidan) point of view; besides, prognosis (Sadhyasadhyata) and proper application of the treatment measures(Chikitsa karma) can be planned followed by assessment of Dosh- Gati through its classified aspects as the Tridosha  is the Samavayee karan of the Roga. Amlapitta is a very common disease in the present era. Amlapitta is one of the commonest vyadhi of Annavaha srotas, caused by vitiated agni. Amlapitta is a condition where amlaguna of pachak pitta (gastric juice) increases due to Samata. Amlapitta  has been considered as pittapradhana Kaphapradhana Tridoshaja Vyadhi. Acharya Madhava and Bhavamishra classified Amlapitta in two types according to doshagati or sthan dushti. The first type is Urdhvag amlapitta exhibits symptoms of pittaja and kaphaja Amlapitta and the second type is Adhog Amlapitta exhibits symptoms of vataja amlapitta. By understanding the various lakshanas of different type of Amlapitta in lite of doshagati can be beneficial for lakshana and samprapti vighatanatmak chikitsa.

scholarly journals Twenty-five years since the identification of the first SCA gene: history, clinical features and perspectives for SCA1

2018 ◽  
Vol 76 (8) ◽  
pp. 555-562 ◽  
Author(s):  
Carlos Roberto Martins Junior ◽  
Fabrício Castro de Borba ◽  
Alberto Rolim Muro Martinez ◽  
Thiago Junqueira Ribeiro de Rezende ◽  
Iscia Lopes Cendes ◽  
...  
Keyword(s):  
Clinical Features ◽  
Autosomal Dominant ◽  
Trinucleotide Repeat ◽  
Point Of View ◽  
Spinocerebellar Ataxias ◽  
Coding Region ◽  
The Past ◽  
Monogenic Diseases ◽  
Repeat Expansions ◽  
Core Features

ABSTRACT Spinocerebellar ataxias (SCA) are a clinically and genetically heterogeneous group of monogenic diseases that share ataxia and autosomal dominant inheritance as the core features. An important proportion of SCAs are caused by CAG trinucleotide repeat expansions in the coding region of different genes. In addition to genetic heterogeneity, clinical features transcend motor symptoms, including cognitive, electrophysiological and imaging aspects. Despite all the progress in the past 25 years, the mechanisms that determine how neuronal death is mediated by these unstable expansions are still unclear. The aim of this article is to review, from an historical point of view, the first CAG-related ataxia to be genetically described: SCA 1.

scholarly journals Malignant Sinonasal Tumors: Update on Histological and Clinical Management

2021 ◽  
Vol 28 (4) ◽  
pp. 2420-2438
Author(s):  
Alessandra Bracigliano ◽  
Fabiana Tatangelo ◽  
Francesco Perri ◽  
Giuseppe Di Lorenzo ◽  
Roberto Tafuto ◽  
...  
Keyword(s):  
Clinical Features ◽  
Locally Advanced ◽  
Treatment Strategies ◽  
Tp53 Gene ◽  
Point Of View ◽  
Therapeutic Implications ◽  
Pathologic Features ◽  
Tert Gene ◽  
Immunohistochemical Assessment ◽  
Genetic Assessment

Tumors of nasal cavity and paranasal sinuses (TuNSs) are rare and heterogeneous malignancies, presenting different histological features and clinical behavior. We reviewed the literature about etiology, biology, and clinical features of TuNSs to define pathologic features and possible treatment strategies. From a diagnostic point of view, it is mandatory to have high expertise and perform an immunohistochemical assessment to distinguish between different histotypes. Due to the extreme rarity of these neoplasms, there are no standard and evidence-based therapeutic strategies, lacking prospective and large clinical trials. In fact, most studies are retrospective analyses. Surgery represents the mainstay of treatment of TuNSs for small and localized tumors allowing complete tumor removal. Locally advanced lesions require more demolitive surgery that should be always followed by adjuvant radio- or chemo-radiotherapy. Recurrent/metastatic disease requires palliative chemo- and/or radiotherapy. Many studies emphasize the role of specific genes mutations in the development of TuNSs like mutations in the exons 4–9 of the TP53 gene, in the exon 9 of the PIK3CA gene and in the promoter of the TERT gene. In the near future, this genetic assessment will have new therapeutic implications. Future improvements in the understanding of the etiology, biology, and clinical features of TuNSs are warranted to improve their management.

scholarly journals CLINICO-ANATOMICAL FEATURES OF INTEGUMENTARY TISSUES IN THE ACHILLES TENDON FROM THE POINT OF VIEW OF PLASTIC SURGERY. THE ANALYSIS OF WAYS OF ELIMINATION OF CICATRICIAL DEFORMATIONS IN THE ACHILLES TENDON AREA: THEIR ADVANTAGES, DISADVANTAGES

2018 ◽  
Vol 22 (6) ◽  
pp. 317-320
Author(s):  
Olga V. Filippova ◽  
A. V. Govorov ◽  
K. A. Afonichev ◽  
N. S. Galkina ◽  
Ya. N. Proshchenko ◽  
...  
Keyword(s):  
Achilles Tendon ◽  
Plastic Surgery ◽  
Clinical Features ◽  
Normal Skin ◽  
Point Of View ◽  
Anatomical Features ◽  
Advantages And Disadvantages ◽  
Skin Repair

The article deals with the features of integumentary tissues in the Achilles tendon region, which must be taken into account in the planning of reconstructive surgeries, the clinical features of this scar localization, as well as the advantages and disadvantages of existing methods of normal skin repair in the Achilles tendon area.

scholarly journals The clinical and (dermato) pathological signifcance of neural crest cells. Blaschko lines and dermatoses. Neurocristopathies

2021 ◽  
Vol 97 (6) ◽  
pp. 333-341
Author(s):  
Zsuzsanna Lengyel ◽  
◽  
Evelin Csernus ◽  
Imre Schneider ◽  
Csaba Gyömörei
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Hair Follicles ◽  
Point Of View ◽  
The Body ◽  
Signal Molecules ◽  
Lichen Striatus ◽  
Blaschko Lines ◽  
Pathological Development ◽  
Cutaneous Mosaicism

In the course of their migration the neural crest cells reach all parts of the developing embryo. The frst wave of the derivatives of these cells the melanoblasts and melanocytes harbour in the epidermis and hair follicles during the dorsolateral migration. A number of signal molecules and proteases play an important role in the course of melanocyte migration through the extracellular matrix. The Mongolian spots appear as a consequence of the transient inhibition of melanocyte migration and in the case of fnal obstruction the Ota-, or. Ito nevuses. The Blaschko lines based on cutaneous mosaicism are of great diagnostic importance and on the ground of these lines the blaschkitises can appear under the exogenous factors. The blaschkolinear acquired infammatory skin eruption (BLAISE) is an acquired infammatory process. One of its variants is the lichen striatus and the other is the blaschkitis. The blaschkolinear dermatoses can appear usually as a nevoid disease. The pathological development of the neural crest cells can induce pathological processes in other tissues of the body as well, which may appear in the form of the so-called neurocristopathies including approximately ffty manifestations. The knowledge of the diferent pigmentation forms as well as the pathological symptoms of neurocristopathies is of great importance for the clinican from a diagnostic point of view.

scholarly journals Antiandrogenic therapy with ciproterone acetate in female patients who suffer from both androgenetic alopecia and acne vulgaris

2014 ◽  
Vol 87 (4) ◽  
pp. 226-234 ◽  
Author(s):  
Andrei Coneac ◽  
Adriana Muresan ◽  
Meda Sandra Orasan
Keyword(s):  
Hair Loss ◽  
Ethinyl Estradiol ◽  
Acne Vulgaris ◽  
Hair Follicles ◽  
Point Of View ◽  
Androgenetic Alopecia ◽  
Oil Glands ◽  
Clinical Criteria ◽  
Severe Acne ◽  
Antiandrogenic Therapy

Background. Androgenetic Alopecia in Women (AGA) occurs due to an underlying susceptibility of hair follicles to androgenic miniaturization, caused by androgens. Clinically, AGA is characterized by progressive hair loss, with a marked hair thinning in the fronto-parietal area so that the scalp can be easily seen. Acne vulgaris is androgen-dependent and often affects the skin that has an increased number of oil glands: face, back and chest. Although the sebaceous glands are present on the scalp too, it is very rare to get acne at this site, as the hair acts as a wig and allows the sebum to drain and does not block the pores. Both AGA and Acne Vulgaris are signs of hyperandrogenism. Cyproterone acetate/ethinyl estradiol (2mg/0.035mg) products are authorized for the treatment of androgenetic symptoms in women, such as acne, seborrhea, mild forms of hirsutism and androgenetic alopecia. Our study had a double purpose: - To evaluate the result of the study regimen Melleva 35 (one pill per day, for 3 consecutive months) in patients with moderate to severe acne, suffering also from Androgenetic Alopecia; - To establish the efficacy of the drug on acne and alopecia improvement, both from the doctor’s and patient’s point of view. Patients and methods. After being informed of the aims and procedures of the study, participants provided a written informed consent. A number of 35 female subjects with moderate to severe acne vulgaris remained in the study. The subjects had also been diagnosed as suffering from AGA, on the basis of clinical criteria, including the pattern of hair loss and trichoscopy assessment. Results. 83% of study subjects reported that their hair did not continue to fall after 3 months of antiandrogen therapy. The females were evaluated using trichoscopy and the doctor noticed hair regrowth in 77% of the cases. Regarding the improvement of acne lesions after the treatment, 40% of study subjects recorded good improvement and 26% recorded excellent results with Melleva 35. The acceptance of the treatment was very high, 86% patients were compliant with the study therapy. The rate of adverse events (5 cases) was within the limits of the treatment tested by the study. Almost a third of the total number of subjects (28.5%) reached a good satisfaction level after the treatment, while 37.1% claimed moderate satisfaction. Conclusion. There was no correlation between the age of the subjects and the treatment for acne therefore our first hypothesis was rejected. As a conclusion, antiandrogenic therapy with Melleva 35, 1 pill per day, for 3 consecutive months, shows good results for patients who suffer from both Androgenetic Alopecia and Acne Vulgaris.

scholarly journals Keratolysis exfoliativa-like eruption induced by ranolazione

2021 ◽  
Author(s):  
Elena Pierobon ◽  
Lerica Germi ◽  
Andrea Sechi ◽  
Giampaolo Trevisan ◽  
Elena Pezzolo ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Clinical Features ◽  
Point Of View ◽  
Occupational Dermatitis ◽  
Drug Induced ◽  
Patient’S History

Dermatoses affecting palms may represent a dermatologic challenge from both the diagnostic, and therapeutic point of view. Patients with supposedly occupational dermatitis can spend months or even years in a frustrating attempt to avoid contact with possible irritants or allergens. To underline the importance of a thorough unbiased analysis of the patient’s history and clinical features, we present the iconic case of a bricklayer affected by a chronic, disabling desquamation of palms which in the end was classified as keratolysis exfoliativa (KE) attributed to ranolazine-intake, an antianginal drug. To the best of our knowledge, this specific adverse effect of drug-induced KE of palms has never been reported before in association with ranolazine.

scholarly journals Association between anti-citrullinated alpha enolase antibodies and clinical features in a cohort of patients with rheumatoid arthritis: a pilot study

Reumatismo ◽  
2018 ◽  
Vol 70 (2) ◽  
pp. 67
Author(s):  
A. Alunno ◽  
O. Bistoni ◽  
F. Pratesi ◽  
F. Topini ◽  
I. Puxeddu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Pilot Study ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Clinical Features ◽  
Prognostic Significance ◽  
Point Of View ◽  
Erosive Disease ◽  
Bone Erosions

In recent years several antibodies against citrullinated peptides (ACPAs) have been identified in patients with rheumatoid arthritis (RA) and their pathogenic, diagnostic and prognostic significance is under intense investigation. Among ACPAs, those targeting citrullinated alpha enolase (anti-CEP1) have been identified in RA but data about their ability to predict the development of erosive disease are conflicting. Furthermore, no data are currently available concerning their possible association with extra-articular manifestations (EAMs) in RA. The aim of this study was to investigate the prevalence and significance of anti-CEP1 from a prognostic point of view. In this pilot study we confirmed that anti-CEP1 Abs are associated with higher prevalence of bone erosions, but we also provided the first evidence of an association between anti-CEP1 Abs and RA interstitial lung disease (ILD). These results provide the basis to investigate the association between anti-CEP1 Abs and EAMs in larger cohorts of RA patients to possibly confirm its role as biomarker for RA-ILD.

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