Formulation and Evaluation of Anti-inflammatory Herbal gel using Sarcosteema acidum

2020 ◽  
Vol 1 (28) ◽  
pp. 62-69
Keyword(s):  
Medicinal Plants ◽  
Blood Cells ◽  
Defense Mechanism ◽  
Folk Medicine ◽  
Biological Evaluation ◽  
Safety And Efficacy ◽  
Complex Events ◽  
Anti Inflammatory ◽  
Living Tissues ◽  
Local Accumulation

Abstract-Inflammation is a pathophysiological response of living tissues to injuries that leads to the local accumulation of plasmatic fluid and blood cells. Although it is a defense mechanism, the complex events and mediators involved the inflammatory reaction can induce, maintain or aggravate many diseases. Therefore, the uses of anti-inflammatory agents are helpful in the therapeutic treatment of these pathologies. In this context, medicinal plants are widely used in folk medicine of many countries to treat differentinflammatoryconditionsand,inparticular, skin inflammations. Present work was designed to formulate herbal gel using extract of Sarcosteema acidumstem which provide better efficacy and to ensure biological evaluation of prepared herbal gel for safety and efficacy.

scholarly journals Medicinal Plants in the Records of Latvian Folk Medicine and Analysis of Their Practical Applications. Doctoral Thesis

2021 ◽  
Author(s):  
◽  
Inga Sīle ◽  
Keyword(s):  
Medicinal Plants ◽  
Molecular Mechanisms ◽  
Ex Vivo ◽  
Folk Medicine ◽  
European Medicines Agency ◽  
Evidence Based ◽  
Traditional Use ◽  
Practical Applications ◽  
Anti Inflammatory

Medicinal plant knowledge in Europe is rooted in a long history of health traditions. Numerous ethnobotanical studies across Europe have addressed the increasing importance of the traditional use of medicinal plants. Latvia is a country with old folk medicine traditions and an extensive folk knowledge archive. The aim of this thesis was to collect and analyse knowledge about the use of the medicinal plants found in the records of Latvian folk medicine and to search for new ideas regarding the practical applications of these plants. This thesis reveals, for the first time to the international scientific community, the important ethnobotanical information contained in the records of Latvian folk medicine that had not yet been translated into English and are therefore less visible to researchers from all over the world. This thesis provides a list of the used plant species and plant parts, the dosage forms of herbal medicines, the routes of administration, and the disorders treated with medicinal plants mentioned in the records of Latvian folk medicine and used by indigenous people of Latvia in the end of 19th and the beginning of 20th centuries. In total, the thesis includes information on 211 plant taxa, most of which were utilized for the treatment of digestive and respiratory system disorders. To understand whether the information mentioned in the folklore material is relevant today, it was compared with evidence-based information regarding the uses of the listed plant, including official herbal monographs. During this study, it was concluded that only 59 plant taxa mentioned in the studied records of Latvian folk medicine are included in the official monographs of the European Medicines Agency, and most of the plant indications mentioned in the records have not been described in evidence-based monographs. After the systematic analysis of folklore materials, additional information on the molecular mechanisms of the anti-inflammatory activities of Pelargonium sidoides DC. and Prunus padus L. were investigated to confirm their traditional use for the treatment of inflammatory conditions. The obtained results provide evidence that both plant extracts exhibit pronounced in vitro and ex vivo anti-inflammatory activities, supporting their use in Latvian ethnomedicine as effective anti-inflammatory agents. The obtained results are important as they provide ideas for further research related to possibilities regarding the use of plants growing in the territory of Latvia and allow new perspectives to be gained for both national and international ethnobotanical research.

scholarly journals Isolation and Biological Properties of the Natural Flavonoids Pectolinarin and Pectolinarigenin—A Review

Antibiotics ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 417
Author(s):  
Thamere Cheriet ◽  
Balkeis Ben-Bachir ◽  
Oumelkhir Thamri ◽  
Ramdane Seghiri ◽  
Ines Mancini
Keyword(s):  
Medicinal Plants ◽  
Fruits And Vegetables ◽  
Biological Properties ◽  
Biological Evaluation ◽  
Biological Agent ◽  
Antitumor Activities ◽  
Anti Inflammatory ◽  
Antidiabetic Effects

Flavonoids are metabolites widely distributed in plants and commonly present in foods, such as fruits and vegetables. Pectolinarin, which belongs to the flavone subclass, has attracted considerable attention due to its presence in many medicinal plants. It has turned out to be a good biological agent especially due to its antioxidant, anti-inflammatory, antidiabetic, and antitumor activities, evaluated both in vitro and in vivo. Its aglycone, the metabolite pectolinarigenin, is also known for a series of biological properties including anti-inflammatory and antidiabetic effects. In the first overview on the two metabolites here presented, their collection, isolation and the results of their biological evaluation are reported.

scholarly journals Biological Evaluation of Different Extracts of Aerial Parts of Nepeta deflersiana and Standardization of Active Extracts Using 8-Epi-7-Deoxyloganic Acid and Ursolic Acid by Validated HPTLC Method

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Raha Orfali ◽  
Nasir Ali Siddiqui ◽  
Perwez Alam ◽  
Tawfeq Abdullah Alhowiriny ◽  
Areej Mohammad Al-Taweel ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ursolic Acid ◽  
Folk Medicine ◽  
Biological Evaluation ◽  
Bioactive Metabolites ◽  
Cytotoxic Activities ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Hptlc Method ◽  
Acid Compound

Nepeta deflersiana (Lamiaceae) is a well-known medicinal plant that grows in Saudi Arabia. This plant is used in Saudi and Yemeni folk medicine as an anti-inflammatory, carminative, and antirheumatic agent. In order to prove its use in folk medicine, four different extracts from the aerial parts of the plant: petroleum ether, chloroform, ethyl acetate, and n-butanol extracts were subjected to biological assays to screen PPARα and PPARϒ agnostic, antioxidant, anti-inflammatory, and cytotoxic activities. Ethyl acetate and n-butanol extracts of N. deflersiana NDEE and NDBE, respectively, showed a decrease in oxidative stress and inhibition of both NF-kB and iNOS activities with no cytotoxic effects on four human cancer cell lines. Both active extracts were standardized using two bioactive metabolites which were isolated from the aerial parts of the same plant [8-epi-7-deoxyloganic acid (compound 1) and Ursolic acid (compound 2)] by developing a validated HPTLC method. It was found to provide a sharp and compact band of compound 1 at Rf = 0.07 and Rf = 0.57 for compound 2, using chloroform, methanol, and formic acid (8.9:0.8:0.3, v/v/v) as mobile phase at 550 nm. Compounds 1 and 2 were found in NDEE by 9.59 %, w/w, and 84.63 %, w/w, respectively, and by 11.97 %, w/w, and 21.26 %, w/w, respectively, in NDBE.

scholarly journals Medicinal Plants in the Records of Latvian Folk Medicine and Analysis of Their Practical Applications. Summary of the Doctoral Thesis

2021 ◽  
Author(s):  
◽  
Inga Sīle ◽  
Keyword(s):  
Medicinal Plants ◽  
Molecular Mechanisms ◽  
Ex Vivo ◽  
Folk Medicine ◽  
European Medicines Agency ◽  
Evidence Based ◽  
Traditional Use ◽  
Practical Applications ◽  
Anti Inflammatory

Medicinal plant knowledge in Europe is rooted in a long history of health traditions. Numerous ethnobotanical studies across Europe have addressed the increasing importance of the traditional use of medicinal plants. Latvia is a country with old folk medicine traditions and an extensive folk knowledge archive. The aim of this thesis was to collect and analyse knowledge about the use of the medicinal plants found in the records of Latvian folk medicine and to search for new ideas regarding the practical applications of these plants. This thesis reveals, for the first time to the international scientific community, the important ethnobotanical information contained in the records of Latvian folk medicine that had not yet been translated into English and are therefore less visible to researchers from all over the world. This thesis provides a list of the used plant species and plant parts, the dosage forms of herbal medicines, the routes of administration, and the disorders treated with medicinal plants mentioned in the records of Latvian folk medicine and used by indigenous people of Latvia in the end of 19th and the beginning of 20th centuries. In total, the thesis includes information on 211 plant taxa, most of which were utilized for the treatment of digestive and respiratory system disorders. To understand whether the information mentioned in the folklore material is relevant today, it was compared with evidence-based information regarding the uses of the listed plant, including official herbal monographs. During this study, it was concluded that only 59 plant taxa mentioned in the studied records of Latvian folk medicine are included in the official monographs of the European Medicines Agency, and most of the plant indications mentioned in the records have not been described in evidence-based monographs. After the systematic analysis of folklore materials, additional information on the molecular mechanisms of the anti-inflammatory activities of Pelargonium sidoides DC. and Prunus padus L. were investigated to confirm their traditional use for the treatment of inflammatory conditions. The obtained results provide evidence that both plant extracts exhibit pronounced in vitro and ex vivo anti-inflammatory activities, supporting their use in Latvian ethnomedicine as effective anti-inflammatory agents. The obtained results are important as they provide ideas for further research related to possibilities regarding the use of plants growing in the territory of Latvia and allow new perspectives to be gained for both national and international ethnobotanical research.

scholarly journals Botanical and phyto-pharmacological reports on Stephania japhonica

2017 ◽  
Vol 2 (01) ◽  
pp. 1-7 ◽  
Author(s):  
Muhammad Torequl Islam ◽  
Mohammad Hossain ◽  
Md. Abul Kalam Azad ◽  
Syed Mohammed Tareq
Keyword(s):  
Medicinal Plants ◽  
Medicinal Plant ◽  
Human Health ◽  
Skin Diseases ◽  
Folk Medicine ◽  
Urinary Disorders ◽  
Plant Parts ◽  
Anti Inflammatory ◽  
Analgesic Activities ◽  
A Current

Medicinal plants play a key role in the human health. The use of plants, plant parts and their derived products is ancient. To date, a number of medicinal plants have gained attention of the medicinal scientists for their important phytoconstituents and in the treatment of various diseases. The plants of the genus Stephania (Family: Menispermaceae) are widely distributed, and are being used in the folk medicine for the treatment of various ailments, such as asthma, tuberculosis, fever, dysentery, hyperglycemia, malaria, and cancer. Stephania japonica belonging to this genus has been reported for many important phytochemicals and folk usages in the treatment of fever, diarrhea, dyspepsia, convulsions, skin diseases, cough, asthma, and urinary disorders. The scientific evidences suggest that, S. japonica has antioxidant, anti-inflammatory, antibacterial, antifungal, cytotoxic, anti-diabetic, anti-diarrheal, and analgesic activities. This review presents a current morphological and phyto-pharmacological scenario on this hopeful medicinal plant.

1167-P: Safety and Efficacy of 52 Weeks' Therapy with Hydroxychloroquine (HCQ)—First Anti-inflammatory Drug Approved in India for T2D

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1167-P
Author(s):  
ANIL PAREEK ◽  
RAVI TEJRAJ MEHTA ◽  
SHRUTI DHARMADHIKARI ◽  
KUMAR BHASKAR NAIDU
Keyword(s):  
Safety And Efficacy ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Thiazole-Based Chalcone Derivatives as Potential Anti-inflammatory Agents: Biological Evaluation and Molecular Modelling

2020 ◽  
Vol 21 ◽  
Author(s):  
Michelyn Haroun ◽  
Christopher Tratrat ◽  
Evangelia Tsolaki ◽  
Anthi Petrou ◽  
Antonis Gavalas ◽  
...  
Keyword(s):  
Aromatic Aldehyde ◽  
Molecular Modelling ◽  
Biological Evaluation ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Chalcone Derivatives ◽  
Treat Ment ◽  
Anti Inflammatory

Background.: Inflammation is a multifactorial process reflecting response of the organismto various stimuli and is associated to a number of disorders such as arthritis, asthma and psoriasis, which require long-lasting or repeated treat-ment. Objective.: The aim of this paper is to evaluate the anti-inflammatory activity of previous synthesized thiazole-based chal-cone derivatives. Method.: Chalcones were synthesized via Cliazen-Schmidt condensation1-(4-methyl-2-alkylamino)thiazol-5-yl) ethanone with corresponding aromatic aldehyde. For the evaluation of possible anti-inflammatory activity carrageneen mouse paw edema was used. Results.: Eight out of thirteen tested chalcones showed anti-inflammatory activity in range of 51-55%. Prediction of toxicity revealed that these compounds are not toxic. Conclusion.: In general, it can be concluded that these compounds can be used for further modifications in order to develop more active and safe agents.

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