scholarly journals A systematic review on Valproate induced rat model of autism: Pathophysiology, treatment, developmental and neurobehavioral assessment of rat offsprings

Biomedicine ◽  
2021 ◽  
Vol 41 (1) ◽  
pp. 9-15
Author(s):  
U Kavitha ◽  
E Kayalvizhi ◽  
K Revathy ◽  
T.R. Brindha ◽  
R Muthulakshmi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Model ◽  
Social Communication ◽  
Literature Search ◽  
Autism Spectrum ◽  
Treatment Modalities ◽  
Extensive Literature ◽  
Repetitive Behaviour ◽  
Behavioural Assessment ◽  
Extensive Literature Search

Autism Spectrum disorder (ASD) is charecterised by certain degrees of disabilities in social communication, restrictive repetitive behaviour and altered motor and sensory perception. Translational research is carried out by creating animal models of autism to find out the correlation between behavioural changes and the pathology of brain tissue and for clinical trials of newer therapeutic formulations. Valproate induced animal model of autism has significant validity to demonstrate ASD manifestations. An early appreciation of ASD symptoms is needed for a better prognosis. So assessment of behavioural abnormalities and development stones in the first month of animal life are much important to study ASD.An extensive literature search was done on different databases. (PUBMED-MeSH, PMC, Webof Science, Google scholar and Research Gate). Original articles reported between the years 2000-2020 were selected. PRISMA protocol was followed. There are good quantities of studies on behavioural assessment of valproate induced animal model. This review explains the pathophysiology and various treatment modalities tried in valporate induced animal model and it also enlists the developmental and behavioural assessment methods of rat off springs. It will be useful to demonstrate all signs of autism.  

scholarly journals A Rare Case of Advanced Urethral Diverticular Adenocarcinoma and a Review of Treatment Modalities

2019 ◽  
Vol 7 ◽  
pp. 232470961982840
Author(s):  
Fatai Oluyadi ◽  
Preethi Ramachandran ◽  
Vladmir Gotlieb
Keyword(s):  
Literature Search ◽  
Treatment Approach ◽  
Urethral Diverticulum ◽  
Treatment Modalities ◽  
Final Decision ◽  
Extensive Literature ◽  
Platinum Based Chemotherapy ◽  
Advanced Stages ◽  
Extensive Literature Search ◽  
Tract Infections

Female urethral diverticular cancer is a very rare entity with only around 100 cases reported so far in literature and accounts for <1% of all malignancies. In this article, we present a 47-year-old African American female with repeated hospital visits for urinary retention, hematuria, and urinary tract infections. Initial computed tomography imaging and cystoscopy was unremarkable except for a distended urinary bladder. Subsequent magnetic resonance imaging and corresponding cystoscopy eventually indicated the presence of a urethral diverticulum. She underwent urethral diverticulectomy and was found to have a mass arising from urethral diverticulum extending to vaginal walls. Her biopsy was suggestive of invasive adenocarcinoma in advanced stages, for which she subsequently underwent a total pelvic exenteration. Next-generation sequencing of the tumor showed CDKN2A/B loss, MSI-stable, and low TMB, thereby ruling out the options for targeted therapies. Extensive literature search and expert opinions were sought for her case since no consensus exists regarding the optimal therapeutic approach due to the rarity of this tumor. A final decision was made to treat her with platinum-based chemotherapy. Different treatment approaches including neoadjuvant chemoradiation followed by surgery, surgery followed by adjuvant chemotherapy, and surgery followed by chemoradiation have been tried. Platinum-based chemotherapy has generally been preferred based on an extensive literature search. Multimodality treatment approach seems to be the current approach to management for advanced stages for better overall survival. This case illustrates the challenges faced in making diagnosis and treatment decisions due to the rarity of this type of tumor and lack of consensus in the treatment approach.

scholarly journals Metastatic sebaceous cell carcinoma, review of the literature and use of electrochemotherapy as possible new treatment modality

2016 ◽  
Vol 50 (3) ◽  
pp. 308-312 ◽  
Author(s):  
Simone Ribero ◽  
Eugenio Sportoletti Baduel ◽  
Matteo Brizio ◽  
Franco Picciotto ◽  
Emi Dika ◽  
...  
Keyword(s):  
Literature Search ◽  
Treatment Options ◽  
Objective Response ◽  
Rare Event ◽  
Sebaceous Carcinoma ◽  
Treatment Modalities ◽  
Extensive Literature ◽  
Initial Stage ◽  
Extensive Literature Search ◽  
New Treatment

AbstractBackgroundMetastatic extraorbital sebaceous carcinoma is a rare event that could involve the head and neck. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.Material and methodsExtensive literature search was done, and the treatment options are discussed.ResultsResults. The literature search found several treatment modalities in use for the treatment of metastatic extraorbital sebaceous carcinoma. Electrochemotherapy was not included in the reported treatments. We used this technique for a man of 85 years old with a recurrent and locally metastatic extraorbital sebaceous carcinoma of the scalp. During the period of 8 months, two sessions of electrochemotherapy were employed, which resulted in an objective response of the tumour and good quality of life.ConclusionsElectrochemotherapy has shown to be a interesting tools for treatment of metastatic extraorbital sebaceous carcinoma when other radical options are not available or convenient.

scholarly journals Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Julio Vaquerizo-Serrano ◽  
Gonzalo Salazar de Pablo ◽  
Jatinder Singh ◽  
Paramala Santosh
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Literature Search ◽  
Meta Analysis ◽  
Autism Spectrum ◽  
Clinical High Risk ◽  
Psychotic Experiences ◽  
Attenuated Psychosis Syndrome ◽  
The Mean ◽  
Spectrum Disorders

AbstractPsychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD.

scholarly journals Musculoskeletal biomechanics in sit-to-stand and stand-to-sit activities with stroke subjects: a systematic review

2010 ◽  
Vol 23 (1) ◽  
pp. 35-52 ◽  
Author(s):  
Christina Danielli Coelho de Morais Faria ◽  
Viviane Amaral Saliba ◽  
Luci Fuscaldi Teixeira-Salmela
Keyword(s):  
Systematic Review ◽  
Methodological Quality ◽  
Weight Bearing ◽  
Experimental Studies ◽  
Quality Parameters ◽  
Lower Limbs ◽  
Extensive Literature ◽  
Manual Search ◽  
Sit To Stand ◽  
Extensive Literature Search

INTRODUCTION: Sit-to-stand and stand-to-sit are two of the most mechanically demanding activities undertaken in daily life and which are usually impaired in stroke subjects. OBJECTIVES: To determine the distinguishing characteristics in musculoskeletal biomechanical outcomes of the sit-to-stand and stand-to-sit activities with stroke subjects, with an emphasis on the clinical management of stroke disabilities, in a systematic review. MATERIAL AND METHODS: An extensive literature search was performed with the MEDLINE, CINAHL, EMBASE, PEDro, LILACS, and SciELO databases, followed by a manual search, to select studies on musculoskeletal biomechanical outcomes in both activities with stroke subjects, without language restrictions, and published until December/2007. RESULTS: Out of the 432 studies, only 11 reported biomechanical outcomes of both activities and none reached the total score on the selected quality parameters. The majority of the experimental studies which compared groups did not achieve acceptable scores on their methodological quality (PEDRo). The investigated conditions and interventions were also restricted. Only one study compared biomechanical outcomes between the activities, but only evaluated the time spent to perform them. Few musculoskeletal biomechanical outcomes have been investigated, being weight bearing on the lower limbs and duration of the activities the most investigated. CONCLUSION: There is little information regarding musculoskeletal biomechanical outcomes during these activities with stroke subjects and no definite conclusions can be drawn regarding the particularities of these outcomes on their performance with stroke survivors.

scholarly journals Magnetic Suspension with Motorization to Measure the Speed of Gravity

2017 ◽  
Vol 45 ◽  
pp. 1760020
Author(s):  
Henrique Linares ◽  
Carlos Frajuca ◽  
Fabio S. Bortoli ◽  
Givanildo A. Santos ◽  
Francisco Y. Nakamoto
Keyword(s):  
High Speed ◽  
Literature Search ◽  
Magnetic Bearing ◽  
Magnetic Suspension ◽  
Extensive Literature ◽  
Sliding Bearing ◽  
Speed Of Gravity ◽  
Engineering Problems ◽  
Extensive Literature Search ◽  
Hybrid Bearing

This work aims to design a magnetic suspension for an experiment to measure gravitys velocity. Such device must rotate two objects symmetrically with the greatest mass and largest radius as possible, at the speed of [Formula: see text], which means this device falls into the high-speed machines category. The guidelines and solutions proposed in this paper constitute a contribution to this class of engineering problems and were based on an extensive literature search, contacts with experts, the tutors and author’s experience, as well as on experimental results. The main solution proposed is a hybrid bearing that combines a radial passive magnetic bearing with an axial sliding bearing, here called MPS (Magnetic Passive and Sliding) bearing.

The genus Carex (Cyperaceae) in Armenia

Phytotaxa ◽  
2021 ◽  
Vol 494 (1) ◽  
pp. 1-41
Author(s):  
JACOB KOOPMAN ◽  
TARON ALEKSANYAN ◽  
ALLA ALEKSANYAN ◽  
GEORGE FAYVUSH ◽  
MARINA OGANESIAN ◽  
...  
Keyword(s):  
Literature Search ◽  
Field Research ◽  
Extensive Literature ◽  
Extensive Literature Search

In this paper we present an updated checklist, key and maps for all the currently known Carex taxa present in Armenia. The present work is based on the revision of the vouchers in herbaria ERE, W and MW, extensive literature search, and field research carried out in 2015–2019. As a result, 71 species of Carex are known from Armenia. Besides, the first Carex hybrid in Armenia has been found and provided here with a binomial name.

Impact of dental implant diameter on the efficiency of fatigue - a systematic review analysis

2021 ◽  
pp. 1-12
Author(s):  
Mohamed Tharwat Hamed ◽  
Hisham Abdullah Mously ◽  
Moayyad Motaz Ghulman ◽  
Ghada Hussein Naguib
Keyword(s):  
Systematic Review ◽  
Dental Implant ◽  
Extensive Literature ◽  
Wide Diameter ◽  
Review Analysis ◽  
Body Fracture ◽  
Extensive Literature Search ◽  
Technical Complication ◽  
Performance Results ◽  
The Impact

Abstract Objective: The present study explains the success and failure of dental implant diameter on the efficiency of fatigue by conducting a systematic review analysis. Methods: An extensive literature search was conducted to carry out systematic review using different scholarly platforms and libraries. A total of 12 studies published within the past 20-year time (1999-2019) were included following the inclusion and exclusion criteria based on the PRISMA guidelines. Additionally, the study outcomes were evaluated to determine their perceptions regarding the role of dental implant diameter in influencing the implant’s fatigue performance. Results: The implant diameter can be categorized into wide diameter (5-6 mm), regular diameter (3.75-4 mm), and small/narrow diameter (3-3.4 mm). The narrow diameter implants are indicated through thin alveolar ridges and mesiodistal spaces (less than 7 mm). The implants with narrow diameter would offer greater risk of fatigue failure for clinical situations with significant functional loading. No significant differences were found either in success or failure of dental implant diameter on fatigue efficiency after 1-year and 3-year follow-up. Conclusion: The technical complication of dental implant include abutment screw loosening or fracture, abutment and superstructure fracture, and implant body fracture. The study has study has mainly focused on the impact of dental implant diameter on the efficiency of fatigue and reviewed a significant impact of dental implant diameter on the fatigue efficiency. Keywords: Dental Implants, Efficiency, Perception. Continuous...

On the value of taxonomic standardization in evolutionary studies

Paleobiology ◽  
1987 ◽  
Vol 13 (2) ◽  
pp. 169-176 ◽  
Author(s):  
Stephen J. Culver ◽  
Martin A. Buzas ◽  
Laurel S. Collins
Keyword(s):  
Benthic Foraminifera ◽  
Literature Search ◽  
Extensive Literature ◽  
Museum Collections ◽  
Duration Data ◽  
Evolutionary Studies ◽  
Extensive Literature Search

Species duration data for living benthic foraminifera derived from an extensive literature search have been compiled and analyzed to investigate rates and patterns of species origination. The same data subjected to taxonomic standardization through examination of many specimens lodged in museum collections indicate strikingly different, and more realistic, rates and patterns.Evolutionary generalizations based on data generated from the literature only are often unreliable and may be directly in opposition to reality. Extensive attempts at taxonomic standardization should be the norm in paleobiological investigations.

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