scholarly journals Effect of vitamin D supplementation on fetal growth and development in pregnant women

Biomedicine ◽  
2021 ◽  
Vol 41 (4) ◽  
pp. 821-824
Author(s):  
Srilekha V. ◽  
B. Vijayalakshmi ◽  
I. Yogananda Reddy ◽  
Nayiema Fathima
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Vitamin D Supplementation ◽  
Mean Difference ◽  
Post Intervention ◽  
Biparietal Diameter ◽  
Before And After ◽  
The Mean

Introduction and Aim:  Fetal growth is a dynamic process that must be monitored in pregnant women to reduce the long-term consequences of fetal anomalies and post-natal effects on their life. The current study was aimed to find out the effectiveness and association of vitamin D on fetal growth during the prenatal period.   Materials and Methods: It was a randomized control trial undertaken in 100 pregnant women who were allocated randomly into two groups based on calcemic state. After giving 6000 IU of vitamin D intervention the fetal growth was measured at the end of 3 months and the variables were obtained before and after the intervention.   Results: The mean difference of fetal weight between groups was 77g was significantly increased to 277g (p<0.01) after 3 months. The mean difference of femur length before intervention was 0.95mm (p-0.18) significantly increased to 3.03mm (p<0.01). Further, the mean biparietal diameter difference was 0.13mm (p-0.92) was substantially increased to 4.77mm(p<0.01).   Conclusion: The current study suggests that the fetal growth variables were significantly increased in post-intervention phases which can be attributed to vitamin D. It has an immense effect on fetal growth which can be supplemented during different trimesters to enhance fetal development.

scholarly journals The Impact of The Strengthened Gender Sensitive Midwifery Care on Pregnant Women’s Knowledge, Attitude and Acceptance of Midwifery Care

2021 ◽  
Vol 1 (3) ◽  
pp. 39-46
Author(s):  
Maryanah Maryanah ◽  
Indra Supradewi ◽  
Tut Barkinah
Keyword(s):  
Pregnant Women ◽  
Negative Impact ◽  
Mean Difference ◽  
P Value ◽  
Midwifery Care ◽  
Before And After ◽  
The Mean ◽  
Women's Knowledge ◽  
The Impact ◽  
Women’S Knowledge

Background: Gender sensitive midwifery services are needed by women, especially during pregnancy, childbirth and puerperium. Gender inequality in society has a negative impact on the acceptance of antenatal care for mothers. Gender sensitive midwifery care is needed to improve maternal health status during pregnancy. Purpose: This study aims to determine the impact of gender sensitive midwifery care on pregnant women’s knowledge, attitude and acceptance of midwifery care Method: This was a quantitative experimental study with pre-posttest for 1 group design. The subjects of this study were pregnant women who received midwifery care from 40 midwives, totaling 200 pregnant women obtained through purposive sampling in 2 provinces. Paired t-test was used to measure the difference in the results of the variables measured in pregnant women before and after 3 months of the intervention given by midwives. Results: Pregnant women’s knowledge, attitude and acceptance of midwifery care increased after they received intervention from midwives. The mean difference (MD) for knowledge was -2.07 (r=0.864), p value=0.000 in DKI Jakarta, and MD=-2.70 (r=0.467), p value= 0.000 in South Kalimantan. For attitude in DKI Jakarta, MD=-1.03 (r= 0.99, p value=0.000) and in South Kalimantan the mean difference (MD) was -2.8 (r= 0.445, p value=0.000). For acceptance of gender sensitive midwifery care in DKI Jakarta MD=-2.71 (r= 0.67, p value= 0.000) and South Kalimantan MD=-4.5 (r= p value=0.000). Conclusion: There was a difference and increase in score for knowledge, attitude and acceptance of midwifery care with gender sensitivity in pregnant women before and after the intervention was given to the midwives in the two provinces. It takes great attention from midwives to ensure that all pregnant women receive a gender sensitive midwifery care.    

scholarly journals Hypovitaminosis D and effect of vitamin D supplementation in type 2 diabetes mellitus: a rural population based study

2019 ◽  
Vol 6 (4) ◽  
pp. 1293
Author(s):  
Sathiyanarayanan Janakiraman ◽  
Girija Subramanian
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Supplementation ◽  
Vitamin D Levels ◽  
Short Period ◽  
Before And After ◽  
The Mean

Background: Deficiency of Vitamin D in general population and its association with various disease conditions have been studied worldwide. Type 2 Diabetes mellitus is increasing at an alarming rate in Indian subcontinent, contributing to increased morbidity and mortality. This study aimed to estimate level of Vitamin D and its association with patients with type 2 diabetes mellitus of rural origin. This study objective was to estimate the Vitamin D level of patients with Type 2 Diabetes mellitus and the effect of Vitamin D supplementation on glycemic statusMethods: This study was conducted at the Department of General medicine for a period of 1 year. Eighty patients with type 2 Diabetes mellitus were recruited in the study and baseline parameters of glycemic control and Vitamin D levels were assessed. Only 36 patients complied with the recommendation and evaluated further.Results: All the patients included in the study had insufficient or deficient levels of Vitamin D. The mean vitamin D levels before and after supplementation were 17.75±6.30 and 29.33±6.34 respectively. The mean plasma HbA1c level before and after supplementation were 7.78 and 7.30 respectively. Patients after vitamin D replacement showed significant improvement in their glycaemic status.Conclusions: Vitamin D supplementation of 2000 IU/day had shown to improve the glycaemic status. The beneficial effect of Vitamin D on diabetes was evident in a short period of supplementation.

scholarly journals Safety of Early Vitamin D Supplementation in Premature Infants at Risk of Bronchopulmonary Dysplasia (BPD) and Growth Failure (P11-070-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Mary Holder ◽  
Ariel Salas
Keyword(s):  
Vitamin D ◽  
Growth Failure ◽  
Vitamin D Supplementation ◽  
Mean Difference ◽  
Target Range ◽  
Orogastric Tube ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
The Mean ◽  
Study Participants

Abstract Objectives To determine safety and efficacy profiles of enteral vitamin D in extremely preterm infants (< 28 weeks of gestation) exposed to early vitamin D supplementation. Methods We analyzed demographic, clinical, and supplementation data of 74 study participants randomly assigned to receive three different regimens of early vitamin D supplementation: placebo (G1), 200 IU/day (G2) or 800 IU/day (G3) (CT.gov: NCT01600430). Study participants included in this analysis received ≥ 70 doses (0.5 ml of vitamin D or placebo every 6 hours through an orogastric tube) in the first 28 days after birth. We defined safety outcomes based on 25 (OH) vitamin D concentrations at birth (D0), postnatal day 14 (D14), and postnatal day 28 (D28). Efficacy outcomes were defined using the new BPD classification and length z-scores. Results The median gestational age of study participants was 26 weeks and the mean birth weight was 815g [+ /- 199]. Thirty-one participants received placebo (42%), 20 received 200 IU/day (27%), and 23 received 800 IU/day (31%). Half were male and 56% were black. Most infants received the first dose of vitamin D on or before D5 (90%). The median value of vitamin D doses given was 90 [IQR: 84-94]. The mean difference between 25 (OH) D concentrations (in ng/ml) at D14 and 25 (OH) D concentrations at D0 was + 5 in G1, + 18 in G2, + 33 in G3 (P < 0.05). The increase in 25 (OH) D concentrations from D0 to D14 was higher among black participants (26 vs 14; P < 0.05). The mean difference between 25 (OH) D concentrations at D28 and 25 (OH) D concentrations at D14 was + 2 in G1, + 6 in G2, and + 25 in G3. Vitamin D concentrations in G3 at D14 (57, IQR: 41–67) were not significantly different than vitamin D concentrations in G2 at D28 (38, IQR: 21–50; P = 0.08). At 36 weeks postmenstrual age, moderate or severe BPD was more common in infants that received placebo (31% vs 16%; P = 0.16). A decline in length-for-age Z score of > 1.2 SD was also more common in infants that received placebo (85% vs. 75%; P = 0.33). Conclusions In this secondary analysis, a vitamin D dose of 800 IU/day increased vitamin D concentrations to target range by D14 and a vitamin D dose of 200 IU/day increased vitamin D concentrations to target range by D28. A combination of these two supplementation regimens seems ideal to avoid toxicity. Funding Sources KPRI.

Effect of Vitamin D Supplementation on Lipid Profile in Vitamin D-Deficient Children with Type 1 Diabetes and Dyslipidemia

2019 ◽  
Vol 91 (5) ◽  
pp. 311-318 ◽  
Author(s):  
Mona Hafez ◽  
Noha Musa ◽  
Sahar Abdel Atty ◽  
Mohamed Ibrahem ◽  
Nehal Abdel Wahab
Keyword(s):  
Vitamin D ◽  
Lipid Profile ◽  
Vitamin D Supplementation ◽  
Lipid Profiles ◽  
Mean Difference ◽  
Hydroxyvitamin D ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
History Of ◽  
The Mean

Background: Vitamin D (VD) was suggested to have both direct and indirect effects on modifying lipid profile in patients with diabetes through its regulatory action that increases the activity of lipoprotein lipase in adiposity. Objectives: To detect the relationship between serum 25-hydroxyvitamin D (25OHD) and lipid profiles in dyslipidemic T1D patients and study the effect of VD supplementation on lipid profiles of VD-deficient T1D patients. Methods: Fifty patients with T1D (for >2 years) and dyslipidemia were included. 25OHD was assessed and patients were divided accordingly into 2 groups: VD sufficiency (>30 ng/mL) and VD deficiency (VDD) or insufficiency (<29 ng/mL) who were allocated to VD3 supplementation for 4 months, then lipid profile was reevaluated in both groups. Results: Thirty patients had VDD, while 20 patients had VD sufficiency. There was no significant correlation between 25OHD and different study parameters (p > 0.05). A significant difference was found among both groups in the family history of coronary heart disease (p = 0.036) and free tetraiodothyronine 4 (p = 0.035). After 4 months of VD supplementation in VDD group, the mean difference (at 0 and 4 months) in low-density lipoproteins (LDL) and hemoglobin A1c (HbA1c) was statistically significant (p = 0.02 and 0.04 respectively) between both groups. The mean basal LDL was 126.91 mg/dL in VDD group that improved to 117.13 mg/dL after 4 months of VD therapy with a mean difference of –9.7 mg/dL compared to a mean difference of –2 mg/dL in VD sufficiency group. Conclusions: VDD was highly prevalent in patients with T1D. There was no significant correlation between 25OHD levels and lipid profile in patients with T1D. VD supplementation for 4 months had a significant lowering effect on LDL and HbA1c.

scholarly journals Bone Mineral Density Changes in Long-Term Kidney Transplant Recipients: A Real-Life Cohort Study of Native Vitamin D Supplementation

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 323
Author(s):  
Yuri Battaglia ◽  
Antonio Bellasi ◽  
Alessandra Bortoluzzi ◽  
Francesco Tondolo ◽  
Pasquale Esposito ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Femoral Neck ◽  
Vitamin D Supplementation ◽  
Z Score ◽  
Mineral Density ◽  
T Score ◽  
The Mean ◽  
25 Oh Vitamin D

Vitamin D insufficiency has been associated with reduced bone mineral density (BMD) in kidney transplant patients (KTRs). However, the efficacy of vitamin D supplementation on BMD remains poorly defined, especially for long-term KTRs. We aimed to investigate the effect of native vitamin D supplementation on the BMD of KTRs during a 2-year follow-up. Demographic, clinical, and laboratory data were collected. BMD was evaluated with standard DEXA that was performed at baseline (before vitamin D supplementation) and at the end of study period. BMD was assessed at lumbar vertebral bodies (LV) and right femoral neck (FN) by a single operator. According to WHO criteria, results were expressed as the T-score (standard deviation (SD) relative to young healthy adults) and Z-score (SD relative to age-matched controls). Osteoporosis and osteopenia were defined as a T-score ≤ −2.5 SD and a T-score < −1 and a > −2.5 SD, respectively. Based on plasma levels, 25-OH-vitamin D (25-OH-D) was supplemented as recommended for the general population. Data from 100 KTRs were analyzed. The mean study period was 27.7 ± 3.4 months. At study inception, 25-OH-D insufficiency and deficiency were recorded in 65 and 35 patients. At the basal DEXA, the percentage of osteopenia and osteoporosis was 43.3% and 18.6% at LV and 54.1% and 12.2% at FN, respectively. At the end of the study, no differences in the Z-score and T-score gains were observed. During linear mixed model analysis, native vitamin D supplementation was found to have a negative nitration with Z-score changes at the right femoral neck in KTRs (p < 0.05). The mean dose of administered cholecalciferol was 13.396 ± 7.537 UI per week; increased 25-OH-D levels were found (p < 0.0001). Either low BMD or 25-OH-vitamin D concentration was observed in long-term KTRs. Prolonged supplementation with 25-OH-D did not modify BMD, Z-score, or T-score.

Cost-effectiveness of a Vitamin D supplementation programme in pregnant women and children to prevent rickets in the UK

2019 ◽  
Author(s):  
Vilius Floreskul ◽  
Fatima Juma ◽  
Anjali Daniel ◽  
Imran Zamir ◽  
Zulf Mughal ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cost Effectiveness ◽  
Pregnant Women ◽  
Vitamin D Supplementation ◽  
Women And Children ◽  
The Uk

Evaluation of the hormonal and biochemical changes in obese and non-obese PCOS Iraqi women before and after vitamin D supplementation

2019 ◽  
Vol 9 (o3) ◽  
Author(s):  
Suaad Muhssen Ghazi ◽  
Fatin Shallal Farhan
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Follicular Development ◽  
High Body Mass Index ◽  
Vitamin D Supplementation ◽  
The Body ◽  
Obese People ◽  
Serum Vitamin D ◽  
Before And After ◽  
Granulose Cells

Vitamin D deficiency is common in women with polycystic ovarian syndrome. Vitamin D plays an important physiologic role in reproductive functions of ovarian follicular development and luteinization through altering anti-müllerian hormone signaling, follicular stimulating hormone activity and progesterone production in human granulose cells. Vitamin D is precipitated in adipose fat tissues, making it notable to be used for the body as a result; obese people with high body mass index are already highly expected to have low levels of serum vitamin D.

High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients

2020 ◽  
Vol 16 ◽  
Author(s):  
Natércia Neves Marques de Queiroz ◽  
Franciane Trindade Cunha de Melo ◽  
Fabrício de Souza Resende ◽  
Luísa Corrêa Janaú ◽  
Norberto Jorge Kzan de Souza Neto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Blood Pressure Monitoring ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Before And After ◽  
Patients With Diabetes ◽  
Morning Blood Pressure ◽  
Cholecalciferol Supplementation ◽  
Lipids Profile

Background: Vitamin D (VD) deficiency has been related to several endocrine metabolic and cardiovascular diseases. Effect of VD supplementation on blood pressure (BP) in patients with diabetes is controversial. Objective: The aim of this study was to evaluate high-dose vitamin D supplementation effects on blood pressure of normotensive type 1 diabetes mellitus (T1DM) patients by 24-hour ambulatory blood pressure monitoring (ABPM). Methods: We performed a clinical trial including 35 T1DM normotensive patients, who received doses of 4,000 or 10,000 IU/day of cholecalciferol for 12 weeks according to previous VD levels. They underwent 24-hour ABPM, along with glycated hemoglobin, creatine, lipids profile and PCRus dosage before and after VD supplementation. Results and discussion: We found an expressive reduction of systolic and diastolic morning blood pressures (117±14 vs 112±14, p<0,05; 74±9 vs 70±10 mmHg, p<0,05, respectively) with no changes in other pressoric markers. Besides, we noticed a relation between levels of VD after supplementation and diastolic morning blood pressure (r= -0,4; p<0.05). Conclusion: Our study suggests an association between supplementation of high doses of vitamin D and the reduction of morning blood pressure in normotensive T1DM patients.

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