Prescription for Change

Author(s):  
Michael Kinch

The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes--and indeed because of them--our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy. To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come.

Text Matters ◽  
2018 ◽  
pp. 229-243
Author(s):  
Alicja Piechucka

The article focuses on an analysis of Hart Crane’s essay “Note on the Paintings of David Siqueiros.” One of Crane’s few art-historical texts, the critical piece in question is first of all a tribute to the American poet’s friend, the Mexican painter David Siqueiros. The author of a portrait of Crane, Siqueiros is a major artist, one of the leading figures that marked the history of Mexican painting in the first half of the twentieth century. While it is interesting to delve into the way Crane approaches painting in general and Siqueiros’ oeuvre in particular, an analysis of the essay with which the present article is concerned is also worthwhile for another reason. Like many examples of art criticism—and literary criticism, for that matter—“Note on the Paintings of David Siqueiros” reveals a lot not only about the artist it revolves around, but also about its author, an artist in his own right. In a text written in the last year of his life, Hart Crane therefore voices concerns which have preoccupied him as a poet and which, more importantly, are central to modernist art and literature.


2021 ◽  
Author(s):  
Brian Piitz

This applied thesis is focused on the full cataloguing and contextualizing of a collection of one hundred and sixteen postcards at the Art Gallery of Ontario (AGO) depicting scenes of Toronto a the beginning of the twentieth century. Twenty-seven publishers representing international, national and regional manufacturers are identified with their imprint on the verso of the postcard. The applied thesis includes a literature survey discussing a rationale for the cataloguing of postcards, as well as a brief overview of the history of postcards and the history of the urbanization of the City of Toronto. A description and analysis of the AGO postcards provides information about the production cycle of postcards, the scope of commercial photography and the dissemination of photographic imagery in Toronto. The thesis also examines the way images were altered in the production cycle and the manner in which photographers and publishers exchanged photographs intended for postcard production.


2021 ◽  
Author(s):  
Brian Piitz

This applied thesis is focused on the full cataloguing and contextualizing of a collection of one hundred and sixteen postcards at the Art Gallery of Ontario (AGO) depicting scenes of Toronto a the beginning of the twentieth century. Twenty-seven publishers representing international, national and regional manufacturers are identified with their imprint on the verso of the postcard. The applied thesis includes a literature survey discussing a rationale for the cataloguing of postcards, as well as a brief overview of the history of postcards and the history of the urbanization of the City of Toronto. A description and analysis of the AGO postcards provides information about the production cycle of postcards, the scope of commercial photography and the dissemination of photographic imagery in Toronto. The thesis also examines the way images were altered in the production cycle and the manner in which photographers and publishers exchanged photographs intended for postcard production.


Author(s):  
Vernon Bogdanor

This concluding chapter sums up the key findings of this study on the history of the British constitution in the twentieth century. The findings reveal that while there was widespread confidence in the virtues of the constitution at the beginning of the twentieth century, that confidence seemed to have evaporated. This loss of confidence coincided with a collapse of national self-confidence that had begun in the 1960s when British political and intellectual elites began to come to terms with the fact that Great Britain was falling economically behind her continental competitors.


Author(s):  
Meredith Martin

This chapter begins with a discussion of metrical mastery, outlining the way that Robert Bridges's intervention in his best-selling treatise Milton's Prosody expanded and popularized the theories that he and Gerard Manley Hopkins discussed together. It shows how Bridges and his influential competitor, George Saintsbury, were jostling for position during the height of the prosody wars between 1900 and 1910, and how their successes and failures characterize much of our contemporary thinking about early twentieth-century prosody. Author of the three-volume History of English Prosody (1906–10), Saintsbury was a prime mover in both the foundation of English literary study and the institutionalization of the “foot” as the primary measure of English poetry. Infused with Edwardian-era military rhetoric, Sainstbury's foot marched to a particularly English rhythm, which he traced through the ages with wit and martial vigor.


2019 ◽  
pp. 1-14
Author(s):  
Mary Augusta Brazelton

This introductory chapter provides a background of how mass immunization programs made vaccination a cornerstone of Chinese public health and China a site of consummate biopower, or power over life. Over the twentieth century, through processes of increasing force, vaccines became medical technologies of governance that bound together the individual and the collective, authorities and citizens, and experts and the uneducated. These programs did not just transform public health in China—they helped shape the history of global health. The material and administrative systems of mass immunization on which these health campaigns relied had a longer history than the People's Republic of China itself. The Chinese Communist Party championed as its own invention and dramatically expanded immunization systems that largely predated 1949 and had originated with public health programs developed in southwestern China during the Second Sino-Japanese War from 1937 to 1945. The nationwide implementation of these systems in the 1950s relied on transformations in research, pharmaceutical manufacturing, and concepts of disease that had begun in the first decades of the twentieth century. These processes spanned multiple regime changes, decades of war, and diverse forms of foreign intervention. Most important, they brought with them new ideas about what it meant to be a citizen of China.


Author(s):  
Lucy C. M. M. Jackson

As well as bringing together all the relevant evidence for the quality and activity of the chorus of drama in the fourth century, this monograph has raised certain key questions about the current understanding of the nature and development of Attic drama as a whole. First, it shows that the supposed ‘civic’ quality of the chorus of drama is, in fact, an association loaned, inappropriately, from the genre of circular, ‘dithyrambic’, choral performance. Being attentive to the cultural differences between these two genres should prompt a further re-evaluation of how to read dramatic choruses more generally. Second, the way in which key fourth-century authors such as Plato and Xenophon use the image of the chorus to discuss the concept of leadership has profoundly shaped ways of construing choreia in ancient Greek drama, and the ancient Mediterranean more generally. Armed with this knowledge, it is possible to retell the story and history of the chorus in drama.


2014 ◽  
Vol 23 (2) ◽  
pp. 167-192 ◽  
Author(s):  
ANNA KRYLOVA

‘Modernity’ has long been a working category of historical analysis in Russian and Soviet studies. Like any established category, it bears a history of its own characterised by founding assumptions, conceptual possibilities and lasting interpretive habits. Stephen Kotkin's work has played a special role in framing the kind of scholarship this category has enabled and the kind of modernity it has assigned to twentieth-century Russia. Kotkin's 1995Magnetic Mountainintroduced the concept of ‘socialist modernity’. His continued work with the concept in his 2001Kritikaarticle ‘Modern Times’ and his 2001Armageddon Avertedmarked crucial moments in the history of the discipline and have positioned the author as a pioneering and dominant voice on the subject for nearly two decades. Given the defining nature of Kotkin's work, a critical discussion of its impact on the way the discipline conceives of Soviet modernisation and presents it to non-Russian fields is perhaps overdue. Here, I approach Kotkin's work on modernity as the field's collective property in need of a critical, deconstructive reading for its underlying assumptions, prescribed master narratives, and resultant paradoxes.


2019 ◽  
Vol 2 (2) ◽  
pp. 83
Author(s):  
Halim Wiryadinata

The parable of the Kingdom of God brings the seriousness of studying about the meaning of what the Lord Jesus Christ wants to say. There are many arguments to say about the meaning of the Kingdom of God, while a new approach of the twentieth century appears. The study of historical Jesus by N. T Wright gives the idea of Jesus, Israel, and the Cross. If the parable of the Kingdom of God is retelling the story of Israel, then the new concept of the Kingdom of God should be different from the old Israel. The concept of humility should be seen as the way out of the Kingdom of God. Mark 10: 13 – 16 where the Lord Jesus Christ uses the concept of the little children, it apparently shows the helplessness and humility concepts as the way out for the Kingdom of God. However, the concept of humility should be seen as the proclamation of the Kingdom of God in the perspective of a mission to the people. Finally, the concept of humility also should not beyond the limitation of the Gospel. It should be in the line of the meaning of the Gospel itself. We are encouraged not to repeat what history happens, but rather to learn from the history of Liberation Theology.   


2015 ◽  
Vol 5 (2) ◽  
pp. 113
Author(s):  
MA. Arben Salihu

Globalisation is continually shaping the way we live, we travel and also the way and structure we work. It is generally acknowledged that there are a number of fundamental factors that play a crucial role in the business life cycle. Management is one of the main pillars of the organization because it provides direction, implementation, and coordination, so that organizations can attain their goals. An organisation’s life depends heavily on the quality of management. If there is any lack within the management element, it may severely limit an organisation’s existence. It is thus imperative to put all the elements in the right shape and place. Yet still this may be insufficient, due to ever growing competitiveness. Vision, strategy and innovation are fundamental in business enterprises but there are other issues related that have an effect to the management and need careful consideration. This study lists a number of specific challenges (namely leadership, innovation and human resources) that businesses and management is encountering and ought to be facing in several decades to come, and offers recommendation to the topics brought forward


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