scholarly journals The Relationship between Temporal Integration and Temporal Envelope Perception in Noise by Males with Mild Sensorineural Hearing Loss

2019 ◽  
Vol 15 (2) ◽  
pp. 257-262
Author(s):  
Saransh Jain ◽  
◽  
Nuggehalli Puttareviyah Nataraja ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 36-40
Author(s):  
İhsan Kuzucu ◽  
Tuba Çandar ◽  
Deniz Baklacı ◽  
İsmail Güler ◽  
Rauf Oğuzhan Kum ◽  
...  

Objectives. Calprotectin, a protein released by neutrophils, has been used in many studies as a biomarker showing the presence of inflammation. In this study, it was aimed to investigate the relationship between serum calprotectin level and response to the treatment of idiopathic sudden sensorineural hearing loss (ISSHL).Methods. The present study is a prospective, cross-sectional historical cohort study. The study group consisted of 44 patients with ISSHL, and the control group consisted of 41 healthy volunteers without ear pathology. At the same time, patients in the study group were divided into three groups according to the response to ISSHL treatment (recovered, partially recovered, unrecovered). The relationship between the groups was statistically evaluated in terms of serum calprotectin levels.Results. The mean serum calprotectin value was 75.67±19.48 ng/mL in the study group and 50.24±29.14 ng/mL in the control group (<i>P</i>=0.001). Serum calprotectin value according to the severity of hearing loss in the mild, moderate and severe was 66.20±8.82, 70.35±16.77, and 91.23±19.73 ng/mL, respectively. Serum calprotectin value in the severe group was significantly higher compared to the moderate and mild groups (<i>P</i>=0.004, <i>P</i>=0.001, respectively). Serum calprotectin value according to the treatment response in the recovered, partially recovered and unrecovered groups was 63.36±11.54, 80.17±12.06, and 85.33±22.33 ng/mL, respectively. Serum calprotectin value in the recovered group was significantly lower compared to the partially recovered and unrecovered groups (<i>P</i>=0.002, <i>P</i>=0.001, respectively).Conclusion. Serum calprotectin value informs the clinician about both the severity of hearing loss and the response to treatment. Hence, serum calprotectin can be used as an important biomarker in ISSHL patients for the determination of the prognosis of disease.


Author(s):  
Saeid Aarabi ◽  
Nasrin Yazdani ◽  
Javad Fakhri ◽  
Vida Rahimi ◽  
Parsa Cheraghipour ◽  
...  

Introduction: This study aimed to investigate the relationship between sudden sensorineural hearing loss, vestibular neuritis, and infection with COVID-19. Materials and Methods: In this study, a total of 56 Iranians (32 females and 24 males) with a Mean±SD age of 45.12±14 years were studied in Tehran City, Iran. Individuals diagnosed with Sudden Sensorineural Hearing Loss (SSNHL) or vestibular neuritis based on definitive diagnostic criteria were included in the study. The methodology comprised four sections of underlying Sudden Hearing Loss,, auditory and vestibular inspection, SARS-CoV-2 Reverse Transcription-Polymerase Chain Reaction (RT-PCR) test, and statistical analysis. Also, the videonystagmography test was used in participants with vertigo to diagnose vestibular neuritis. Pure tone audiometry confirmed SSNHL in some patients with a complaint of hearing loss. Furthermore, tuning fork, Rinne and Weber tests were also performed. Results: The results of SARS-CoV-2 RT-PCR in 56 subjects showed that eight subjects (22.2%) with vestibular neuritis and two with SSNHL (10%) had a positive RT-PCR test. The Chi- square and Fisher exact-tests with a 95% confidence interval revealed no statistically significant (P>0.05) relationship between COVID-19 infection and vestibular neuritis or SSNHL. Conclusion: The present study showed no statistically significant relationship between audiovestibular disorders and positive SARS-CoV-2 RT-PCR test. However, the possibility of this relationship cannot be ruled out, and there is a need for studies with larger sample sizes.


Metabolites ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 262
Author(s):  
Trinh ◽  
Blasco ◽  
Emond ◽  
Andres ◽  
Lefevre ◽  
...  

Perilymph metabolomic analysis is an emerging innovative strategy to improve our knowledge of physiopathology in sensorineural hearing loss. This study aims to develop a metabolomic profile of human perilymph with which to evaluate the relationship between metabolome and the duration of hearing loss. Inclusion criteria were eligibility for cochlear implantation and easy access to the round window during surgery; patients with residual acoustic hearing in the ear to be implanted were excluded. Human perilymph was sampled from 19 subjects during cochlear implantation surgery. The perilymph analysis was performed by Liquid Chromatography−High-Resolution Mass and data were analyzed by supervised multivariate analysis based on Partial Least-Squares Discriminant Analysis and univariate analysis. Samples were grouped according to their median duration of hearing loss. We included the age of patients as a covariate in our models. Statistical analysis and pathways evaluation were performed using Metaboanalyst. Nineteen samples of human perilymph were analyzed, and a total of 106 different metabolites were identified. Metabolomic profiles were significantly different for subjects with ≤ 12 or > 12 years of hearing loss, highlighting the following discriminant compounds: N-acetylneuraminate, glutaric acid, cystine, 2-methylpropanoate, butanoate and xanthine. As expected, the age of patients was also one of the main discriminant parameters. Metabolic signatures were observed for duration of hearing loss. These findings are promising steps towards illuminating the pathophysiological pathways associated with etiologies of sensorineural hearing loss, and hold open the possibilities of further explorations into the mechanisms of sensorineural hearing loss using metabolomic analysis.


2020 ◽  
Vol 41 (4) ◽  
pp. 1009-1019
Author(s):  
U-Cheng Leong ◽  
Douglas M. Schwarz ◽  
Kenneth S. Henry ◽  
Laurel H. Carney

2015 ◽  
Vol 124 (9) ◽  
pp. 681-690 ◽  
Author(s):  
Eric J. Formeister ◽  
Adam P. Campbell ◽  
Baishakhi Choudhury ◽  
Benjamin Huang ◽  
Valerie Jewells ◽  
...  

2020 ◽  
Vol 5 (2) ◽  
pp. 162-173
Author(s):  
Rahmi Sibagariang ◽  
Muhammad Edy Syahputra Nasution ◽  
Siti Masliana Siregar ◽  
Isra Thristy

Obesity is an increase in total body fat, that is if found to be overweight > 20% in men and 25% in women due to fat. Increased obesity cannot beseparated from lifestyle, such as decreased physical activity.    One complication   that   can   be   caused   by   obesity   is   hearing   loss, especiallysensorineural hearing loss caused by microangiopathic abnormalities, especially in the inner ear. But the relationship of events between obesity withhearing loss is still often a debate, because there is no definite consensus. The purpose of this research determine the relationship of obesity with sensorineural hearing loss. This research is an analytic study by obtaining cross-sectional study, with data obtained from the assessment of bodyweight and height to see the status of the mass index, physical examination of the ear, and audiometric examination. Data analysis techniques using the chi square test statistics. Research result obtained relationship between obesity with sensorineural hearing loss as much as 49.09% and the highest degree of hearing loss is mild degrees as much as 27.07%. Research conclusions there is a significant relationship between obesity with sensorineural hearing loss. Keyword:  Hearing Loss, Obesity, Obesity with Hearing Loss, Pure Tone Audiometry, Sensorineural Hearing Loss,


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