scholarly journals Clinical management protocol of an acute contagious bovine pleuropnuemonia in a 6- year-old Bunaji cow in Sakaru village of Soba local government area, Kaduna state, Nigeria

2020 ◽  
Vol 47 (2) ◽  
pp. 51-56
Author(s):  
S. Danbirni ◽  
B. Y Kaltungo ◽  
B. B. Daudu ◽  
F. U. Mohammed ◽  
U. B Abubakar ◽  
...  
Keyword(s):  
Body Condition ◽  
Clinical Management ◽  
Clinical Signs ◽  
Latex Agglutination ◽  
Contagious Bovine Pleuropneumonia ◽  
Inflammatory Agent ◽  
Management Protocol ◽  
Anti Inflammatory ◽  
Long Acting ◽  
Appetite Stimulant

The test and slaughter policy of the federal government of Nigeria on contagious bovine pleuropneumonia (CBPP) in cattle is no longer feasible because it lacked the political will as a result, farmers tend to treat their cattle of the disease most which has been ineffective. herefore, the quest for a supportive clinical management protocol for CBPP in cattle aimed at enabling the cow regain its body condition in order to allow the farmer sell the cow for slaughter at a profit was the aim of this case report. A 6-year-old Bunaji cow weighing 350kg with history of not feeding well, lagging behind during grazing, difficulty in breathing, intermittent cough and bloat was presented. Physical examination was carried out and differential diagnoses which included contagious bovine pleuropneumonia, mango choke, Pasteurellosis and tuberculosis were considered. After a careful scrutiny of the differentials, a tentative diagnosis of contagious bovine pleuropneumonia which was confirmed by the Latex agglutination test (LAT) was arrived at. A supportive clinical management protocol was instituted with the sole aim of enabling the cow regain its body condition in order to allow the farmer sell the cow for slaughter at a profit. The protocol involved isolation of the cow and administration of 20% tetracycline long acting through a combination of conventional (intra-muscular) and non-conventional (intra-venous) routes of administration along with an anti-inflammatory agent and an appetite stimulant. Six days after the commencement of therapy, the observed clinical signs subsided greatly and the cow became apparently healthy. The study showed that, the protocol of administering 20%tetracycline long acting through a combination of conventional (intra-muscular) and nonconventional (intra-venous) routes along with an anti-inflammatory agent (dexamethasone) and an appetite stimulant (vit. B. complex) was effective and profitable to the farmer. The client was advised to sell the cow for slaughter after observing the 21- day withdrawal period of the drugs. 

Helenalin: An Anti-Inflammatory and Anti-Neoplastic Agent: A Review

2020 ◽  
Vol 16 (8) ◽  
pp. 1134-1146
Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve ◽  
Uttam S. Baghel
Keyword(s):  
Rheumatoid Arthritis ◽  
Adverse Effects ◽  
Chronic Conditions ◽  
Review Article ◽  
Google Scholar ◽  
Medical Community ◽  
Inflammatory Agent ◽  
Skin Cancers ◽  
Medicinal Properties ◽  
Anti Inflammatory

Objective: Helenalin is a natural anti-inflammatory agent that is proving its efficacy to treat various medical conditions. Though many plants are proving their effectiveness but their mechanisms are still not well understood. The objective of the review is to summarize various mechanisms of helenalin to treat inflammatory disorders and cancers, adverse effects, and avenues of further research. Methods: Structured research was carried out including Pub med, Science direct Medline, Research Gate and Google Scholar to find all articles published on helenalin. Various keywords used were “helenalin”, “Arnica”, “cancer”, “anti-inflammatory”, “cardiovascular”, “IBD”, “pharmacokinetics” etc. The aim of the review was to find out the problem prevailing in the data published to date which will help the researchers to investigate the molecule clinically. Results: Seventy articles are included in the review. Helenalin is found to cure chronic conditions like rheumatoid arthritis, ulcers and malignancies like stomach, colon, breast, larynx, lung and skin cancers via multiple mechanisms. These diseases do not proceed via a unilateral pathway. So, it can be a useful molecule to treat numerous diseases. Conclusion: This review article will help us to systemically analyze the wealth of information concerning the medicinal properties of helenalin and to recognize the gaps which have vetoed its pervasive application in the medical community.

scholarly journals Inflammatory Neuropsychiatric Disorders and COVID-19 Neuroinflammation

2021 ◽  
pp. 1-55
Author(s):  
Siu Wa Tang ◽  
Daiga Helmeste ◽  
Brian Leonard
Keyword(s):  
Immune Responses ◽  
Clinical Management ◽  
Neuronal Damage ◽  
Treatment Resistance ◽  
Neuropsychiatric Disorders ◽  
Acute Stage ◽  
Management Approach ◽  
Neuropsychiatric Diseases ◽  
Anti Inflammatory

Abstract Neuropsychiatric sequalae to COVID-19 infection are beginning to emerge, like previous Spanish influenza and SARS episodes. Streptococcal infection in pediatric patients causing OCD (PANDAS) is another recent example of an infection-based psychiatric disorder. Inflammation associated with neuropsychiatric disorders has been previously reported but there is no standard clinical management approach established. Part of the reason is that it is unclear what factors determine the specific neuronal vulnerability and the efficacy of anti-inflammatory treatment in neuroinflammation. The emerging COVID-19 data suggested that in the acute stage, wide-spread neuronal damage appears to be the result of abnormal and overactive immune responses and cytokine storm is associated with poor prognosis. It is still too early to know if there are long term specific neuronal or brain regional damages associated with COVID-19, resulting in distinct neuropsychiatric disorders. In several major psychiatric disorders where neuroinflammation is present, patients with abnormal inflammatory markers may also experience less than favorable response or treatment resistance when standard treatment is used alone. Evidence regarding the benefits of co-administered anti-inflammatory agents such as COX-2 inhibitor is encouraging in selected patients though may not benefit others. Disease modifying therapies are increasingly being applied to neuropsychiatric diseases characterized by abnormal or hyperreactive immune responses. Adjunct anti-inflammatory treatment may benefit selected patients and is definitely an important component of clinical management in the presence of neuroinflammation.

scholarly journals The potential effects of Centella asiatica ethanolic extracts as an anti-inflammatory agent through decreasing TNF-α expression in indomethacin-induced gastric ulcer model rats

2021 ◽  
Author(s):  
Priscilla Maiselina Sriepindonnta ◽  
Fatimah Nur Fitriani ◽  
Savannah Quila Thirza ◽  
Made Dinda Pratiwi ◽  
Dwi Evan Prima Putra Noviardi ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Centella Asiatica ◽  
Inflammatory Agent ◽  
Tnf Α ◽  
Ethanolic Extracts ◽  
Ulcer Model ◽  
Anti Inflammatory

Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review

2021 ◽  
Author(s):  
Moein Ala ◽  
Mehdi Ghasemi ◽  
Razieh Mohammad Jafari ◽  
Ahmad Reza Dehpour
Keyword(s):  
Systematic Review ◽  
Inflammatory Agent ◽  
Anti Inflammatory

scholarly journals Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rine Christopher Reuben ◽  
Shovon Lal Sarkar ◽  
Habiba Ibnat ◽  
Md. Ali Ahasan Setu ◽  
Pravas Chandra Roy ◽  
...  
Keyword(s):  
Growth Performance ◽  
Feed Efficiency ◽  
Biochemical Parameters ◽  
Pasteurella Multocida ◽  
White Blood Cells ◽  
Clinical Signs ◽  
Basal Diet ◽  
Prostaglandin E ◽  
Fowl Cholera ◽  
Anti Inflammatory

AbstractPasteurella multocida causes fowl cholera, a highly contagious poultry disease of global concern, causing significant ecological and economic challenges to the poultry industry each year. This study evaluated the effects of novel multi-strain probiotics consisting of Lactobacillus plantarum, L. fermentum, Pediococcus acidilactici, Enterococcus faecium and Saccharomyces cerevisiae on growth performance, intestinal microbiota, haemato-biochemical parameters and anti-inflammatory properties on broilers experimentally challenged with P. multocida. A total of 120 birds were fed with a basal diet supplemented with probiotics (108 CFU/kg) and then orally challenged with 108 CFU/mL of P. multocida. Probiotics supplementation significantly (P < 0.05) improved growth performance and feed efficiency as well as reducing (P < 0.05) the population of intestinal P. multocida, enterobacteria, and mortality. Haemato-biochemical parameters including total cholesterol, white blood cells (WBC), proteins, glucose, packed cell volume (PCV) and lymphocytes improved (P < 0.05) among probiotic fed birds when compared with the controls. Transcriptional profiles of anti-inflammatory genes including hypoxia inducible factor 1 alpha (HIF1A), tumor necrosis factor- (TNF) stimulated gene-6 (TSG-6) and prostaglandin E receptor 2 (PTGER2) in the intestinal mucosa were upregulated (P < 0.05) in probiotics fed birds. The dietary inclusion of the novel multi-strain probiotics improves growth performance, feed efficiency and intestinal health while attenuating inflammatory reaction, clinical signs and mortality associated with P. multocida infection in broilers.

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