THE ROLE OF THREE-DIMENSIONAL SCAFFOLDS IN THE REGENERATION OF JOINT CARTILAGE

2010 ◽  
Keyword(s):  
Three Dimensional ◽  
Joint Cartilage

The Role of Three-Dimensional Imaging in Evaluation of the Sinonasal Mass

1996 ◽  
Vol 34 (1) ◽  
pp. 27
Author(s):  
Sue Yon Shim ◽  
Ki Joon Sung ◽  
Young Ju Kim ◽  
In Soo Hong ◽  
Myung Soon Kim ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Three Dimensional Imaging ◽  
Sinonasal Mass

Homogenization and Mass Identity vs. Individual Identity. An Analysis in the Light of the Theory of “The Three Dimensional Spiral of Sense

2016 ◽  
Vol 2 (2) ◽  
pp. 40
Author(s):  
Miriam Aparicio
Keyword(s):  
Three Dimensional ◽  
Individual Identity ◽  
Cognitive Effects ◽  
The Media

This study tests some hypotheses included in the psycho-social-communicational paradigm, which emphasizes the cognitive effects of the media and the role of the psychosocial subject as the recipient

Dysregulation of HOX as a Potential Therapeutic Target in Breast Cancer

2020 ◽  
Vol 27 ◽  
Author(s):  
Ji-Yeon Lee ◽  
Myoung Hee Kim
Keyword(s):  
Breast Cancer ◽  
Hox Genes ◽  
Therapeutic Potential ◽  
Expression Patterns ◽  
Genome Structure ◽  
Control Cell ◽  
Three Dimensional ◽  
Cellular Processes ◽  
Hox Protein

: HOX genes belong to the highly conserved homeobox superfamily, responsible for the regulation of various cellular processes that control cell homeostasis, from embryogenesis to carcinogenesis. The abnormal expression of HOX genes is observed in various cancers, including breast cancer; they act as oncogenes or as suppressors of cancer, according to context. In this review, we analyze HOX gene expression patterns in breast cancer and examine their relationship, based on the three-dimensional genome structure of the HOX locus. The presence of non-coding RNAs, embedded within the HOX cluster, and the role of these molecules in breast cancer have been reviewed. We further evaluate the characteristic activity of HOX protein in breast cancer and its therapeutic potential.

Central ossifying fibroma of mandible

2020 ◽  
Vol 13 (12) ◽  
pp. e239286
Author(s):  
Kumar Nilesh ◽  
Prashant Punde ◽  
Nitin Shivajirao Patil ◽  
Amol Gautam
Keyword(s):  
Fibrous Tissue ◽  
Three Dimensional ◽  
Facial Asymmetry ◽  
Ossifying Fibroma ◽  
Mandible Reconstruction ◽  
Three Dimensional Printing ◽  
Osseous Lesion ◽  
Large Size ◽  
Dimensional Printing

Ossifying fibroma (OF) is a rare, benign, fibro-osseous lesion of the jawbone characterised by replacement of the normal bone with fibrous tissue. The fibrous tissue shows varying amount of calcified structures resembling bone and/or cementum. The central variant of OF is rare, and shows predilection for mandible among the jawbone. Although it is classified as fibro-osseous lesion, it clinically behaves as a benign tumour and can grow to large size, causing bony swelling and facial asymmetry. This paper reports a case of large central OF of mandible in a 40-year-old male patient. The lesion was treated by segmental resection of mandible. Reconstruction of the surgical defect was done using avascular fibula bone graft. Role of three-dimensional printing of jaw and its benefits in surgical planning and reconstruction are also highlighted.

scholarly journals Charge algebra in Al(A)dSn spacetimes

2021 ◽  
Vol 2021 (5) ◽  
Author(s):  
Adrien Fiorucci ◽  
Romain Ruzziconi
Keyword(s):  
Boundary Conditions ◽  
Dirichlet Boundary ◽  
Three Dimensional ◽  
Dirichlet Boundary Conditions ◽  
Boundary Structure ◽  
Asymptotic Symmetry ◽  
Renormalization Procedure ◽  
Field Dependent ◽  
Odd Dimensions

Abstract The gravitational charge algebra of generic asymptotically locally (A)dS spacetimes is derived in n dimensions. The analysis is performed in the Starobinsky/Fefferman-Graham gauge, without assuming any further boundary condition than the minimal falloffs for conformal compactification. In particular, the boundary structure is allowed to fluctuate and plays the role of source yielding some symplectic flux at the boundary. Using the holographic renormalization procedure, the divergences are removed from the symplectic structure, which leads to finite expressions. The charges associated with boundary diffeomorphisms are generically non-vanishing, non-integrable and not conserved, while those associated with boundary Weyl rescalings are non-vanishing only in odd dimensions due to the presence of Weyl anomalies in the dual theory. The charge algebra exhibits a field-dependent 2-cocycle in odd dimensions. When the general framework is restricted to three-dimensional asymptotically AdS spacetimes with Dirichlet boundary conditions, the 2-cocycle reduces to the Brown-Henneaux central extension. The analysis is also specified to leaky boundary conditions in asymptotically locally (A)dS spacetimes that lead to the Λ-BMS asymptotic symmetry group. In the flat limit, the latter contracts into the BMS group in n dimensions.

scholarly journals Learning by Doing: The Use of Distance, Corners and Length in Rewarded Geometric Tasks by Zebrafish (Danio rerio)

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2001
Author(s):  
Greta Baratti ◽  
Angelo Rizzo ◽  
Maria Elena Miletto Petrazzini ◽  
Valeria Anna Sovrano
Keyword(s):  
Danio Rerio ◽  
Three Dimensional ◽  
Reference Memory ◽  
Spatial Abilities ◽  
Learning By Doing ◽  
Surface Distance ◽  
Extended Surfaces ◽  
Unequal Length ◽  
Over Time

Zebrafish spontaneously use distance and directional relationships among three-dimensional extended surfaces to reorient within a rectangular arena. However, they fail to take advantage of either an array of freestanding corners or an array of unequal-length surfaces to search for a no-longer-present goal under a spontaneous cued memory procedure, being unable to use the information supplied by corners and length without some kind of rewarded training. The present study aimed to tease apart the geometric components characterizing a rectangular enclosure under a procedure recruiting the reference memory, thus training zebrafish in fragmented layouts that provided differences in surface distance, corners, and length. Results showed that fish, besides the distance, easily learned to use both corners and length if subjected to a rewarded exit task over time, suggesting that they can represent all the geometrically informative parts of a rectangular arena when consistently exposed to them. Altogether, these findings highlight crucially important issues apropos the employment of different behavioral protocols (spontaneous choice versus training over time) to assess spatial abilities of zebrafish, further paving the way to deepen the role of visual and nonvisual encodings of isolated geometric components in relation to macrostructural boundaries.

A comparison between the CS-TOF and the CTA/DSA for WEB device management

2021 ◽  
pp. 159101992110147
Author(s):  
Oktay Algin ◽  
Gokhan Yuce ◽  
Ural Koc ◽  
Gıyas Ayberk
Keyword(s):  
Mr Angiography ◽  
Three Dimensional ◽  
Morphological Parameters ◽  
Perfect Agreement ◽  
Device Management ◽  
Web Device ◽  
Sensing Time ◽  
The Web

Purpose There is no study on the role of three-dimensional compressed sensing time of flight MR angiography (3D-CS-TOF) in the management of the WEB device. We evaluated the efficacy of 3-tesla 3D-CS-TOF for the management and follow-up of the WEB device implantations. Materials and methods Seventy-three aneurysms of 69 patients treated with the WEB device were retrospectively examined. Morphological parameters and embolization results of the aneurysms were assessed and compared on 3D-CS-TOF, CTA, and DSA images. Results Occluded, neck remnant, and recurrent aneurysms were observed in 61 (83.6%), 7 (9.6%), and 5 (6.8%) aneurysms, respectively. Inter- and intra-reader agreement values related to aneurysm size measurements were perfect. Aneurysms size, age, and proximal vessel tortuosity were negatively correlated with the visibility of the aneurysms and parent vessels on 3D-CS-TOF images (p = 0.043; p = 0.032; p < 0.001, respectively). Subarachnoid hemorrhage and age are associated with 3D-CS-TOF artifacts (p = 0.031; p = 0.005, respectively). 3D-CS-TOF findings are in perfect agreement with DSA or CT angiography (CTA) results (p < 0.001). Conclusion According to our results, 3D-CS-TOF can be an easy, fast, and reliable alternative for the management or follow-up of WEB assisted embolization.

scholarly journals Kidney organoid systems for studies of immune-mediated kidney diseases: challenges and opportunities

2021 ◽  
Author(s):  
Melissa C. Stein ◽  
Fabian Braun ◽  
Christian F. Krebs ◽  
Madeleine J. Bunders
Keyword(s):  
Kidney Diseases ◽  
Three Dimensional ◽  
Renal Tissue ◽  
Chronic Kidney Diseases ◽  
Immune Mediated ◽  
Primary Epithelial Cell ◽  
Challenges And Opportunities ◽  
Underlying Mechanisms ◽  
Global Population

AbstractAcute and chronic kidney diseases are major contributors to morbidity and mortality in the global population. Many nephropathies are considered to be immune-mediated with dysregulated immune responses playing an important role in the pathogenesis. At present, targeted approaches for many kidney diseases are still lacking, as the underlying mechanisms remain insufficiently understood. With the recent development of organoids—a three-dimensional, multicellular culture system, which recapitulates important aspects of human tissues—new opportunities to investigate interactions between renal cells and immune cells in the pathogenesis of kidney diseases arise. To date, kidney organoid systems, which reflect the structure and closer resemble critical aspects of the organ, have been established. Here, we highlight the recent advances in the development of kidney organoid models, including pluripotent stem cell-derived kidney organoids and primary epithelial cell-based tubuloids. The employment and further required advances of current organoid models are discussed to investigate the role of the immune system in renal tissue development, regeneration, and inflammation to identify targets for the development of novel therapeutic approaches of immune-mediated kidney diseases.

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