Vertigo in Systemic Lupus Erythematosus: A Case Report

2021 ◽  
Vol 8 (9) ◽  
pp. 327-330
Author(s):  
Amira Fitriananda Putri ◽  
Hanik Badriyah Hidayat
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Inner Ear ◽  
Lupus Erythematosus ◽  
Chronic Inflammatory Disease ◽  
Head Impulse Test ◽  
Vestibular Disorders ◽  
Autoimmune Process ◽  
Systemic Lupus ◽  
Hearing Disorders ◽  
Balance System

Introduction: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease with multiorgan involvement based on an autoimmune process. SLE, although rare, is associated with comorbid vertigo. Vertigo in SLE is caused by a disturbance in the balance system in the inner ear. Few journals discuss SLE related to vertigo. We will report a case SLE with complaints of recurrent vertigo. Case: A-37-year-old woman came with complaints of recurrent vertigo since 1 day ago with a duration of about 15 minutes associated with nausea, vomiting and nystagmus. Patient did not complain tinnitus or hearing disorders. The patient has been diagnosed as SLE since two years ago. The physical examination showed normal and Neuro-otological examination revealed nystagmus horizontal unidirectional, negative skew deviation test, positive Head Impulse Test (HIT). Conclusion: Patients with a diagnosis of SLE can find comorbid peripheral vestibular disorders such as vertigo where there is an antibody mechanism that can damage the inner ear. Treatment of audiovestibular symptoms is usually strongly associated with systemic conditions and in patients with vertigo used betahistine to treatment. Keywords: SLE, Inner Ear, Vertigo.

scholarly journals Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Danielle Perez-Bercoff ◽  
Hélène Laude ◽  
Morgane Lemaire ◽  
Oliver Hunewald ◽  
Valérie Thiers ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cell Death ◽  
Lupus Erythematosus ◽  
Immunosuppressive Treatment ◽  
Elevated Serum ◽  
Serum Levels ◽  
Chronic Inflammatory Disease ◽  
Mrna Levels ◽  
Systemic Lupus ◽  
Inflammatory Conditions

AbstractAPOBEC3 (A3) enzymes are best known for their role as antiviral restriction factors and as mutagens in cancer. Although four of them, A3A, A3B, A3F and A3G, are induced by type-1-interferon (IFN-I), their role in inflammatory conditions is unknown. We thus investigated the expression of A3, and particularly A3A and A3B because of their ability to edit cellular DNA, in Systemic Lupus Erythematosus (SLE), a chronic inflammatory disease characterized by high IFN-α serum levels. In a cohort of 57 SLE patients, A3A and A3B, but also A3C and A3G, were upregulated ~ 10 to 15-fold (> 1000-fold for A3B) compared to healthy controls, particularly in patients with flares and elevated serum IFN-α levels. Hydroxychloroquine, corticosteroids and immunosuppressive treatment did not reverse A3 levels. The A3AΔ3B polymorphism, which potentiates A3A, was detected in 14.9% of patients and in 10% of controls, and was associated with higher A3A mRNA expression. A3A and A3B mRNA levels, but not A3C or A3G, were correlated positively with dsDNA breaks and negatively with lymphopenia. Exposure of SLE PBMCs to IFN-α in culture induced massive and sustained A3A levels by 4 h and led to massive cell death. Furthermore, the rs2853669 A > G polymorphism in the telomerase reverse transcriptase (TERT) promoter, which disrupts an Ets-TCF-binding site and influences certain cancers, was highly prevalent in SLE patients, possibly contributing to lymphopenia. Taken together, these findings suggest that high baseline A3A and A3B levels may contribute to cell frailty, lymphopenia and to the generation of neoantigens in SLE patients. Targeting A3 expression could be a strategy to reverse cell death and the generation of neoantigens.

Inner Ear Hemorrhage in Systemic Lupus Erythematosus

2006 ◽  
Vol 116 (5) ◽  
pp. 826-828 ◽  
Author(s):  
Makoto Sugiura ◽  
Shinji Naganawa ◽  
Masaaki Teranishi ◽  
Eisuke Sato ◽  
Sawako Kojima ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Inner Ear ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Systemic Lupus Erythematosus and implications for the oral cavity

2020 ◽  
Vol 3 (9) ◽  
pp. 444-453
Author(s):  
Inês Lopes Cardoso ◽  
M. Fernanda C. Leal ◽  
Renan C. D. Regis
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Oral Cavity ◽  
Inflammatory Disease ◽  
Lupus Erythematosus ◽  
Chronic Inflammatory Disease ◽  
Systemic Lupus ◽  
Early Signs ◽  
The World

Systemic Lupus Erythematosus affects several people around the world and because it is characterized as a chronic inflammatory disease of multifactorial origin, and with systemic impairment, great attention must be paid from diagnosis to treatment in order to optimize the entire follow-up of the patient. The dental doctor plays an important role in the diagnosis of the condition and must be attentive to the early signs that can appear in the oral cavity with a frequency of up to 21%. In this way, through this bibliographic review, which has as main goal to correlate Systemic Lupus Erythematosus with its direct consequences in the oral cavity, it will be possible to help dentists in the diagnosis, to understand in detail the development of the disease and what attitude should be taken in its presence.

The essential role of costimulatory molecules in systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (5) ◽  
pp. 575-582 ◽  
Author(s):  
Z X Xiao ◽  
N Olsen ◽  
S G Zheng
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Biological Effects ◽  
Critical Role ◽  
Chronic Inflammatory Disease ◽  
Costimulatory Molecules ◽  
Systemic Lupus ◽  
System Disorder

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease with immune system disorder mediated through complex autoimmune pathways that involve immune cells, nonimmune cells, cytokines, chemokines, as well as costimulatory molecules. Costimulatory signals play a critical role in initiating, maintaining and regulating immune reactions, and these include ligands and receptors and their interactions involving multiple types of signal information. Dysfunction of costimulatory factors results in complicated abnormal immune responses, with biological effects and eventually, clinical autoimmune diseases. Here we outline what is known about various roles that costimulatory families including the B7 family and tumor necrosis factor super family play in SLE. The aim of this review is to understand the possible association of costimulation with autoimmune diseases, especially SLE, and to explore possible therapeutic target(s) of costimulatory molecules and pathways that might be used to develop therapeutic approaches for patients with these conditions.

Hearing and vestibular disorders in patients with systemic lupus erythematosus

Lupus ◽  
2013 ◽  
Vol 22 (5) ◽  
pp. 437-442 ◽  
Author(s):  
A Batuecas-Caletrío ◽  
J del Pino-Montes ◽  
C Cordero-Civantos ◽  
MI Calle-Cabanillas ◽  
JA Lopez-Escamez
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Vestibular Disorders ◽  
Systemic Lupus

scholarly journals Complement Activation on Endothelial Cell-Derived Microparticles—A Key Determinant for Cardiovascular Risk in Patients with Systemic Lupus Erythematosus?

Medicina ◽  
2020 ◽  
Vol 56 (10) ◽  
pp. 533
Author(s):  
Naomi Martin ◽  
Xiaodie Tu ◽  
Alicia J. Egan ◽  
Cordula Stover
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Risk ◽  
Lupus Erythematosus ◽  
Cardiovascular Complications ◽  
Chronic Inflammatory Disease ◽  
Systemic Autoimmune Disease ◽  
Systemic Lupus ◽  
Additional Risk ◽  
Increased Risk ◽  
Circulating Microparticles

Systemic lupus erythematosus is a classical systemic autoimmune disease that overactivates complement and can affect all organs. Early diagnosis and effective management are important in this immune-complex-mediated chronic inflammatory disease, which has a strong component of vasculitis and carries an increased risk of thrombosis, even in the absence of antiphospholipid antibodies. Development of lupus nephritis can be life limiting but is managed with dialysis and renal transplantation. Therefore, data have become available that cardiovascular risk poses a serious feature of systemic lupus erythematosus that requires monitoring and prospective treatment. Cell-derived microparticles circulate in plasma and thereby intersect the humoral and cellular component of inflammation. They are involved in disease pathophysiology, particularly thrombosis, and represent a known cardiovascular risk. This viewpoint argues that a focus on characteristics of circulating microparticles measured in patients with systemic lupus erythematosus may help to classify certain ethnic groups who are especially at additional risk of experiencing cardiovascular complications.

scholarly journals Life experiences with Systemic Lupus Erythematosus as reported in outpatients' perspective: a clinical-qualitative study in Brazil

2006 ◽  
Vol 14 (4) ◽  
pp. 475-482 ◽  
Author(s):  
Gilberto Dari Mattje ◽  
Egberto Ribeiro Turato
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Life Experience ◽  
Life Experiences ◽  
Chronic Inflammatory Disease ◽  
Psychosocial Adaptation ◽  
Semistructured Interview ◽  
Systemic Lupus ◽  
Interpersonal Conflicts ◽  
Purposive Sample

This study aimed to know lupus outpatients' life experiences, in terms of the meanings they attributed to several phenomena associated to the process of becoming ill. Systemic Lupus Erythematosus is a chronic inflammatory disease, probably caused by a combination of inborn/hereditary predispositions and environmental factors, which leads to an abnormal stimulation of the immune system. Lupus life experience is associated to important psychosocial adaptation mechanisms of affected people. This work had a clinical-qualitative design and was performed in the dermatology service of a Brazilian General Hospital. The method included purposive sample, and a semistructured interview with open-ended questions was applied. After categorizing the interviewees' discourse, the discussion employed psychodynamic theories. The patients' reactions included the attempt to rebuild their relationships with their own strengths. Lupus patients' familiar and interpersonal conflicts seem to be associated with the idea that family and friends do not understand the nature of the disease.

Carpal Tunnel Syndrome and Trigger Fingers in a Patient with Rheumatoid Arthritis and Systemic Lupus Erythematosus: Case Example

2016 ◽  
Vol 21 (3) ◽  
pp. 10-14
Author(s):  
Christopher R. Brigham ◽  
J. Mark Melhorn ◽  
Charles N. Brooks ◽  
Steven D. Feinberg ◽  
James B. Talmage
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Lupus Erythematosus ◽  
Chronic Inflammatory Disease ◽  
Systemic Lupus ◽  
Disc Disease ◽  
Tunnel Syndrome ◽  
Causation Analysis

Abstract Causation analysis involves determining what conditions are related to a compensable injury or illness; apportionment is the allocation of responsibility among two or more probable causes; and assessing impairment is based on the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides). These three are separate activities, but sometimes all three must be addressed in a single evaluation and may be required for a specified jurisdiction (eg, California). Evaluators thus must ask if jurisdictional issues dictate or influence the approach to causation and apportionment; which edition of the AMA Guides to use; and how to approach causation and apportionment in the present case example: A 63-year-old woman with rheumatoid arthritis and systemic lupus erythematosus is assessed by an orthopedic surgeon who is the agreed medical evaluator (AME). In addition to her pre-existing rheumatoid arthritis and lupus, the individual also had Sjogren's syndrome, osteoarthritis, degenerative disc disease, left carpal tunnel syndrome, osteopenia, and obesity. She has undergone multiple surgical procedures, and treatment for her collagen vascular disease includes leflunomide (immunosuppressant), hydroxychloroquine, and prednisone. In this case, impairments were not the result of “cumulative trauma” but rather were secondary to underlying chronic inflammatory disease, and her occupational permanent impairment rating accordingly would be zero.

1H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus

Lupus ◽  
2011 ◽  
Vol 20 (13) ◽  
pp. 1411-1420 ◽  
Author(s):  
X Ouyang ◽  
Y Dai ◽  
JL Wen ◽  
LX Wang
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Principal Component ◽  
Chronic Inflammatory Disease ◽  
Low Density ◽  
Healthy Controls ◽  
Systemic Lupus ◽  
Serum Samples

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by multi-system involvement, diverse clinical presentation, and alterations in circulating metabolites. In this study, a 1H NMR spectroscopy-based metabolomics approach was applied to establish a human SLE serum metabolic profile. Serum samples were obtained from patients with SLE ( n = 64), patients with rheumatoid arthritis (RA) ( n = 30) and healthy controls ( n = 35). The NOESYPR1D spectrum combined with multi-variate pattern recognition analysis was used to cluster the groups and establish a disease-specific metabolites phenotype. Principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) models were capable of distinguishing SLE or RA patients from healthy subjects. The OPLS-DA model was able to predict diagnosis of SLE with a sensitivity rate of 60.9% and a specificity rate of 97.1%. For diagnosing RA, the model has much higher sensitivity (96.7%) and specificity (91.4%). The SLE serum samples were characterized by reduced concentrations of valine, tyrosine, phenylalanine, lysine, isoleucine, histidine, glutamine, alanine, citrate, creatinine, creatine, pyruvate, high-density lipoprotein, cholesterol, glycerol, formate and increased concentrations of N-acetyl glycoprotein, very low-density lipoprotein and low-density lipoprotein in comparison with the control population. Theresults not only indicated that serum NMR-based metabolomic methods had sufficient sensitivity and specificity to distinguish SLE and RA from healthy controls, but also have the potential to be developed into a clinically useful diagnostic tool, and could also contribute to a further understanding of disease mechanisms.

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