scholarly journals CLINICAL EFFECTIVENESS OF AZITHROMYCIN VERSUS CIPROFLOXACIN IN THE TREATMENT OF UNCOMPLICATED ENTERIC FEVER IN CHILDREN;

2020 ◽  
Vol 28 (4) ◽  
pp. 372-376
Author(s):  
Iqbal Hussain ◽  
Muhammad Saleh Faisal ◽  
Arshad Khan ◽  
Arif Jamal ◽  
Waqar Hayat
Keyword(s):  
Enteric Fever ◽  
Controlled Trial ◽  
Sampling Technique ◽  
Clinical Effectiveness ◽  
Group A ◽  
Level Of Significance ◽  
Group B ◽  
Oral Ciprofloxacin ◽  
Oral Azithromycin ◽  
Selection Of

ABSTRACT Objective: To compare the clinical effectiveness of oral azithromycin with oral ciprofloxacin in the treatment of uncomplicated enteric fever in children. Material and Methods: A randomized controlled trial was carried out in the Pediatric department of Khyber Teaching Hospital for which a sample size of 282 patients was determined using WHO calculator with 5% level of significance and 80% power of test (Two sided). Non-probability consecutive sampling technique was used for selection of children age 6 to 18 years and either gender. They were divided into two groups (141 in each) where Group A was treated with oral azithromycin while Group B with ciprofloxacin for 7 days. Clinical effectiveness was determined when the patient remained afebrile for more than 48 hours without antipyretics. Results: In group A, 128 children (90.78%) while in Group B, 105 (74.46%) children become clinically cure. Conclusion: Oral Azithromycin is more effective than oral Ciprofloxacin in the treatment of typhoid fever in children.

scholarly journals Clinical Efficacy Of Ceftriaxone Versus Ciprofloxacin In Paediatric Enteric Fever

2018 ◽  
Vol 08 (02) ◽  
pp. 67-71
Author(s):  
Anila Farhat ◽  
Asma Shaukat ◽  
Tariq Mahmood Khan
Keyword(s):  
Enteric Fever ◽  
Research Study ◽  
Controlled Trial ◽  
Clinical Effectiveness ◽  
Randomized Controlled ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Objective Determination

Objective: Determination of the clinical effectiveness of ciprofloxacin versus ceftriaxone in children with enteric fever on the basis of defervescence within 72 hours of commencement of treatment. Duration and Place of Study: This randomized controlled trial was carried out from 15th May to 15th November 2017 in pediatrics units of Benazir Bhutto Shaheed Teaching Hospital Abbottabad and Jinnah International Hospital Abbottabad. Methodology: 90 children with uncomplicated enteric fever were admitted and divided randomly into two groups, Group A was administered I/V Ceftriaxone 75mg/kg OD and Group B was given I/V Ciprofloxacin 10mg/kg BD for seven days. Response to drug was taken as defervescence within 72 hours while continued fever after 72 hours was taken as no response. The data was analyzed by using SPSS Version 21.00. Results: In our research study 53(58.9%) children were male and 37(41.1%) patients were female. The mean age was 8.43±3.17 years encompassing 4 to 14 years, mean weight of the patients in kg was 29.54±10.8 kg. Efficacy of ceftriaxone group was 93.3% while in ciprofloxacin group 62.2% patients became afebrile in 72 hours. The proportion of achieving defervescence within 72 hours was higher with ceftriaxone than with ciprofloxacin Conclusion: Ceftriaxone is more efficacious in terms of achieving defervescence than ciprofloxacin in children having enteric fever.

scholarly journals SUPERSTITIOUS BEHAVIOR AMONG JUDO, TAEKWONDO AND BOXING PLAYERS

2016 ◽  
Vol 20 (2) ◽  
pp. 50-59
Author(s):  
Dureja Gaurav ◽  
Singh Gagandeep
Keyword(s):  
Sampling Technique ◽  
College Level ◽  
Mean Values ◽  
Superstitious Behavior ◽  
Group A ◽  
The Mean ◽  
Level Of Significance ◽  
Group B ◽  
Post Hoc ◽  
Affiliated Colleges

Purpose: The present study was designed to measure superstitious behavior among Judo, Taekwondo and Boxing players. Material: Thirty (N=30) male inter-college level players with the age group of 19-25 years were selected through purposive sampling technique to act as subjects from affiliated colleges of Panjab University, Chandigarh. They were further divided into three groups: Group-A [Judo (n=10)], Group-B [Taekwondo (n=10)] and Group-C [Boxing (n=10)]. One Way Analysis of Variance (ANOVA) was applied to find out the differences among judo, taekwondo and boxing players. Where F values found significant, Least Significant Differences (LSD) Post-hoc test was applied to find out the direction and degree of difference. Results: The level of significance was set at 0.05. The result revealed significant differences among judo, taekwondo and boxing players on the sub parameters: clothing and appearance, preparation, team ritual and coach. However, no significant differences have been observed on the sub-parameters fetish, game/competition, prayer and parameter superstitious (Total). Conclusions: The obtained results showed significant differences on the sub-parameter Coach among Judo, Taekwondo and Boxing players. While calculating the mean values of entire groups, it has been observed that Boxing players demonstrate significantly better on the sub-parameter Coach. Therefore, it can be ascertained that Boxing players are more confident that coach bring a lucky charm to our game.

scholarly journals Comparison of Efficacy of Nd-YAG Laser with Adjuvant Eflornithine Cream versus Nd-YAG Laser alone for the treatment of facial hirsutism in women

2021 ◽  
Vol 15 (7) ◽  
pp. 1685-1688
Author(s):  
Iqbal Hassan Khan ◽  
Annum Ashraf ◽  
Uzma Sarwar ◽  
Amna Munir ◽  
Habiba Tariq ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Sampling Technique ◽  
Clinical Syndrome ◽  
Combination Group ◽  
Age Group ◽  
Treatment Area ◽  
Yag Laser ◽  
Randomized Controlled ◽  
Group A ◽  
Group B

Background: Hirsutism is an important array of clinical syndrome that ranges from various dermatological to gynecological concerns. This is characterized by growth terminal hairs in women in male-pattern. Aim: To compare the efficacy of Nd-YAG laser with adjuvant eflornithine cream versus Nd-YAG laser treatment alone for facial hirsutism in women. Methods: It was a Randomized Controlled Trial conducted in the Department of Dermatology, Shalamar Hospital, Lahore from 25th February, 2020 to 25th October, 2020. Sampling technique used was probability consecutive sampling. In this study female cases with age 18-40 years with Fitzpatrick type III-IV were enrolled having facial hirsutism for > 6 months and were randomly allocated in two groups A and B. In group A, cases were provided with eflornithine cream to apply on face after cleaning and drying in the form of a thin film only on the treatment area every night. Results: A total 162 cases (81 in each group) were enrolled in this study. Mean age of the subjects in group B and A was 30.23±5.43 vs 30.94±4.88 years. Efficacy was observed in 64(79.01%) cases in group B managed with ND-Yag laser alone and 78(96.30%) cases in group A managed with ND-Yag laser along with Eflornithine with p=0.001. For age group 30-40 years efficacy in group B was 41(80.39%) cases and in all the 49(100%) cases in group A with p= 0.001.In cases with BMI up to 25 kg/m2 efficacy in group B and A was observed in 44(88%) vs 49(100%) cases (p=0.03) and those with BMI more than this, this efficacy was found in 20(64.52%) and 29(90.63%) cases respectively with p=0.02. Conclusion: Efficacy in facial hirsutism is significantly better in ND-Yag laser combined with Eflornithine as compared to ND-Yag laser alone and this difference is also significantly better for combination group in terms of age group 30-40 years, BMI up to 25mg/m2 and in those with duration of complaint upto 2 years. Keywords: Hirsutism, Efficacy, Eflornithine, Nd-YAG laser

scholarly journals Comparison of angiosome based incision with conventional aggressive debridement for the treatment of diabetic foot ulcers.

2020 ◽  
Vol 27 (06) ◽  
pp. 1097-1102
Author(s):  
Naveed Akhtar ◽  
Muhammad Ilyas Anjum ◽  
Shafiq Ullah ◽  
Shahid Mansoor Nizami ◽  
Uzma Rasheed ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Controlled Trial ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Sampling Technique ◽  
University Hospital ◽  
Foot Ulcers ◽  
Group A ◽  
Group B ◽  
Aggressive Debridement

Objectives: To compare the efficacy of angiosome based incisions versus aggressive debridement for the treatment of diabetic foot ulcer. Study Design: Randomized Controlled Trial. Setting: Surgical Unit 1 Nishtar Medical University/ Hospital Multan. Period: 9 months duration, from 1st January 2017 to 30th September 2017. Material & Methods: Sample Size: Total 210 patients, 105 in each group. Sampling Technique: Non-probability, consecutive sampling. 210 patients of both genders with history of diabetes mellitus having Grade II diabetic foot ulcer below the ankle. Before the procedure, foot ulcers were measured and ulcer dimensions equal or greater than 4 cm2 were included in the study. 105 patients were in angiosome based incision group (Group A), while105 patients were in aggressive debridement group (Group B). Patients were called for follow up after every 5 days. Regular dressings were done to allow more regular wound inspection and cleansing to avoid infection. Efficacy of treatment was finally determined after 30 days by measuring the ulcer dimension by similar procedure as done before the start of procedure. Data was noted on especially designed proforma. Results: Age range in this study was from 30 to 60 years with mean age of 45.971± 4.89 years in Group A while 46.457± 6.22 years in Group B. Mean duration of diabetes was 10.171±4.09 years in Group A and 10.561±5.58 years in Group B. Mean duration of foot ulcer was 3.895±2.72 months in Group A and 3.790±2.03 months in Group B. Mean size of foot ulcer was 5.047±1.52 cm2 in Group A and 4.895±1.67 cm2 in Group B. Mean weight of the patients was 68.238±10.44 kg in Group A and 67.742±9.53 Kg in Group B. Majority of the patients were of 46-60 years in  group A (63.8%) and in group B  (66.7%). Male gender was dominant in both group (73.3% and 55.25). In group A efficacy was seen in 96 (91.4%) patients as compare to 47 (44.8%) patients in group B, (P=0.000). Conclusion: Angiosome based incision in the treatment of diabetic foot ulcer has shown outstanding outcome with respect to wound healing compared with aggressive debridement.

EFFICACY OF PROPHYLACTIC INTRAVENOUS ADMINISTRATION OF ONDANSETRON FOR PREVENTION OF SPINAL ANESTHESIA INDUCED HYPOTENSION IN ELDERLY PATIENTS

2021 ◽  
pp. 47-48
Author(s):  
Smriti Anand ◽  
Arjun Prasad ◽  
Debarshi Jana
Keyword(s):  
Elderly Patients ◽  
Spinal Anesthesia ◽  
Intravenous Administration ◽  
Controlled Trial ◽  
Sampling Technique ◽  
P Value ◽  
Double Blind ◽  
Induced Hypotension ◽  
Group A ◽  
Group B

Objective: Hypotension is the commonest side effect associated with spinal anesthesia. Multiple modalities have been tested to nd adequate preventive measure. Main objective of this study is to nd out the effectiveness of prophylactic administration of inj. ondansetron for prevention of spinal anesthesia induced hypotension in elderly patients.Study design: Double blind, randomized controlled trial. Place and duration of study: This study was conducted in our anesthesiology department from March 2020 to August 2020.Method: 100 patients were selected for the study using non-probability sampling technique, and divided into two groups of 50 each using random numbers table. Each patient was preloaded with ringer's lactate solution in a dose of 10 ml/kg. Patients of Group A received 8 mg of ondansetron IV ve minutes prior to administration of spinal anesthesia; whereas patients of Group B were injected normal saline IV. Data were collected and analyzed using IBM SPSS version 20. Chi square test was used to compare hypotension between two groups. A p-value < 0.05 was taken as signicant. Results: Mean age of Group A was 64.16 ± 8.47 years, whereas that of Group B was 62.58 ± 8.99 (p value=0.39). Mean weight of Group A was 72.64 ± 5.82 kg, whereas that of Group B was 70.66 ± 5.96 kg (p - value=0.295). Hypotension was present in 23 (46%) patients in Group A, where as it was present in 34 (68%) patients in Group B (p value= 0.026). Bradycardia was recorded in 3(06%) vs.11(22%) patients in Group A and B respectively (p=0.021). Conclusion: We conclude that intravenous administration of 8 mg of ondansetron, 5 minutes prior to subarachnoid block, is effective in decreasing frequency of hypotension and bradycardia in elderly patients.

COMPARISON OF EFFECTIVENESS OF MOBILIZATION AND SELF-EXERCISES IN ADHESIVE CAPSULITIS OF SHOULDER

2018 ◽  
Vol 7 (1) ◽  
pp. 35-41
Author(s):  
Muhammad Usman Khan ◽  
Ghazala Noor Nizami ◽  
Ali Farhad
Keyword(s):  
Pain Intensity ◽  
Adhesive Capsulitis ◽  
Descriptive Analysis ◽  
Tertiary Care ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
T Test ◽  
P Value ◽  
Group A ◽  
Group B

OBJECTIVE To compare the effectiveness of mobilization and self-exercises in the management of adhesive capsulitis of shoulder STUDY DESIGN Randomized Control Trial SAMPLE SELECTION 30 patients of adhesive capsulitis of shoulder from physiotherapy department of tertiary care hospitals of Karachi were selected through simple random sampling technique. PROCEDURE Treatment was continued for 5 days per week for the period of 3 weeks followed by assessment. Patients were randomly divided into two equal groups. Group A was treated with midrange mobilization while group B performed self-exercises. Both groups received TENS and hot pack prior to the exercises. Mean ± SD, frequencies and percentages were used for descriptive analysis. ROM via goniometry and pain intensity through VAS was analyzed by paired t-test within the groups and by independent t-test between the groups, using SPSS. P-value of less than 0.05 was considered significant. RESULTS 60% were females (n=18) and 40% were males (n=12) with mean age of 50.17±6.37 years. Significant improvement (p-value <0.05) in pain and shoulder ROM was observed among patients of Group A as compared to Group B. Pain intensity was decreased to 1.67 ± 0.62 in group A, whereas ROMs in these patients were also better than other group.

scholarly journals Oral Tranexamic Acid for the Treatment of Melasma

2014 ◽  
Vol 10 (4) ◽  
pp. 40-43 ◽  
Author(s):  
D Karn ◽  
S KC ◽  
A Amatya ◽  
EA Razouria ◽  
M Timalsina
Keyword(s):  
Tranexamic Acid ◽  
Controlled Trial ◽  
Severity Index ◽  
Sustained Improvement ◽  
Treatment Measures ◽  
Group A ◽  
Group B ◽  
Novel Concept ◽  
High Treatment

Background Melasma poses a great challenge as its treatment is unsatisfactory and recurrence is high. Treatment of melasma using tranexamic acid (oral, topical or intralesional) is a novel concept. Objective To compare the efficacy of oral tranexamic acid with routine topical therapies for the treatment of melasma. Methods It is a prospective, interventional, randomized controlled trial conducted among 260 melasma patients. Patients were divided into two groups consisting of 130 patients each. First group (Group A) was given routine treatment measures and oral Tranexamic Acid while second group (Group B) was treated only with routine topical measures. Capsule Tranexamic Acid was prescribed at a dose of 250 mg twice a day for three months and cases were followed for three months. Response was evaluated on the basis of Melasma Assessment Severity Index (MASI). Mean scores between the two groups were then compared. Results Statistically significant decrease in the mean Melasma Assessment Severity Index from baseline to 8 and 12 weeks was observed among group A patients (11.08±2.91 vs 8.95±2.08 at week 8 and vs. 7.84±2.44 at week 12; p<0.05 for both). While among group B patients the decrease in mean score was significant at 8 weeks and insignificant at 12 weeks follow up (11.60±3.40 vs 9.9±2.61 at 8 weeks and vs. 9.26±3 at 12 weeks; p<0.05 for former but p>0.05 for later). Conclusion Addition of oral tranexamic acid provides rapid and sustained improvement in the treatment of melasma. DOI: http://dx.doi.org/10.3126/kumj.v10i4.10993 Kathmandu Univ Med J 2012;10(4):40-43

Radiofrequency ablation for markedly incompetent perforators versus compression therapy in the management of post-phelebtic venous ulcers: A randomized controlled trial

Vascular ◽  
2021 ◽  
pp. 170853812110100
Author(s):  
Mohamed Shukri Abdelgawad ◽  
Amr M El-Shafei ◽  
Hesham A Sharaf El-Din ◽  
Ehab M Saad ◽  
Tamer A Khafagy ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Radiofrequency Ablation ◽  
Controlled Trial ◽  
Compression Therapy ◽  
Randomized Controlled ◽  
Venous Ulcers ◽  
Group A ◽  
Group B ◽  
To Receive

Background Venus ulcers developed mainly due to reflux of incompetent venous valves in perforating veins. Patients and methods In this randomized controlled trial, 119 patients recruited over two years, with post-phelebtic venous leg ulcers, were randomly assigned into one of two groups: either to receive radiofrequency ablation of markedly incompetent perforators (Group A, n = 62 patients) or to receive conventional compression therapy (Group B, n = 57 patients). Follow-up duration required for ulcer healing continued for 24 months post randomization. Results Statistically significant shorter time to healing (ulcer complete healing or satisfactory clinical improvement) between both groups (56 patients, 90.3% of cases in Group A versus 44 patients 77.2% of cases in Group B) over the follow-up period of 24 months was attained ( p  = 0.001). Also, significantly different ulcer recurrence was recorded between both groups, 8 patients (12.9%) in Group A versus 19 patients (33.3%) in Group B ( p = 0.004). Conclusion In absence of deep venous obstruction, the monopolar radiofrequency ablation for incompetent perforators is a feasible and effective method that surpasses the traditional compression protocol for incompetent perforator-induced venous ulcers in terms of time required for healing even in the presence of unresolved deep venous valvular reflux.

scholarly journals Effects of different thermal insulation methods on the nasopharyngeal temperature in patients undergoing laparoscopic hysterectomy: a prospective randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Guanyu Yang ◽  
Zefei Zhu ◽  
Hongyu Zheng ◽  
Shifeng He ◽  
Wanyue Zhang ◽  
...  
Keyword(s):  
Thermal Insulation ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Laparoscopic Hysterectomy ◽  
Control Group ◽  
Prospective Randomized Controlled Trial ◽  
Warming Blanket ◽  
Group A ◽  
Insulation Effect ◽  
Group B

Abstract Background This study explored the comparison of the thermal insulation effect of incubator to infusion thermometer in laparoscopic hysterectomy. Methods We assigned 75 patients enrolled in the study randomly to three groups: Group A: Used warming blanket; group B: Used warming blanket and infusion thermometer; group C: Used warming blanket and incubator. The nasopharyngeal temperature at different time points during the operation served as the primary outcome. Results The nasopharyngeal temperature of the infusion heating group was significantly higher than that of the incubator group 60 min from the beginning of surgery (T3): 36.10 ± 0.20 vs 35.81 ± 0.20 (P<0.001)90 min from the beginning of surgery (T4): 36.35 ± 0.20 vs 35.85 ± 0.17 (P<0.001). Besides, the nasopharyngeal temperature of the incubator group was significantly higher compared to that of the control group 60 min from the beginning of surgery (T3): 35.81 ± 0.20 vs 35.62 ± 0.18 (P<0.001); 90 min from the beginning of surgery (T4): 35.85 ± 0.17 vs 35.60 ± 0.17 (P<0.001). Regarding the wake-up time, that of the control group was significantly higher compared to the infusion heating group: 24 ± 4 vs 21 ± 4 (P = 0.004) and the incubator group: 24 ± 4 vs 22 ± 4 (P = 0.035). Conclusion Warming blanket (38 °C) combined infusion thermometer (37 °C) provides better perioperative thermal insulation. Hospitals without an infusion thermometer can opt for an incubator as a substitute. Trial registration This trial was registered with ChiCTR2000039162, 20 October 2020.

scholarly journals Management of walled-off necrosis with nasocystic irrigation with hydrogen peroxide versus biflanged metal stent: randomized controlled trial

2021 ◽  
Vol 09 (07) ◽  
pp. E1108-E1115
Author(s):  
Sudhir Maharshi ◽  
Shyam Sunder Sharma ◽  
Sandeep Ratra ◽  
Bharat Sapra ◽  
Dhruv Sharma
Keyword(s):  
Hydrogen Peroxide ◽  
Adverse Events ◽  
Clinical Success ◽  
Controlled Trial ◽  
Procedure Time ◽  
Metal Stent ◽  
Technical Success ◽  
Group A ◽  
Group B ◽  
Walled Off Necrosis

Abstract Background and study aims Walled-off necrosis (WON) is a known complication of acute necrotizing pancreatitis (ANP). There is no study comparing nasocystic irrigation with hydrogen peroxide (H2O2) versus biflanged metal stent (BMS) in the management of WON. The aim of this study was to compare the clinical efficacy of both the treatment strategies. Patients and methods This study was conducted on patients with symptomatic WON who were randomized to nasocystic irrigation with H2O2 (Group A) and BMS placement (Group B). Primary outcomes were clinical and technical success while secondary outcomes were procedure time, adverse events, need for additional procedures, duration of hospitalization, and mortality. Results Fifty patients were randomized into two groups. Group A (n = 25, age 37.8 ± 17.6 years, 16 men) and Group B (n = 25, age 41.8 ± 15.2 years, 17 men). There were no significant differences in baseline characteristics between the two groups. The most common etiology of pancreatitis was alcohol, observed in 27 (54 %) patients. Technical success (100 % vs 96 %, P = 0.98), clinical success (84 % vs 76 %, P = 0.76), requirement of additional procedures (16 % vs 24 %, P = 0.70) and adverse events (4 vs 7, P = 0.06) were comparable in both the groups. The duration to clinical success (34.4 ± 12 vs 14.8 ± 10.8 days, P = 0.001) and procedure time (36 ± 15 vs 18 ± 12 minutes, P = 0.01) were longer in Group A compared to Group B. Conclusions Nasocystic irrigation with H2O2 and BMS are equally effective in the management of WON but time to clinical success and procedure time is longer with nasocystic irrigation.

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