scholarly journals Renal functional reserve by measuring the creatinine clearance in children : previously diagnosed and improved after acute renal failure

2015 ◽  
Vol 6 (1) ◽  
pp. 15-17
Author(s):  
Fahmuda Akhter ◽  
BH Nazma Yasmeen ◽  
Mohammad Hanif ◽  
Shushoma Roy
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Functional Reserve ◽  
Dialysis Unit ◽  
Renal Functional Reserve ◽  
Medical College ◽  
Stage 4 ◽  
Threatening Condition ◽  
Life Threatening ◽  
Stage 1

Background : Acute Renal Failure (ARF) is a life threatening condition causing significant morbidity and mortality in children. Many studies on adult ARF survivors showed that renal insufficiency persisted after an attack of ARF. Children may be more susceptible to this injury due to immaturity and ongoing growth of the kidney.Objective : This study was conducted to assess the renal functional reserve or detect any sign of renal injury in children after an episode of Acute Renal FailureMethods : This prospective study was carried out in the Renal and Dialysis unit, Dhaka Shishu Hospital in 2007, January . Thirty patients were enrolled in this study by searching data held in the study centre.Results : Thirty (30) patients were selected in this study. Among them 46.7% was in the group > 5-10 years, only 10.0% was in age group < 1 year and more than 10 years respectively. Male were 63.3%, female were 36.7%.Causes of acute renal failure were diarrhoea with dehydration 43.3%, septicaemia 20.0%, Haemolytic Uraemic Syndrome (HUS) 20%, Acute Glomerulo Nephrities (AGN) 10.0%, Henoch Schonlein Purpura ( HSP) 3.3% and hepato renal syndrome 3.3%. During follow up Glomerular Filtration Rate(GFR) of the patients were in stage 1 in 76.7% cases , 10.0% in stage 2, 6.7% in stage 3 stage and in stage 4 & 5 3.3% cases.23.3% patients were found with GFR between stage 2 to stage 5, who had ARF due to HUS and HSP. The incidence of hypertension and proteinuria was found in 13.3% cases of HUS.Conclusion : The progressive nature of acute renal failure which may cause chronic kidney disease is an important observation.Northern International Medical College Journal Vol.6(1) 2014: 15-17

scholarly journals Seven-Digit Creatine Kinase in Acute Rhabdomyolysis in a Child

2017 ◽  
Vol 4 ◽  
pp. 2329048X1668439 ◽  
Author(s):  
Nuha Basheer ◽  
Sirin Mneimneh ◽  
Mariam Rajab
Keyword(s):  
Renal Failure ◽  
Creatine Kinase ◽  
Acute Renal Failure ◽  
Creatine Kinase Level ◽  
Peak Plasma ◽  
Renal Dialysis ◽  
Acute Rhabdomyolysis ◽  
Threatening Condition ◽  
Life Threatening ◽  
Plasma Creatine Kinase

Rhabdomyolysis is an acute life-threatening condition that can occur in childhood secondary to many causes. The authors report the case of a 3-year-old male child who presented with acute rhabdomyolysis. The peak plasma creatine kinase level was extremely high. The 2 main causes of rhabdomyolysis in childhood are viral myositis and trauma, which can sometimes lead to acute renal failure. The highest creatine kinase levels reported in the literature so far was a 6-digit level in 2014 case report. In this study, the authors report the case of a 7-digit creatine kinase level in a child secondary to viral myositis who did not require renal dialysis.

Alcohol Related Non-traumatic Rhabdomyolysis and Compartment Syndrome

2007 ◽  
Vol 6 (1) ◽  
pp. 33-34
Author(s):  
JPL Ong ◽  
◽  
LA Thomas ◽  
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Lower Extremity ◽  
Compartment Syndrome ◽  
Early Recognition ◽  
Clinical Entity ◽  
Threatening Condition ◽  
Life Threatening ◽  
Renal Support

Rhabdomyolysis is a serious and life-threatening condition in which skeletal muscle is damaged, commonly resulting in acute renal failure. The causes of this clinical entity can be traumatic and non-traumatic. In the latter group, alcohol is the commonest cause. This report describes the case of a 25 year old man who presented with rhabdomyolysis leading to acute renal failure after an alcohol binge. He presented with painful legs and lower extremity compartment syndrome. The patient recovered with surgical fasciotomy and renal support. This case illustrates the importance of early recognition and treatment of alcohol related non-traumatic rhabdomyolysis and compartment syndrome.

A rare case of rhabdomyolysis and acute renal failure following spinal surgery

2008 ◽  
Vol 9 (4) ◽  
pp. 387-389 ◽  
Author(s):  
Michael Papadakis ◽  
George Sapkas ◽  
Apostolos Tzoutzopoulos
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Spinal Surgery ◽  
Rare Case ◽  
Neurogenic Claudication ◽  
Intermittent Hemodialysis ◽  
Lumbar Surgery ◽  
Adequate Treatment ◽  
Threatening Condition ◽  
Life Threatening

Spinal surgery–associated rhabdomyolysis, although rare, is a life-threatening condition. Presented here is the case of a middle-aged, overweight man who underwent posterior lumbar surgery because of pain and neurogenic claudication. His postoperative course was complicated by the occurrence of rhabdomyolysis. Despite adequate treatment, acute renal failure developed as a sequela. His condition was grave enough to require the administration of intermittent hemodialysis. After a prolonged hospitalization and 5 sessions of hemodialysis, the patient achieved a full recovery. In view of the fact that rhabdomyolysis-induced acute renal failure is associated with a mortality rate of 20–50%, the outcome was favorable.

Ultrastructure of experimental crush injury in rats

1995 ◽  
Vol 53 ◽  
pp. 1002-1003
Author(s):  
Raymond Coleman ◽  
Ludmilla Mazor ◽  
Michael Silbermann ◽  
Irit Rubinstein ◽  
Ori S. Better
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Volcanic Eruptions ◽  
External Pressure ◽  
Muscle Pathology ◽  
Threatening Condition ◽  
Life Threatening ◽  
Muscle Breakdown ◽  
Basic Biology ◽  
Collapsed Building

Crush Syndrome is a potentially life-threatening condition that develops in humans trapped under debris of collapsed building such as occur in mass catastrophes such as earthquakes, volcanic eruptions and following explosions such as those of bombings or missile attacks. Traumatic pressure damage on limbs can result in myopathy and rhabdomyolysis. The consequences of muscle breakdown lead to major physiological disturbances and may result in acute renal failure if the condition is not recognised and dealt with as an emergency. Whereas there is now considerable progress in treating the condition, much less is known about the basic biology of the muscle pathology and the potential for repair of the traumatized muscle. In the present study we have developed a rat model in which controlled external pressure is used to mimic crush damage in humans, and we have followed the early stages of muscle damage and repair using histological and ultrastructural techniques.

scholarly journals A clinical observational study in cases of eclampsia

2019 ◽  
Vol 8 (9) ◽  
pp. 3524
Author(s):  
Bipin Kanani ◽  
Nirav J. Garala
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Post Partum ◽  
Economic Status ◽  
Fetal Outcome ◽  
Adverse Outcomes ◽  
Tertiary Referral Centre ◽  
Threatening Condition ◽  
Life Threatening ◽  
Associated Risk Factors

Background: Eclampsia is a life threatening condition and one of the leading causes of maternal deaths worldwide. It is also associated with complications like acute renal failure, DIC, postpartum hemorrhage, etc. and adverse fetal outcomes.  Hence we aimed to study fetomaternal outcomes in cases of Eclampsia.Methods: A total of 75 cases of eclampsia out of 13524 deliveries were evaluated, from 1st January 2016 to 30th June 2017 at RZ Hospital, a government tertiary referral centre. Maternal outcomes were studied for its complications, effectiveness of magnesium sulphate treatment, fetal outcome and mode of delivery.Results: Incidence rate of eclampsia was 0.55%, 62.66% of all cases were primigravida, 76% of cases were in age group of 21-26 years, 84% cases were from lower socio economic status, maternal mortality occurred in 2 of 75 cases. 66.67% of patients were of term pregnancy (37 to 42 weeks). 71%(53) patients delivered vaginally out of which 9 deliveries were spontaneous and 44 deliveries were induced vaginal delivery. 22 patients required caesarean section.Conclusions: Early detection and prevention of pregnancy induced hypertension and pre-eclampsia and other associated risk factors for eclampsia might help to reduce the incidence of eclampsia. Maternal adverse outcomes in this study were magnesium toxicity, acute renal failure (ARF), disseminated intravascular coagulation (DIC) and post partum hemorrhage (PPH) while 92% patients had no complications.

scholarly journals Contrast-Induced Rhabdomyolysis Occurring after ERCP in a Patient with Pancreatic Cancer: A Case Report

2020 ◽  
Author(s):  
Natassja Moriarty ◽  
Jonathan Moriarty ◽  
John Keating
Keyword(s):  
Skeletal Muscle ◽  
Pancreatic Cancer ◽  
Renal Failure ◽  
Creatine Kinase ◽  
Acute Renal Failure ◽  
Case Report ◽  
Mortality Rate ◽  
Appropriate Treatment ◽  
Threatening Condition ◽  
Life Threatening

Objective: We present a patient with pancreatic cancer who developed weakness, acute renal failure and significantly raised creatine kinase levels post-ERCP and who was assessed as having contrast-induced rhabdomyolysis. Results: The patient underwent haemofiltration and ultimately succumbed to his condition. Conclusion: Rhabdomyolysis is a potentially life-threatening condition which occurs because of damage to skeletal muscle, with release of myoglobin and electrolytes into the circulation. The mortality rate is 59% in severe cases, despite appropriate treatment.

scholarly journals CHRONIC KIDNEY DISEASE

2018 ◽  
Vol 25 (06) ◽  
pp. 887-891
Author(s):  
Tanveer Fatima ◽  
Aurangzeb Afzal ◽  
Sania Ashraf
Keyword(s):  
Renal Failure ◽  
The Body ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Waste Products ◽  
Dialysis Unit ◽  
Complex Procedure ◽  
Back Ache ◽  
Life Threatening ◽  
Stage Renal Disease

Introduction: Hemodialysis is a process of removal of waste products andtoxic substances from the body using an extracorporeal system. During the procedure, lotsof hemodynamic and metabolic changes occur in the body as a result of which patientsundergoing hemodialysis may suffer from complications both acutely during or just after dialysisas well as in long term. Objective: To determine the frequencies of various acute intradialyticcomplications in our hemodialysis patients. Study Design: Cross sectional survey. Setting:Lahore General Hospital, Lahore. Period: 3 months from May 2017 to July 2017. Method:End stage renal disease patients on regular hemodialysis in the dialysis unit of a tertiary carehospital. A total of 81 patients were included in the study. Patients with acute renal failure andacute on chronic renal failure were excluded from the survey. Results: Common complicationsobserved in our studied population included muscle cramps (70.7%), post dialysis fatigue(57.3%), back ache (56.1%), intradialytic shivering (57.3%), hypoglycemia (21.4%), hypotension(37.8%), hypertension (8.5%), headache (13.4%), vomiting (13.4%) and anaphylaxis in 2.4%.Conclusion: Hemodialysis is a complex procedure and can cause many complications mostof which are not life threatening. With proper monitoring and immediate treatment thesecomplications can be overcome without causing interruption in hemodialysis.

scholarly journals The Role of Patiromer in Delaying the Onset of Renal Replacement Therapy in Patients with Advanced Renal Failure

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Nand K. Wadhwa ◽  
Jason A. Kline ◽  
Sreedhar R. Adapa
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Case Series ◽  
Cardiovascular Morbidity And Mortality ◽  
Increased Risk ◽  
Stage 4 ◽  
Initiation Of Dialysis ◽  
Life Threatening ◽  
Potassium Binding

Patients with chronic kidney disease (CKD) are at an increased risk of developing hyperkalemia, which can be potentially life threatening. Hyperkalemia is frequently encountered with renin-angiotensin-aldosterone system inhibitor (RAASi) therapy use in patients with CKD and often results in the underdosing or discontinuation of these drugs. RAASi therapy has been proven to delay the progression of CKD, ameliorate proteinuria, and reduce the overall risk of cardiovascular morbidity and mortality. Patiromer is a sodium-free, potassium-binding polymer used for the treatment of hyperkalemia. We present a case series of four patients with Stage 4 or 5 CKD in whom the initiation of dialysis was delayed with the use of patiromer. For one patient, dialysis was delayed by 18 months, whereas the remaining three patients, in whom hyperkalemia was one of the main complications, remain dialysis independent to date.

Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon

2019 ◽  
Vol 69 (8) ◽  
pp. 1440-1442 ◽  
Author(s):  
Jose Diego Brito-Sousa ◽  
Thalie C Santos ◽  
Sara Avalos ◽  
Gustavo Fontecha ◽  
Gisely C Melo ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Plasmodium Vivax ◽  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Brazilian Amazon ◽  
Clinical Spectrum ◽  
Life Threatening ◽  
Endemic Areas ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract Despite glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence of 5% in the Amazon, primaquine is administered without G6PD screening. This is an important cause of hospitalization among Plasmodium vivax–infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, the frequency of primaquine-induced hemolysis was 85.2 cases per 100 000 primaquine users.

scholarly journals A Rare Adverse Event of Rhabdomyolysis Caused by Sacubitril/Valsartan

Diseases ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 38 ◽  
Author(s):  
Prashanth Rawla ◽  
Jeffrey Pradeep Raj ◽  
Sajid Melvin George ◽  
Pavani Nathala ◽  
Anantha R. Vellipuram
Keyword(s):  
Renal Failure ◽  
Adverse Event ◽  
Acute Renal Failure ◽  
Muscle Damage ◽  
Cardiac Arrhythmias ◽  
Skeletal Muscles ◽  
Creatine Phosphokinase ◽  
Drug Induced ◽  
Life Threatening ◽  
Extensive Damage

Rhabdomyolysis is caused by extensive damage to skeletal muscles resulting in elevated creatine phosphokinase (CPK), Lactate dehydrogenase (LDH), and aspartate aminotransferase (AST), leading to life-threatening consequences like acute renal failure, cardiac arrhythmias, and hyperthermia. A variety of causes for muscle damage are known, and one of the most common is drug-induced. Statins and many other agents are known to induce muscle damage, but here we report Entresto™ (Sacubitril/Valsartan) induced rhabdomyolysis which has not been previously reported as solely responsible in the literature.

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