Plasma-Mediated Bipolar Radiofrequency Ablation of Overlong Soft Palate in the Dog: A Pilot Study

2018 ◽  
Vol 54 (5) ◽  
pp. 267-275 ◽  
Author(s):  
Sophie Palierne ◽  
Patricia Meynaud ◽  
Alexis Bilmont ◽  
Maxence Delverdier ◽  
Marie-Odile Semin ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Soft Palate ◽  
Tissue Damage ◽  
C Reactive Protein ◽  
Future Studies ◽  
Reactive Protein ◽  
Bipolar Radiofrequency ◽  
Duration Of Surgery ◽  
Group A ◽  
Histopathologic Changes

ABSTRACT The objective of this study was to compare the clinical, biological, macroscopic, and histologic outcomes after resection of the soft palate by plasma-mediated bipolar radiofrequency ablation (PBRA) or traditional incisional techniques (incisional soft palate resection [INC]) in dogs. Ten dogs were divided in two groups. In the INC group, the soft palate was incised with scissors and the wound was sutured in a continuous pattern. In the PBRA group, a wand was used to ablate the desired portion of the soft palate, without suture. Clinical, biological, macroscopic, and histologic assessments were scheduled over 14 days. The duration of surgery was significantly shorter for the PBRA group. The C-reactive protein concentrations were significantly higher in the PBRA group at 6 hr and on day 3 (P < .05) but with values very close to the baseline. C-reactive protein concentrations were maximal, but with low values (<25 mg/L), at day 1 for both techniques. The irregularity scores for the soft palate caudal border on days 1, 3, and 14 were significantly higher in the INC group than in the PBRA group (P < .05). The main histopathologic changes were the presence of superficial granulomas and a significantly greater depth of tissue damage in the INC group (2.5 ± 0.3 mm) compared with the PBRA group (1.5 ± 0.1 mm; P < .05). PBRA compared favorably with the traditional technique in terms of ease, duration of surgery, and depth of tissue damage. Future studies are warranted to validate its effectiveness for treating brachycephalic airway obstruction syndrome in dogs.

scholarly journals Comparison of Clinical Features Between Patients with Positive and Negative Appendectomy

2020 ◽  
Author(s):  
Guner Cakmak ◽  
Baris Mantoglu ◽  
Emre Gonullu ◽  
Kayhan Ozdemir ◽  
Burak Kamburoglu
Keyword(s):  
Acute Appendicitis ◽  
Clinical Features ◽  
Total Bilirubin ◽  
Negative Appendectomy ◽  
C Reactive Protein ◽  
Future Studies ◽  
Female Patients ◽  
Reactive Protein ◽  
Male Patients ◽  
The Mean

Abstract Background: The objective of this study was to retrospectively compare clinical features and prognostic values between the patients who were referred to the general surgery clinic of our hospital with the presumed diagnosis of acute appendicitis and underwent positive or negative appendectomy.Methods: Patients were divided into two groups as positive (PA) (n:362) and negative appendectomy (NA) (n:284) and the data obtained were compared between these two groups.Laboratory investigations were performed in all patients, and white blood cell (WBC), mean platelet volume (MPV), neutrophils count (NEU), neutrophils (%) (NEU%), C-reactive protein (CRP) and total bilirubin (TBIL) values were studied.Results: The mean MPV value was found as 7.88 fl in PA groups and 8.09 fl in NA group, and the mean MPV value was not statistically significantly difference in PA group, compared to NA groups (p=0.012). Laboratory parameters were also compared between genders. Accordingly, the mean MPV value was statistically significantly higher in female patients compared to male patients in PA group (p = 0.04). The mean TBIL value was 0.97 mg/dl in PA group and 0.69 mg/dl in NA group, and the mean TBIL value was statistically significantly higher in PA group (p< 0.001). Finally, TBIL value was statistically significantly lower in female patients compared to male patients in NA and PA group (p < 0.05).Conclusions: According to the results of our study, MPV and T. BIL values differ in PA and NA groups depending on gender. Therefore, these values may not be used as specific biomarkers in predicting positive acute appendicitis. We believe that these results will contribute to the literature and will be guiding for future studies.

Significance of Quantitative Salivary Cultures for Group A and Non-group A β-Hemolytic Streptococci in Patients with Pharyngitis and in Their Family Contacts

PEDIATRICS ◽  
1979 ◽  
Vol 64 (6) ◽  
pp. 904-912
Author(s):  
Edward L. Kaplan ◽  
Robert Couser ◽  
Barbara Ballard Huwe ◽  
Carolyn Mckay ◽  
Lewis W. Wannamaker
Keyword(s):  
Antibody Response ◽  
Respiratory Tract ◽  
Group A Streptococci ◽  
Upper Respiratory Tract ◽  
C Reactive Protein ◽  
Throat Culture ◽  
Reactive Protein ◽  
Group A ◽  
Bona Fide ◽  
Upper Respiratory

One hundred ninety-six individuals, 86 with clinically overt pharyngotonsillitis and 110 of their clinically negative contacts were studied to evaluate the sensitivity and the specificity of quantitative saliva cultures for group A β-hemolytic streptococci. We also compared this technique with semiquantitative throat cultures as a means of isolating group A streptococci and of differentiating the streptococcal carrier state from patients with bona fide streptococcal upper respiratory tract infection as defmed by the presence of an antibody response. The data indicate that the throat culture is a more reliable means of identifying group A β-hemolytic streptococci in the upper respiratory tract than is the saliva culture. The converse is true for non-group A β-hemolytic streptococci; the saliva culture is a much better means for isolating these organisms. In individuals positive by both techniques we found good correlation between the degree of positivity of the saliva culture and the degree of positivity of the throat culture. Furthermore, while there was a definite trend for individuals with strongly positive cultures to demonstrate more often an antibody rise in either antistreptolysin O and/or antideoxynibonuclease B—indicating bona fide infection—this relationship was not sufficiently constant to provide a clear differentiation. This study also indicates that discordance (one positive, one negative) of simultaneous duplicate semiquantitative throat cultures is much more common among individuals who do not show an antibody response ("carriers") than among those with an antibody response (bona fide infection). This study confirms our previous observations suggesting that the presence of C-reactive protein in the serum of patients with a positive culture for group A streptococci and clinical signs and symptoms of pharyngitis is often an indication of true streptococcal upper respiratory tract infection, and that even with a positive saliva culture at the initial visit, a negative C-reactive protein is only infrequently (25%) associated with an antibody response.

Early verification of myocardial ischemia with a novel biomarker of acute tissue damage: C-reactive protein fractional forms

2012 ◽  
Vol 413 (19-20) ◽  
pp. 1536-1541 ◽  
Author(s):  
Charles R. Kiefer ◽  
Rachel E. Stock ◽  
Sharon S. Flanagan ◽  
Chad E. Darling ◽  
Craig S. Smith ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Tissue Damage ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-Reactive Protein Predicts Progression of Peripheral Arterial Disease in Patients with Type 2 Diabetes: A 5-Year Follow-Up Study

2014 ◽  
Vol 33 (4) ◽  
pp. 347-355
Author(s):  
Ljiljana Popović ◽  
Katarina Lalić ◽  
Olga Vasović ◽  
Danijela Drašković Radojković ◽  
Nataša Rajković ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Group A ◽  
Hs Crp ◽  
Group B ◽  
Peripheral Arterial

Summary Background: Previous studies have indicated that high sensitivity C-reactive protein (hs-CRP) is a risk factor for the peripheral arterial disease (PAD) in diabetes. This study aimed to evaluate the possible predictive significance of hs-CRP for the development and progression of PAD in patients with type 2 diabetes (T2D). Methods: The study included 80 patients previously diagnosed with T2D, aged 45–70 years, divided into group A (T2D patients with PAD; n=38) and group B (T2D patients without PAD; n=42). After five years, all the patients were re-examined and divided into subgroups depending on de novo development of PAD or progression of previously diagnosed PAD. Ankle-Brachial Index (ABI) measurement was used for PAD diagnosis and hs-CRP was determined by nephelometry. Results: We found significantly higher hs-CRP levels in group A compared to group B, but only at baseline. Among the patients in group A, those with later progression of PAD (subgroup A1) had the highest levels of hs-CRP at baseline, although not significantly different from those in subgroup A2 (non-progressors). In contrast, hs-CRP level was significantly higher in subgroup B1 (progressors) in comparison to subgroup B2 (non-progressors) at both the first and second exam. Of all the investigated metabolic parameters, hs-CRP was the only independent predictor of PAD progression (OR=0.456, 95% CI=0.267–0.7815, p=0.004). The cut-off point for hs-CRP was 2.5 mg/L (specificity 75% and sensitivity 73.3%) with the relative risk for PAD of 2.93 (95% CI=1.351–6.3629). Conclusions: Our study implies that hs-CRP can be used as a reliable predictor for the progression of PAD in patients with T2D.

Response of Serum Interleukin-6 in Patients Undergoing Elective Surgery of Varying Severity

1990 ◽  
Vol 79 (2) ◽  
pp. 161-165 ◽  
Author(s):  
A. M. Cruickshank ◽  
W. D. Fraser ◽  
H. J. G. Burns ◽  
J. Van Damme ◽  
A. Shenkin
Keyword(s):  
Interleukin 6 ◽  
Elective Surgery ◽  
Venous Blood ◽  
Surgical Trauma ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Duration Of Surgery ◽  
Minor Surgery ◽  
Protein Response ◽  
Major Vascular Surgery

1. Recent studies have suggested that interleukin-6 is a major mediator of the acute-phase protein response in man. The aim of the present study was to investigate the relationships between the response of serum interleukin-6 to surgery, the type of surgical procedure performed and the response of serum C-reactive protein. 2. Timed venous blood samples were taken from 26 patients in five broad surgical categories (minor surgery, cholecystectomy, hip replacement, colorectal surgery and major vascular surgery). C-reactive protein and interleukin-6 were measured in each sample. 3. Serum interleukin-6 rose within 2–4 h of incision in all patients and the magnitude of the response differed among the various surgical groups. The response of interleukin-6 correlated (r = 0.80, P < 0.001) with the duration of surgery. In contrast, serum C-reactive protein was not detectable after minor surgery (< 10 mg/l) and the response of C-reactive protein did not differ among the more major surgical groups. The response of interleukin-6 showed a weak, but significant, correlation with the response of C-reactive protein (r = 0.67, P < 0.001). 4. We conclude that serum interleukin-6 is a sensitive, early marker of tissue damage. In general, the greater the surgical trauma, the greater the response of serum interleukin-6 and the greater the peak serum concentration of interleukin-6. Our results are consistent with a role for interleukin-6 in the induction of C-reactive protein synthesis.

scholarly journals Study of High sensitive C - reactive protein and Gamma-glutamyl transferase in Type 2 Diabetes Mellitus with Hypertension

2020 ◽  
Vol 11 (3) ◽  
pp. 3478-3483
Author(s):  
Ramya S ◽  
Sureka Varalakshmi V ◽  
Uma Maheswari K ◽  
Chandan Bala R
Keyword(s):  
Diabetes Mellitus ◽  
Gamma Glutamyl Transferase ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Group A ◽  
Hs Crp ◽  
Group B ◽  
Glutamyl Transferase

C-reactive protein (CRP), produced by the hepatocytes is a primary inflammatory marker of T2DM. Higher levels of gamma-glutamyl transferase enzyme (GGT) and Hs CRP (High sensitive CRP)are associated with the complication of poor glycemic control.This study was aimed to find the association of Hs CRP and GGT for cardiovascular risk factors in Type 2 diabetes mellitus (T2DM)and Hypertension in the suburbs of Chennai. This study includes 57 subjects with T2DM and Hypertension (Group A) and 62 subjects with T2DM (GroupB) within the age group of 40-60 years. FBS, HbA1C, Hs CRP, GGT and blood pressure were determined. Statistical analysis was performed using Statistical Package for the SPSS 17 version. Mean values of FBS, blood HbA1C, Hs CRP and GGT were significantly higher among participants of Group A than Group B. Significant difference of FBS, HbA1C were found between the two groups. In contrast, no significant difference of GGT was found between the groups. Differences were considered statistically significant at two-sided P < 0.05. Within the group, Hs CRP shows the significance and positive correlation with FBS, SBP and DBP. Still, GGT does not show any significance in Group A. In contrast, in Group B, both Hs CRP and GGT shows the importance and positive correlation with FBS and HbA1C.It is concluded that high levels of HsCRP are associated with T2DM and Hypertension, indicating increased cardiovascular risk, and it should be included in regular monitoring of type-2 diabetic patients.

scholarly journals The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes

2019 ◽  
Vol 38 (2) ◽  
pp. 126-133 ◽  
Author(s):  
Dragana Popovic ◽  
Katarina Lalic ◽  
Aleksandra Jotic ◽  
Tanja Milicic ◽  
Jelena Bogdanovic ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Favorable Effect ◽  
Obese Patients ◽  
Risk Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hyperosmolar Hyperglycemic State ◽  
Group A

Summary Background We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Results Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p<0.001; B: p<0.001, C: p<0.05; D: p<0.001 mg/L), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B: p <0.001; C: p<0.05, D: p=0.001 μmol/L), respectively, at resolving AHC. However, CRP persisted higher (p<0.001, p<0.01), IL-6 lower (p<0.05, p<0.001), while homocysteine levels turned out to be similar to controls. Conclusions AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP

scholarly journals Changes in Blood Lipoproteins, Inflammation Response and Tissue Damage After a Single Bout of Exhaustive Exercise

2010 ◽  
Vol 16 (1) ◽  
pp. 67-72
Author(s):  
Chieh Chung LIU ◽  
Jui Kun CHUANG ◽  
Chun Hong LIN ◽  
Pu Hsi TSAI ◽  
Jun Yen LEE ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Tissue Damage ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
C Reactive Protein ◽  
Low Density Lipoprotein Cholesterol ◽  
Reactive Protein

LANGUAGE NOTE | Document text in Chinese; abstract also in English. The objective of this study was to determine the effects on plasma lipoproteins, inflammation response and tissue-­damage markers level during their recovery following exhaustive run. These biochemical concentrations were measured before 30 min, immediately after, and 30 min, 1hr, 2hr, 24hr, 48hr, 72hr after an exhaustive run on treadmill in 15 health male subjects with 80%VO2max intensity. The result of one-way ANOVA with measure repeated analysis indicated that there were no significant changes in low-density lipoprotein cholesterol post run, and high-density lipoprotein cholesterol level was remain significant elevated (by 18%) until 2hr post run. The inflammatory marker of C-reactive protein level was significant elevated (by 42%) immediately and returned to baseline post 0.5hr. The neutrophils ratio remain significant increased (by 51%) during 0.5hr until 2hr and returned to baseline post 24hr. The tissue-damage markers were remain elevated by 23% immediately until 2hr in lactate dehydrogenase and only reach to peak (by 108%) significantly post 24hr in creatine kinase. It is concluded that an exhaustive exercise could induce the delay-onset damage and transient inflammatory response in tissue, and have enough rest or suitable antioxidant supplements for recovery. 目的：本研究旨在探討單次衰竭運動後恢復期對於血脂蛋白濃度變化與發炎損傷指標之影響。方法：受試者為15名健康男性(年齡22.8 ± 0.89歲，體重67. ± 1.81公斤)，以高強度(80%VO2max)的固定負荷運動至衰竭，並於運動前30分鐘、運動後立即、0.5hr、lhr、2hr、24hr、48hr、72hr等時間點靜脈採血進行生化值分析。結果：以單因子相依樣本變異數分析顯示，低密度脂蛋白膽固醇(low density lipoprotein-cholesterol, LDL-C)在運動後均無明顯變化；而高密度脂蛋白膽固醇(high den­sity lipoprotein-cholesterol, HDL-C)則在衰竭運動後2hr明顯持續增加約18.3% (p < .05)；發炎指標：C-反應蛋白(C-reactive protein, CRP)於衰竭後立即顯著上升約42%，隨即0.5hr後恢復。嗜中性球比例(neutrophils, net-s%)在運動後0.5hr至2hr持續增加約51%，於24hr之後恢復。組織損傷情形，乳酸脱氫酶(lactate dehydrogenase, LDH)活性在衰竭後立即至2hr期間顯著增加約23%，而肌酸激酶(creatine kinase, CK)活性則在24hr後才明顯增加約108%的峰值反應。結論：本研究血脂蛋白與發炎、損傷等生化反應結果，意味著單次衰竭運動後可能誘發體內組織的延遲性損傷與組織的短暫發炎反應，需要有足夠的休息時間或運用適當的抗氧化增補劑來進行運動恢復。

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