scholarly journals Prevalence of Tuberculosis in Diabetic Patients

2021 ◽  
Vol 15 (5) ◽  
pp. 1058-1060
Author(s):  
Shamshad Ali ◽  
M Imran Aslam ◽  
Nayyar M Elahi ◽  
Waseem A Khan ◽  
M Saqib Musharaf ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Extra Pulmonary Tuberculosis ◽  
Medical College ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
The Mean ◽  
Extra Pulmonary

Aim: To determine the frequency of tuberculosis in the patients of diabetes. Study design: Cross-Sectional Place and duration of study: Department of Pulmonology, Avicenna Medical College, Lahore from 1st March 2020 to 31st August 2020. Methodology: Two hundred patients of both genders were presented in this study. Patients detailed demographics age, sex and body mass index were recorded after taking proper consent. Patients admitted in outpatient department with diabetic duration greater than 5years. The different variants of pulmonary and extra pulmonary tuberculosis were measured. Results: There were 120(60%) males and 80(40%) were females with mean age was 51.8±18.22 years. The mean duration of diabetes was 11.5±9.19 years. 60% patients were addicted to gutka and smoking. Active tuberculosis was only found in 30(15%) cases. Pulmonary tuberculosis were 17(56.7%) and the rest 13(43.3%) were extra pulmonary tuberculosis. Eighteen (60%) patients had smear positive and 12(40%) had smear -ve TB. Conclusion: The frequency of tuberculosis in the diabetic patients was high as compared to other population. It can be cure by early diagnosed of disease otherwise multidrug-resistant tuberculosis can become serious health problem among public. Key words: Prevalence, Tuberculosis, Diabetic patient, Multidrug-resistant tuberculosis

scholarly journals KARAKTERISTIK PENDERITA TUBERKULOSIS PARU DENGAN MULTIDRUG-RESISTANT TUBERCULOSIS (MDR-TB) DI RSUD ULIN BANJARMASIN

2017 ◽  
Vol 13 (1) ◽  
pp. 23
Author(s):  
Gusti Andhika Azwar ◽  
Dewi Indah Noviana ◽  
FX. Hendriyono
Keyword(s):  
High School ◽  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
Senior High School ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Acid Fast Bacilli ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb

Abstract: Tuberculosis is the main health problem in the world and getting worse with Multidrug-Resistant Tuberculosis (MDR-TB) cases. Many research about MDR-TB patients is conducted to describe MDR-TB patients characteristics. This research aims to describe the characteristics of pulmonary tuberculosis MDR-TB at RSUD Ulin Banjarmasin on December 2015-May 2016. This was a descriptive research with crossectional approaches. Data were collected from clinical pathology laboratory and patients medical record. The Result indicate that as many as 19 pulmonary TB patients with MDR-TB at RSUD Ulin Banjarmasin on December 2015-May 2016 with characteristics were dominated by men 84,2% (16 subjects); age 45-54 years 35,8% (7 subjects); junior and senior high school both 21,1% (4 subjects); private employees 31,6% (6 subjects); came with TB relapses 68,4% (13 subjects); and the acid-fast bacilli examination showed negative and positive both 21,1% (4 subjects). In conclusion, the characteristics of pulmonary tuberculosis patients with Multidrug-Resistant Tuberculosis (MDR-TB) at RSUD Ulin Banjarmasin on December 2015-May 2016 are dominated by men, age 45-54 years old, junior and senior high school, private employees, from Banjarmasin, come with TB relapses and the acid-fast bacilli examination showed negative and positive. Keywords:     multidrug-resistant tuberculosis (MDR-TB), Tuberculosis patient’s characteristics, RSUD Ulin Banjarmasin Abstrak: Tuberkulosis merupakan masalah kesehatan utama di dunia dan bertambah berat dengan munculnya kasus multidrug-resistant tuberculosis (MDR-TB). Berbagai penelitian dilakukan untuk mengetahui karakteristik penderita MDR-TB. Oleh karena itu, penelitian ini bertujuan untuk mengetahui karakteristik penderita tuberkulosis paru dengan MDR-TB di RSUD Ulin Banjarmasin periode Desember 2015-Mei 2016. Penelitian  ini adalah penelitian deskriptif dengan rancangan cross-sectional. Data diambil dari Laboratorium Patologi Klinik dan rekam medis penderita. Hasil penelitian menunjukkan 19 penderita tuberkulosis paru dengan MDR-TB di RSUD Ulin Banjarmasin periode Desember 2015-Mei 2016 didominasi oleh laki-laki 84,2% (16 orang); usia 45-34 35,8% (7 orang); pendidikan SMP dan SMA masing-masing 21,1% (4 orang); pekerja swasta 31,6% (6 orang); berasal dari Banjarmasin 57,9% (11 orang); datang dengan keadaaan TB kasus relaps kategori 1 dan kategori 2 68,4% (13 orang); dan dengan hasil pemeriksaan sputum BTA positif dan negatif masing-masing 21,1% (4 orang). Kesimpulan penelitian ini adalah karakteristik penderita tuberkulosis paru dengan multidrug-resistant Tuberculosis (MDR-TB) di RSUD Ulin Banjarmasin periode Desember 2015-Mei 2016 didominasi oleh laki-laki, usia 45-54 tahun, pendidikan SMP dan SMA, pekerja swasta, berasal dari Banjarmasin, datang dengan keadaan kasus TB relaps dan hasil sputum BTA negatif dan positif. Kata-kata kunci:        Multidrug-resistant tuberculosis (MDR-TB), karakteristik penderita Tuberkulosis Paru

scholarly journals Knowledge and practice of health workers about control and prevention of multidrug-resistant tuberculosis in referral hospitals, Ethiopia: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e022948 ◽  
Author(s):  
Kefyalew Addis Alene ◽  
Akilew Awoke Adane ◽  
Sisay Yifiru ◽  
Bikes Destaw Bitew ◽  
Aynishet Adane ◽  
...  
Keyword(s):  
Health Workers ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
History Of ◽  
The Mean ◽  
Knowledge And Practice

ObjectiveThe aim of this study was to assess the knowledge and practice of health workers about multidrug-resistant tuberculosis (MDR-TB) prevention and control.Study design and settingsA cross-sectional study was conducted at Gondar University Referral Hospital and Felege Hiwot Referral Hospital.ParticipantsRandomly selected health workers (ie, medical doctor, nurse, health officer, pharmacy, medical laboratory and midwifery) were the study participants.Outcome measuresThe main outcomes were knowledge and self-reported practice of health workers about MDR-TB.ResultsA total of 377 health workers (with a response rate of 93.7%) participated in the study. The majority of respondents were nurses (52.5%, n=198) and medical doctors (15.6%, n=59). The mean knowledge score was seven out of 10; 149 (39.5%) of respondents scored seven or more which was considered as good knowledge. MDR-TB knowledge of health workers was significantly associated with having a postgraduate degree (adjusted odds ratio (AOR)=5.78; 95% CI 2.33 to 14.33), taking infection prevention training (AOR=1.79; 95% CI 1.00, to 3.17) and having a history of tuberculosis (TB) (AOR=1.85; 95% CI 1.12, to 3.03). The mean self-reported practice score was four out of seven; one-fifth (19.6%) of respondents scored four or more which was considered as good practice. Self-reported practice of health workers was significantly associated with working at internal medicine (AOR=4.64; 95% CI 1.99, to 10.81) and paediatrics (AOR=3.85; 95% CI 1.11, to 13.34) wards, being in the age groups of 26–30 years (AOR=2.70; 95% CI 1.27, to 5.76), and 30 years and above (AOR=4.42; 95% CI 1.77, to 11.00).ConclusionsThis study found low knowledge and self-reported practice score among health workers. MDR-TB knowledge of health workers was significantly associated with educational status, infection prevention training and previous history of TB. This finding highlights the potential of providing MDR-TB training for health workers to increase their knowledge about MDR-TB.

scholarly journals Proportion of Rifampicin Resistance in Sputum Smear Positive Pulmonary Tuberculosis with Diabetes Mellitus in Urban Bengaluru - A Cross-Sectional Study

2021 ◽  
Vol 8 (23) ◽  
pp. 1888-1893
Author(s):  
Srinivasa Kaligonahalli Venkataramanappa ◽  
Jeevan Basavaraj
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
Rifampicin Resistance ◽  
Sputum Smear ◽  
Diabetic Patients ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

BACKGROUND Pulmonary tuberculosis (PTB) still remains a global public health problem. Diabetes along with poor glycaemic control leads to an immune compromised state. Type 2 diabetes (DM) is a strong risk factor for tuberculosis (TB) and is associated with a slower response to TB treatment and a higher mortality rate. Objective of the study was to determine the prevalence of rifampicin resistance in pulmonary tuberculosis in patients with DM. METHODS The study was conducted in General Medicine Department, Dr. B.R. Ambedkar Medical College, Bengaluru, Karnataka, from July 2018 to December 2019. Sputum was collected from a total of 100 patients who were sputum smear positive for acid fast bacilli (AFB). Sample was collected and was subjected to GeneXpert testing for the evaluation of resistance against rifampicin. RESULTS In our study the incidence of rifampicin resistance was 45.16 % in diabetes and 5.79 % in non-diabetes which was statistically significant ( 2 -1.1; p-0.01) between rifampicin resistance and diabetic patients’ status with active TB in South Karnataka, India. This result supports previous research showing a higher multidrug-resistant tuberculosis risk in tuberculosis & diabetes patients relative to those with no diabetes. Additionally, correlation of other findings between type 2 diabetes & multidrug-resistant tuberculosis as well as delayed time to sputum smear conversion were confirmed. CONCLUSIONS The results showed correlation between diabetes & rifampicin resistance and probably suggest the necessity of integrated diabetes and tuberculosis surveillance programs in South Karnataka, India. KEYWORDS Rifampicin, Tuberculosis, Diabetes Mellitus

scholarly journals Risk Factors for Multidrug-Resistant Tuberculosis among Patients with Pulmonary Tuberculosis at the Central Chest Institute of Thailand

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0139986 ◽  
Author(s):  
Charoen Chuchottaworn ◽  
Vipa Thanachartwet ◽  
Piamlarp Sangsayunh ◽  
Thu Zar Myint Than ◽  
Duangjai Sahassananda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals Feasibility of Identifying Household Contacts of Rifampin-and Multidrug-resistant Tuberculosis Cases at High Risk of Progression to Tuberculosis Disease

2019 ◽  
Vol 70 (3) ◽  
pp. 425-435 ◽  
Author(s):  
Amita Gupta ◽  
Susan Swindells ◽  
Soyeon Kim ◽  
Michael D Hughes ◽  
Linda Naini ◽  
...  
Keyword(s):  
High Risk ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Preventive Therapy ◽  
Interferon Gamma Release Assay ◽  
Cross Sectional ◽  
Household Contacts ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb

Abstract Background We assessed multidrug-resistant tuberculosis (MDR-TB) cases and their household contacts (HHCs) to inform the development of an interventional clinical trial. Methods We conducted a cross-sectional study of adult MDR-TB cases and their HHCs in 8 countries with high TB burdens. HHCs underwent symptom screenings, chest radiographies, sputum TB bacteriologies, TB infection (TBI) testing (tuberculin skin test [TST] and interferon gamma release assay [IGRA]), and human immunodeficiency virus (HIV) testing. Results From October 2015 to April 2016, 1016 HHCs from 284 MDR-TB cases were enrolled. At diagnosis, 69% of MDR-TB cases were positive for acid-fast bacilli sputum smears and 43% had cavitary disease; at study entry, 35% remained smear positive after a median MDR-TB treatment duration of 8.8 weeks. There were 9 HHCs that were diagnosed with TB prior to entry and excluded. Of the remaining 1007 HHCs, 41% were male and the median age was 25 years. There were 121 (12%) HHCs that had new cases of TB identified: 17 (2%) were confirmed, 33 (3%) probable, and 71 (7%) possible TB cases. The TBI prevalence (defined as either TST or IGRA positivity) was 72% and varied by age, test used, and country. Of 1007 HHCs, 775 (77%) were considered high-risk per these mutually exclusive groups: 102 (10%) were aged <5 years; 63 (6%) were aged ≥5 and were infected with HIV; and 610 (61%) were aged ≥5 years, were negative for HIV or had an unknown HIV status, and were TBI positive. Only 21 (2%) HHCs were on preventive therapy. Conclusions The majority of HHCs in these high-burden countries were at high risk of TB disease and infection, yet few were receiving routine preventive therapy. Trials of novel, preventive therapies are urgently needed to inform treatment policy and practice.

scholarly journals Assessment of Knowledge and Attitude of Tuberculosis Patients in Direct Observation Therapy Program towards Multidrug-Resistant Tuberculosis in Addis Ababa, Ethiopia: A Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Firew Tadesse Kusheno ◽  
Teklehaimanot Mezgebe Nguse ◽  
Gebremedhin Beedemariam Gebretekle
Keyword(s):  
Addis Ababa ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Therapy Program ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Health Centres ◽  
Mdr Tb ◽  
Knowledge And Attitude

Background. Multidrug-resistant tuberculosis (MDR-TB) is becoming a major challenge of tuberculosis (TB) control program globally but more serious in developing countries like Ethiopia. In 2013, a survey result showed that in Ethiopia, tuberculosis patients from new cases and retreatment cases had resistance to at least isoniazid and rifampicin with a significant increase over time. Inadequate knowledge and wrong perception about MDR-TB by patients were detrimental to TB control programs. The study aimed at assessing the knowledge and attitude of TB patients of direct observation therapy program towards multidrug-resistant tuberculosis in health centres of Addis Ababa, Ethiopia. Methods. A cross-sectional study was conducted in 10 health centres of Addis Ababa which were selected by simple random sampling technique. A total of 422 TB patients were included in the study, and participants from each health centres were taken proportional to the number of clients in each health centres. Data was entered and analyzed using SPSS version 20. Association between outcome and independent variables was explored using logistic regression. Results. The level of knowledge of TB patients about MDR-TB was poor and only 55.0% of TB patients attained good overall knowledge. A significant association was found between good knowledge and attending tertiary level of education (AOR=4.3, 95%CI=1.9, 9.8), gender (AOR=1.62, 95%CI=1.1, 2.4), income of respondents’ family (OR=0.4, 95%CI=0.2, 0.9), and sleeping practice (AOR=8.0, 95%CI=4.0, 15.7). Nearly three-fourths (73.5%) of TB patients had a favourable attitude towards MDR-TB. Occupational status (AOR=4.4, 95%CI=2.5, 7.6) and sleeping practices (AOR=2.4, 95%CI=1.2, 5.0) were significantly associated with the attitude of the TB patients. Conclusions. Knowledge of TB patients toward MDR-TB was poor. Although a large proportion of patients had a favourable attitude, it still needs to be improved. Hence, efforts should be made to implementing health education to improve awareness of TB patients about MDR-TB.

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