Molecular diagnosis of adenovirus, mycoplasma pneumoniae and Chlamydia pneumoniae infection in hospitalized children

2004 ◽  
Author(s):  
Chi-kit, Patrick Pun
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Molecular Diagnosis ◽  
Chlamydia Pneumoniae ◽  
Hospitalized Children

scholarly journals Identification of Coinfections by Viral and Bacterial Pathogens in COVID-19 Hospitalized Patients in Peru: Molecular Diagnosis and Clinical Characteristics

Antibiotics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1358
Author(s):  
Giancarlo Pérez-Lazo ◽  
Wilmer Silva-Caso ◽  
Juana del Valle-Mendoza ◽  
Adriana Morales-Moreno ◽  
José Ballena-López ◽  
...  
Keyword(s):  
Hospital Admission ◽  
Mycoplasma Pneumoniae ◽  
Molecular Diagnosis ◽  
Clinical Characteristics ◽  
Chlamydia Pneumoniae ◽  
Severe Pneumonia ◽  
Hospitalized Patients ◽  
Respiratory Pathogens ◽  
Ministry Of Health ◽  
The Impact

The impact of respiratory coinfections in COVID-19 is still not well understood despite the growing evidence that consider coinfections greater than expected. A total of 295 patients older than 18 years of age, hospitalized with a confirmed diagnosis of moderate/severe pneumonia due to SARS-CoV-2 infection (according to definitions established by the Ministry of Health of Peru) were enrolled during the study period. A coinfection with one or more respiratory pathogens was detected in 154 (52.2%) patients at hospital admission. The most common coinfections were Mycoplasma pneumoniae (28.1%), Chlamydia pneumoniae (8.8%) and with both bacteria (11.5%); followed by Adenovirus (1.7%), Mycoplasma pneumoniae/Adenovirus (0.7%), Chlamydia pneumoniae/Adenovirus (0.7%), RSV-B/Chlamydia pneumoniae (0.3%) and Mycoplasma pneumoniae/Chlamydia pneumoniae/Adenovirus (0.3%). Expectoration was less frequent in coinfected individuals compared to non-coinfected (5.8% vs. 12.8%). Sepsis was more frequent among coinfected patients than non-coinfected individuals (33.1% vs. 20.6%) and 41% of the patients who received macrolides empirically were PCR-positive for Mycoplasma pneumoniae and Chlamydia pneumoniae.

scholarly journals Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ying Bi ◽  
Yifan Zhu ◽  
Xiao Ma ◽  
Jiejing Xu ◽  
Yun Guo ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Mycoplasma Pneumoniae ◽  
Assessment Scale ◽  
Prognostic Indicators ◽  
Hospitalized Children ◽  
Early Prediction ◽  
Prognostic Assessment ◽  
Standard Clinical Practice ◽  
Children First ◽  
A Prospective Study

AbstractNow there is no clinical scale for early prediction of refractory Mycoplasma pneumoniae pneumonia (RMPP). The aim of this study is to identify indicators and develop an early predictive scale for RMPP in hospitalized children. First we conducted a retrospective cohort study of children with M. pneumoniae pneumonia admitted to Children’s Hospital of Nanjing Medical University, China in 2016. Children were divided into two groups, according to whether their pneumonia were refractory and the results were used to develop an early predictive scale. Second we conducted a prospective study to validate the predictive scale for RMPP in children in 2018. 618 children were included in the retrospective study, of which 73 with RMPP. Six prognostic indicators were identified and included in the prognostic assessment scale. The sensitivity of the prognostic assessment scale was 74.0% (54/73), and the specificity was 88.3% (481/545) in the retrospective study. 944 children were included in the prospective cohort, including 92 with RMPP, the sensitivity of the prognostic assessment scale was 78.3% (72/92) and the specificity was 86.2% (734/852). The prognostic assessment scale for RMPP has high diagnostic accuracy and is suitable for use in standard clinical practice.

scholarly journals Clinical Presentation and Bacterial Etiology of Adult Community Acquired Pneumonia

2017 ◽  
Vol 34 (3) ◽  
pp. 128-134
Author(s):  
Md Abdus Salam ◽  
Md Robed Amin ◽  
Quazi Tarikul Islam
Keyword(s):  
Streptococcus Pneumoniae ◽  
Blood Culture ◽  
Mycoplasma Pneumoniae ◽  
Chlamydia Pneumoniae ◽  
Community Acquired Pneumonia ◽  
Sputum Culture ◽  
Gram Positive ◽  
Gram Negative ◽  
The Mean ◽  
Gram Positive Cocci

Introduction: Pneumonia is a worldwide, serious threat to health and an enormous socio-economic burden for health care system. According to recent WHO data, each year 3-4 million patients die from pneumonia. The clinical presentations and bacterial agents responsible for community acquired pneumonia (CAP) varies according to geography and culture.Methods: A cross sectional observational study conducted among the 53 consecutive patients with a clinical diagnosis of CAP in admitted patient in the department of Medicine, DMCH, during January 2010 to December 2010. Hematological measurements (TC of WBC, Hb%, ESR, platelet count), blood culture, chest X-ray P/A view, sputum for Gram staining and culture sensitivity, sputum for AFB, blood urea and random blood sugar were done in all cases. ELISA for IgM antibody of Mycoplasma pneumoniae and Chlamydia pneumoniae were done in sputum culture negative cases.Results: The mean (±SD) age was 38.9±17.3 years and Male female ratio was 3:1. Fever, chest pain and productive cough were the most common clinical features. The mean (±SD) respiratory rate was 23.0±2.8 /minute . COPD and DM were found in 17.0% and 5.7% of patients respectively . Blood culture was found positive in only 1.9% of the study patients. Gram positive Cocci 62.26%, Gram negative Bacilli 9.43%, mixed Gram positive cocci and Gram negative bacilli 11.32% and Gram negative Cocco Bacilli 1.9% were observed and in 15.03 % cases, no bacteria could be seen. Sputum culture revealed 53.8% streptococcus pneumoniae, 26.9% Klebsiella pneumonia as predominant organism. Mycoplasma pneumoniae and Chlamydia pneumoniae were found in 7.4% and 3.7% respectively by serological test. For Streptococcus pneumoniae, sensitive antibiotics were Amoxyclav and Levofloxacin. For Gram negative bacilli and coccobacilli, more sensitive antibiotics were Meropenem, Ceftriaxone, and Clarithromycin. The best sensitive drug were found meropenem. The mean (±SD) duration of hospital stay was 5.0±1.7 days with ranging from 3 to 10 days.Conclusion: Region based bacteroiological diagnosis of Cap is important for selecting the best and sensitive drugs for complete cure.J Bangladesh Coll Phys Surg 2016; 34(3): 128-134

scholarly journals Chlamydia pneumoniae infection-associated erythema multiforme

2013 ◽  
Vol 5 (2) ◽  
pp. 9 ◽  
Author(s):  
Shinsaku Imashuku ◽  
Naoko Kudo
Keyword(s):  
Herpes Simplex ◽  
Mycoplasma Pneumoniae ◽  
Erythema Multiforme ◽  
Chlamydia Pneumoniae ◽  
Elisa Test ◽  
The Past

There is a well-known correlation between <em>Herpes simplex</em> (HSV) infection and erythema multiforme (EM). More recently, in Japan, it was found that <em>Chlamydia pneumoniae </em>(Cp) may promote the development of EM. All cases of Cp infection-associated EM that had been diagnosed in our clinic over the past two years (from 2011 to 2012) were analyzed. Cp infection was diagnosed on the basis of a significant increase (&gt;2.00) in anti-Cp IgM titers, as measured by the HITAZYME-ELISA test. There were 7 cases of Cp-EM, one male and 6 females. Median age was 13 years (range 3-29 years). It is recommended that the possible involvement of Cp infection, besides HSV or <em>Mycoplasma pneumoniae</em> infections, should be considered in all cases of EM.

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