scholarly journals Night- Time Chronotherapy With Diuretics: Effect On Sleep Quality And Duration In Patients With Hypertension In Lusaka, Zambia

2020 ◽  
Vol 4 (3) ◽  
pp. 1-9
Author(s):  
David Band ◽  
◽  
Tyson L. Muungo ◽  
Nason Lambwe ◽  
◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sleep Quality ◽  
Blood Pressure Level ◽  
Poor Sleep ◽  
Blood Pressure Lowering ◽  
Quality Of Sleep ◽  
Night Time ◽  
Pressure Lowering

Poor sleep plays an important role in the prevalence of hypertension. It increases the prevalence rate to 60%. The night-time dosing of blood pressure-lowering drugs has yielded positive results. Scholars have rarely investigated the relationship between night-time dosing of diuretics and the quality of sleep. The study aimed at evaluating the quality and duration of sleep while on night-time dosing of diuretics and determine the commonly used blood pressure-lowering medication at University Teaching Hospital. The study was a Prospective Cohort Study with 12 weeks of follow-up. The sample consisted of 46 patients with hypertension and on a diuretic, 25 of whom were taking their medication in the evening at 10 PM (study group), and 18 were in the 10 AM dosing schedule as a control. Overall, 43 were included in the analysis. Baseline and follow-up at 2, 8 and 12 Sleep quality and duration, and blood pressure level were available for 43 (93.5%) individuals. The study recruited more women (76.1%) and the majority were on hydrochlorothiazide and amiloride combination (65.2%). The 10 PM dosing showed better quality of sleep and duration, and blood pressure-lowering as the follow-up continued with a p-value of less than 0.05 for Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS), and for the blood pressure-lowering at 12 weeks. The study showed beneficial effects of 10 PM dosing of diuretics in hypertensive patients and the diuretic effect does not affect the quality and duration of sleep. Further, 10 PM dosing lowers the blood pressure significantly compared with 10 AM.

scholarly journals The relationshipof the quality of sleep in patients with stage 5 chronickidney disease, treated with hemodialysis, with melatonin-producing function

2021 ◽  
pp. 23-30
Author(s):  
V. Ye. Кondratiuk ◽  
A. S. Petrova
Keyword(s):  
Blood Pressure ◽  
Sleep Quality ◽  
Pineal Gland ◽  
Sleep Duration ◽  
Poor Sleep ◽  
Quality Of Sleep ◽  
Group I ◽  
Number Of Patients ◽  
Falling Asleep

The researcheddemonstrated the relationship between functional state of the pineal gland and sleepdeterioration. However, impaired melatonin-producing function of the pineal gland (MFE) in patients with chronic kidney disease (CKD), treated with hemodialysis (HD), and its association with sleep disturbance in this cohort of patients required further investigations.Aim — to assess the quality of sleepin patients with stage 5 CKD treated with HD and investigate itsrelationship with the pineal dysfunction.Materials and methods. Examinations involved 130 patients (50 % of men) with stage 5 CKD, treated with hemodialysis, with the mean age 58.5 [43; 66]. The day and night melatoninlevels (MT) in saliva were determined and based on the results the patients were divided into two groups: group I — 110 patients with impaired MFE, group II — 20 patients with normal MFE. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. All patients underwent clinical and laboratory tests: general and biochemical blood tests, office blood pressure (BP) measurements, Holter blood pressure monitoring.Results. Analysis of the insomniastructure in patients with stage 5 CKD, treated with HD, according to the PSQI questionnaire, demonstrated the problems with falling asleep in 96.2 % of patients, feeling of heat in 56.8 %, frequent awakenings in 52.9 %, daytime dysfunction in 40.8 %, breathing problems in 40.5 %, sleep problems due to coughing or snoring in 37.8 %, having bad dreams in 18.9 %, the use of sleeping meds in 8 % of patients. The total PSQI score in patients with impaired MFE was higher by 71.4 % (p < 0.001) compared to the value obtained in the group with preserved pineal gland function, demonstrating the effects of MFE on sleep quality.The component of «sleep delay» and «sleep duration» in patients with pineal gland dysfunction was 66.7 % higher than in the group with preserved MFE (p < 0.001). Comparative analysis of the number of minutes required for patients to fall asleep in the study groups demonstrateda greater sleep delay in HD-treated patients with impaired MFE. From them, the majority of subjects (71.8 %) needed more than 60 minutes to fall asleep, while in the group with preserved MFE such patients were not identified (p < 0.05). The number of patients with the period of falling asleep of 31 to 60 minutes in the group with pineal gland dysfunction was 30 % less than in patients with preserved MFE (p < 0.05). The number of patients in whom it took 16—30 minutes to fall asleep in the group with preserved MFE was 92.5 % (p < 0.05) more than in patients with pineal gland dysfunction, and patientswith the period of falling asleep of less than 15 minutes was by 62 % higher than patients with impaired MFE (p < 0.05). The decreased sleep duration was established in all patients treated with HD, however the most worsening of the sleep quality was revealed in the groupof MFE disorders. Thus, thenumber of patients with sleep duration < 5 hourswas by 90.8 % (р < 0.05) higher in the groupof impairedMFEvs group with the preserved MFE, with sleep duration of 5—6 hours by 81.7 % (р < 0.05), the number of subjects with duration of 6—7 hours by 76.4 % lower (р < 0.05), and those who slept > 7 hours by 84.0 % (р < 0.05).Conclusions. Patients with stage 5 CKD, treated with HD, were characterized with combination of MFE impairment (84.6 %) with poor sleep quality (86.2 %), including problems withfalling asleep, felling hot, frequent waking up, and daytime dysfunction. The low quality of sleep was determined bylow melatonin levels in saliva, the presence of hypoalbuminemia and arterial hypertension, hypertension duration and HDtreatment

Abstract 13827: Sleep Quality Improved After Intensified Blood Pressure Lowering Therapy

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Roland E Schmieder ◽  
Kristina Striepe ◽  
Agnes Bosch ◽  
Karin Högerl ◽  
Roland Veelken ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sleep Quality ◽  
Antihypertensive Therapy ◽  
Prospective Observational Study ◽  
Multiple Drug ◽  
Poor Sleep ◽  
Blood Pressure Lowering ◽  
Lowering Therapy ◽  
Pressure Lowering ◽  
Single Pill

Insufficient and poor sleep on a chronic basis raises blood pressure (BP), the risk of hypertension and cardiovascular disease which in turn further leads to sleep disturbances.In a prospective observational study we tested the hypothesis whether intensification of antihypertensive therapy improves sleep quality Patients with arterial hypertension on multiple drug medication were followed for 3 months if according to the physician‘s perception BP control was insufficient or patients profit from simplification of drug therapy. Intensification of antihypertensive therapy consisted of switching from multiple pills per day to a single pill combination. Office BP readings and out-of-BP measurements were monitored. The abbreviated PITTSBURGH SLEEP INVENTORY (PSQI) was applied to assess sleep duration and quality Results: In 229 patients (mean age 65 years, 62 % were males) office BP decreased from 158 ± 15/92 ± 8 to 132 ± 10/87 ± 8 mmHg (both p<0.001). In parallel, sleep quality improved in 45 % and remained equal/worse in 53 % (p<0.001) after 3 months In patients whose sleep quality improved (N=95) office BP dropped from 160±15/94±10 to 131±8.6/80±7 mmHg (both p<0.001), whereas in patients with equal or worse sleep quality (N=119) BP fell only from 156±15/90±5 to 133±10/80±8 mmHg (both p<0.001). BP fall was significantly greater in those with improved sleep quality as opposed to those with equal/worse sleep quality after 3 months of therapy (4.98±1.5/2.71±0.94 mmHg, p<0.001 and p=0.005, respectively). Change in out-office systolic BP measurements was greater in those with improved as opposed to those with equal/worse sleep quality (5.80±1.9 mmHg, p=0.003). Thus, intensification of antihypertensive treatment by using single pill combination resulted in significant fall in BP accompanied by an improvement in sleep quality. Abstract Sleep quality improved after intensified blood pressure lowering therapy.docx

scholarly journals The Relationship Between Quality of Sleep with Blood Pressure of Hypertension Patient in Mojolangu PHC, Malang

2018 ◽  
Vol 6 (1) ◽  
pp. 25
Author(s):  
Wahid Nur Alfi ◽  
Roni Yuliwar
Keyword(s):  
Blood Pressure ◽  
Sleep Quality ◽  
Poor Sleep ◽  
United States Department ◽  
Quality Of Sleep ◽  
Cross Sectional ◽  
Department Of Health ◽  
National Heart Lung ◽  
The Relationship

ABSTRAKWHO memperkirakan pada tahun 2020 Penyakit Tidak Menular (PTM) akan menyebabkan 73% kematian dan 60% seluruh kesakitan di dunia (WHO, 2013). Penyakit hipertensi di Indonesia banyak diderita oleh perempuan dengan persentase sebesar 28,8% dan sering tidak menunjukkan gejala serta baru disadari setelah menyebabkan gangguan organ. National Heart, Lung, and Blood Institut dari United States Department of Health and Human Services menginformasikan bahwa kurang tidur atau kualitas tidur yang buruk meningkatkan risiko tekanan darah tinggi, penyakit jantung, dan penyakit lainnya. Penelitian ini bertujuan untuk mengetahui hubungan kualitas tidur dengan tekanan darah pasien hipertensi di Puskesmas Mojolangu Kota Malang. Jenis penelitian ini adalah observasional analitik dengan desain penelitian cross sectional. Populasi dalam penelitian ini adalah seluruh pasien hipertensi di Puskesmas Mojolangu. Penelitian ini menggunakan total populasi dan tidak ada pengambilan sampel. Besar sampel diperoleh berdasarkan periode waktu dan diperoleh besar sampel sejumlah 30 dengan menetapkan beberapa kriteria inklusi dan eksklusi. Variabel dependennya yaitu tekanan darah dan variabel independennya adalah kualitas tidur. Analisis data menggunakan uji koefisien kontingensi. Hasil penelitian menunjukkan mayoritas responden dengan tekanan darah tidak normal sebanyak 53,3% berjenis kelamin perempuan, 43,3% berada dalam kelompok umur 41-60 tahun, 66,7% dengan kualitas tidur buruk. Ada hubungan antara kualitas tidur dengan tekanan darah pada pasien hipertensi dengan kuat hubungan 0,649. Kesimpulan penelitian, sebagian besar responden yang memiliki kualitas tidur buruk akan memiliki kenaikan tekanan darah, sehingga perlu dilakukan penyuluhan dan pendampingan pada penderita hipertensi.Kata Kunci: kualitas tidur, tekanan darah, pasien hipertensi ABSTRACT WHO estimate that, in 2020 non-communicable disease causes of death 73% and 60% of all morbidity in the world (WHO, 2013). In Indonesia, hypertension is suffered by women with 28.8% and often shows no symptoms, only realized after causing organ disorders. The National Heart, Lung, and Blood Institute of the United States Department of Health and Human Services informs that less sleep or poor sleep quality increases the risk of high blood pressure, heart disease and other diseases. This study aims to determine the relationship between the quality of sleep with blood pressure in hypertensive patients in Mojolangu Public Health Center, Malang. The type of this research is observational analytic with cross sectional design. Population in this research is all patient of hypertension in Mojolangu Public Health Center. This study uses total population. The sample size is generated based on the time period and a sample size of 30 is obtained by specifying some inclusion and exclusion criteria. The dependent variable is blood pressure and the independent variable is sleep quality. Analizing data by coeficient contingency. The result of this research are respondents with abnormal blood pressure were 53.3% female, 43.3% were in the 41-60 years old, 66.7% with poor sleep quality. There is a relationship between the quality of sleep with blood pressure in hypertensive patients with a strong relationship (0.649). The  conclusion is respondents who have poor quality of sleep have an increase in blood pressure, so there are needs to be counseling and menthoring for hypertensive patients.Keywords: quality of sleep, blood pressure, hypertension patient

scholarly journals Quality of sleep and hypertension in adolescents

2017 ◽  
Vol 56 (5) ◽  
pp. 272 ◽  
Author(s):  
Arie Taufansyah P. Nasution ◽  
Rafita Ramayati ◽  
Sri Sofyani ◽  
Oke RRna Ramayani ◽  
Rosmayanti Siregar
Keyword(s):  
Blood Pressure ◽  
Sleep Quality ◽  
Later Life ◽  
Cross Sectional Study ◽  
Poor Quality ◽  
Poor Sleep ◽  
Quality Of Sleep ◽  
Poor Sleep Quality ◽  
Cross Sectional

Background Adolescents with hypertension are at risk of morbidity and mortality due to cardiovascular problems in later life. Hypertension may be influenced by poor quality of sleep, so early detection of hypertension and ensuring good quality of sleep in adolescence is needed.Objective To assess for a possible association between poor sleep quality and hypertension in adolescents.Methods We conducted a cross-sectional study from January to March 2013 in Mustafawiyah Boarding School, Mandailing Natal, North Sumatera. Subjects’ quality of sleep was assessed by the Pittsburgh Sleep Quality Index (PSQI) questionnaire and their systolic and diastolic blood pressures were measured. Quality of sleep was categorized as either good or poor. Blood pressure was categorized as either normotensive or hypertensive. An association between poor sleep quality and hypertension was analyzed by Chi-square test.Results Two hundred forty adolescents participated in this study, of whom 210 (87.5%) subjects were normotensive and 30 (12.5%) subjects were hypertensive. We found higher systolic blood pressure [114.9 (SD 11.7) vs. 109.5 (SD 10.5) mmHg as well as diastolic blood pressure [74 (SD 9.1) vs. 69.9 (SD 7.5) mmHg in adolescents with poor sleep quality compared to  those with good sleep quality (P=0.001).Conclusion Poor sleep quality is associated with hypertension in adolescents.

scholarly journals Quality of Sleep Among Elderly with Hypertension at Werdha Institusion in West Java Province

2021 ◽  
Vol 9 (1) ◽  
pp. 133-142
Author(s):  
Wening Handayani ◽  
◽  
Mamat Lukman ◽  
Citra Windani Mambang Sari
Keyword(s):  
Blood Pressure ◽  
Sleep Quality ◽  
Sleep Disturbances ◽  
Vulnerable Groups ◽  
Future Research ◽  
Measuring Instruments ◽  
Poor Sleep ◽  
Quality Of Sleep ◽  
Poor Sleep Quality

Elderly are particularly vulnerable groups that is prone to experiencing a decline in health related to a physiological decline. Vulnerability such as changes in structure of blood vessel walls lead to increased incidence of hypertension. Moreover, in uncontrolled conditions, elderly with hypertension can suffer symptoms of sleeping disorder, changes of sleep pattern that triggers the increasing of blood pressure and affect sleep quality. The purpose of this descriptive quantitative research was to describe the sleep quality of elderly with hypertension based on seven components of sleep quality assessment. The research design used a descriptive quantitative with a cross-sectional approach. The study was conducted at Ciparay and Garut Elderly Social Rehabilitation Centre, with number of the sample obtained 37 elderlies who were elected by total sampling technique. The result of this study showed that 89,2% of respondents had poor sleep quality. Several conditions that stimulate poor sleep quality in the elderly come from high blood pressure which causes sleep disturbances, thereby changing several sleep components such as short sleep duration less than 6 hours, sleep latency 15-30 minutes, decreased sleep efficiency below 85%, and activity dysfunction in daytime. Future research is expected to be able to modify sleep quality measuring instruments that are specifically used to measure the quality of sleep for people with hypertension.

scholarly journals Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kazuhisa Sugai ◽  
Tomoyoshi Tamura ◽  
Motoaki Sano ◽  
Shizuka Uemura ◽  
Masahiko Fujisawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Parasympathetic Nervous System ◽  
Pressure Control ◽  
Hydrogen Gas ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Night Time ◽  
Lowering Effect ◽  
Pressure Lowering

AbstractA recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2 significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H2 was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H2 on hypertension, we used an implanted telemetry system to continuously monitor blood pressure. H2 exerted an anti-hypertensive effect not only during daytime rest, but also during night-time activities. Spectral analysis of blood pressure variability revealed that H2 improved autonomic imbalance, namely by suppressing the overly active sympathetic nervous system and augmenting parasympathetic nervous system activity; these effects co-occurred with the blood pressure-lowering effect. In conclusion, 1-h daily exposure to H2 exerts an anti-hypertensive effect in an animal model of hypertension.

Burden of Care and Its Relationship with Sleep Quality of Cancer Patients’ Caregivers

2021 ◽  
Author(s):  
Mohammadreza Boostaneh ◽  
Mohammad Zirak ◽  
Ramezan Fallah
Keyword(s):  
Sleep Quality ◽  
Cancer Patients ◽  
Poor Sleep ◽  
Burden Of Care ◽  
Quality Of Sleep ◽  
Study Results ◽  
Northwest Of Iran ◽  
The Mean ◽  
Convenience Sampling

Abstract Purpose: This study aimed to assess the burden of care and its relationship with sleep quality of cancer patients’ caregivers.Methods: This descriptive-correlational study was conducted in a referral center of cancer in Zanjan, northwest of Iran. 135 caregivers of cancer patients were recruited through convenience sampling method. The data were collected using a demographic characteristics questionnaire, Novak and Guest’s caregiver burden inventory and Pittsburgh sleep quality index (PSQI). The collected data was analyzed using descriptive and inferential statistics.Results: The mean (± SD) age of the participants was 39.71 (± 10.74) years. The mean (± SD) burden of care and sleep quality of the participants was 45.22 (± 17.75) and 8.88 (± 4.21), respectively. It was found that there is a significant positive relationship between burden of care and quality of sleep scores (r = 0.65, P < 0.001).Conclusion: cancer patients’ caregivers endure a remarkable burden of care and their sleep quality is undesirable. Results indicated that an increase in the burden of care reduces the caregiver’s quality of sleep. High burden of care and poor sleep quality may reduce the quality of the provided care that increase the costs and weakens the disease prognosis. According to the study results, reducing burden of care is an effective strategy regarding improving the caregivers’ quality of sleep that can improve the quality of provided cares by caregivers.

scholarly journals Sleep quality, daytime sleepiness and daytime functioning among Thai obstructive sleep apnea patients receiving continuous positive airway pressure therapy

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Theerakorn Theerakittikul ◽  
Jindarat Chaiard ◽  
Jirawan Deeluea
Keyword(s):  
Sleep Quality ◽  
Daytime Sleepiness ◽  
Positive Airway Pressure ◽  
Quality Of Sleep ◽  
Daytime Functioning ◽  
Content Type ◽  
Cpap Treatment ◽  
Obstructive Sleep

PurposeThe purpose is to assess the effectiveness of continuous positive airway pressure (CPAP) treatment on sleep quality, daytime sleepiness and daytime functioning among Thai obstructive sleep apnea (OSA) patients.Design/methodology/approachA repeated measures clinical intervention design was implemented. Participants were 50 patients first time diagnosed with OSA and prescribed CPAP treatment. The intervention composed of CPAP health education, and follow-up evaluation. Data on CPAP adherence were downloaded from Smartcards of the CPAP device. The Thai PSQI, ESS and FSAQ-10 questionnaires were administered at baseline, 1-month, and 3-months. Descriptive statistics and repeated measure analysis with multilevel mixed-effects modeling approach were used.FindingsThirty-nine participants completed the study. Approximately 53% (n = 25) and 71.1% (n = 27) of the patients adhered to CPAP treatment by the end of the 1- and 3-months, respectively. After controlling for patients’ adherence, at 1-month follow-up, the intervention improved quality of sleep (β = −2.65, 95% CI = −1.60, −4.13), daytime functioning (β = 3.24, 95% CI = 1.87, 4.61) and decreased daytime sleepiness (β = −3.29, 95% CI = −1.85, −4.73). At 3 months, the intervention still improved quality of sleep (β = −3.53, 95% CI = −2.05, −5.01), and daytime functioning (β = 4.34, 95% CI = 2.76, 5.92), and decreased daytime sleepiness (β = −4.82, 95% CI = −3.16, −6.49).Originality/valueAdherence to CPAP treatment is effective in improving sleep quality, daytime functioning and reducing daytime sleepiness. Patient-oriented strategies for enhancing CPAP adherence should be developed and implemented as a standard care in sleep clinics.

scholarly journals Quality of sleep and burnout among undergraduate medical students at the university of Nairobi, Kenya

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S279-S279
Author(s):  
Linda Nyamute ◽  
Muthoni Mathai ◽  
Anne Mbwayo
Keyword(s):  
Academic Performance ◽  
Medical Students ◽  
Sleep Quality ◽  
Poor Sleep ◽  
Quality Of Sleep ◽  
Undergraduate Medical Students ◽  
Poor Sleep Quality ◽  
Significant Positive Association ◽  
The University

AimsThe main objective was to determine whether quality of sleep is associated with burnout among undergraduate medical students at the University of Nairobi.The null hypothesis in our study population was; 'There is no significant association between poor sleep quality and burnout'.BackgroundIn a pressure prevailing environment, medical students find themselves in a vicious cycle of cutting down on sleep in attempts to cope and adjust to increasing workloads. Students with poor sleep quality have been found to perform worse in their board exam and have strained social engagements. Ultimately, this chronic sleep deprivation may lead to burnout which may cause diminished sense of accomplishment and impaired professional conduct, that may be carried on to the career as a physician. High levels of burnout have been associated with suicides.MethodThe sample size obtained was 384 and participants were selected by a mixed sampling method. Data collection was through self-administered questionnaires. Scales used for this study were the Pittsburg Sleep Quality Index(PSQI) and the Oldenburg Burnout Inventory(OLBI).Ethical considerations were adhered to and approval obtained from the Kenyatta National Hospital-University of Nairobi(KNH-UON) Ethics Board. Data entry and analysis was by SPSS v23. Data from 336 questionnaires were deemed fit for analysis.ResultWith a response rate of 87.5%, the prevalence of poor sleep quality and burnout were 69.9% and 74.7% respectively. There was a significant positive association between poor sleep quality and female gender, clinical years of study, living with family, poorly perceived socio-economic state and poor subjective academic performance. In addition, being female, younger, pre-clinical years, living independently off-campus and poor subjective academic performance were significantly associated with higher levels of burnout.Burnout had a significant correlation with poor sleep quality. Daytime functioning, a component of sleep quality had the highest correlation with components of burnout, disengagement and exhaustion. Overall, 57% of the respondents had both poor sleep quality &burnout, while only 12% were good sleepers with no burnout. Furthermore, having poor sleep increased the risk of having burnout by 2.8times. It is crucial that students adopt better sleeping habits to reduce the risk of burnout.ConclusionWith the high prevalence of poor sleep quality and burnout, peer-support groups and peer-led mentorship programs are recommended within this population to help deal with expectations, challenges and difficulties encountered within the course of medical education, in addition to preparing for the early future careers.

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