Synthesis and Structural Properties of Copper(II), Nickel(II) and Cobalt(II) Complexes with 2,4-Furyliminobenzylacetophenone

The new Schiff base ligand (FIAS) 2,4-furyliminobenzylacetophenone has been synthesized with 4-aminoacetophenone and furane-2-carboxaldehyde by condensation in ethanol. Metal complexes of the ligand were prepared with chloride salts of copper(II), nickel(II) and cobalt(II) in ethanol. The ligand and its metal complexes have been characterized by microanalysis, magnetic susceptibility, FTIR, 1H and 13C NMR, mass spectrum, and UV-visible spectroscopy techniques. From these findings, it is suggested that metal ion coordinate by imines nitrogen and carboxylic oxygen atoms of FIAS to form octahedral geometry. All the newly compounds were tested antimicrobial activity against bacterial and fungal species.

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Synthesis, Characterization and Antimicrobial Studies of N1-[(1E)-1-(2-Hydroxyphenyl) ethylidene]-2-oxo-2H-chromene-3-carbohydrazide and its Metal Complexes

E-Journal of Chemistry ◽

10.1155/2009/416836 ◽

2009 ◽

Vol 6 (3) ◽

pp. 615-624 ◽

Cited By ~ 2

Author(s):

K. Siddappa ◽

K. Mallikarjun ◽

Tukaram Reddy ◽

M. Mallikarjun ◽

C. V. Reddy ◽

...

Keyword(s):

Antimicrobial Activity ◽

Magnetic Susceptibility ◽

Schiff Base ◽

Metal Complexes ◽

Molar Conductance ◽

Tetrahedral Geometry ◽

H Nmr ◽

Antimicrobial Studies ◽

Mononuclear Complexes ◽

Uv Visible

A new complexes of the type ML, MʹL and M″L [where M=Cu(II), Co(II), Ni(II) and Mn(II), Mʹ=Fe(III) and M″=Zn(II), Cd(II) and Hg(II) and L=N1-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-oxo-2H-chromene- 3-carbohydrazide (HL)] Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly monodentate bridge for metal ions and form mononuclear complexes. The complexes Ni(II), Co(II), Cu(II) Mn(II) and Fe(III) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal complexes were screened for their antimicrobial activity.

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Studies of Mixed Ligand Lanthanum Complexes: Synthesis, Spectral Interpretations and Antibacterial Study

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i37a31992 ◽

2021 ◽

pp. 161-174

Author(s):

Sunil Patil ◽

Bhushan Langi ◽

Minakshi Gurav ◽

Digambar Patil

Keyword(s):

Magnetic Susceptibility ◽

Ftir Spectroscopy ◽

Elemental Analysis ◽

Metal Ion ◽

Antibacterial Activities ◽

Decomposition Temperature ◽

Mixed Ligand ◽

Visible Spectroscopy ◽

Uv Visible ◽

Xrd Techniques

The mixed ligand lanthanum complexes have been synthesized using polydentate ligands. The (2Z)-2-(N-hydroxyimino)-1,2-diphenylethan-1-ol (cupron) was used as a primary ligand and L-isolucine, L-threonine, L-lysine and L-glycine were used as secondary ligands for the synthesis. Conductometry, elemental analysis, magnetic susceptibility measurements, complexometric estimation, UV-Visible spectroscopy, FTIR spectroscopy, thermal analysis and XRD methods were used for structural interpretation of all synthesized complexes. All complexes were solid and white and slight yellow in colour. They are non-electrolytic and diamagnetic in nature, as confirmed by conductometric and magnetic susceptibility methods respectively. All the complexes were synthesized by combination of lanthanum metal ion, primary ligand and secondary ligands in 1:2:1 ratio which was confirmed by elemental analysis. During reaction between lanthanum ion, primary ligand and secondary ligands there was transition of electrons which was confirmed by UV-Visible spectroscopy. Identification of functional group in the complexes was carried out and confirmed by FTIR spectroscopy. The decomposition temperature and thermal behaviour of the complexes have been concluded by thermal and XRD techniques. Tube dilution and agar cup methods have been employed to study antibacterial activities of all synthesized lanthanum complexes. The inhibition potential was seen to some extent.

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Synthesis, Characterization and Biological Activity of Ni(II), Cu(II) and Fe(III) Complexes Derived from N2,N6-bis(5-Mercapto-1,3,4-thiadiazol-2-yl)pyridine-2,6-dicarboxamide

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22627 ◽

2020 ◽

Vol 32 (7) ◽

pp. 1691-1696

Author(s):

Anuroop Kumar ◽

Netra Pal Singh ◽

Uma Agrawal ◽

Kaushal Kumar

Keyword(s):

Antimicrobial Activity ◽

Metal Complexes ◽

Metal Ion ◽

Inhibitory Concentration ◽

Inhibition Zone ◽

Molar Conductance ◽

Minimal Bactericidal Concentration ◽

Spectroscopic Techniques ◽

Uv Visible ◽

Bacteria And Fungi

Novel metal complexes of the type [M(L)X] (where M= Cu(II), Ni(II) and Fe(III), L = N2,N6-bis(5-mercapto-1,3,4-thiadiazol-2-yl)pyridine-2,6-dicarboxamide, X= Cl−, CH3COO−) were synthesized by the reaction of pyridine-2,6-dicarboxylic acid and 2-amino-5-mercepto-1,3,4-thiadiazole. The synthesized ligand was reacted in THF with metal salts (Cu, Ni and Fe) to form complexes. Deprotonated ligand shows tridentate nature and coordinate to metal ion to form pincer cavity. In all, complexes metals were surrounded by three nitrogen atom and other site coordinated by other groups (chloride, acetate). All the synthesized complexes were characterized by spectroscopic techniques like UV-visible, 13C NMR and 1HNMR, IR spectroscopy, DSC, elemental analysis and molar conductance measurements. The ligand and its metal complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity and antifungal activity when tested against bacteria and fungi

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Synthesis, Characterization and Antimicrobial Activity of Ni(II), Zn(II), and Cd(II) Complexes of 3/4-Bromo-Benzoic Acid (Phenyl-Pyridine-2-yl-Methylene)-Hydrazide Ligand

Letters in Applied NanoBioScience ◽

10.33263/lianbs94.15291537 ◽

2020 ◽

Vol 9 (4) ◽

pp. 1529-1537

Keyword(s):

Antimicrobial Activity ◽

Benzoic Acid ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Metal Ion ◽

Trichophyton Rubrum ◽

Salmonella Typhi ◽

Spectral Studies ◽

Mass Analysis ◽

Uv Visible

New transition metal complexes [Ni(L)2], [Zn(L)Cl], [Zn(L)2] and [Cd(L)2] were synthesized from 3-bromo-benzoic acid (phenyl-pyridin-2-yl-methylene)-hydrazide (3Bbpph) and 4-bromo-benzoic acid (phenyl-pyridin-2-yl-methylene)-hydrazide (4Bbpph) ligands and were characterized by different physicochemical and spectral studies - IR, elemental, UV Visible, 1H NMR spectra and mass analysis. The data revealed the presence of tetra-coordinate [Zn (L)Cl], whereas [Ni(L)2], [Zn(L)2], and [Cd(L)2] complexes consist of metal ion coordinated with two molecules of ligand to form octahedral geometry. The ligands act as monobasic, tridentate, and coordinated through enolate-O, azomethine-N, and pyridyl-N atoms. The antimicrobial activity of the ligands and metal complexes was investigated against Staphylococcus Aureus, Streptococcus Pyogenes, Escherichia coli, Salmonella typhi, Candida Albicans and Trichophyton Rubrum which revealed that the metal complexes exhibit greater activity than the parent ligands.

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Synthesis, Characterization and Antimicrobial Screening of Novel Hydrazide Ligand & It’s Transition Metal Complexes

Asian Journal of Chemistry ◽

10.14233/ajchem.2019.21795 ◽

2019 ◽

Vol 31 (4) ◽

pp. 938-942

Author(s):

S.P. Bhale ◽

A.R. Yadav ◽

S.U. Tekale ◽

R.B. Nawale ◽

R.P. Marathe ◽

...

Keyword(s):

Transition Metal ◽

Metal Ions ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Metal Ion ◽

Octahedral Geometry ◽

Tetrahedral Geometry ◽

Metal Acetate ◽

Spectral Techniques ◽

Chloride Salts

Different transition metal complexes were synthesized from novel 3-bromo-2-[1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)ethylidene]hydrazide ligand (H2L) and characterized by spectral techniques. The synthesized ligand was found to act mono as well as di deprotonated (OH, NH) manner and stoichiometry of the ligand to metal ions was confirmed to be 1:1 in case of complex using metal chloride salts, whereas 1:2 in case of metal(II) complexes using metal acetate(II) salt. Structures of metal complexes were confirmed by IR, 1H NMR, TGA, XRD, elemental analysis and UV technique which revealed that Mn(II), Co(II), Ni(II), Cu(II) complexes were octahedral geometry and those of Cu(II), Zn(II) showed square planner and tetrahedral geometry around metal ion respectively. Furthermore H2L and its metal complexes were screened for antimicrobial activity which showed that ligand enhanced its biological activity after coordination with metal ions. In particular, Cd(II) and Mn(II) complexes exhibited excellent antifungal activity.

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Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens

Journal of Chemistry ◽

10.1155/2020/2720697 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Alberta Ade ◽

Cedric D. K. Amengor ◽

Abena Brobbey ◽

Isaac Ayensu ◽

Benjamin K. Harley ◽

...

Keyword(s):

Streptococcus Pneumoniae ◽

Klebsiella Pneumoniae ◽

Inhibitory Concentration ◽

Fungal Species ◽

Human Pathogens ◽

Visible Spectroscopy ◽

Active Compounds ◽

Gram Negative ◽

Uv Visible

A library of six novel phenylhydrazones were synthesized and evaluated for their in vitro antimicrobial and resistance modulating activity against a panel of Gram-positive, Gram-negative, and fungal species. The compounds were produced in good yields of 60–92% w/w and characterized using melting point, UV-visible spectroscopy, infrared, and nuclear magnetic resonance (1H, 13C, and DEPT-Q) techniques. Mass spectroscopy was used to confirm the identity of one of the most active compounds, 5 [SA5]. The phenylhydrazones showed activity against all the six selected microorganisms with minimum inhibitory concentration (MIC) values of the most active compounds, 1 [BP1] and 5 [SA5], at 138 µM (Klebsiella pneumoniae) and 165 µM (Streptococcus pneumoniae), respectively. Compound 1 [BP1] further demonstrated a high resistance modulatory activity at 1.078 µM against Streptococcus pneumoniae and Klebsiella pneumoniae.

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Structural Characterization, Antimicrobial Activity, and In Vitro Cytotoxicity Effect of Black Seed Oil

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/6515671 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 6

Author(s):

Sewara J. Mohammed ◽

Hassan H. H. Amin ◽

Shujahadeen B. Aziz ◽

Aram M. Sha ◽

Sarwar Hassan ◽

...

Keyword(s):

Antimicrobial Activity ◽

Structural Characterization ◽

Seed Oil ◽

Double Bonds ◽

Visible Spectroscopy ◽

Cytotoxic Effects ◽

Black Seed ◽

Uv Visible ◽

Black Seed Oil

This study was aimed to investigate the structure of bioactive components of black seed oil (BSO) and their antimicrobial and cytotoxic effects. Initially, the structural examination was conducted using various spectroscopic techniques, such as FTIR, TLC, and UV-visible spectroscopy, which are important in determining substituents, functional groups, and the presence of conjugated double bonds in BSO. From the FTIR spectra, a variety of sharp, strong, and weak peaks were specified relating to the main components of thymoquinone (TQ), dithymoquinone, thymohydroquinone, and thymol in BSO. The results of UV-visible spectroscopy confirmed the presence of thymoquinone as a major compound, and conjugated double bonds were also found. In addition, qualitative TLC analysis was used to identify thymoquinone from the methanol-extracted layer in BSO, by calculating the retention factor (Rf) value. Furthermore, antimicrobial activity of BSO was studied against various types of bacteria. Strong bacterial inhibitory effects were observed, especially against Bacillus subtilis, with an average inhibition zone of 15.74 mm. Moreover, through the use of the MTT assay in vitro, it was shown that BSO does not exhibit any cytotoxicity towards human peripheral blood mononuclear cells (PBMCs). It was also found from the structural characterization of BSO that the existence of TQ is responsible for potential antibacterial activity without any cytotoxic effects. The main observation of this work is that BSO has antimicrobial activity even against methicillin-resistant Staphylococcus aureus (MRSA).

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Studies on complexes of VO(II), Mn(II), Cu(II), Ni(II), Co(II), Zn(II), Fe(III), and UO2(II) with hydrazone β-diketone ligands

Canadian Journal of Chemistry ◽

10.1139/v90-122 ◽

1990 ◽

Vol 68 (5) ◽

pp. 774-781 ◽

Cited By ~ 5

Author(s):

Mohamed S. Abdel-Moez ◽

Shaker L. Stefan ◽

Mostafa M. El-Behairy ◽

Mohamed M. Mashely ◽

Basheir A. El-Shetary

Keyword(s):

Magnetic Susceptibility ◽

Transition Metal ◽

Ir Spectra ◽

Metal Ions ◽

Metal Complexes ◽

Stability Constants ◽

Transition Metal Complexes ◽

Elemental Analysis ◽

Water Solvent ◽

Uv Visible

The stepwise stability constants of VO(II), Mn(II), Cu(II), Ni (II), Co(II), Zn(II), Fe(III), and UO2(II) metal ions with 2-(2-acetylphenylhydrazone)-5,5-dimethyl-1,3-cyclohexane dione (2-APHDm), 3-(2-acetylphenylhydrazone)pentane-2,4-dione (2-APHA), 2-(2-acetylphenylhydrazone)-1-phenyl-1,3-butane dione (2-APHB), 2-(2-acetylphenylhydrazone)-1,3-diphenyl-1,3-propane dione (2-APHDB), and 3-(2-acetylphenylhydrazone)-1,1,1-trifluoropentane-2,4-dione (2-APHTA) were determined at 30 °C by pH titrations in 75% (v/v) dioxane–water solvent. In addition, metal complexes of three related β-diketones, 2-APHA, 2-APHB, and 2-APHDB have been synthesized and characterized by elemental analysis, uv–visible, ir spectra, and conductance in DMF and magnetic susceptibility measurements. The structure of the complexes have been proposed. Keywords: transition metal complexes of hydrazone-β-diketone ligands.

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Antimicrobial Applications of Transition Metal Complexes of Benzothiazole Based Terpolymer: Synthesis, Characterization, and Effect on Bacterial and Fungal Strains

Bioinorganic Chemistry and Applications ◽

10.1155/2014/764085 ◽

2014 ◽

Vol 2014 ◽

pp. 1-16 ◽

Cited By ~ 10

Author(s):

Mohamed A. Riswan Ahamed ◽

Raja S. Azarudeen ◽

N. Mujafar Kani

Keyword(s):

Metal Complexes ◽

Elemental Analysis ◽

Biological Activities ◽

Gel Permeation Chromatography ◽

Spectral Studies ◽

X Ray Diffraction ◽

Spectral Techniques ◽

H Nmr ◽

Uv Visible ◽

C Nmr

Terpolymer of 2-amino-6-nitro-benzothiazole-ethylenediamine-formaldehyde (BEF) has been synthesized and characterized by elemental analysis and various spectral techniques like FTIR, UV-Visible, and1H and13C-NMR. The terpolymer metal complexes were prepared with Cu2+, Ni2+, and Zn2+metal ions using BEF terpolymer as a ligand. The complexes have been characterized by elemental analysis and IR, UV-Visible, ESR,1H-NMR, and13C-NMR spectral studies. Gel permeation chromatography was used to determine the molecular weight of the ligand. The surface features and crystalline behavior of the ligand and its complexes were analyzed by scanning electron microscope and X-ray diffraction methods. Thermogravimetric analysis was used to analyze the thermal stability of the ligand and its metal complexes. Kinetic parameters such as activation energy(Ea)and order of reaction (n) and thermodynamic parameters, namely,ΔS,ΔF,S*, andZ, were calculated using Freeman-Carroll (FC), Sharp-Wentworth (SW), and Phadnis-Deshpande (PD) methods. Thermal degradation model of the terpolymer and its metal complexes was also proposed using PD method. Biological activities of the ligand and its complexes were tested againstShigella sonnei,Escherichia coli,Klebsiellaspecies,Staphylococcus aureus,Bacillus subtilis, andSalmonella typhimuriumbacteria andAspergillus flavus,Aspergillus niger,Penicilliumspecies,Candida albicans,Cryptococcus neoformans,Mucor speciesfungi.

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Synthesis and Antimicrobial Activity of a Silver-Hydroxyapatite Nanocomposite

Journal of Nanomaterials ◽

10.1155/2009/498505 ◽

2009 ◽

Vol 2009 ◽

pp. 1-6 ◽

Cited By ~ 55

Author(s):

Marcos Díaz ◽

Flora Barba ◽

Miriam Miranda ◽

Francisco Guitián ◽

Ramón Torrecillas ◽

...

Keyword(s):

Antimicrobial Activity ◽

Reduction Process ◽

Bactericidal Effect ◽

Gram Negative Bacteria ◽

Subsequent Reduction ◽

Visible Spectroscopy ◽

High Antimicrobial Activity ◽

Chemical Route ◽

Uv Visible ◽

High Degree

A silver-hydroxyapatite nanocomposite has been obtained by a colloidal chemical route and subsequent reduction process in H2/Ar atmosphere at350∘C. This material has been characterized by TEM, XRD, and UV-Visible spectroscopy, showing the silver nanoparticles (∼65 nm) supported onto the HA particles (∼130 nm) surface without a high degree of agglomeration. The bactericidal effect against common Gram-positive and Gram-negative bacteria has been also investigated. The results indicated a high antimicrobial activity forStaphylococcus aureus, PneumococcusandEscherichia coli,so this material can be a promising antimicrobial biomaterial for implant and reconstructive surgery applications.

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