scholarly journals Nodal mycobacterial spindle cell pseudotumor: A diagnostic pitfall

2021 ◽  
Vol 8 (1) ◽  
pp. 33
Author(s):  
Daniel Christensen ◽  
Esteban Gnass ◽  
Guldeep Uppal
Keyword(s):  
Lymph Node ◽  
Mediastinal Mass ◽  
Spindle Cell ◽  
Immunosuppressed Patient ◽  
Diagnostic Challenge ◽  
Diagnostic Pitfall ◽  
Diagnostic Confusion ◽  
Inflammatory Pseudotumors ◽  
Generalized Lymphadenopathy ◽  
Benign Mass

Inflammatory pseudotumor (IPT) is a rare benign mass forming lesion that has been reported in virtually every organ, and can closely mimic spindle cell neoplasms. Mycobacterial spindle cell pseudotumor (MSP) represents a small proportion of IPT of the lymph node, which occur in immunocompromised patients, posing a diagnostic challenge. We report three cases of MSP involving two AIDS patients who presented with generalized lymphadenopathy, and one immunosuppressed patient with a mediastinal mass. Biopsy in these cases revealed effaced architecture replaced by proliferating fibrohistiocytic spindle cells, fibrosis and polymorphic inflammatory infiltrate. Inflammatory pseudotumors and other spindle cell neoplasms of the lymph node can show overlapping morphologic features, resulting in diagnostic confusion. A differential diagnosis of Mycobacterial spindle cell pseudotumor should be kept in mind when approaching localized or generalized lymphadenopathy in an immunocompromised patient.

Spindle cell lipoma mimicking pleomorphic adenoma: A diagnostic challenge on cytology

2018 ◽  
Vol 47 (4) ◽  
pp. 341-344
Author(s):  
Manveen Kaur ◽  
Debajyoti Chatterjee ◽  
Reetu Kundu ◽  
Rajpal S. Punia ◽  
Vaibhav Saini
Keyword(s):  
Pleomorphic Adenoma ◽  
Spindle Cell ◽  
Spindle Cell Lipoma ◽  
Diagnostic Challenge

A Sarcocystis-like Protozoon in a Sheep with Lymphadenopathy and Myocarditis

1978 ◽  
Vol 15 (2) ◽  
pp. 186-195 ◽  
Author(s):  
T. Landsverk ◽  
H. Gamlem ◽  
R. Svenkerud
Keyword(s):  
Electron Microscopy ◽  
Endothelial Cells ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Light Microscopy ◽  
Vascular Endothelial Cells ◽  
Protozoan Parasite ◽  
Capillary Endothelium ◽  
Vascular Endothelial ◽  
Generalized Lymphadenopathy

A generalized enlargement of the lymph nodes was found in an emaciated adult ewe. Additional autopsy findings included tiny grey-white necrotic foci in the heart muscle, aspiration pneumonia and diffuse pleuritis. Light microscopy showed a generalized lymphadenopathy with Perilymphadenitis, depletion of lymphocytes and histiocytosis of the lymph node. In histiocytes and vascular endothelial cells of lymph nodes, septal capillary endothelium of lungs and capillary endothelium of myocardium, early stages of a protozoan parasite were found. In the myocardium, there were many foci of necrosis, some of which contained young cysts in the periphery. These cysts were morphologically similar to those of Sarcocystis. Electron microscopy of the early protozoan stages yielded evidence of schizogony and formation of merozoites.

Reactive Lymphoid Hyperplasia or Tubercular Lymphadenitis: Can Real-Time PCR on Fine-Needle Aspirates Help Physicians in Concluding the Diagnosis?

2018 ◽  
Vol 62 (3) ◽  
pp. 204-208 ◽  
Author(s):  
Vivek Gupta ◽  
Arvind Bhake
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Real Time ◽  
Predictive Value ◽  
Lymphoid Hyperplasia ◽  
Reactive Lymphoid Hyperplasia ◽  
Rt Pcr ◽  
Likelihood Ratios ◽  
Diagnostic Challenge ◽  
Cross Sectional

Background: Enlarged lymph nodes in adult patients often present a diagnostic challenge. In the absence of granuloma or necrosis, the cytology/tissue findings are misleading and relate the enlarged lymph nodes to reactive lymphoid hyperplasia (RLH), because granuloma formation is an immunological response that usually takes 14–100 days to develop. This study assesses the role of real-time (RT)-PCR in the diagnosis of the Mycobacterium complex (MTBC) in lymph node aspirates compared with culture in cases of RLH. Methods: A cross-sectional study was conducted on 112 patients, aged 15–74 years, with a diagnosis of RLH on cytology. RT-PCR for MTBC detection and culture on Löwenstein-Jensen medium for tubercular bacilli was done on lymph node aspirates. Comparative values with reference to culture were calculated. The χ2 value, positive predictive value (PPV), negative predictive value (NPV), and likelihood ratios (LR) were calculated. Results: Out of 112 RLH cases, 35 (31%) were positive on both RT-PCR and culture. RT-PCR was positive in 43 cases and culture was positive in 44 cases. The χ2 test was found to be highly significant. PPV, NPV, positive LR, and negative LR were 81.4%, 87%, 6.76, and 0.23, respectively. Conclusion: RT-PCR for MTBC proves to be useful in arriving at a conclusive diagnosis in patients with a cytological diagnosis of RLH.

Malignant Transformation of Metaplastic Thymoma into High-Grade Sarcomatoid Carcinoma: A Case Report

2021 ◽  
pp. 106689692110704
Author(s):  
Zheng Hua Piao ◽  
Jin Ping Chen ◽  
Hai Ren Chen ◽  
Xin Cheng Zhou
Keyword(s):  
Mediastinal Mass ◽  
Spindle Cell ◽  
Postoperative Radiotherapy ◽  
Sarcomatoid Carcinoma ◽  
Anterior Mediastinal Mass ◽  
High Grade ◽  
Ki 67 ◽  
Cellular Atypia ◽  
Spindle Cells ◽  
Cell Components

The correlation of histogenesis between metaplastic thymoma and thymic sarcomatoid carcinoma is unclear. We report a case of metaplastic thymoma transformed into high-grade sarcomatoid carcinoma. A 64  ×  54  ×  32 mm anterior mediastinal mass in a 61-year-old woman microscopically consisted mainly of classic metaplastic thymoma, with the center dominated by high-grade sarcomatoid carcinoma. In some areas, both epithelial and spindle cell components of the metaplastic thymoma showed increased cellular atypia, mitotic activity, and focal necrosis and gradually transformed into the polygonal/pleomorphic and spindle cell components of sarcomatoid carcinoma. Immunohistochemically, the characteristics of the polygonal/pleomorphic sarcomatoid cells were similar to those of the epithelial component of metaplastic thymoma, while the spindle sarcomatoid cells were more similar to the spindle cells component of metaplastic thymoma. The Ki-67 index was less than 5% in the metaplastic thymoma areas but up to 70% in the sarcomatoid carcinoma area. Radical operation and postoperative radiotherapy were performed. Multifocal relapses at the pleura occurred 13 months after surgery.

GENERALIZED LYMPHADENOPATHY AND HEPATOSPLENOMEGALY INDUCED BY DIPHENYLHYDANTOIN

PEDIATRICS ◽  
1961 ◽  
Vol 28 (6) ◽  
pp. 943-945
Author(s):  
Mehdi Bajoghli
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Drug Therapy ◽  
Biopsy Specimen ◽  
Lymphoid Hyperplasia ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Generalized Lymphadenopathy

A 6-year-old child developed generalized lymphadenopathy and hepatosplenomegaly 2 weeks after diphenylhydantoin therapy was begun. The patient recovered 4 weeks after discontinuance of the drug therapy. There was eosinophilia in blood and in bone marrow, and a lymph node biopsy specimen showed reticulum and lymphoid hyperplasia.

Results of initial lymph node biopsy in homosexual men with generalized lymphadenopathy.

1986 ◽  
Vol 4 (2) ◽  
pp. 165-169 ◽  
Author(s):  
A M Levine ◽  
P R Meyer ◽  
P S Gill ◽  
R L Burkes ◽  
M Krailo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Laboratory Data ◽  
Clinical Parameter ◽  
Lymph Node Biopsy ◽  
Homosexual Men ◽  
Laboratory Findings ◽  
Node Biopsy ◽  
Significant Difference ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy

Persistent, generalized lymphadenopathy (PGL) is considered part of the acquired immunodeficiency syndrome (AIDS)-related complex. The clinical course is usually benign, although some patients may evolve to AIDS. Characteristic features on lymph node biopsy have been described. Recently, large series of PGL have been reported in which many study patients have not undergone initial diagnostic biopsy. The value of such biopsy has been questioned. We report the clinical, pathologic, and laboratory findings in six homosexual men initially considered as potential candidates for study of the natural history of PGL. They were excluded by initial lymph node biopsy, which revealed small-cleaved lymphoma in two, focal Kaposi's sarcoma in two, disseminated mycobacterium tuberculosis in one, and histoplasma encapsulatum in one. The clinical and laboratory data from these six patients were compared with those from 34 patients with biopsy-proven PGL; no statistically significant difference in any prebiopsy clinical parameter was found. We conclude that initial lymph node biopsy may reveal changes other than reactive hyperplasia in homosexual men with generalized lymphadenopathy.

scholarly journals LAPAROSCOPIC LYMPHADENECTOMY FOR POSTOPERATIVE LYMPH-NODE METASTASIS OF RENAL MUCINOUS TUBULAR AND SPINDLE CELL CARCINOMA: A CASE REPORT

2017 ◽  
Vol 108 (1) ◽  
pp. 30-34
Author(s):  
Hikaru Mikami ◽  
Yuki Endo ◽  
Masato Yanagi ◽  
Kaoru Nemoto ◽  
Tsutomu Hamasaki ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Node Metastasis

scholarly journals Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report

2020 ◽  
Vol 12 (1) ◽  
pp. 70-75
Author(s):  
Erika Wernheden ◽  
Hannah Trøstrup ◽  
Anette Pedersen Pilt
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Regional Lymph Node ◽  
Single Cells ◽  
Gluteal Region ◽  
Inguinal Lymph Node Dissection ◽  
Desmoplastic Melanoma

Cutaneous spindle cell squamous cell carcinoma (SpSCC) is a rare and often aggressive subtype of squamous cell carcinoma (SCC), which usually appears in sun-exposed areas, in areas that have received prior ionizing radiation, or in immunosuppressed individuals. SpSCCs are histologically characterized by keratinocytes infiltrating the dermis as single cells with elongated nuclei rather than as cohesive nests or islands and, in contrast to conventional SCC, are lacking features of keratinization. Immunohistochemical studies are useful to distinguish SpSCC from other spindle cell neoplasms, such as spindle cell/desmoplastic melanoma, cutaneous leiomyosarcoma, and atypical fibroxanthoma. We present a rare case of a patient with SpSCC in the gluteal region with regional lymph node metastasis. The patient was treated with wide excision of the tumor, inguinal lymph node dissection, and adjuvant radiotherapy. Cutaneous SpSCC is clinically similar to conventional SCC but can demonstrate more aggressive behavior. This case is rare since it was localized in the gluteal region of an otherwise healthy man.

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