Effects of alpha-lipoic acid and its combined use with vitamin C on periodontal tissues and markers of oxidative stress in rats with experimental periodontitis

Antioxidants are known to minimize oxidative stress by interacting with free radicals produced as a result of cell aerobic reactions. Oxidative stress has long been linked to many diseases, especially tumours. Therefore, antioxidants play a crucial role in the prevention or management of free radical-related diseases. However, most of these antioxidants have anticancer effects only if taken in large doses. Others show inadequate bioavailability due to their instability in the blood or having a hydrophilic nature that limits their permeation through the cell membrane. Therefore, entrapping antioxidants in liposomes may overcome these drawbacks as liposomes have the capability to accommodate both hydrophilic and hydrophobic compounds with a considerable stability. Additionally, liposomes have the capability to accumulate at the cancer tissue passively, due to their small sizes, with enhanced drug delivery. Additionally, liposomes can be engineered with targeting moieties to increase the delivery of chemotherapeutic agents to specific tumour cells with decreased accumulation in healthy tissues. Therefore, combined use of liposomes and antioxidants, with or without chemotherapeutic agents, is an attractive strategy to combat varies tumours. This mini review focuses on the liposomal delivery of selected antioxidants, namely ascorbic acid (AA) and alpha-lipoic acid (ALA). The contribution of these nanocarriers in enhancing the antioxidant effect of AA and ALA and consequently their anticancer potentials will be demonstrated.

Download Full-text

Antioxidants Supplementation In Acute Amitriptyline Abuse for Pain

10.21203/rs.3.rs-724699/v1 ◽

2021 ◽

Author(s):

Hameed Kadar Ali S ◽

Wasim Ali Raja K ◽

IRFAN Navabshan ◽

Mohammad Habeeb ◽

Ismail Y

Keyword(s):

Oxidative Stress ◽

Vitamin C ◽

Lipoic Acid ◽

Standard Treatment ◽

Human Subjects ◽

Control Group ◽

P Value ◽

Alpha Lipoic Acid ◽

Group V ◽

Group I

Abstract The fundamental aim of this study is to establish the role of anti-oxidant supplementation in alleviating acute amitriptyline induced oxidative stress. The effect of supplementation was compared on treatment of acute amitriptyline intoxication cases for pain management, with Alpha lipoic acid (ALA) alone or with vitamin C, with that of healthy individuals (Group I), and those receiving only routine standard treatment (RST) as control (Group II). Total of 132 human subjects divided into 5 groups were supplemented with either placebo, RST, RST with Vitamin C, RST with ALA, or RST with Vitamin C and ALA. Results of this study revealed that the decrease in the level of oxidative stress and enzyme activity was observed among those supplemented with either Alpha lipoic acid alone or along with vitamin C, with a slightly more decrease in the latter group. P value < 0.001 was considered statistically significant. The percentage of benefit of treatment on supplementation with vitamin C and Alpha lipoic acid showed a marked increase in-group V cases after supplementation with both in combination. The results provided that the oxidative stress induced by acute amitriptyline poisoning is comparatively decreased by supplementation with antioxidants like Alpha lipoic acid and Vitamin C, than those only on routine standard treatment.

Download Full-text

OXIDATIVE STRESS IN EXPERIMENTAL PERIODONTITIS

Bulletin Biomedicine and sociology ◽

10.26787/nydha-2618-8783-2020-5-4-67-72 ◽

2020 ◽

pp. 67-72

Author(s):

Zakhvatov A.N. ◽

Hajdar D.A. ◽

Tarasova T.V. ◽

Avanesov A.M. ◽

Samarina D.V. ◽

...

Keyword(s):

Oxidative Stress ◽

Free Radical ◽

Free Radical Oxidation ◽

Total Activity ◽

The Body ◽

Antioxidant Potential ◽

Radical Oxidation ◽

Periodontal Tissues ◽

Markers Of Oxidative Stress ◽

Experimental Periodontitis

Relevance. The study of bioradical processes in periodontitis in the dynamics of the disease and the establishment of the role of predictors of periodontal tissue damage will provide a deeper understanding of the links of pathogenesis and, on this basis, introduce new therapeutic and diagnostic technologies into practice. The purpose of the study: Assessment of the level of markers of oxidative stress in experimental periodontitis in the dynamics of the study. Materials and methods. The study was conducted on white non-linear rats, reproducing the model of periodontitis proposed by Shkolnaya K. D., Atrushkevich V. G. (Patent RU No. 2625295 of 12.07.2017). The total activity of free radical oxidation and the body's antioxidant potential were evaluated by biochemiluminescence, the intensity of lipoperoxidation processes, and the enzyme antioxidant potential. Results. A comprehensive analysis of the overall oxidative and antioxidant capacity of the body was carried out, during which it was revealed that progressive experimental periodontitis causes inhibition of the antioxidant potential and is characterized by a violation of the processes of neutralization of reactive oxygen species and the inability to inhibit the launched reactions of free radical oxidation, as evidenced by the dynamics of an increased level of markers of oxidative stress. Conclusion. Thus, in periodontitis, oxidative stress develops, which contributes to the progression of destructive processes of periodontal tissues, which substantiates the feasibility of using markers of the intensity of free radical oxidation as diagnostic and prognostic criteria for the course of the disease and the introduction of antioxidant-type drugs in complex therapy.

Download Full-text