scholarly journals In vivo wound Healing Activity of Ointment based Formulation for Prunus amygdalus (Batsch.) on Rats

2022 ◽  
Vol 56 (1) ◽  
pp. 184-190
Author(s):  
Diksha Singh ◽  
Kashmira J Gohil ◽  
Vikash Sharma ◽  
Shiv Shankar Shukla
Keyword(s):  
Wound Healing ◽  
Prunus Amygdalus ◽  
Wound Healing Activity ◽  
Prunus Amygdalus Batsch

In Vivo Wound Healing Activity of Spirulina platensis

2019 ◽  
Vol 18 (1) ◽  
pp. 06-16
Author(s):  
R. Seghiri ◽  
A. Essamri
Keyword(s):  
Wound Healing ◽  
Spirulina Platensis ◽  
Therapeutic Agent ◽  
Conventional Medicine ◽  
Folk Medicine ◽  
Chemical Burns ◽  
Amount Of Substance ◽  
Test Population ◽  
Wound Healing Activity

Spirulina is a microalga used in traditional folk medicine in Morocco for the treatment of various health disorders. The wound healing activity of Moroccan Spirulina is unknown. In the current study, aqueous extracts of Spirulina platensis were investigated for acute toxicity and wound healing activity in Swiss Albino mice and White New Zealand rabbits, respectively. The LD50 (amount of substance required to kill 50% of the test population) of the microalga was greater than 5,000 mg/kg. Healing after application of the same amount of ointment on differently induced (mechanical, chemical, and thermal) wounds was about the same, over five weeks. Aqueous extract had remarkable healing activity on rabbits’ skin, possessing significantly greater healing effect for mechanical and chemical burns than controls. Moreover, the hair growing time was faster in treated groups; Spirulina-treated groups did not show any contamination with microbes compared to others. This study affirms that Spirulina platensis can be considered as a potential therapeutic agent for wound healing not only as a complementary medicine but also in conventional medicine.

scholarly journals In-vivo wound healing activity of a novel composite sponge loaded with mucilage and lipoidal matter of Hibiscus species

2021 ◽  
Vol 135 ◽  
pp. 111225
Author(s):  
Riham O. Bakr ◽  
Reham I. Amer ◽  
Dalia Attia ◽  
Mai M. Abdelhafez ◽  
Asmaa K. Al-Mokaddem ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Healing Activity

Eugenol-acacia gum-based bifunctional nanofibers as a potent antifungal transdermal substitute

Nanomedicine ◽  
2021 ◽  
Author(s):  
Payal Gupta ◽  
Purusottam Mishra ◽  
Lalita Mehra ◽  
Kartikey Rastogi ◽  
Ramasare Prasad ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inclusion Complex ◽  
Polyvinyl Alcohol ◽  
Rat Model ◽  
Candida Species ◽  
Antibiofilm Activity ◽  
Acacia Gum ◽  
Rat Experiments ◽  
Wound Healing Activity

Aim: Fungal biofilms interfere with the wound healing processes. Henceforth, the study aims to fabricate a biomaterial-based nano-scaffold with the dual functionalities of wound healing and antibiofilm activity. Methods: Nanofibers comprising acacia gum, polyvinyl alcohol and inclusion complex of eugenol in β-cyclodextrin (EG-NF) were synthesized using electrospinning. Antibiofilm studies were performed on Candida species, and the wound-healing activity was evaluated through an in vivo excision wound rat model. Results: The EG-NF potentially eradicated the mature biofilm of Candida species and their clinical isolates. Further, EG-NF also enhanced the re-epithelization and speed of wound healing in in vivo rat experiments. Conclusion: The study established the bifunctional applications of eugenol nanofibers as a transdermal substitute with antifungal potency.

In vivo evaluation of cutaneous wound healing activity of Mirabilis jalapa L radix

2013 ◽  
Vol 14 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Jyotchna Gogoi ◽  
Khonamai Sewa Nakhuru ◽  
Pronobesh Chattophadhayay ◽  
Ashok Kumar Rai ◽  
Hemanta Kumar Gogoi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cutaneous Wound Healing ◽  
In Vivo Evaluation ◽  
Cutaneous Wound ◽  
Mirabilis Jalapa ◽  
Wound Healing Activity

scholarly journals Metabolite profiling and wound-healing activity of Boerhavia diffusa leaf extracts using in vitro and in vivo models

2020 ◽  
Vol 10 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Kriti Juneja ◽  
Rutusmita Mishra ◽  
Samrat Chauhan ◽  
Sumeet Gupta ◽  
Partha Roy ◽  
...  
Keyword(s):  
Wound Healing ◽  
Metabolite Profiling ◽  
Leaf Extracts ◽  
In Vivo Models ◽  
Boerhavia Diffusa ◽  
Wound Healing Activity

scholarly journals HIBISCUS ROSA SINENSIS LOADED SOLID LIPID NANOPARTICLES AND IN VIVO WOUND HEALING ACTIVITY IN WISTAR ALBINO RATS

2020 ◽  
pp. 78-83
Author(s):  
VIJAYANAND P. ◽  
JYOTHI V. ◽  
MOUNIKA A.
Keyword(s):  
Wound Healing ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Albino Rats ◽  
Herbal Extracts ◽  
Solid Lipid ◽  
Hibiscus Rosa Sinensis ◽  
Wistar Albino Rats ◽  
Wound Healing Activity

Objective: The objective of the present research was to investigate the wound-healing potency of solid lipid nano particles of Hibiscus rosa sinensis extract. Crude herbal extracts and rudimentary formulations containing herbal extracts are good for demonstrating the feasibility of the concept; however, such formulations suffer with poor oral bioavailability and variability within groups of subjects. Converting herbal extracts into novel drug delivery systems may prove effective in addressing some of these problems. Methods: In the present study an attempt was made to develop Hibiscus rosa sinensis extract loaded solid lipid nanoparticles (HSLNs) using lipids glycerol monostearate (GMS) or beeswax. The prepared HSLNs were characterised for their size, surface charge and morphology. The optimized HSLNs were incorporated into Carbopol gel and tested for wound healing activity in male Wistar albino rats using excision wound model. Results: HSLNs of ~175 nm in size carrying negative charge were obtained with the optimised procedure using beeswax. The shape of the HSLNs was nearly spherical. The HSLNs (10 mg/ml) treated wounds healed much faster compared to raw crude extract and healing was comparable to marketed preparation. Conclusion: It is concluded that converting crude herbal extracts into SLNs can be an effective way to enhance the effectiveness of herbal extracts and their in vivo activity.

(+)-epi-α-Bisbolol Is the Wound-Healing Principle ofPeperomiagalioides: Investigation of the in Vivo Wound-Healing Activity of Related Terpenoids

2001 ◽  
Vol 64 (10) ◽  
pp. 1357-1359 ◽  
Author(s):  
León F. Villegas ◽  
Ana Marçalo ◽  
Jennifer Martin ◽  
Irma D. Fernández ◽  
Holger Maldonado ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Healing Activity

scholarly journals In Vivo Wound Healing Activity of Abrus cantoniensis Extract

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Qi Zeng ◽  
Hui Xie ◽  
Hongjin Song ◽  
Fayu Nie ◽  
Jiahua Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chemical Constituents ◽  
Blood Stasis ◽  
Acute Oral Toxicity ◽  
Test Results ◽  
Dermal Toxicity ◽  
Oral Toxicity ◽  
Incision Wound ◽  
Wound Healing Activity

Abrus cantoniensis (Leguminosae sp.) is a traditionally used remedy for treating rheumatism, blood stasis, and internal injuries. In order to reveal a new insight of the utilization of the plant, solvent extraction by ethyl acetate (EA) was performed in order to evaluate the plant extracts’ in vivo excision and incision-wound potentials with models. The contents of the EA fraction, wound healing activity, acute oral toxicity, and acute dermal toxicity were studied. As a result, the main chemical constituents of the EA fraction were alkaloids, flavonoids, and steroids. The acute oral toxicity test results and assessment of skin hypoallergenicity showed that the plant extract was safe at LD50 as high as 5000 mg/kg. Both excision and incision model tests results indicated that the EA fraction of A. cantoniensis showed a significant wound healing capacity at a concentration of 5% (v/w) (p<0.01) as observed by the increased wound contraction, decreased epithelialization time, and increased hydroxyproline content compared to the ones of the controls. The present study showed that the EA fraction of A. cantoniensis possesses potential wound healing activities and provided recent results for the use of A. cantoniensis for wound curing.

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