scholarly journals Retrospective Evaluation of Pediatric Patients With Abdominal Tuberculosis: A Single Center Experience

2020 ◽  
Vol 54 (4) ◽  
pp. 204-211
Author(s):  
Sevgi Yaşar Durmuş ◽  
Gönül Tanır ◽  
Ayşe Seçil Ekşioğlu ◽  
Türkan Aydın Teke ◽  
Yasemin Taşçı Yıldız ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Extrapulmonary Tuberculosis ◽  
Abdominal Tuberculosis ◽  
Diagnostic Methods ◽  
Mycobacterium Tuberculosis Infection ◽  
Reactive Protein ◽  
Single Center Experience ◽  
Antituberculosis Treatment ◽  
History Of ◽  
The Mean

Objective: Abdominal tuberculosis is a kind of extrapulmonary tuberculosis that can usually occur during the lymphohematogenous spread of first Mycobacterium tuberculosis infection, develop by neighborhood from an abdominal focus or a mesenteric lymph node. The aim of this study is to evaluate pediatric cases diagnosed with abdominal tuberculosis. Material and Methods: Between 2012-2018, seven patients diagnosed with abdominal tuberculosis through patients who diagnosed with extrapulmonary tuberculosis in our hospital, were included in study. Demographic and clinical characteristics, diagnostic methods, commenced treatments and clinical follow up of patients were listed from medical records. Results: Of patients, four were female. The mean age was 144.2 ± 42.7 months. None of the patients had a history of tuberculosis contact. The median complaint time was 20 days (5-180). The most frequent complaint was abdominal pain and the most frequent physical examination finding was abdominal tenderness. Mean white blood cell count was 9.26 x 103 ± 4.77 x 103 μ/L, C reactive protein level: 79.9 ± 54.9 mg/dL, erytrocyte sedimentation rate: 45 ± 30 mm/h. Tuberculin skin test was positive in two patients, interferon gamma releasing assay was positive in three patients, and in two patients, both tests were positive. There were findings suggesting tuberculosis on pulmonary imaging in five patients and abdominal imaging in all patients. Histopathological examination of the specimens of six patients revealed findings consistent with tuberculosis. The presence of M. tuberculosis was confirmed microbiologically in clinical specimens taken from three patients. The most common abdominal tuberculosis type was mesenteric lymphadenitis. The mean time from admission to diagnosis was 15 ± 12.8 days. All patients recieved antituberculosis treatment. Conclusion: Abdominal tuberculosis should be kept in mind, in patients presenting with abdominal complaints lasting more than five days. Ultrasonography and computed tomography are useful to determine abdominal tuberculosis type. The disease can be sucsessfully treated with standart antituberculosis treatment.

scholarly journals Retrospective Evaluation Of Pediatric Patients With Abdominal Tuberculosis: A Single Center Experience

2020 ◽  
Vol 54 (4) ◽  
pp. 224-230
Author(s):  
Sevgi Yaşar Durmuş ◽  
Gönül Tanır ◽  
Ayşe Seçil Ekşioğlu ◽  
Türkan Aydın Teke ◽  
Yasemin Taşçı Yıldız ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Extrapulmonary Tuberculosis ◽  
Abdominal Tuberculosis ◽  
Diagnostic Methods ◽  
Mycobacterium Tuberculosis Infection ◽  
Reactive Protein ◽  
Single Center Experience ◽  
Antituberculosis Treatment ◽  
History Of ◽  
The Mean

Objective: Abdominal tuberculosis is a kind of extrapulmonary tuberculosis that can usually occur during the lymphohematogenous spread of first Mycobacterium tuberculosis infection, develop by neighborhood from an abdominal focus or a mesenteric lymph node. The aim of this study is to evaluate pediatric cases diagnosed with abdominal tuberculosis. Material and Methods: Between 2012-2018, seven patients diagnosed with abdominal tuberculosis through patients who diagnosed with extrapulmonary tuberculosis in our hospital, were included in study. Demographic and clinical characteristics, diagnostic methods, commenced treatments and clinical follow up of patients were listed from medical records. Results: Of patients, four were female. The mean age was 144.2 ± 42.7 months. None of the patients had a history of tuberculosis contact. The median complaint time was 20 days (5-180). The most frequent complaint was abdominal pain and the most frequent physical examination finding was abdominal tenderness. Mean white blood cell count was 9.26 x 103 ± 4.77 x 103 μ/L, C reactive protein level: 79.9 ± 54.9 mg/dL, erytrocyte sedimentation rate: 45 ± 30 mm/h. Tuberculin skin test was positive in two patients, interferon gamma releasing assay was positive in three patients, and in two patients, both tests were positive. There were findings suggesting tuberculosis on pulmonary imaging in five patients and abdominal imaging in all patients. Histopathological examination of the specimens of six patients revealed findings consistent with tuberculosis. The presence of M. tuberculosis was confirmed microbiologically in clinical specimens taken from three patients. The most common abdominal tuberculosis type was mesenteric lymphadenitis. The mean time from admission to diagnosis was 15 ± 12.8 days. All patients recieved antituberculosis treatment. Conclusion: Abdominal tuberculosis should be kept in mind, in patients presenting with abdominal complaints lasting more than five days. Ultrasonography and computed tomography are useful to determine abdominal tuberculosis type. The disease can be sucsessfully treated with standart antituberculosis treatment.

scholarly journals A Clinical Study on Extrapulmonary Tuberculosis

1970 ◽  
Vol 24 (1) ◽  
pp. 19-28 ◽  
Author(s):  
MM Karim ◽  
SA Choudhury ◽  
MM Husain ◽  
MA Faiz
Keyword(s):  
Lymph Node ◽  
Histopathological Examination ◽  
Extrapulmonary Tuberculosis ◽  
Previous History ◽  
Abdominal Tuberculosis ◽  
Cervical Lymph Nodes ◽  
Economic Class ◽  
History Of ◽  
Tuberculosis Diagnosis ◽  
Lymph Node Tuberculosis

Findings of 80 patients of extra-pulmonary tuberculosis are described in this study. Most of the patients were under 30 years of age (71.2%), female patients were 56.3% and housewives were 37.3%. Lower socio-economic class were commonly affected (66.2%). Eighteen patients (22.5%) were smoker and almost equal number of cases had the history of intake of un-boiled milk. 44% patients were not vaccinated against tuberculosis. 36.2% patients had history of contact with tuberculous patients and 18.8% had previous history of tuberculosis. 70% patients had the history of fever and 30% had history of cough. Significant weight loss was noted in 85% patients. Lymph node tuberculosis was 36.2%, abdominal tuberculosis 35%. Cervical lymph nodes alone (37.9%) were commonly affected among the lymph node tuberculosis. Diagnosis was mainly based on histopathological examination or biopsy of specimen (97.5%) and demonstrations of AFB was possible in 2.5% cases. Along with surgical treatment medical treatment (chemotherapy) were prescribed in every patient. Forty-eight patients came for follow up. All responded to anti tubercular chemotherapy. (J Bangladesh Coll Phys Surg 2006; 24: 19-28)

scholarly journals Laboratory and demographic findings among patients with coronavirus disease 2019: A review

2021 ◽  
Author(s):  
Atefeh Mir ◽  
Khadijeh Kalan Farmanfarma ◽  
Hamid Salehiniya ◽  
Abolfazl Shakiba ◽  
Neda Mahdavifar
Keyword(s):  
Web Of Science ◽  
Troponin I ◽  
Diagnostic Methods ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Lung Scan ◽  
The Mean ◽  
The One ◽  
Increasing Trends ◽  
D Dimer

Coronavirus disease 2019 (COVID-19) is the third known animal coronavirus, after severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome coronavirus (MERS-CoV). The mean age of the infected patients was estimated to be between 50 and 69 years old. Accordingly, the COVID-19 mortality rate was calculated as 15%. In this regard, the essential component of prevention and planning is knowledge of laboratory and demographic findings among COVID-19 patients; therefore, the present study was conducted to investigate laboratory and demographic findings among these patients worldwide. This systematic review was performed on the articles published in English between January 1, 2019 and May 4, 2020, using MeSH-compliant keywords such as "COVID-19", "Laboratory, coronavirus disease-19 testing", and " demography " in international databases (PubMed, and web of science Scopus). Thereafter, the articles relevant to laboratory and demographic findings among COVID-19 patients were included in the final review. Reviewing the included articles showed changes in the mean lymphocytes count ranged from 0.7 to 39 in hospital or severe cases. Moreover, Leukopenia was not observed in patients with thrombocytopenia. In addition, C-reactive protein (CRP), leukocytes, D-dimer, FDP, FIB, neutrophils, AST, serum creatinine, t-troponin, troponin I, and blood bilirubin levels showed increasing trends in most studies conducted on COVID-19 patients. Notably, the elevated LDH level was more common among children than adults. According to the results of the present study, and by considering the clinical characteristics of COVID-19 patients on the one hand, and considering the changes in laboratory samples such as lymphocytes and other blood markers due to the damaged myocardial, hepatic, and renal tissues on the other hand, it is recommended to confirm the diagnosis of this infection by evaluating the patients’ blood samples using other diagnostic methods like lung scan.

scholarly journals Abdominal Tuberculosis

2004 ◽  
Vol 43 (151) ◽  
pp. 40-48 ◽  
Author(s):  
Mani Prasad Gautam ◽  
P Karki ◽  
S Rijal
Keyword(s):  
Pulmonary Tuberculosis ◽  
Extrapulmonary Tuberculosis ◽  
Abdominal Tuberculosis ◽  
Antimicrobial Treatment ◽  
Molecular Techniques ◽  
Diagnostic Methods ◽  
Clinical Feature ◽  
Common Disease ◽  
Abdominal Organs ◽  
Clinical Awareness

Tuberculosis is a common disease and its incidence is in rising tendency in developed world because of AIDSand transglobal migration. Abdominal tuberculosis is more common in immunocompromised populationand manifests as infection of peritoneum, hollow or solid abdominal organs and abdominal lymphatics withmycobacterium tuberculosis organism. The peritoneum and ileo-cecal region are the most likely sites ofinfection and are involved in the majority of cases by hematogenous spread or through swallowing of infectedsputum from primary pulmonary tuberculosis. Pulmonary tuberculosis is evident in less than half of patientseither in active or latent form. Abdominal tuberculosis has a protean manifestation although the mostcommon clinical feature is the triad of abdominal pain, fever and weight loss. The diagnosis is often delayedbecause of non-specific presentation and is usually made through a combination of radiologic, microbiologic,histopathologic, endoscopic and molecular techniques. None of them provide a gold standard by themselves.However, an algorithm of these diagnostic methods leads to considerably higher precision in the diagnosisof abdominal tuberculosis which primarily necessitates a clinical awareness of this serious health problem.Abdominal tuberculosis is a serious condition and if untreated outcome is fatal. Early diagnosis and immediateinitiation of treatment along with dietary support is crucial for better outcome. Antimicrobial treatment isthe same as for pulmonary tuberculosis and management often requires combination of antituberculardrugs and surgery – for diagnosis as well as therapy.Key Words: Tuberculosis; Abdominal Tuberculosis; Extrapulmonary Tuberculosis.

scholarly journals Epidemiological Profile and Determinants of Tuberculosis in Urban Nepalese Population

2019 ◽  
Vol 2 (2) ◽  
pp. 250-254
Author(s):  
Subash Bhatta ◽  
Nayana Pant
Keyword(s):  
Extrapulmonary Tuberculosis ◽  
Female Ratio ◽  
Short Course ◽  
Increased Risk ◽  
The Family ◽  
Directly Observed Treatment ◽  
History Of ◽  
The Mean ◽  
Epidemiological Profile ◽  
Male To Female

Introduction: Tuberculosis has evolved through ages to remain a major cause of morbidity and mortality worldwide. Despite having a very successful Directly Observed Treatment, Short-course program, tuberculosis is still one of the most widespread infections in Nepal. This study was done to observe the epidemiological profile of tuberculosis patients in an urban Nepalese population.Materials and Methods: 585 newly diagnosed cases of pulmonary and extrapulmonary tuberculosis in two tertiary level hospitals in the country were enrolled in the study during a period of 18months. A standard questionnaire was formatted and the required information was acquired with the help of interview and investigation reports.Results: The mean age of presentation was 35.76 with a male to female ratio of 1.48:1.57% of the cases had less than primary education with 26 % being illiterates. The most commonly involved occupational group was farmers (22%) followed by students (20%) and laborers (14%). 22% of cases had a history of contact with tuberculosis in the family. 41 % were smokers and 18 % abused alcohol. Pulmonary tuberculosis comprised 68% of the total cases. The most common extrapulmonary presentation was lymph node TB (28%) followed by pleural effusion (21.5%) and tubercular meningitis (16%).Conclusions: Young people with lower literacy levels and with a family history of tuberculosis are at increased risk of acquiring tuberculosis and community approaches for tuberculosis control should target this group to reduce the burden of the disease

SARS-CoV-2 Infection in a Spanish Cohort of CKD-5D Patients: Prevalence, Clinical Presentation, Outcomes, and De-Isolation Results

2020 ◽  
pp. 1-8
Author(s):  
José Jesús Broseta ◽  
Diana Rodríguez-Espinosa ◽  
Elena Cuadrado ◽  
Elena Guillén-Olmos ◽  
Evelyn Hermida ◽  
...  
Keyword(s):  
Health Resources ◽  
Maintenance Hemodialysis ◽  
Common Symptom ◽  
Time To Death ◽  
Reactive Protein ◽  
Increased Risk ◽  
Discharged Patients ◽  
History Of ◽  
The Mean ◽  
Mean Time

<b><i>Introduction:</i></b> COVID-19 is a highly contagious disease that has easily spread worldwide. Outpatient maintenance hemodialysis seems to entail an increased risk of contagion, and previous reports inform of increased mortality among this population. <b><i>Methods:</i></b> We retrospectively analyzed clinical and laboratory parameters, outcomes, and management once discharged of CKD-5D patients infected with SARS-CoV-2 from our health area. <b><i>Results:</i></b> Out of the 429 CKD-5D population, 36 were diagnosed with SARS-CoV-2 infection (8%): 34 on in-center hemodialysis and 2 on peritoneal dialysis. Five were asymptomatic. The most common symptom was fever (70%), followed by dyspnea and cough. History of cardiovascular disease and elevation of LDH and C-reactive protein during admission were associated with higher mortality. Thirteen patients died (36%), 8 patients were admitted to an ICU, and survival was low (38%) among the latter. The mean time to death was 12 days. Most discharged patients got negative rRT-PCR in nasopharyngeal swabs within 26 days of diagnosis. However, there is a portion of cured patients that continue to have positive results even more than 2 months after the initial presentation. <b><i>Conclusions:</i></b> Patients on dialysis have an increased mortality risk if infected with SARS-CoV-2. Preventive measures have proven useful. Thus, proper ones, such as universal screening of the population and isolation when required, need to be generalized. Better de-isolation criteria are necessary to ensure an appropriate use of public health resources.

scholarly journals 511 A Case Report of A 16-Year-Old Girl with Peritoneal Tuberculosis

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
C Fabelurin ◽  
D Arora
Keyword(s):  
Case Report ◽  
Young Patients ◽  
Abdominal Tuberculosis ◽  
Final Diagnosis ◽  
Paediatric Population ◽  
Peritoneal Tuberculosis ◽  
Mycobacterium Tuberculosis Infection ◽  
Crohns Disease ◽  
Laparoscopic Biopsy ◽  
History Of

Abstract Peritoneal Tuberculosis (PTB) is a rare extra-pulmonary manifestation of Mycobacterium tuberculosis infection. It usually presents with non-specific symptoms that can mimic other intra-abdominal pathology. Therefore, a high index of suspicion is needed for diagnosis and early treatment of PTB. Some of the intra-abdominal conditions in young patients that may have similar presentations to PTB include Crohns’ disease, ovarian pathology and acute appendicitis. Diagnosing PTB in the paediatric population tends to be even more challenging as an obvious history of exposure may be difficult to obtain. Diagnostic laparoscopic biopsy and histopathology provides definitive diagnosis. Most studies recommend a 6-month course of anti-TB therapy for abdominal tuberculosis with a planned regimen using Isoniazid, Rifampicin, Pyrazinamide and Ethambutol. This case report presents the case of a 16-year-old girl who presented with a history of recurrent abdominal pain, vomiting and pyrexia. Radiological, laparoscopic, and histopathological findings were used for final diagnosis of this condition. The patient was treated using the anti-tuberculosis therapy for 6 months following which, she was able to make a full recovery.

scholarly journals Chronic and Subacute Meningitis: Differentiating Neoplastic From Non-Neoplastic Etiologies

2018 ◽  
Vol 8 (4) ◽  
pp. 177-182 ◽  
Author(s):  
Mariano Marrodan ◽  
Catalina Bensi ◽  
Lucas Alessandro ◽  
Alejandro D. Muggeri ◽  
Mauricio F. Farez
Keyword(s):  
Latin American ◽  
Comprehensive Evaluation ◽  
Case Series ◽  
Incidence Rates ◽  
Neoplastic Meningitis ◽  
Diagnostic Methods ◽  
Single Center ◽  
Reactive Protein ◽  
Fluid Analysis ◽  
History Of

Background and Purpose: Although incidence rates vary, infectious, autoimmune, and neoplastic diseases can all cause chronic and subacute meningitis (CSM). We report a Latin-American, single center, CSM case series, analyzing the main clinical characteristics as well as ancillary diagnostic methods differentiating neoplastic from non-neoplastic etiologies. Methods: Retrospective review of CSM cases from a single center in Buenos Aires, Argentina. Results: Seventy patients with CSM diagnosis were identified, 49 with neoplastic and 21 with non-neoplastic meningitis. A history of previous cancer was significantly higher in neoplastic cases, whereas prevalence of autoimmune disease and fever was more common in non-neoplastic meningitis. C-reactive protein values were higher in non-neoplastic CSM, as was pleocytosis in cerebrospinal fluid analysis. The most frequent etiologies were breast and lung cancer for neoplastic meningitis cases; and idiopathic, tuberculous, and fungal infection for non-neoplastic cases. Conclusions: Chronic and subacute meningitis diagnosis is challenging in daily neurological practice. The results we report contribute information from Latin America regarding etiologies of CSM, which can be identified after a comprehensive evaluation in a majority of cases.

scholarly journals Abdominal Tuberculosis: A Histopathological Study with Special Reference to Intestinal Perforation and Mesenteric Vasculopathy

2009 ◽  
Vol 1 (02) ◽  
pp. 056-061 ◽  
Author(s):  
Alakananda Dasgupta ◽  
Navjeevan Singh ◽  
Arati Bhatia
Keyword(s):  
Histopathological Examination ◽  
Intestinal Tuberculosis ◽  
Granulomatous Inflammation ◽  
Abdominal Tuberculosis ◽  
Epithelioid Cell ◽  
Histopathological Study ◽  
Ulcer Formation ◽  
Microscopic Features ◽  
History Of ◽  
One Year

ABSTRACT Background: Along with the increased incidence of pulmonary tuberculosis in parallel with the increase in population in various parts of the world, in recent years, the incidence of abdominal tuberculosis has also increased. The pathogenetic events in intestinal tuberculosis, which culminate in ulcer formation, perforation, and stricture, still have to be identified. Aim: To correlate the gross and microscopic features in intestinal tuberculosis, in particular tuberculous perforation with changes in mesenteric vasculature. Patients and Methods: A one-year prospective study of excised/resected tissues from patients with abdominal tuberculosis requiring surgical intervention was conducted. Tissues from fifty-six patients were included in the study — of which 36 were resected intestinal segments and 20 were intestinal and lymph node biopsies. Hematoxylin and Eosin and Ziehl-Neelsen stains were used for histopathological examination. Results: Tuberculous enteritis was found to be present in 49 of the 56 patients (87.5%) (ileum being the site most commonly affected), while nodal involvement was seen in 39 (69.6%) patients. Perforations were present in 39 out of 49 (79.6%) intestinal tissues; most being solitary and ileum was the commonest site. Typical epithelioid cell granulomas were seen in the intestine and lymph nodes, with caseation being more prevalent in the latter. The mesenteric vasculature was frequently involved by granulomatous inflammation, with intravascular organizing thrombus being present in 30% of the resected specimens with perforation. Acid fast bacilli were demonstrated in the tissue sections of 37.5% of the patients. AFB positivity was higher in caseating granulomas. Conclusion: Involvement of mesenteric vasculature by granulomatous inflammation was commonly associated with the ulcerative type with perforation, suggesting that ischemia caused by vascular thrombosis is responsible for tissue breakdown. This implies that vasculitis plays an important role in the natural history of abdominal tuberculosis.

scholarly journals Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea

2020 ◽  
Vol 9 (6) ◽  
pp. 1688 ◽  
Author(s):  
Hee-Yeon Jung ◽  
Jeong-Hoon Lim ◽  
Seok Hui Kang ◽  
Seong Gyu Kim ◽  
Yong-Hoon Lee ◽  
...  
Keyword(s):  
South Korea ◽  
Antiviral Agents ◽  
Common Symptom ◽  
Advanced Chronic Kidney Disease ◽  
Reactive Protein ◽  
History Of ◽  
Pulmonary Infiltration ◽  
The Mean ◽  
Mean Time ◽  
Increased Susceptibility

Patients with advanced chronic kidney disease (CKD) or who are on hemodialysis (HD) could have increased susceptibility to the 2019 coronavirus disease (COVID-19) given their pre-existing comorbidities, older age, compromised immune system, and regular visits to populated outpatient dialysis centers. This study included 14 consecutive patients on HD or with advanced CKD who initiated HD after being diagnosed with laboratory-confirmed COVID-19 from February to April 2020 in hospitals throughout Daegu, South Korea. The included patients, 42.9% of whom were men, had a mean age of 63.5 years. Four patients had a history of contact with a patient suffering from COVID-19. The most common symptom was cough (50.0%), followed by dyspnea (35.7%). The mean time from symptom onset to diagnosis and admission was 2.6 and 3.5 days, respectively. Patients exhibited lymphopenia and elevated inflammatory markers, including C-reactive protein and ferritin. Chest radiography findings showed pulmonary infiltration in 10 patients. All patients underwent regular HD in a negative pressure room and received antiviral agents. Four patients received mechanical ventilation and continuous renal replacement therapy at a median duration of 14.0 and 8.5 days, respectively. One patient underwent extracorporeal membrane oxygenation for three days. Among the 14 patients included, two died due to acute respiratory distress syndrome, nine were discharged from the hospital, and three remained hospitalized. Despite the high-risk conditions associated with worse outcomes, patients on HD did not exhibit extremely poor overall COVID-19 outcomes perhaps due to early diagnosis, prompt hospitalization, and antiviral therapy.

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