Additional risk factors associated with symptomatic hydrochlorothiazide-induced hyponatremia in hypertensive patients

AbstractThe loss of a pet can be particularly distressing for owners, whether the method of death is euthanasia or is unassisted. Using primary-care clinical data, this study aimed to report the demographic and clinical factors associated with euthanasia, relative to unassisted death, in dogs. Method of death (euthanasia or unassisted) and clinical cause of death were extracted from a random sample of 29,865 dogs within the VetCompass Programme from a sampling frame of 905,544 dogs under UK veterinary care in 2016. Multivariable logistic regression modelling was used to evaluate associations between risk factors and method of death. Of the confirmed deaths, 26,676 (89.3%) were euthanased and 2,487 (8.3%) died unassisted. After accounting for confounding factors, 6 grouped-level disorders had higher odds in euthanased dogs (than dogs that died unassisted), using neoplasia as the baseline. The disorders with greatest odds included: poor quality of life (OR 16.28), undesirable behaviour (OR 11.36) and spinal cord disorder (OR 6.00). Breed, larger bodyweight and increasing age were additional risk factors for euthanasia. The results highlight that a large majority of owners will face euthanasia decisions and these findings can support veterinarians and owners to better prepare for such an eventuality.

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COGNITIVE FUNCTION IN HYPERTENSIVE PATIENTS WITH OR WHITHOUT OTHER RISK FACTORS ASSOCIATED

Journal of Hypertension ◽

10.1097/00004872-200402001-00398 ◽

2004 ◽

Vol 22 (Suppl. 1) ◽

pp. S93

Author(s):

H Fraga ◽

E Figueiredo

Keyword(s):

Risk Factors ◽

Cognitive Function ◽

Hypertensive Patients ◽

Factors Associated

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The role of some additional risk factors in the occurrence of paroxysmal / persistent atrial fibrillation in patients with arterial hypertension

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

S Grigoryan ◽

LG Hazarapetyan ◽

AA Ter-Markaryan ◽

AA Stepanyan

Keyword(s):

Risk Factors ◽

Atrial Fibrillation ◽

Arterial Hypertension ◽

Diastolic Pressure ◽

Control Group ◽

Additional Risk ◽

Hypertensive Patients ◽

Markers Of Inflammation ◽

Hypertensive Crises ◽

Tgf Β1

Abstract Funding Acknowledgements Type of funding sources: None. Background Arterial hypertension (AH) and atrial fibrillation (AF) are two important public health problems and often coexist in the same patient. AH ultimately increases the risk of AF and several pathogenetic mechanisms underlying the higher risk of AF in hypertensive patients are still incompletely known. AH is one of the main reasons for the remodeling process in these patients and makes a significant contribution to the development of structural changes. The aim of this study is to identify predictors of paroxysmal/persistent AF occurrence and progression in hypertensive patients Methods In this study where enrolled 109 hypertensive patients with non-valvular paroxysmal/persistent AF (mean age 61.6 ±6.4) who were hospitalized at Institute of Cardiology between 2008 and 2016 year. As a control group, 44 hypertensive patients without AF were also examined. The study lasted 8 years. After the enrollment the echocardiography examination and 24-hour ambulatory Holter monitoring ECG were registered in each patient. We measured plasma indexes of inflammation (hsCRP, IL-6) and fibrosis marker - transforming growth factor (TGF-β1). The database consisting of 33 indicators that characterize the clinical, hemodynamic and structural-functional state of the heart, as well as markers of inflammation and fibrosis was created. .All data were analyzed by SPSS 13 and EXCEL - 2013 programs using logistic analysis by odds ratio (OR). Results The comparative results of clinical, hemodynamic, inflammation and fibrosis markers OR with AF in hypertensive patients relative to the control group showed that in hypertensive patients with AF there was a significant increase in diastolic pressure (OR 1.09, р=0.017) , the number of hypertensive crises episodes ( OR 1.56 р=0.001) and patients of older age groups (OR 1.18, р= 0.001) There was a significant deterioration in electrical remodeling (Pmax 3.92, р=0.001, P dispersion 4.90, р=0.001), LV diastolic function (isometric ventricular contraction time 1.69, р=0.042) and of left atrial volume (OR 3.69, р=0.001). There were significant increases in levels of inflammatory and fibrosis markers concentrations in comported with hypertensive patients without AF (OR of hsСRP 5.57, р=0.01; IL-6 4.80, р=0.001 and TGF-β1 3.84, р=0.005). Conclusions The multifactorial analysis revealed that increased diastolic pressure, frequency of hypertensive crises, age, deterioration of diastolic function, as well as an increase in markers of inflammation and fibrosis concentration are additional risk factors for AF in patients with hypertension.

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A 10-Year Analysis of Rearrests Among a Cohort of Domestic Violence Offenders

Violence and Victims ◽

10.1891/0886-6708.vv-d-13-00145 ◽

2014 ◽

Vol 29 (6) ◽

pp. 887-906 ◽

Cited By ~ 13

Author(s):

Tara N. Richards ◽

Wesley G. Jennings ◽

Elizabeth Tomsich ◽

Angela Gover

Keyword(s):

Risk Factors ◽

Domestic Violence ◽

Survival Analysis ◽

Policy Implications ◽

Additional Risk ◽

Factors Associated ◽

Batterer Treatment ◽

Type Study

In this study, survival analysis is used to examine time to rearrest for both domestic violence and nondomestic violence crimes among a cohort of domestic violence offenders (N = 286) over a 10-year period. In addition, risk factors for rearrest such as demographic, offending history, and batterer treatment variables are examined to determine their influence on domestic and nondomestic violence recidivism. Overall, the results suggest that approximately half of domestic violence offenders are rearrested. Furthermore, among those who are rearrested, they are rearrested fairly quickly and for generalized (both domestic and nondomestic violence offenses) versus specialized offending. Risk factors associated with both types of rearrest included age, marriage, and domestic violence offense history. Several additional risk factors were unique to rearrest type. Study limitations are explicitly stated and policy implications are discussed.

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Hyperhomocysteinemia is one of the risk factors associated with cerebrovascular stiffness in hypertensive patients, especially elderly males

Scientific Reports ◽

10.1038/srep05663 ◽

2014 ◽

Vol 4 (1) ◽

Cited By ~ 31

Author(s):

Takafumi Okura ◽

Ken-ichi Miyoshi ◽

Jun Irita ◽

Daijiro Enomoto ◽

Tomoaki Nagao ◽

...

Keyword(s):

Risk Factors ◽

Hypertensive Patients ◽

Factors Associated ◽

Elderly Males

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A study to evaluate risk factors and factors associated with non-adherence to the prescribed treatment among essential hypertensive patients attending tertiary care hospital

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20203933 ◽

2020 ◽

Vol 7 (9) ◽

pp. 3623

Author(s):

Venkat Sunil Bommishetty ◽

Suresh Keshav Kumbhar

Keyword(s):

Risk Factors ◽

Medication Adherence ◽

Life Style ◽

Tertiary Care ◽

Positive Family History ◽

Cross Sectional Study ◽

Care Hospital ◽

Cross Sectional ◽

Hypertensive Patients ◽

Factors Associated

Background: Prevalence of hypertension is on rising trend with rise in life style and behavioral changes. It is also a major risk factor for most of the dreadful conditions like coronary artery disease, stroke, etc. Medication adherence would help in reducing the chance of occurrence of such complications. Thus objectives of study are 1) to evaluate the risk factors of hypertension among the diagnosed essential hypertensive patients; and 2) to assess the magnitude and the factors associated with non-adherence to the prescribed treatment.Methods: A hospital based cross-sectional study among 71 participants was conducted, using a pre-structured questionnaire and physical examination to assess risk factors of hypertension and CULIG’s 16 questionnaire medication adherence scale to assess the non-adherence. Data analysed with proportions and Chi square test.Results: Out of 71 participants, 60 (84.5%) were found to be non-adherent to their anti-hypertensive medication and factors like being male (p=0.0055), alcohol consumption (p=0.0485) and paid medication (p=0.0091) were found to be significantly affecting the medication non-adherence. Positive family history, sedentary life style, preference of extra salt and smoking/tobacco products usage were the most common risk factors of essential hypertension observed along with others.Conclusions: The participants who experienced the complications/ill effects of hypertension were more adherent as compared to others. Factors which are responsible for non -adherence need to be addressed and appropriate interventions required to improve adherence by educating the people about its importance in prevention of complications.

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Determination of clinical risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus

10.1101/613711 ◽

2019 ◽

Author(s):

Mohammed S. Ellulu

Keyword(s):

Physical Activity ◽

Diabetes Mellitus ◽

Risk Factors ◽

Diabetic Patients ◽

Physically Active ◽

Hypertensive Patients ◽

Factors Associated ◽

Hs Crp ◽

Active Patients

ABSTRACTBackgroundObesity and chronic diseases associated with the development of inflammation have remained unclear if the observed inflammatory state in diabetic patients is due to excess adipose tissue mass and/or directly associated with the diabetic state. Therefore, this study determined the risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus.MethodsA total of 164 hypertensive diabetic patients aged 38 to 60 years were selected from seven primary health care centers in Gaza city, Palestine. Interview and questionnaire were employed to collect data related to age, gender, smoking habits, and physical activity pattern. Besides, the selection of patients depended on objective criteria.ResultsThe study involved 118 (72%) women and 46 (28%) men. The mean of age for all patients was 53.7±0.46 years old. 76 patients (46.3%) were categorized as current smokers, 88 patients (53.7%) categorized as non-smokers. The baseline distribution of patients according to physical activity has displayed that 130 (79.3%) were low physically active patients, 28 (27.1%) were moderate, and 6 (3.7%) were highly physically active patients. A tertile of inflammation feature with high sensitivity C-reactive protein (hs-CRP) was developed. The highest tertile of hs-CRP was significantly associated with women, higher obesity indices, metabolic dysregulation involving lipid profile markers, fasting blood glucose (FBG) and blood pressure, higher interleukin 6 (IL-6), and lower adiponectin. Via ordinal logistic regression analysis, after adjusting for age, gender, smoking habits, and physical activity; the risk factors for hs-CRP were the increased body mass index [OR: 1.17, P=0.018], IL-6 [OR: 2.22, P=0.025] and FBG [OR: 1.01, P=0.007], as well as reduced adiponectin [OR: 0.81, P=0.002].ConclusionThe inflammation state was affected by obesity and had been related to altered adipokines levels of IL-6 and adiponectin, as well as affected by the disease condition of diabetes, as evidenced by higher serum level of FBG.

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