scholarly journals Significant fall in stroke admissions in the Malopolska Voivodeship of Poland during the COVID-19 pandemic

2020 ◽  
Vol 54 (5) ◽  
pp. 471-472
Author(s):  
Agnieszka Słowik ◽  
Ryszard Nowak ◽  
Tadeusz Popiela
Keyword(s):  
Significant Fall

EFFECT OF LITHIUM ON THYROID FUNCTION IN MAN

1972 ◽  
Vol 70 (2) ◽  
pp. 266-272 ◽  
Author(s):  
J. H. Lazarus ◽  
E. H. Bennie
Keyword(s):  
Thyroid Function ◽  
Lithium Carbonate ◽  
Lithium Therapy ◽  
Thyroid Status ◽  
Prospective Survey ◽  
Significant Fall ◽  
Concentrating Mechanism ◽  
Before And After

ABSTRACT Thyroid function was assessed in a prospective survey of 13 manicdepressive patients before and after 3 months on lithium carbonate and in a further 12 patients who had received lithium for 20 months. There was a significant increase in thyroid size as measured by quantitative scintiscanning in 8 patients in the first group. One male in the second group had a goitre. There was a rise in plasma TSH in the first group and a significant fall in saliva to plasma iodide. It is suggested that pathogenesis of lithium induced goitre is related to a disturbance in the iodide concentrating mechanism. Thyroid status should be evaluated in patients who are suitable for lithium therapy.

AMPK activation with AICAR provokes an acute fall in plasma [K+]

2008 ◽  
Vol 294 (1) ◽  
pp. C126-C135 ◽  
Author(s):  
Dan Zheng ◽  
Anjana Perianayagam ◽  
Donna H. Lee ◽  
M. Douglas Brannan ◽  
Li E. Yang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Infusion Rate ◽  
Extracellular Fluid ◽  
Ampk Activation ◽  
Conscious Rats ◽  
Significant Fall ◽  
Ampk Phosphorylation ◽  
Atp Levels ◽  
Ampk Activity ◽  
Amp Activated Protein Kinase

AMP-activated protein kinase (AMPK), activated by an increase in intracellular AMP-to-ATP ratio, stimulates pathways that can restore ATP levels. We tested the hypothesis that AMPK activation influences extracellular fluid (ECF) K+ homeostasis. In conscious rats, AMPK was activated with 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) infusion: 38.4 mg/kg bolus then 4 mg·kg−1·min−1 infusion. Plasma [K+] and [glucose] both dropped at 1 h of AICAR infusion and [K+] dropped to 3.3 ± 0.04 mM by 3 h, linearly related to the increase in muscle AMPK phosphorylation. AICAR treatment did not increase urinary K+ excretion. AICAR lowered [K+] whether plasma [K+] was chronically elevated or lowered. The K+ infusion rate needed to maintain baseline plasma [K+] reached 15.7 ± 1.3 μmol K+·kg−1·min−1 between 120 and 180 min AICAR infusion. In mice expressing a dominant inhibitory form of AMPK in the muscle (Tg-KD1), baseline [K+] was not different from controls (4.2 ± 0.1 mM), but the fall in plasma [K+] in response to AICAR (0.25 g/kg) was blunted: [K+] fell to 3.6 ± 0.1 in controls and to 3.9 ± 0.1 mM in Tg-KD1, suggesting that ECF K+ redistributes, at least in part, to muscle ICF. In summary, these findings illustrate that activation of AMPK activity with AICAR provokes a significant fall in plasma [K+] and suggest a novel mechanism for redistributing K+ from ECF to ICF.

scholarly journals Mythic rights and conflict-related prisoner ‘re-integration’

2018 ◽  
Vol 43 (1) ◽  
pp. 39-55 ◽  
Author(s):  
Peter Shirlow
Keyword(s):  
Northern Ireland ◽  
Rhetorical Devices ◽  
The Past ◽  
Significant Fall

This article argues that within Northern Ireland the processes of disarmament, demobilisation and re-integration (DDR) remain incomplete. Despite general disarmament and demobilisation and a very significant fall in paramilitary violence, those imprisoned as a consequence of the conflict remain marginalised by vetting laws and other instruments of civic exclusion. This has significant consequences in terms of acknowledging that the conflict has ceased as a violent/military episode. This is due to rhetorical devices and positions that uphold variant readings of the past, especially those that impose a humiliated status upon conflict-related prisoners.

A STUDY OF THE EFFECT OF COLD ON JOINT TEMPERATURE AND MOBILITY

1951 ◽  
Vol 29 (5) ◽  
pp. 255-262 ◽  
Author(s):  
John Hunter ◽  
M. G. Whillans
Keyword(s):  
Knee Joint ◽  
Test Object ◽  
Joint Stiffness ◽  
Ambient Temperatures ◽  
Significant Fall ◽  
Average Skin ◽  
Skin Temperatures ◽  
Rectal Muscle

Exposure to zero and subzero ambient temperatures results in a significant fall in joint temperature, where the knee joint of the cat was used as test object. The fall in rectal, muscle, and “average” skin temperatures for similar exposures is considerably less. Low joint temperature is associated with increased joint stiffness.

Mechanisms of the antinatriuretic action of physiological doses of angiotensin II in man

1989 ◽  
Vol 76 (6) ◽  
pp. 653-658 ◽  
Author(s):  
Peter H. Seidelin ◽  
John J. McMurray ◽  
Allan D. Struthers
Keyword(s):  
Creatinine Clearance ◽  
Sodium Excretion ◽  
Free Water ◽  
Sodium Reabsorption ◽  
Ang Ii ◽  
Distal Nephron ◽  
Aldosterone Secretion ◽  
Significant Fall ◽  
Parallel Change ◽  
Proximal Tubular

1. Angiotensin 11 (ANG II; 1 ng min−1 kg−1) or 5% (w/v) d-glucose (placebo) was infused in six normal male volunteers, pretreated with 500 mg of lithium carbonate, who were undergoing maximal water diuresis. 2. This dose of ANG II caused a circulating increment within the physiological range (27 ± 4 to 48 ± 9 pmol/l). 3. Compared with placebo, ANG II caused a significant fall in urinary sodium excretion (113 ± 13 to 82 ± 10 μmol/min). This antinatriuretic effect occurred without a fall in creatinine clearance (107 ± 3 versus 113 ± 3 ml/min). 4. ANG II caused a significant fall in fractional lithium clearance (28 ± 2 to 23 ± 2%). This may indicate a proximal tubular effect of ANG II. 5. ANG II also reduced fractional distal delivery [(sodium clearance plus free water clearance) divided by creatinine clearance], another measure of proximal tubular outflow. A parallel change in these two separate markers of proximal function supports an action of ANG II at this nephron segment. 6. Furthermore, the antinatriuretic effect of ANG II was unlikely to be due to stimulation of aldosterone secretion because (a) the fall in sodium excretion was temporally dissociated from the rise in aldosterone secretion, (b) potassium excretion also tended to fall during ANG II infusion and (c) aldosterone has a distal nephron effect, while, in this study, proximal nephron fractional reabsorption of sodium increased and distal nephron fractional reabsorption of sodium was unchanged. 7. These observations suggest that physiological increments in ANG II can have an antinatriuretic effect in man, which, at least initially, results from increased proximal tubular sodium reabsorption and is independent of the effect of aldosterone.

Effect on Blood Pressure of Changing from High to Low Dose Steroid Preparations in Women with Oral Contraceptive Induced Hypertension

1982 ◽  
Vol 27 (3) ◽  
pp. 212-215 ◽  
Author(s):  
R. J. Weir
Keyword(s):  
Blood Pressure ◽  
Oral Contraceptive ◽  
Oral Contraceptives ◽  
Low Dose ◽  
Significant Fall ◽  
Induced Hypertension ◽  
One Year

Thirty women with hypertension induced by oral contraceptives containing 50 μg oestrogen and 1 to 4 mg. progestagen showed a marked significant fall in blood pressure when given either (a) a combination of 30 μg ethinyloestradiol with 150 to 250 μg levonorgestrel or (b) 350 μg norethisterone alone. One year after changing to either of these low dose preparations blood pressure had not fully returned to pre-oral contraceptive levels.

Inhibition of gastric secretion by thyroid preparations

1959 ◽  
Vol 196 (6) ◽  
pp. 1262-1265 ◽  
Author(s):  
E. S. Nasset ◽  
V. W. Logan ◽  
M. L. Kelley ◽  
Mary Thomas
Keyword(s):  
Gastric Secretion ◽  
Gastric Juice ◽  
Gradual Decline ◽  
Heidenhain Pouch ◽  
Significant Fall ◽  
Lean Beef ◽  
Inhibition Of Gastric Secretion

Four dogs with Thomas gastric pouches and one dog with a Heidenhain pouch were stimulated to secrete gastric juice by feeding 100 gm of lean beef. Feeding whole desiccated thyroid ordinarily caused a significant fall in volume of gastric juice and in the total quantity of HCl secreted. Crystalline thyroxine yielded erratic results and one trial with triiodothyronine produced a significant increase in gastric secretion. Thyroidectomy in one dog resulted in a gradual decline in secretion, but hypothyroidism produced by administration of mercaptoimidazole in another animal lead to a significant increase in secretion.

Hyperfibrinolysis In A Patient With IgG-Paraproteinemia

1981 ◽  
Author(s):  
R Egbring ◽  
H G Klingemann ◽  
N Heimburger ◽  
H E Karges ◽  
K Havemann
Keyword(s):  
Bone Marrow ◽  
Male Patient ◽  
Plasma Cells ◽  
Normal Values ◽  
Simultaneous Increase ◽  
Bleeding Tendency ◽  
Spontaneous Bleeding ◽  
Significant Fall ◽  
Coagulation Status ◽  
Plasmin Inhibitor

In patients with various malignancies (prostata, thyreoid, gastric), a hyperfibrinolytic syndrome has been described. We would like to give a report on a 56 year-old male patient who became clinically apparent by his spontaneous bleeding tendencies with large haematoma. Analysis of the coagulation status revealed a primary hyperfibrinolysis characterized by a prolonged TT and PTT, decreased fibrinogen (F I) and a simultaneous increase of FDP, associated with the consumption of F I. There was also a significant fall of plasminogen(Pig) and an alpha2-plasmin-inhibitor α2PI) down to about 10% of the norm. However, a Pig activator as a trigger of hyperfibrinolysis could not be detected in plasma, a malignoma could not be diagnosed. However, a IgG-paraproteinemia and uria associated with a 20% infiltration of bone marrow with plasma cells was assessed. The bleeding tendency was treated successfully with aprotinin (AntagosanR). Under the infusion (1 Mio KIU/d) a normalization of the coagulation status was observed as measured by means of the TT and PTT; simultaneously an increase of F I and the disappearance of FDP was observed. Pig and α2PI also rised but did not reach normal values. Based on these observations an interrelationship between hyperfibrinolysis and paraproteinemia appears to be possible.

Fasting gastric content of the squirrel monkey (Saimiri sciurea)

1963 ◽  
Vol 204 (4) ◽  
pp. 681-685 ◽  
Author(s):  
D. A. Brodie ◽  
R. W. Marshall
Keyword(s):  
Gastric Juice ◽  
Squirrel Monkey ◽  
Acid Concentration ◽  
Gastric Content ◽  
Free Acid ◽  
Squirrel Monkeys ◽  
Total Acid ◽  
Significant Fall ◽  
Gastric Contents ◽  
Saimiri Sciurea

Free acid was found in the fasting gastric contents of each of 13 squirrel monkeys studied. A comparison of gastric contents from unrestrained and restrained monkeys indicated that restraint significantly increased the free acid concentration. Over a 24-hr period, there was a decrease in volume, free acid and total acid concentration, and pepsin value of the gastric juice. Histamine (0.1 mg/kg hr, subcutaneously) produced a significant increase in free acid and total acid concentration, while the volume and pepsin values were not changed. Methacholine, at cumulative doses of 1.0 and 2.0 mg/kg, subcutaneously, produced a significant decrease in free and total acid concentration while the volume was not altered. Atropine, in cumulative doses of 8, 16, and 48 mg/kg, intraperitoneally, produced a significant fall in volume of gastric juice collected. However, free acid concentration was reduced only at the highest dose and total acid concentration was not changed by any of the doses tested.

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