scholarly journals The importance of mucormycosis infections on example of Rhino Orbital Cerebral Mucormycosis

2021 ◽  
Vol 75 ◽  
pp. 211-216
Author(s):  
Łukasz Pałka ◽  
Vivek Gaur
Keyword(s):  
Fungal Infection ◽  
General Health ◽  
Clinical Manifestations ◽  
Medical Intervention ◽  
Health Condition ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Proper Treatment ◽  
General Health Condition ◽  
Immunocompetent Patients

Mucormycosis is an angioinvasive fungal infection, characterized by high morbidity and mortality and is strongly dependent on the patient’s general health condition, initial site of infection, and the time from diagnosis to treatment commencement. It has been reported that the occurrence of mucormycosis has increased rapidly, also among immunocompetent patients. Moreover, the rise in number is expected to continue. Among all clinical manifestations of mucormycosis, the rhino-orbital-cerebral type (ROCM) is the most common. The aim of this article is to increase the awareness of mucoral infections, especially ROCM, and to describe its first symptoms, as proper treatment requires immediate surgical and medical intervention.

scholarly journals A case series on post-covid deadly fungal infection: mucormycosis

2021 ◽  
Vol 7 (9) ◽  
pp. 1503
Author(s):  
Kalpana G. ◽  
Amol A. Patil ◽  
Manohar Shaan ◽  
Mitusha Verma ◽  
Gayatri Harshe
Keyword(s):  
Fungal Infection ◽  
Opportunistic Infection ◽  
Surgical Intervention ◽  
Case Series ◽  
Medical Intervention ◽  
Morbidity And Mortality ◽  
Diabetic Patients ◽  
High Morbidity ◽  
Per Se

<p class="abstract">The prevailing pandemic situation by SARS-CoV-2 infection is not only worrisome by the disease per se but also for the accompanying opportunistic infection are in the rise especially in diabetic patients. We presented a case series of post-covid rhino orbital cerebral mucormycosis infection in diabetic patients resulting in high morbidity. The need to present this was to emphasis on the timely surgical and medical intervention needed to reduce morbidity and mortality by the infection. The study highlighted the importance of surgical intervention in the deadly infection.</p>

scholarly journals Efficacy of Levamisole with Standard Care Treatment vs Standard Care in Clinical Presentations of Non-Hospitalized Patients with COVID-19: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Mohammad Hossein Asgardoon ◽  
Hamid Emadi koochak ◽  
Mohammad Hassan Kazemi-Galougahi ◽  
Ali Zare Dehnavi ◽  
Behzad Khodaei ◽  
...  
Keyword(s):  
Clinical Benefit ◽  
General Health ◽  
Standard Care ◽  
Intervention Group ◽  
Health Condition ◽  
Hospitalized Patients ◽  
Care Group ◽  
Control Group ◽  
Significant Difference ◽  
General Health Condition

Abstract Introduction: Levamisole (LVM) demonstrated clinical benefit in a trial in patients with mild to moderate coronavirus disease 2019 (COVID-19), but its effect in a larger sample size needs to be confirmed. Methods In this randomized open-label trial, we enrolled non-hospitalized patients with mild to moderate COVID-19 at nine health centers in Tehran province, Iran, in 2021. Patients were randomly assigned to receive a 10-day course of LVM with standard care (n = 185), or standard care (n = 180) in a 1:1 ratio. On days 1 to 10, LVM was administered orally at a dosage of 50 mg. The participants were called and followed on days 1, 3, 5, 7, 9, and 14. The outcomes were general health condition, hospitalization rate, sign and symptoms, and adverse events (AEs). Generalized Estimating Equations model was used for analysis. Results Among 507 randomized patients, 473 started the experiment and received LVM in addition to standard care or received only the standard care (median age, 40 [IQR, 32-50.75] years; 164 [44.9%] women; 9.4% had diabetes, 8.8% hypertension, 1.6% cardiovascular disease), and 346 (98%) completed the trial. Compared to control group, LVM decreased the general health condition of the patients (B=-0.635; CI= -0.041, -0.329; P= 0.000). Patients in the LVM with standard care group had significantly lower odds of developing fever (OR= 0.260; 95% CI= ‎0.11‎‎3‎-0.59‎‎9‎; P = .002), chills (OR= 0.223; 95% CI= ‎‎0.07‎‎6‎-‎0.64‎‎8‎; P = 0.006), fatigue (OR= 0.576; 95% CI= ‎0.34‎‎6‎-‎0.96‎‎0‎‎; P = ‎0.034), and myalgia (OR= 0.54‎‎4‎; 95% CI= ‎0.31‎‎7‎-‎0.93‎‎2‎‎; P =0.027). During the therapy, there was no significant difference in the parameters of dyspnea, cough, diarrhea, nausea, vomiting, sore throat, hyposmia, dysgeusia, and anorexia (P > 0.05). No significant difference was observed in the rate of hospitalization. Although the intervention group had greater AEs than the control group, yet, the difference was not statistically significant. Conclusions LVM has clinical benefit in improving health condition of patients with mild to moderate COVID-19. Further studies are needed to confirm our findings. Trial Registration: Iranian Registry of Clinical Trials: IRCT20201124049480N1; Registration date: 28/03/2021.

scholarly journals Gastrointestinal Mucormycosis: A Rare but Lethal Mimicker of Necrotising Enterocolitis

2016 ◽  
Vol 36 (2) ◽  
pp. 198-200 ◽  
Author(s):  
Veerbhadra Radhakrishna ◽  
Krishna Kumar Govindarajan ◽  
Bharathi Balachandar ◽  
Nishad Plakkal ◽  
Sree Rekha Jinkala
Keyword(s):  
Fungal Infection ◽  
Necrotizing Enterocolitis ◽  
Necrotising Enterocolitis ◽  
Morbidity And Mortality ◽  
High Morbidity

Neonatal Gastrointestinal mucormycosis is a rare fungal infection carrying high morbidity and mortality. Clinically, it is not easily distinguishable from the more common necrotizing enterocolitis. Diagnosis is made by histopathology of the involved bowel. We report a neonate with gastrointestinal mucormycosis, bringing to notice the fatality of this infection.J Nepal Paediatr Soc 2016;36(2):198-200.

MO370PREGNANCY-RELATED ACUTE KIDNEY INJURY IN TUNISIA: A CLINICAL CHALLENGE

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Menel Msehli ◽  
Hela Jbali ◽  
Mami Ikram ◽  
Badreddine Ben kaab ◽  
Fethi Ben hamida ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Renal Failure ◽  
Prenatal Care ◽  
Clinical Manifestations ◽  
Kidney Injury ◽  
Morbidity And Mortality ◽  
Renal Outcome ◽  
Clinical Feature ◽  
High Morbidity

Abstract Background and Aims Acute kidney injury (AKI) is a complex disorder that occurs in several clinical settings. During pregnancy, there are additional unique conditions that contribute to AKI. The clinical manifestations of Pregnancy related acute kidney injury(PRAKI) range from a minimal elevation in serum creatinine to severe renal failure requiring renal replacement therapy and may be associated with significant morbidity and mortality in young healthy women. This study aims to describe epidemiologic features, study clinical profile and outcomes of women with PRAKI and identify risk factors related to requiring hemodialysis among patients. Method We performed a retrospective study over a 5-year period (2015–2019) in a Tunisian intensive care unit. All patients presenting PRAKI were included. Results Ninety-six cases of PRAKI were listed. The rate of AKI during pregnancy-related hospitalizations was 16% .the average age was 31 ± 5 years. Most women were from urban areas (62%) but with insufficient prenatal care (57%).Seventy-eight percent underwent cesarean section delivery. PRAKI occurred in the postpartum in 79%of the cases. Oligo-anuria was the most common clinical feature of PRAKI, noted in 82% of our patients. The leading etiological causes were pre eclampsia, eclampsia, postpartum haemorrhage and sepsis respectively, in 49%, 38%, and 24% of the cases. Hemodialysis was required in 23% of cases. In the adjusted regression analysis, factors associated with dialysis were insufficient prenatal care (p=0,010 ; O Ra=24,113), HELLP syndrome (p=0,003 ; ORa=35,129), disseminated intravascular coagulation (p=0,007 ; OR=11,854), average duration of oliguria (p=0,001; ORa=3,025) , Failure stage of RIFLE criteria while admitted (p=0,009; ORa=2,09) and length of ICU stay (p=0,042 ; ORa=1,118). Renal outcome was favorable, with a complete renal function recovery for 72 patients (75%). Only four patients (4%) developed chronic renal failure. Mortality rate was 13%. Conclusion PRAKI is a dreaded complication of pregnancy with high morbidity and mortality. Prevention of PRAKI requires an improvement of the sanitary infrastructures with the implementation of an obligatory prenatal consultation in order to prompt management of the underlying risk factors

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): What Can Africa Learn from Ongoing Research in Epidemiology, Clinical Manifestations, Chemotherapy and Prevention?

2020 ◽  
pp. 17-27
Author(s):  
Silas Lendzele Sevidzem ◽  
Aubin Armel Koumba ◽  
Christophe Roland Zinga- Koumba ◽  
Nonvignon Marius Kedote ◽  
Gaël Darren Maganga ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Clinical Manifestations ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Geographical Differences ◽  
Cultural Economic ◽  
Ongoing Research ◽  
Animal Host ◽  
Drug Of Choice ◽  
The World

The world is experiencing an outbreak due to the new and mysterious SARS-CoV-2. Information regarding its source and transmission dynamics in different environments as well as medications for its prevention and cure is weak. This review seeks to document on the epidemiology, clinical signs, control, prevention, and present some perspectives for SARS-CoV-2 research in Africa. There are geographical differences in morbidity and mortality rates of this disease all over the world. The scientific community strongly reject claims regarding the fact that the virus has been genetically manipulated, but supports the theory that it has a natural origin from animal host as any other emerging viral disease. Although animals are thought to be the original source of global spill over, person-to-person transmission is well comprehended. Transmission could be enhanced by symptomatic and asymptomatic individuals with high contaminations reported in dense urban environments. Scientific evidences from the Center for Disease Control (CDC) and other publications reported that contaminated surfaces and air could possibly be the underlying mechanism through which SARS-CoV-2 spreads. Cohort studies reveal that children as well as adults could be vulnerable to the disease, but others attribute it to health care workers, some risky habits (drinking and smoking) and comorbid individuals due to their immune suppressed status. There is no drug of choice for SARS-CoV-2, but clinical studies including several antiviral drugs are underway. Similarly, vaccine studies and clinical trial studies are ongoing. Because there is no medication, preventive measures such as Personal Protective Equipments (PPEs), ventilators, sanitation, social distancing, and quarantine are the gears globally used to curb the spread of this virus. The African continent does not have high morbidity and mortality compared to other continents that are highly affected. The following lessons could be learned by Africans from ongoing research: that the SARS-CoV-2 originated from an animal host, individuals could be infected irrespective of their age, sex, race, and origin, there is a broad spectrum of clinical signs and confirmatory diagnosis is required, there is no approved drug of choice, vaccine trials are ongoing and community-based prevention is required, the recommendations put in place by the Government and the WHO to curb the spread of this virus should be strictly followed. From the above lessons, a research project to study the ecological epidemiology of SARS-CoV-2 in tropical African settings by including the following aspects: socio-cultural, economic, and political characteristics as well as the evaluation of measures taken by the different countries to combat the disease is required.

scholarly journals Pneumoperitoneum with Subcutaneous Emphysema after Percutaneous Endoscopic Gastrostomy

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Yalin Iscan ◽  
Bora Karip ◽  
Yetkin Ozcabi ◽  
Birol Ağca ◽  
Yesim Alahdab ◽  
...  
Keyword(s):  
Enteral Nutrition ◽  
Percutaneous Endoscopic Gastrostomy ◽  
Subcutaneous Emphysema ◽  
General Health ◽  
Delayed Diagnosis ◽  
Health Condition ◽  
Diagnosis And Treatment ◽  
Endoscopic Gastrostomy ◽  
General Health Condition ◽  
Life Threatening

Percutaneous endoscopic gastrostomy is a safe way for enteral nutrition in selected patients. Generally, complications of this procedure are very rare but due to patients general health condition, delayed diagnosis and treatment of complications can be life threatening. In this study, we present a PEG-related massive pneumoperitoneum and subcutaneous emphysema in a patient with neuro-Behçet.

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