Women in Polish otorhinolaryngology

The first woman with a doctor's degree to practice in Poland was Anna Tomaszewicz-Dobrska (1854-1918). In Polish literature it is difficult to establish which of the women was the first to deal with diseases in the field of otorhinolaryngology. Pioneers in the specialty of otorhinolaryngology could be women who graduated from medical studies and completed "specialization" in clinics outside Poland or in Krakow, where the first department was established in Poland, and women were the first to have the opportunity to study medicine. In Poland, in 1925, out of 738 female doctors, only 4 of them dealt with diseases in the area of the head and neck, in 1938 21 women out of 2018 female doctors, and in 2020 out of 90,435 women, 1991 out of 3,378 doctors practicing the otorhinolaryngology. In Poland, Aleksandra Salomea Mitrinowicz-Modrzejewska was probably the first female otorhinolaryngologist who obtained her habilitation in 1947 and riched the title of associate professor in 1954. Until now, it has been established that only 28 women in Poland associated with otorhinolaryngology who have obtained the full profesor title.

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Bacteriological examination of blood for endocarditis lent a and other septic diseases

Kazan medical journal ◽

10.17816/kazmj58479 ◽

1930 ◽

Vol 26 (9) ◽

pp. 945-946

Author(s):

О. A. German

Keyword(s):

Associate Professor ◽

The State ◽

Bacteriological Examination ◽

Medical Studies ◽

State Institute ◽

Scientific Meetings

Scientific meetings of doctors of the State Institute for Advanced Medical Studies named after V.I. Lenin in Kazan. 121st meeting May 20, 1930 Privat Associate Professor O. A. German. Bacteriological examination of blood in endocarditis lent a and other septic diseases.

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Pedicle flaps in plastic surgery of the head and neck. By Gordon B. New, M.D., F.A.C.S., Professor of Plastic Surgery, and John D. Erich, M.D., F.A.C.S., Associate Professor of Plastic Surgery, Graduate School, University of Minnesota, Minneapolis. 6 × 9 in. Pp. 104 + vii, with 76 illustrations. Springfield, III.: Charles C. Thomas. (Oxford: Blackwell Scientific Publications Ltd.) 21s. 6d

British Journal of Surgery ◽

10.1002/bjs.18003915333 ◽

1951 ◽

Vol 39 (153) ◽

pp. 95-95

Keyword(s):

Head And Neck ◽

Plastic Surgery ◽

Graduate School ◽

Associate Professor ◽

University Of Minnesota ◽

Scientific Publications ◽

Pedicle Flaps

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Treatment of Cancer and Allied DiseasesTreatment of Cancer and Allied Diseases. Volume I: Principles of Treatment by Fifty-Five Authors. Volume II: Tumors of the Nervous System by Thirty Authors. Volume III: Tumors of the Head and Neck by Seventy Authors. Edited by PackGeorge T., M.D., F.A.C.S., Attending Surgeon, Memorial Center for Cancer and Allied Diseases; Associate Professor of Clinical Surgery, Cornell University Medical College; Surgeon, Pack Medical Group, New York, and ArielIrving M., M.D., F.A.C.S., Associate Clinical Professor of Surgery and Associate Attending Surgeon, New York Medical College, Flower and Fifth Avenue Hospitals; Surgeon, Pack Medical Group, New York. Volume I, 646pages, with 505 figures; Volume II, 316pages, with 340 figures; Volume III, 782pages, with 1,028 figures. Published by Paul B. Hoeber, Inc., Medical Book Department of Harper & Brother, New York, N. Y., 2d ed., 1958 (Vol. I), 1959 (Vol. II and III). Price $22.50; $15.00; $30.00.

Radiology ◽

10.1148/73.2.277b ◽

1959 ◽

Vol 73 (2) ◽

pp. 277-278

Keyword(s):

New York ◽

Nervous System ◽

Head And Neck ◽

Associate Professor ◽

Medical Group ◽

York Medical College ◽

Cornell University ◽

Medical College ◽

Medical Book ◽

Principles Of Treatment

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Surgery of head and neck tumors. By Hayes Martin, M.D., Attending Surgeon, Memorial Hospital, Associate Professor of Clinical Surgery, Cornell University Medical College, New York. 10 1/2 × 7 1/2 in. Pp. 430 + xvi, with 599 illustrations. 1958. London: Cassell and Co. Ltd. £6 17s. 6d

British Journal of Surgery ◽

10.1002/bjs.18004519424 ◽

1958 ◽

Vol 45 (194) ◽

pp. 662-662

Keyword(s):

New York ◽

Head And Neck ◽

Associate Professor ◽

Head And Neck Tumors ◽

Memorial Hospital ◽

Cornell University ◽

Medical College ◽

Neck Tumors

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Implications for clinical staging of metastatic cutaneous squamous carcinoma of the head and neck based on a multicenter study of treatment outcomes

The Journal of Laryngology & Otology ◽

10.1017/s0022215106002891 ◽

2005 ◽

pp. 1

Keyword(s):

Head And Neck ◽

Treatment Outcomes ◽

Multicenter Study ◽

Squamous Carcinoma ◽

Clinical Staging

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[Triple-combined therapy of malignant cancer of the head and neck-maxillary cancer]

Journal of Dental Education ◽

10.1002/j.0022-0337.1969.33.4.tb00237.x ◽

1969 ◽

Vol 33 (4) ◽

pp. 596-598

Author(s):

Y Sato

Keyword(s):

Head And Neck ◽

Combined Therapy ◽

Maxillary Cancer

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Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

Biochemical Journal ◽

10.1042/bcj20190591 ◽

2019 ◽

Vol 476 (24) ◽

pp. 3705-3719 ◽

Cited By ~ 2

Author(s):

Avani Vyas ◽

Umamaheswar Duvvuri ◽

Kirill Kiselyov

Keyword(s):

Oxidative Stress ◽

Head And Neck ◽

Transcriptional Activation ◽

Platinum Resistance ◽

Mrna Levels ◽

Strong Positive Correlation ◽

Platinum Compounds ◽

Copper Chelation ◽

Novel Approach ◽

Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

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