The Usefulness of Biosynthetic Vascular Graft Omniflow II and Autologous Veins for the Treatment of Massive Infection of Dacron Vascular Graft with Enterococcus faecalis HLAR

Infections of vascular grafts are the most severe complications in vascular surgery. We present the case of a 73-year-old male with infection of a dacron prosthesis with a strain of Enterococcus faecalis. The patient was treated with replacement of a full prosthesis with a combined graft constructed from Biosynthetic Vascular graft Omniflow and autologous veins. This graft is recommended for implantation in patients with a higher risk of infection. Our case is one of the first reported usage of this kind of graft in the aortic region and in a 2 years observation period no recurrence of infection was observed.

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Effectiveness of distal arterial bypass with porcine decellularized vascular graft for treating diabetic lower limb ischemia

The International Journal of Artificial Organs ◽

10.1177/0391398820980021 ◽

2020 ◽

pp. 039139882098002

Author(s):

Zhu Tong ◽

Zeqin Xu ◽

Yisha Tong ◽

Lixing Qi ◽

Lianrui Guo ◽

...

Keyword(s):

Lower Extremity ◽

Vascular Surgery ◽

Lower Limb ◽

Vascular Graft ◽

Mechanical Stability ◽

Vascular Grafts ◽

Small Diameter ◽

Limb Ischemia ◽

Lower Limb Ischemia ◽

Artery Reconstruction

Background: Application of tissue engineered vascular grafts for small-diameter artery reconstruction has been a much anticipated advance in vascular surgery. The aim of this study is to assess the effectiveness of small-diameter decellularized vascular grafts in below-knee bypass surgery for diabetic lower extremity ischemia. Methods: Three patients with diabetic lower limb ischemia were admitted to the Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University between May, 2010 and June, 2010. Decellularized porcine arteries with modified surface were implanted in the lower extremity for below-knee arterial revascularization. Imaging examination was performed for assessment of graft mechanical stability and patency at 1 month and 6 months after implantation. Results: At 6 months after implantation, all three grafts were patent with no stenosis or aneurysm formation of the grafts were found on imaging assessment with primary patency rate of 100% (3/3) both at 1 month and 6 months after graft insertion. Conclusion: Decellularized vascular graft with surface modification for the small-diameter artery reconstruction had good clinical results after 6 months follow-up in three patients with diabetic lower limb ischemia.

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Electrospun poly-ε-caprolactone scaffold modified with catalytic nitric oxide generation and heparin for small-diameter vascular graft

RSC Advances ◽

10.1039/c7ra02086d ◽

2017 ◽

Vol 7 (30) ◽

pp. 18775-18784 ◽

Cited By ~ 13

Author(s):

Jingchen Gao ◽

Yaping Wang ◽

Siyuan Chen ◽

Di Tang ◽

Li Jiang ◽

...

Keyword(s):

Nitric Oxide ◽

Vascular Surgery ◽

Vascular Graft ◽

Vascular Grafts ◽

Small Diameter ◽

Peripheral Vascular ◽

Peripheral Vascular Surgery ◽

Acute Thrombosis ◽

Neointimal Proliferation ◽

Synthetic Grafts

Vascular grafts are significantly needed in peripheral vascular surgery; however, small diameter grafts are not always available, and synthetic grafts perform poorly because of acute thrombosis and neointimal proliferation after implantation.

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Engineering the Composition of Microfibers to Enhance the Remodeling of a Cell-Free Vascular Graft

Nanomaterials ◽

10.3390/nano11061613 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1613

Author(s):

Fang Huang ◽

Yu-Fang Hsieh ◽

Xuefeng Qiu ◽

Shyam Patel ◽

Song Li

Keyword(s):

Vascular Graft ◽

Animal Studies ◽

Vascular Grafts ◽

Cell Infiltration ◽

Tubular Scaffold ◽

Base Polymer ◽

A Cell ◽

Scaffold Materials ◽

Stromal Cell Derived Factor ◽

Technology Blending

The remodeling of vascular grafts is critical for blood vessel regeneration. However, most scaffold materials have limited cell infiltration. In this study, we designed and fabricated a scaffold that incorporates a fast-degrading polymer polydioxanone (PDO) into the microfibrous structure by means of electrospinning technology. Blending PDO with base polymer decreases the density of electrospun microfibers yet did not compromise the mechanical and structural properties of the scaffold, and effectively enhanced cell infiltration. We then used this technique to fabricate a tubular scaffold with heparin conjugated to the surface to suppress thrombosis, and the construct was implanted into the carotid artery as a vascular graft in animal studies. This graft significantly promoted cell infiltration, and the biochemical cues such as immobilized stromal cell-derived factor-1α further enhanced cell recruitment and the long-term patency of the grafts. This work provides an approach to optimize the microfeatures of vascular grafts, and will have broad applications in scaffold design and fabrication for regenerative engineering.

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Ovine Biosynthetic Grafts for Aortoiliac Reconstructions in Nonsterile Operative Fields

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0041-1723000 ◽

2021 ◽

Author(s):

Hazem El Beyrouti ◽

Mohammad Bashar Izzat ◽

Angela Kornberger ◽

Nancy Halloum ◽

Kathrin Dohle ◽

...

Keyword(s):

Treatment Group ◽

Vascular Grafts ◽

Graft Infection ◽

Prosthetic Graft ◽

Vascular Graft Infection ◽

Vascular Prostheses ◽

Graft Thrombosis ◽

Life Threatening ◽

Omniflow Ii

Abstract Background Prosthetic vascular grafts placed surgically or via endovascular techniques can be subject to the risk of life-threatening graft infections. The Omniflow II vascular prosthesis is a biosynthetic graft that was reported to have favorable properties in resisting infections. Materials and Methods We retrospectively reviewed our 3 years' experience of using the Omniflow II prostheses for aortoiliac reconstructions in patients considered to carry a substantial risk of subsequent prosthetic graft infections (prevention group) as well as in patients with actively infected prosthetic vascular grafts (treatment group). Results Aorto-bi-iliac (n = 4) and aortobifemoral (n = 12) vascular reconstructions were performed using bifurcated Omniflow II prostheses in nine patients in the prevention group and seven patients in the treatment group. During mean follow-up of 28.6 ± 17.2 months, there was one case of graft infection (6.3%) and graft thrombosis (6.3%) with subsequent successful thrombectomy. Early and late surgical revisions were required in eight (50%) and two (12.6%) patients, respectively. All graft prostheses were patent at last follow-up. Conclusion Using bifurcated Omniflow II vascular prostheses in patients with or at a high risk of vascular graft infection is advisable, and is associated with acceptable reinfection and patency rates.

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Which prosthesis is more resistant to vascular graft infection: polytetrafluoroethylene or Omniflow II biosynthetic grafts?

Surgery Today ◽

10.1007/s00595-015-1141-3 ◽

2015 ◽

Vol 46 (3) ◽

pp. 363-370 ◽

Cited By ~ 7

Author(s):

Orhan Bozoglan ◽

Bulent Mese ◽

Erdinc Eroglu ◽

Serdal Elveren ◽

Mustafa Gul ◽

...

Keyword(s):

Vascular Graft ◽

Graft Infection ◽

Vascular Graft Infection ◽

Omniflow Ii

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Editor's Choice – European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Vascular Graft and Endograft Infections

European Journal of Vascular and Endovascular Surgery ◽

10.1016/j.ejvs.2019.10.016 ◽

2020 ◽

Vol 59 (3) ◽

pp. 339-384 ◽

Cited By ~ 38

Author(s):

Nabil Chakfé ◽

Holger Diener ◽

Anne Lejay ◽

Ojan Assadian ◽

Xavier Berard ◽

...

Keyword(s):

Clinical Practice ◽

Vascular Surgery ◽

Clinical Practice Guidelines ◽

Practice Guidelines ◽

European Society ◽

Vascular Graft

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Imaging Modalities for the Diagnosis of Vascular Graft Infections: A Consensus Paper amongst Different Specialists

Journal of Clinical Medicine ◽

10.3390/jcm9051510 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1510 ◽

Cited By ~ 2

Author(s):

Chiara Lauri ◽

Roberto Iezzi ◽

Michele Rossi ◽

Giovanni Tinelli ◽

Simona Sica ◽

...

Keyword(s):

Nuclear Medicine ◽

Mortality Rate ◽

Vascular Surgery ◽

High Mortality ◽

Vascular Graft ◽

Graft Infection ◽

Imaging Modalities ◽

Evidence Based ◽

Vascular Graft Infection ◽

Standardized Diagnostic

Vascular graft infection (VGI) is a rare but severe complication of vascular surgery that is associated with a bad prognosis and high mortality rate. An accurate and prompt identification of the infection and its extent is crucial for the correct management of the patient. However, standardized diagnostic algorithms and a univocal consensus on the best strategy to reach a diagnosis still do not exist. This review aims to summarize different radiological and Nuclear Medicine (NM) modalities commonly adopted for the imaging of VGI. Moreover, we attempt to provide evidence-based answers to several practical questions raised by clinicians and surgeons when they approach imaging in order to plan the most appropriate radiological or NM examination for their patients.

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