Clinical characteristics and laboratory findings of COVID-19 in Istanbul

Introduction: Information on the clinical characteristics of local patients with confirmed COVID-19 is limited. This study aims to report the clinical characteristics of 147 patients admitted and receiving treatment at a teaching hospital. Methodology: Patients’ socio-demographic and epidemiological data, clinical features, laboratory findings and clinical outcomes were extracted using a data sheet. Results: The median patient age was 25 [interquartile range (IQR)] 20–44) years, and most of patients were male (68.7%) and of Malaysian nationality (88.4%). Almost half of the patients were from a case cluster related to a religious event (48.3%) and 12.9% had a history of overseas travel. A total of 33.3% of patients were not related to any case cluster, i.e. sporadic cases. Radiological investigation showed that 13.6% of the patients had chest X-ray changes and all laboratory parameters were within the normal ranges. Sixty-six patients (44.9%) experienced symptoms. The most common symptoms were rhinitis (66.7%), followed by fever (19.7%) and cough (15.2%). Age, gender, case cluster, comorbidity status, haemoglobin, albumin, total protein, bilirubin total and alkaline phosphatase level were associated with symptomatic status. Conclusions: In this single-centre study, COVID-19 infection led not only to case clusters, but also to sporadic infections, with patients being either symptomatic or asymptomatic. These sporadic cases and asymptomatic patients may hamper effective contact tracing, leading to rapid human-to-human transmission in our population. Future studies on the prevalence and clinical significance of asymptomatic and presymptomatic COVID-19 patients would pre-emptively address issues on further containment of the pandemic.

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Clinical Characteristics and Outcomes of Diabetic COVID-19 patients in Kuwait

10.1101/2020.08.20.20178525 ◽

2020 ◽

Cited By ~ 1

Author(s):

Abdullah Alshukry ◽

Mohammad Bu Abbas ◽

Yaseen Ali ◽

Barrak Alahmad ◽

Abdullah A. Al-Shammari ◽

...

Keyword(s):

Clinical Characteristics ◽

Clinical Laboratory ◽

Fasting Blood Glucose ◽

List Type ◽

Laboratory Findings ◽

Reactive Protein ◽

Patients With Diabetes ◽

Laboratory Investigations ◽

Insight Into ◽

Variable Clinical Presentation

AbstractBackgroundCOVID-19 has a highly variable clinical presentation, ranging from asymptomatic to severe respiratory symptoms and death. Diabetes seems to be one of the main comorbidities contributing to a worse COVID-19 outcome.ObjectiveIn here we analyze the clinical characteristics and outcomes of diabetic COVID-19 patients.MethodsIn this single-center, retrospective study of 417 consecutive COVID-19 patients, we analyze and compare disease severity, outcome, associated complications, and clinical laboratory findings between diabetic and non-diabetic COVID-19 patients.ResultsCOVID-19 patients with diabetes had more severe outcomes and higher mortality than non-diabetic COVID-19 patients. Diabetic COVID-19 patients had significantly higher prevalence of comorbidities, such as hypertension. Laboratory investigations also highlighted notably higher levels of C-reactive protein in diabetic COVID019 patients and lower estimated glomerular filtration rate. They also showed a higher incidence of complications.ConclusionDiabetes could be a major contributor to worsening outcomes in COVID-19 patients. Understanding the pathophysiology underlining these findings could provide insight into better management and improved outcome of such cases.Highlights of the StudyA significantly higher proportion of Diabetic COVID-19 patients required admission to the ICU.Higher fasting blood glucose was associated with higher risk of COVID-19 associated mortality.Diabetic COVID-19 patients had significantly higher incidence of complications including sepsis, ARDS, cardiac failure and renal failure.

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Clinical characteristics, laboratory findings and outcomes of Toxoplasma gondii infection in HIV/AIDS patients at Bach Mai Hospital

Journal of Clinical Medicine Bach Mai Hospital ◽

10.52322/jocmbmh.07.en.11 ◽

2021 ◽

Vol 07.en ◽

Keyword(s):

Toxoplasma Gondii ◽

Clinical Characteristics ◽

Aids Patients ◽

Laboratory Findings ◽

Toxoplasma Gondii Infection ◽

Hiv Aids

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Association between incubation period and clinical characteristics of patients with COVID-19

Journal of International Medical Research ◽

10.1177/0300060520956834 ◽

2020 ◽

Vol 48 (9) ◽

pp. 030006052095683

Author(s):

Yeyu Cai ◽

Jiayi Liu ◽

Haitao Yang ◽

Mian Wang ◽

Qingping Guo ◽

...

Keyword(s):

Incubation Period ◽

Disease Severity ◽

Symptom Onset ◽

Clinical Characteristics ◽

Characteristic Curve ◽

Severe Disease ◽

Receiver Operator Characteristic Curve ◽

Hunan Province ◽

Laboratory Findings ◽

Incubation Periods

Purpose To investigate associations between the clinical characteristics and incubation periods of patients infected with coronavirus disease 2019 (COVID-19) in Wuhan, China. Methods Complete clinical and epidemiological data from 149 patients with COVID-19 at a hospital in Hunan Province, China, were collected and retrospectively analyzed. Results Analysis of the distribution and receiver operator characteristic curve of incubation periods showed that 7 days was the optimal cut-off value to assess differences in disease severity between groups. Patients with shorter (≤7 days) incubation periods (n = 79) had more severe disease, longer durations of hospitalization, longer times from symptom onset to discharge, more abnormal laboratory findings, and more severe radiological findings than patients with longer (>7 days) incubation periods. Regression and correlation analyses also showed that a shorter incubation period was associated with longer times from symptom onset to discharge. Conclusion The associations between the incubation periods and clinical characteristics of COVID-19 patients suggest that the incubation period may be a useful marker of disease severity and prognosis.

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Clinical and cell surface marker characterization of the early phase of chronic lymphocytic leukemia

Blood ◽

10.1182/blood.v52.1.25.25 ◽

1978 ◽

Vol 52 (1) ◽

pp. 25-35 ◽

Cited By ~ 14

Author(s):

RA Rudders ◽

JP Howard

Keyword(s):

Cell Proliferation ◽

T Cells ◽

B Cell ◽

Clinical Characteristics ◽

Surface Marker ◽

Lymphocytic Leukemia ◽

Surface Markers ◽

Laboratory Findings ◽

Absolute Lymphocyte Counts

Abstract The immunologic surface markers on lymphocytes and clinical characteristics of 35 patients with established (stages 0–4) CLL with absolute lymphocyte counts greater than 15,000/cu mm were compared to those of a group of 25 patients with CLL in an early or preleukemic phase (counts of less than 15,000/cu mm). We found a monoclonal B cell proliferation in most cases in the latter group, in spite of the paucity of clinical and laboratory findings. Furthermore, early CLL can readily be distinguished from benign lymphocytosis by surface marker criteria. In untreated CLL, surface marker characteristics are stable with time and predominantly reflect expansion of clones expressing only B cell markers; however, small increase of blood T cells are often seen. Surface markers are a simple and clinically useful tool for definding and characterizing the preleukemic phase of CLL and its ultimate progression to established CLL.

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Psychoactive substance use among patients admitted to an acute psychiatric ward: Laboratory findings and associations with clinical characteristics

Nordic Journal of Psychiatry ◽

10.3109/08039488.2010.527014 ◽

2010 ◽

Vol 65 (3) ◽

pp. 208-215 ◽

Cited By ~ 9

Author(s):

Jon Mordal ◽

Bjørn Holm ◽

Michael Gossop ◽

Maria Romøren ◽

Jørg Mørland ◽

...

Keyword(s):

Substance Use ◽

Clinical Characteristics ◽

Psychiatric Ward ◽

Psychoactive Substance ◽

Laboratory Findings ◽

Psychoactive Substance Use ◽

Acute Psychiatric Ward

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Changes in liver function in patients with covid-19 and the demographics of the disease in a mid-sized city of Turkey: A retrospective analysis

Medical Science and Discovery ◽

10.36472/msd.v7i12.442 ◽

2020 ◽

Vol 7 (12) ◽

pp. 739-744

Author(s):

Huseyin Avni Demir

Keyword(s):

Liver Function ◽

Clinical Characteristics ◽

Severe Disease ◽

Close Monitoring ◽

Test Results ◽

Laboratory Findings ◽

Icu Patients ◽

Mortality And Morbidity ◽

The Mean ◽

Significant Mortality

Objective: To define the clinical characteristics of patients hospitalized with COVID-19 in ICU and ward and to evaluate the significance of liver function test results. A new disease caused by SARS-CoV-2 has been devastating the world affecting millions of patients worldwide and leading the significant mortality and morbidity. Material and Methods: The demographic features of a cohort of 125 hospitalized patients between March 2020 and May 2020 were recorded. The clinical characteristics, laboratory findings, and mortality rates were analyzed. Results: A total of 125 patients hospitalized for COVID-19 diagnosis where 113 (90.4%) were followed-up in the ward and 12 (9.6%) were in ICU were included in the study. The mean age of the patients was 44.05±16.95 and 88 (70.4%) of the patients were male. The most common symptoms were in the following order: cough in 80 patients (64%), dyspnea in 40 (32%) and fever in 33 (26.4%). The leukocyte and neutrophil counts were significantly higher in ICU patients with COVID-19 compared to patients in the ward (p=0.002, p<0.05; respectively). The CRP and D-Dimer levels were found elevated in ICU patients with COVID-19 than in the ward (p<0.05; p<0.05, respectively). The AST level of patients with COVID-19 in ICU was significantly heightened than patients in the ward. Conclusion: The present study revealed that patients with elevated AST level were at great risk of progressing to severe disease those require close monitoring.

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