Validation of the Sinhala version of the Morisky Medication Adherence Scale to determine medication adherence in patients with bipolar affective disorder on lithium therapy

2018 ◽  
Vol 6 (1) ◽  
pp. 30
Author(s):  
Uthpali Mannapperuma ◽  
Priyadarshani Galappatthy ◽  
Varuni A De Silva ◽  
Raveen Hanwella ◽  
Raveendra Laal Jayakody ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Internal Consistency ◽  
Lithium Concentration ◽  
Bipolar Affective Disorder ◽  
Lithium Therapy ◽  
Cronbach’S Alpha ◽  
Serum Lithium Concentration ◽  
Cronbach's Alpha ◽  
Morisky Medication Adherence Scale ◽  
Adherence Scale

Rationale, aims and objectives: The Morisky Medication Adherence Scale (MMAS-8) is a self-reported scale used in assessing medication adherence in patients on chronic therapy. Medication adherence is a neglected area of research in Sri Lanka and in this study we have attempted to validate the Sinhala translation of the MMAS-8 to determine medication adherence among patients stabilized on lithium therapy for bipolar disorder (BD).Methods: The MMAS-8 was translated to Sinhala with standard forward and backward translations from English to Sinhala. Patients with BD on stable doses of lithium were administered the Sinhala version of the MMAS-8. During the same visit, the serum lithium concentration was measured. Criterion validity was assessed using therapeutic serum lithium concentrations as the gold standard. Internal consistency was assessed using Cronbach’s alpha and Spearman’s rank correlation was used to assess test-retest reliability.Results: From a sample of 240 patients, 82.1% were considered adherent, with serum lithium concentration >0.4 mmol/L. The mean MMAS-8 score was 6.95±1.3. According to the MMAS-8 scale, 13.3% reported low adherence while 43.3% reported medium and high adherence equally using MMAS cut offs <6, 6 to<8 and 8 respectively. The scale sensitivity to identify adherence at a cut-off score of 6 was 86.3%. The test–retest reliability value was 0.708 (p<0.001). Internal consistency was found with a Cronbach’s alpha value of 0.608 for the 8 items of the scale.Conclusion: The Sinhala version of MMAS-8 can be used as a sensitive instrument to identify medication adherence in patients with bipolar disorders.

scholarly journals Revisiting the internal consistency and factorial validity of the 8-item Morisky Medication Adherence Scale

2016 ◽  
Vol 4 ◽  
pp. 205031211667485 ◽  
Author(s):  
Arsène Zongo ◽  
Line Guénette ◽  
Jocelyne Moisan ◽  
Laurence Guillaumie ◽  
Sophie Lauzier ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Drug Treatment ◽  
Internal Consistency ◽  
Factorial Validity ◽  
Cronbach’S Alpha ◽  
Cross Sectional ◽  
Cronbach's Alpha ◽  
Morisky Medication Adherence Scale ◽  
Adherence Scale ◽  
Scale 8

Objective: To assess the internal consistency and factorial validity of the adapted French 8-item Morisky Medication Adherence Scale in assessing adherence to noninsulin antidiabetic drug treatment. Study Design and Setting: In a cross-sectional web survey of individuals with type 2 diabetes of the Canadian province of Quebec, self-reported adherence to the antidiabetes drug treatment was measured using the Morisky Medication Adherence Scale-8. We assessed the internal consistency of the Morisky Medication Adherence Scale-8 with Cronbach’s alpha, and factorial validity was assessed by identifying the underlying factors using exploratory factor analyses. Results: A total of 901 individuals completed the survey. Cronbach’s alpha was 0.60. Two factors were identified. One factor comprised five items: stopping medication when diabetes is under control, stopping when feeling worse, feeling hassled about sticking to the prescription, reasons other than forgetting and a cross-loading item (i.e. taking drugs the day before). The second factor comprised three other items that were all related to forgetfulness in addition to the cross-loading item. Conclusion: Cronbach’s alpha of the adapted French Morisky Medication Adherence Scale-8 was below the acceptable value of 0.70. This observed low internal consistency of the scale is probably related to the causal nature of the items of the scale but not necessarily a lack of reliability. The results suggest that the adapted French Morisky Medication Adherence Scale-8 is a two-factor scale assessing intentional (first factor) and unintentional (second factor) non-adherence to the noninsulin antidiabetes drug treatment. The scale could be used to separately identify these outcomes using scores obtained on each of the sub-scales.

scholarly journals The 8-item Morisky medication adherence scale: validation of a Portuguese version in HIV patients

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Aguiar ◽  
C Piñeiro ◽  
R Serrão ◽  
R Duarte
Keyword(s):  
Medication Adherence ◽  
Psychometric Properties ◽  
Reliability Analysis ◽  
Cronbach’S Alpha ◽  
Portuguese Version ◽  
Cronbach's Alpha ◽  
Adherence To Medication ◽  
Morisky Medication Adherence Scale ◽  
Adherence Scale ◽  
The Mean

Abstract Background Antiretroviral therapy (ART) has the most effective treatment for people with HIV, but its effectiveness depends on the individual medication adherence. Morisky Medication Adherence Scale (MMAS-8) is one of the most widely used scales to assess patient adherence. Thus, we aimed to validate a Portuguese version of MMAS-8 and determine its psychometric properties in HIV positive patients. Methods A cross-sectional survey was conducted in Centro Hospitalar Universitário São João (Porto, northern Portugal) at the infectious diseases department. After authorization to use the scale - granted by the author - and, a standard forward-backwards procedure to translate MMAS-8 to Portuguese, the questionnaire was applied to 233 patients with HIV doing ART. Reliability was assessed using Cronbach's alpha and test-retest reliability. Three levels of adherence were considered: 0 to &lt; 6 (low), 6 to &lt; 8 (medium), 8 (high). Results In the studied sample, the mean age was 45.03 years (SD = 11.63), 80.3% men, 19.3% women and 1 transgender, and 53.8% had ≤9 years of education. The mean number of prescribed ART per patient was 1.76. The mean score for the medication adherence scale was 7.29 (SD = 6.74). For the reliability analysis, 12 patients were excluded due to missing data (n = 221). Regarding the level of adherence, 22.5% were low adhering, 71.6% medium and 5.9% high. Corrected item-total correlations showed that 1 item does not correlate very well with the overall scale and was dropped. Scale reliability analysis for the remaining 7 items revealed an overall Cronbach's alpha of 0.661. Women had a protective effect on adherence (OR = 0.31;95%CI:0.15-0.66). Number of years doing ART, age of participants, and type of residence didn't show to be correlated with adherence. Conclusions MMAS-8 is a reliable and valid measure to detect patients at risk of non-adherence. A satisfactory Cronbach's alfa (0.661) was obtained. In general, adherence to medication was medium or high. Key messages This scale can be applied nationwide in other different hospitals, as it could serve as a tool for measuring adherence to ART that can allow for better health care to the ones that are low adhering. A Portuguese version of the MMAS-8 was created for measuring adherence to ART that maintained a similar structure to the original MMAS-8 and good psychometric properties.

scholarly journals NON PITTING TYPE PEDAL EDEMA WITH LITHIUM: A CASE REPORT

2016 ◽  
Vol 9 (1) ◽  
pp. 323
Author(s):  
Parvathypriya C. ◽  
Jeslyn Mary Philip ◽  
Christeena George ◽  
Lakshmi R.
Keyword(s):  
Affective Disorder ◽  
Dose Escalation ◽  
Lithium Treatment ◽  
Lithium Concentration ◽  
Bipolar Affective Disorder ◽  
Lithium Therapy ◽  
Psychotic Symptoms ◽  
Drug Induced ◽  
Serum Lithium Concentration ◽  
Pedal Edema

<p><strong>Objective: </strong>To report a case of lithium induced bilateral nonpitting pedal edema.</p><p><strong>Methods: </strong>The clinical data of a bipolar affective disorder patient with current episode of mania and psychotic symptoms who experienced bilateral non pitting pedal edema with lithium.</p><p><strong>Results: </strong>The patient was a 29 yr old female who developed bilateral non-pitting type pedal edema with lithium therapy with normal plasma lithium level (0.72mEq/l). She is a known case of bipolar affective disorder (BPAD) was admitted to psychiatry department with episode of mania with psychotic symptoms. She had history of drug induced hypersensitivity reaction with eosinophilia and systemic symptoms (DRESS) with oxcarbazepine and so the drug was discontinued and was started on tablet lithium 400 mg twice daily. On admission here, the dose of lithium was increased to 1200 mg/day. The patient gradually improved but she developed bilateral non-pitting pedal edema. Serum lithium concentration was normal and there were no other early symptoms of lithium toxicity. But as the patient's distress further increased with increasing pedal edema, it was decided to stop lithium altogether and to maintain the patient on tablet quetiapine 800 mg therapy for BPAD. Within one week of stopping lithium the edema on both her feet decreased significantly. Causality was assessed by naranjo causality assessment scale and a probable relationship was obtained between lithium and pedal edema with a score of 6.</p><p><strong>Conclusion: </strong>This case emphasises that regular physical examination and laboratory investigations are important for patients who are on lithium therapy. Clinicians should always be careful while initiating lithium treatment in a patient with respect to the initial dose and dose escalation even after a period of successful therapy with lithium, as minor dose escalation can cause major changes in the serum lithium concentration and thereby the patient’s tolerability to lithium.</p>

scholarly journals Reliability and validity of the functioning assessment short test for older adults with bipolar disorder (FAST-O)

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Melis Orhan ◽  
Nicole Korten ◽  
Ralph Kupka ◽  
Patricia van Oppen ◽  
Max Stek ◽  
...  
Keyword(s):  
Older Adults ◽  
Bipolar Disorder ◽  
Internal Structure ◽  
Internal Consistency ◽  
Concurrent Validity ◽  
Cronbach’S Alpha ◽  
Occupational Functioning ◽  
Cronbach's Alpha ◽  
Short Test ◽  
Functioning Assessment

Abstract Background Many frequently used instruments fail to assess psychosocial functioning in patients with bipolar disorder. The Functioning Assessment Short Test (FAST) was developed in order to tackle this problem and to assess the main functioning problems experienced by patients with bipolar disorder. However, the original FAST is not fully applicable in older adults due to the domain of occupational functioning. The aim of our study was to validate an adapted version for Older adults (FAST-O) in a group of older adults with bipolar disorder (OABD). Methods 88 patients aged 50 years and over diagnosed with bipolar disorder were included. We adapted the items in the area of “work-related functioning” of the FAST into items assessing “societal functioning”. Several measurements were conducted in order to analyse the psychometric qualities of the FAST-O (confirmatory factor analysis for internal structure, Cronbach’s alpha for internal consistency, Spearman’s rho for concurrent validity, Mann–Whitney U test for discriminant validity). Results Mean age in the study sample was 65.3 (SD = 7.5) and 57.3% was female. The internal structure was most similar to the internal structure of the original FAST. The internal consistency was excellent (Cronbach’s alpha = .93). The concurrent validity when correlated with the Social and Occupational Functioning Assessment Scale was low, but significant. The FAST-O was also able to distinguish between euthymic and symptomatic OABD patients. Conclusions The FAST-O has strong psychometric qualities. Based on our results, we can conclude that the FAST-O is a short, efficient solution in order to replace global rating scales or extensive test batteries in order to assess daily functioning of older psychiatric patients in a valid and reliable manner.

scholarly journals The development of a contextually appropriate measure of psychological distress in Sierra Leone

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Rebecca Horn ◽  
Kanykey Jailobaeva ◽  
Stella Arakelyan ◽  
Alastair Ager
Keyword(s):  
Mental Health ◽  
Factor Analysis ◽  
Psychological Distress ◽  
Sierra Leone ◽  
Exploratory Factor Analysis ◽  
Internal Consistency ◽  
Phase 1 ◽  
Cronbach’S Alpha ◽  
Cronbach's Alpha ◽  
Distress Scale

Abstract Background Studies of psychological distress in Sierra Leone have typically used measures which were developed for use in other contexts, and which often have not been adapted or validated for use in Sierra Leone. This has resulted in a lack of reliable information about the patterns of psychological distress within the population, which is a barrier to the development of effective and appropriate mental health services. The aim of the study was to develop a locally-appropriate measure of psychological distress for Sierra Leone. Methods The new measure consists of two instruments: the Sierra Leone Psychological Distress Scale (SLPDS) and a gendered measure of ability to carry out daily tasks—a Function scale—as an indication of the severity of distress. A three-phase mixed methods exploratory sequential study was conducted. Phase 1 was item generation and testing, leading to the development of a set of potential items for both instruments. Phase 2 was a small pilot study (N = 202) leading to the selection of the final set of items for both measures. Phase 3 was a validation phase where the SLPDS and the Function scale were administered with a larger sample of 904 respondents. Item analysis was used to assess the internal consistency of the scales, and Exploratory Factor Analysis to explore the properties of the SLPDS. Results Exploratory factor analysis using the principal axis factoring with an oblique rotation identified a three-factor structure for the 18-item SLPDS. Internal consistency for the SLPDS (Cronbach’s alpha = 0.89) and three subscales was good (Cronbach’s alpha > 0.73). The internal reliability of the male and female versions of the Function scale was also found to be acceptable (Cronbach’s alpha = 0.90 for the female scale and 0.79 for the male scale). Conclusions Together the SLPD and Function scales provide a locally-validated tool which will enable government bodies and local and international non-governmental organisations in Sierra Leone to assess mental health and psychosocial needs. This will support both effective service provision and the evaluation of initiatives designed to improve mental health and psychosocial wellbeing.

scholarly journals Validation of the French Translated Version of the Osteoporosis Specific Morisky Medication Adherence Scale (OS-MMAS) in France

2013 ◽  
Vol 16 (7) ◽  
pp. A568 ◽  
Author(s):  
M. Feudjo Tepie ◽  
C. Kempf ◽  
A. Letierce ◽  
I. Ferreira ◽  
L. Kalouche-Khalil ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Morisky Medication Adherence Scale ◽  
Adherence Scale

scholarly journals Polish Adaptation of the Italian Spine Youth Quality of Life Questionnaire

2021 ◽  
Vol 10 (10) ◽  
pp. 2081
Author(s):  
Edyta Kinel ◽  
Krzysztof Korbel ◽  
Piotr Janusz ◽  
Mateusz Kozinoga ◽  
Dariusz Czaprowski ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Internal Consistency ◽  
Spinal Deformity ◽  
Cultural Adaptation ◽  
Life Questionnaire ◽  
Alpha Coefficient ◽  
Cronbach’S Alpha ◽  
Quality Of Life Questionnaire ◽  
Cronbach's Alpha

The study aimed to carry on the process of the cultural adaptation of the Italian Spine Youth Quality of Life Questionnaire (ISYQOL) into Polish (ISYQOL-PL). The a priori hypothesis was: the ISYQOL-PL questionnaire is reliable and appropriate for adolescents with a spinal deformity. Fifty-six adolescents (mean age 13.8 ± 1.9) with idiopathic scoliosis (AIS) with a mean Cobb angle 29.1 (±9.7) and two with Scheuermann juvenile kyphosis (SJK) with a kyphosis angle 67.5 (±17.7) degrees were enrolled. All patients had been wearing a corrective TLSO brace for an average duration of 2.3 (±1.8) years. The Institutional Review Board approved the study. The cross-cultural adaptation of the ISYQOL-PL was performed following the guidelines set up by the International Quality of Life Assessment Project. The reliability was assessed using internal consistency (the Cronbach’s alpha coefficient) and test–retest reliability (intraclass correlation coefficient ICC2.1, CI = 95%); moreover, floor and ceiling effects were calculated. The internal consistency was satisfactory (Cronbach’s alpha coefficient 0.8). The test–retest revealed high reliability with the value of ICC2.1 for the entire group 0.90, CI (0.84 to 0.94). There was neither floor nor ceiling effect for the ISYQOL-PL overall score. The ISYQOL-PL is reliable and can be used in adolescents with spinal deformity.

scholarly journals Preliminary stages of cross-cultural adaptation of the Brazilian Portuguese version of McMaster Family Assessment Device

2016 ◽  
Vol 65 (3) ◽  
pp. 201-208 ◽  
Author(s):  
Eliane Traebert ◽  
Karoliny dos Santos ◽  
Luciana Müller Carvalho ◽  
Jane da Silva ◽  
Jefferson Traebert
Keyword(s):  
Internal Consistency ◽  
Cultural Adaptation ◽  
Brazilian Portuguese ◽  
Cross Cultural ◽  
Family Assessment ◽  
Cronbach’S Alpha ◽  
Family Assessment Device ◽  
Cross Cultural Adaptation ◽  
Cronbach's Alpha ◽  
General Functioning

ABSTRACT Objective To carry out the preliminary stages of the cross-cultural adaptation of the Family Assessment Device (FAD) to Brazilian Portuguese language and examine its reliability. Methods The translation and cross-cultural adaptation of the FAD were developed according to the methods internationally recommended. The resulting product was applied to 80 individuals who completed the questionnaire on two different occasions, seven days apart. Internal consistency was obtained through Cronbach’s alpha, and reliability was estimated by using the Bland and Altman method. Results The internal consistency obtained was very good (Cronbach’s alpha = 0.910). The mean differences of FAD dimensions found in the Bland and Altman test were the following: -0.21 (Problem Solving); -0.32 (Communication); -0.17 (Roles); 0.2 (Affective Responsiveness); -0.27 (Affective Involvement); -0.08 (Behavior Control); -0.02 (General Functioning). Conclusion The processes of translation and cross-cultural adaptation were successful. Assessment of the structural validity and external construct validity is recommended for the improvement of the Brazilian version.

scholarly journals Translation and cultural adaptation of the Perceived Stigmatization Questionnaire for burn victims in Brazil

2014 ◽  
Vol 48 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Noélle de Oliveira Freitas ◽  
Marina Paes Caltran ◽  
Rosana Aparecida Spadoti Dantas ◽  
Lidia Aparecida Rossi
Keyword(s):  
Internal Consistency ◽  
Cultural Adaptation ◽  
Adaptation Process ◽  
Methodological Study ◽  
Cronbach’S Alpha ◽  
Burn Victims ◽  
Cronbach's Alpha ◽  
Translation And Cultural Adaptation

This methodological study aimed to describe the process of translation and cultural adaptation of the Perceived stigmatization Questionnaire (PSQ) and analyze the internal consistency of the items in the step of pre-testing. The PSQ was developed to evaluate the perception of stigmatizing behaviors of burn victims. The adaptation process was carried out from August 2012 to February 2013, comprising the steps outlined in the literature. As part of this process, the pre-test with 30 adult burn victims was held. All participants at this step reported to understand the instrument items and the scale of responses. There were no suggestions or changes in the tested version. The value of Cronbach’s alpha at pre-test was 0.87. The contribution of this study is to describe the operation of each of the steps of this methodological process and show the internal consistency of the items in the pre-test.

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