scholarly journals Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System

2018 ◽  
Author(s):  
Ljubica Gavrilović ◽  
Vesna Stojiljković ◽  
Nataša Popović ◽  
Snežana Pejić ◽  
Ana Todorović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Chronic Stress ◽  
Catecholaminergic System

scholarly journals Oxidative Stress as a Therapeutic Target in Amyotrophic Lateral Sclerosis: Opportunities and Limitations

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1546
Author(s):  
Hee Ra Park ◽  
Eun Jin Yang
Keyword(s):  
Oxidative Stress ◽  
Amyotrophic Lateral Sclerosis ◽  
Animal Models ◽  
Motor Neurons ◽  
Neuronal Degeneration ◽  
Upper Motor Neurons ◽  
Potential Therapeutics ◽  
Lateral Sclerosis ◽  
Oxidative Agents

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) and Lou Gehrig’s disease, is characterized by a loss of the lower motor neurons in the spinal cord and the upper motor neurons in the cerebral cortex. Due to the complex and multifactorial nature of the various risk factors and mechanisms that are related to motor neuronal degeneration, the pathological mechanisms of ALS are not fully understood. Oxidative stress is one of the known causes of ALS pathogenesis. This has been observed in patients as well as in cellular and animal models, and is known to induce mitochondrial dysfunction and the loss of motor neurons. Numerous therapeutic agents have been developed to inhibit oxidative stress and neuroinflammation. In this review, we describe the role of oxidative stress in ALS pathogenesis, and discuss several anti-inflammatory and anti-oxidative agents as potential therapeutics for ALS. Although oxidative stress and antioxidant fields are meaningful approaches to delay disease progression and prolong the survival in ALS, it is necessary to investigate various animal models or humans with different subtypes of sporadic and familial ALS.

Possible cardioprotective role of NaHS on ECG and oxidative stress markers in unpredictable chronic mild stress model in rats

2020 ◽  
Author(s):  
Mohammad Ghalwash ◽  
Ahlam Elmasry ◽  
Nisreen Mansour Omar
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Chronic Stress ◽  
Chronic Mild Stress ◽  
Significant Rise ◽  
Mild Stress ◽  
Sprague Dawley ◽  
Sodium Hydrosulfide ◽  
Arterial Blood

The protective effect of H2S against various body organ injuries has been described. The aim of this work is to investigate the potential role of sodium hydrosulfide; NaHS as an H2S donor, in chronic mild stress-induced changes in the heart of rat. Forty adult male Sprague Dawley rats were assigned into four groups: control, stressed group, stressed rats treated with Amino-oxyacetic acid (AOAA), and stressed rats treated with NaHS. Arterial blood pressure (ABP) was recorded. Serum adrenaline, MDA and GSH levels were measured. Chronic stress significantly increased HR and ABP. AOAA produced similar changes, while NaHS mitigated the rise in HR and ABP. Both stressed and AOAA groups showed a significant decrease in QRS amplitude, shortening of R-R, Q-T interval and Q-Tc with an elevation of S-T segment. NaHS produced a significant improvement in ECG recordings. Chronic stress produced a significant rise of adrenaline and MDA levels with a significant decline in GSH level. AOAA group showed similar elevations. NaHS caused significant reduction in adrenaline and MDA levels but significantly improved GSH level. In conclusion, H2S donor has a cardio-protective effect against stress-induced cardiovascular diseases through amelioration of the oxidative stress and raised adrenaline level induced by chronic stress exposure.

The Role of Oxidative Stress and Bioenergetic Dysfunction in Sulfite Oxidase Deficiency: Insights from Animal Models

2018 ◽  
Vol 35 (2) ◽  
pp. 484-494 ◽  
Author(s):  
Angela T. S. Wyse ◽  
Mateus Grings ◽  
Moacir Wajner ◽  
Guilhian Leipnitz
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Sulfite Oxidase ◽  
Oxidase Deficiency ◽  
Sulfite Oxidase Deficiency

Key role of oxidative stress in animal models of aminoglycoside nephrotoxicity revealed by a systematic analysis of the antioxidant-to-nephroprotective correlation

Toxicology ◽  
2017 ◽  
Vol 385 ◽  
pp. 10-17 ◽  
Author(s):  
Alfredo G. Casanova ◽  
Laura Vicente-Vicente ◽  
María Teresa Hernández-Sánchez ◽  
Moisés Pescador ◽  
Marta Prieto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Systematic Analysis

Insights from Animal Models on the Pathophysiology of Hyperphenylalaninemia: Role of Mitochondrial Dysfunction, Oxidative Stress and Inflammation

2021 ◽  
Author(s):  
Angela T. S. Wyse ◽  
Tiago M. dos Santos ◽  
Bianca Seminotti ◽  
Guilhian Leipnitz
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Mitochondrial Dysfunction

scholarly journals Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1439 ◽  
Author(s):  
Gabriela Juszczyk ◽  
Joanna Mikulska ◽  
Kamila Kasperek ◽  
Diana Pietrzak ◽  
Weronika Mrozek ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitamin E ◽  
Chronic Stress ◽  
Antioxidant Properties ◽  
Stress Oxidative ◽  
The Relationship ◽  
The Brain

There is a growing body of scientific research showing the link between depression and dementia in Alzheimer’s disease (AD). The chronic stress contributes to the formation of oxidative stress in the parts of the brain involved in the development of depression and AD. The scientific literature reports the significant role of antioxidants, which are highly effective in treating these diseases. In this review, we have summarized the relationship between chronic stress, oxidative stress, and the changes in the brain they cause occurring in the brain. Among all the compounds showing antioxidant properties, the most promising results in AD treatment were observed for Vitamin E, coenzyme Q10 (CoQ10), melatonin, polyphenols, curcumin, and selenium. In case of depression treatment, the greatest potential was observed in curcumin, zinc, selenium, vitamin E, and saffron.

scholarly journals Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury

2020 ◽  
Vol 57 ◽  
pp. 118-122 ◽  
Author(s):  
Rizha Anshori Nasution ◽  
Andi Asadul Islam ◽  
Mochammad Hatta ◽  
Prihantono ◽  
Agus Turchan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Animal Models
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