p300/CBP Methylation is Involved in the Potential Carcinogenic Mechanism of Lung Cancer
Keyword(s):
A Cell
◽
p300/CBP is involved in the expression of a wide range of genes, both as a histone acetyltransferase (HAT) and as a coactivator of transcription factors. p300/CBP is the specific substrate of CARM1, and its KIX domain and GBD domain are the main sites methylated by arginine methyltransferase 4 (PRMT4/CARM1). p300/CBP plays an important role in lung cancer, which is a cell cycle disease. More importantly, the methylation of p300/CBP by CARM1 affects the progression of lung cancer through the cAMP-PKA pathway, p53 pathway and ER pathway. The structure, function, methylation modification sites, methylation-related enzymes, genes associated with lung cancer and the possible mechanisms of p300/CBP action are reviewed.
2015 ◽
Vol 33
(15_suppl)
◽
pp. 7522-7522
Keyword(s):
2018 ◽
2019 ◽
Vol 116
(17)
◽
pp. 8149-8154
◽