scholarly journals Flooding Fragility Model Development Using Bayesian Regression

2021 ◽  
Author(s):  
Alison Wells ◽  
Chad L. Pope
Keyword(s):  
Probability Model ◽  
Model Development ◽  
Performance Testing ◽  
Bayesian Regression ◽  
Testing Protocol ◽  
Operating Limits ◽  
Testing Techniques ◽  
Traditional Component ◽  
Insight Into ◽  
Selection Of

Traditional component pass/fail design analysis and testing protocol drives excessively conservative operating limits and setpoints as well as unnecessarily large margins of safety. Component performance testing coupled with failure probability model development can support selection of more flexible operating limits and setpoints as well as softening defense-in-depth elements. This chapter discuses the process of Bayesian regression fragility model development using Markov Chain Monte Carlo methods and model checking protocol using three types of Bayesian p-values. The chapter also discusses application of the model development and testing techniques through component flooding performance experiments associated with industrial steel doors being subjected to a rising water scenario. These component tests yield the necessary data for fragility model development while providing insight into development of testing protocol that will yield meaningful data for fragility model development. Finally, the chapter discusses development and selection of a fragility model for industrial steel door performance when subjected to a water-rising scenario.

An Insight into Oligopeptide Transporter 3 (OPT3) family proteins

2020 ◽  
Vol 27 ◽  
Author(s):  
Fırat Kurt
Keyword(s):  
Stress Responses ◽  
Chelating Agent ◽  
Biological Processes ◽  
Biotic And Abiotic Stress ◽  
Oligopeptide Transporter ◽  
Binding Residues ◽  
Fe Homeostasis ◽  
Proteins Interactions ◽  
Insight Into ◽  
Selection Of

: Oligopeptide transporter 3 (OPT3) proteins are one of the subsets of OPT clade, yet little is known about these transporters. Therefore, homolog OPT3 proteins in several plant species were investigated and characterized using bioinformatical tools. Motif and co-expression analyses showed that OPT3 proteins may be involved in both biotic and abiotic stress responses as well as growth and developmental processes. AtOPT3 usually seemed to take part in Fe homeostasis whereas ZmOPT3 putatively interacted with proteins involved in various biological processes from plant defense system to stress responses. Glutathione (GSH), as a putative alternative chelating agent, was used in the AtOPT3 and ZmOPT3 docking analyses to identify their putative binding residues. The information given in this study will contribute to the understanding of OPT3 proteins’ interactions in various pathways and to the selection of potential ligands for OPT3s.

Performance Testing of Coal Fired Power Plants

2007 ◽  
Author(s):  
Shane E. Powers ◽  
William C. Wood
Keyword(s):  
Power Plant ◽  
Power Plants ◽  
Performance Test ◽  
Model Development ◽  
Performance Testing ◽  
The United States ◽  
Plant Performance ◽  
Cycle Performance ◽  
Test Program

With the renewed interest in the construction of coal-fired power plants in the United States, there has also been an increased interest in the methodology used to calculate/determine the overall performance of a coal fired power plant. This methodology is detailed in the ASME PTC 46 (1996) Code, which provides an excellent framework for determining the power output and heat rate of coal fired power plants. Unfortunately, the power industry has been slow to adopt this methodology, in part because of the lack of some details in the Code regarding the planning needed to design a performance test program for the determination of coal fired power plant performance. This paper will expand on the ASME PTC 46 (1996) Code by discussing key concepts that need to be addressed when planning an overall plant performance test of a coal fired power plant. The most difficult aspect of calculating coal fired power plant performance is integrating the calculation of boiler performance with the calculation of turbine cycle performance and other balance of plant aspects. If proper planning of the performance test is not performed, the integration of boiler and turbine data will result in a test result that does not accurately reflect the true performance of the overall plant. This planning must start very early in the development of the test program, and be implemented in all stages of the test program design. This paper will address the necessary planning of the test program, including: • Determination of Actual Plant Performance. • Selection of a Test Goal. • Development of the Basic Correction Algorithm. • Designing a Plant Model. • Development of Correction Curves. • Operation of the Power Plant during the Test. All nomenclature in this paper utilizes the ASME PTC 46 definitions for the calculation and correction of plant performance.

Exact analysis of the bending of wide beams by a modified elastica approach

2011 ◽  
Vol 225 (11) ◽  
pp. 2759-2764 ◽  
Author(s):  
L F Campanile ◽  
R Jähne ◽  
A Hasse
Keyword(s):  
Finite Element ◽  
Substantial Reduction ◽  
Short Review ◽  
Computational Effort ◽  
Two Dimensional ◽  
Finite Element Calculations ◽  
Dimensional Finite Element ◽  
Wide Beams ◽  
Insight Into ◽  
Selection Of

Classical beam models do not account for partial restraint of anticlastic bending and are therefore inherently inaccurate. This article proposes a modification of the exact Bernoulli–Euler equation which allows for an exact prediction of the beam's deflection without the need of two-dimensional finite element calculations. This approach offers a substantial reduction in the computational effort, especially when coupled with a fast-solving schema like the circle-arc method. Besides the description of the new method and its validation, this article offers an insight into the somewhat disregarded topic of anticlastic bending by a short review of the published theories and a selection of representative numerical results.

Design and topological optimization of rear pressure bulkhead for a typical aircraft

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Marshal Thakran ◽  
Meenakshi ◽  
Jitender Sharma ◽  
Charles Gilbert Martin
Keyword(s):  
Numerical Analysis ◽  
Significant Influence ◽  
Design Methodology ◽  
Structural Integrity ◽  
Topological Optimization ◽  
Content Type ◽  
Iterative Design ◽  
Practical Implications ◽  
Insight Into ◽  
Selection Of

Purpose The purpose of this paper is to evaluate the model of a rear pressure bulkhead with different design optimizations to meet the pressurized cabin requirements of an aircraft. Design/methodology/approach This paper presents the results of the static analysis of a dome-shaped rear pressure bulkhead model designed in Catia-v5. Numerical analysis of model meshed in hyper-mesh and solved using Opti-Struct for iterative design optimizations. Findings All the iterative models are analyzed at 9 Psi. Rear pressure bulkhead designed with L-section stringer shows better results than the model optimized with T-section stringer for the same thickness. The model optimized with L-shaped stinger also reduces the weight of the bulkhead without affecting the structural integrity. Practical implications It has been concluded in this paper that the selection of specific shapes of the stringers shows a significant influence on weight reduction. Originality/value This paper provides a topical, technical insight into the design and development of a rear pressure bulkhead. It also outlines the future development of dome-shaped rear pressure bulkhead.

Paradata in Documentation Standards and Recommendations for Digital Archaeological Visualisations

2020 ◽  
Vol 6 (2) ◽  
pp. 191-220
Author(s):  
Lisa Börjesson ◽  
Olle Sköld ◽  
Isto Huvila
Keyword(s):  
Research Data ◽  
Data Reuse ◽  
Lack Of Information ◽  
National Heritage ◽  
Processing History ◽  
International Harmonisation ◽  
Insight Into ◽  
Current Standards ◽  
Selection Of ◽  
As If

Abstract Digitalisation of research data and massive efforts to make it findable, accessible, interoperable, and reusable has revealed that in addition to an eventual lack of description of the data itself (metadata), data reuse is often obstructed by the lack of information about the datamaking and interpretation (i.e. paradata). In search of the extent and composition of categories for describing processes, this article reviews a selection of standards and recommendations frequently referred to as useful for documenting archaeological visualisations. It provides insight into 1) how current standards can be employed to document provenance and processing history (i.e. paradata), and 2) what aspects of the processing history can be made transparent using current standards and which aspects are pushed back or hidden. The findings show that processes are often either completely absent or only partially addressed in the standards. However, instead of criticising standards for bias and omissions as if a perfect description of everything would be attainable, the findings point to the need for a comprehensive consideration of the space a standard is operating in (e.g. national heritage administration or international harmonisation of data). When a standard is used in a specific space it makes particular processes, methods, or tools transparent. Given these premises, if the standard helps to document what needs to be documented (e.g. paradata), and if it provides a type of transparency required in a certain space, it is reasonable to deem the standard good enough for that purpose.

The Effect of E-Service Quality on Football Fan Satisfaction and Fan Loyalty toward the Websites of Their Favorable Football Teams

2016 ◽  
Vol 12 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Javad Khazaei Pool ◽  
Ali Dehghan ◽  
Hadi Balouei Jamkhaneh ◽  
Akbar Jaberi ◽  
Maryam Sharifkhani
Keyword(s):  
Service Quality ◽  
Structural Equation ◽  
Marketing Research ◽  
Strong Support ◽  
Equation Modeling ◽  
Valuable Insight ◽  
Electronic Service ◽  
Sports Club ◽  
Insight Into ◽  
Selection Of

The purpose of the current study was to examine the effect of electronic service quality on fan satisfaction and fan loyalty in the online environment. Selection of three hundred and fifty-six fans of a famous sports club was through random sampling using the club's website. AMOS used structural equation modeling for data analysis. Results provided strong support on the effect of electronic service quality (E-S-QUAL) on fan satisfaction and fan loyalty toward the website of their favorable football teams. Business enterprises have well researched e-service quality and loyalty. However, limited research exists in the sports context. This paper provides valuable insight into the measurement of e-service quality and fan loyalty in the sport and offers a foundation for future marketing research.

scholarly journals Mechanism-Based Model of Parasite Growth and Dihydroartemisinin Pharmacodynamics in Murine Malaria

2012 ◽  
Vol 57 (1) ◽  
pp. 508-516 ◽  
Author(s):  
Kashyap Patel ◽  
Kevin T. Batty ◽  
Brioni R. Moore ◽  
Peter L. Gibbons ◽  
Jürgen B. Bulitta ◽  
...  
Keyword(s):  
Plasmodium Berghei ◽  
Model Development ◽  
Treatment Strategies ◽  
Compartment Model ◽  
Content Type ◽  
Promising Tool ◽  
Efflux Pathway ◽  
Novel Model ◽  
Insight Into ◽  
Late Trophozoite

ABSTRACTMurine models are used to study erythrocytic stages of malaria infection, because parasite morphology and development are comparable to those in human malaria infections. Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) models for antimalarials are scarce, despite their potential to optimize antimalarial combination therapy. The aim of this study was to develop a mechanism-based growth model (MBGM) forPlasmodium bergheiand then characterize the parasiticidal effect of dihydroartemisinin (DHA) in murine malaria (MBGM-PK-PD). Stage-specific (ring, early trophozoite, late trophozoite, and schizont) parasite density data from Swiss mice inoculated withPlasmodium bergheiwere used for model development in S-ADAPT. A single dose of intraperitoneal DHA (10 to 100 mg/kg) or vehicle was administered 56 h postinoculation. The MBGM explicitly reflected all four erythrocytic stages of the 24-hourP. bergheilife cycle. Merozoite invasion of erythrocytes was described by a first-order process that declined with increasing parasitemia. An efflux pathway with subsequent return was additionally required to describe the schizont data, thus representing parasite sequestration or trapping in the microvasculature, with a return to circulation. A 1-compartment model with zero-order absorption described the PK of DHA, with an estimated clearance and distribution volume of 1.95 liters h−1and 0.851 liter, respectively. Parasite killing was described by a turnover model, with DHA inhibiting the production of physiological intermediates (IC50, 1.46 ng/ml). Overall, the MBGM-PK-PD described the rise in parasitemia, the nadir following DHA dosing, and subsequent parasite resurgence. This novel model is a promising tool for studying malaria infections, identifying the stage specificity of antimalarials, and providing insight into antimalarial treatment strategies.

scholarly journals Characterization of Chicken Skin Yellowness and Exploration of Genes Involved in Skin Yellowness Deposition in Chicken

2021 ◽  
Vol 12 ◽  
Author(s):  
Jingwen Wu ◽  
Zetong Lin ◽  
Genghua Chen ◽  
Qingbin Luo ◽  
Qinghua Nie ◽  
...  
Keyword(s):  
Skin Color ◽  
Skin Pigmentation ◽  
Differentially Expressed ◽  
Economic Trait ◽  
Chicken Skin ◽  
Before And After ◽  
Skin Coloration ◽  
Insight Into ◽  
Selection Of

Skin color is an important economic trait in meat-type chickens. A uniform bright skin color can increase the sales value of chicken. Chickens with bright yellow skin are more popular in China, especially in the broiler market of South China. However, the skin color of chickens can vary because of differences in breeds, diet, health, and individual genetics. To obtain greater insight into the genetic factors associated with the process of skin pigmentation in chickens, we used a colorimeter and high-resolution skin photographs to measure and analyze the skin color of chickens. By analyzing 534 chickens of the same breed, age, and feed condition, we found that the yellowness values of the chickens varied within this population. A significant positive correlation was found between the cloacal skin yellowness values before and after slaughter, and the cloacal skin yellowness value of live chickens was positively correlated with the overall body skin yellowness value. Additionally, chicken skin yellowness exhibited low heritability, ranging from 0.07 to 0.27. Through RNA sequencing, 882 genes were found to be differentially expressed between the skin with the highest and lowest yellowness values. Some of these differentially expressed genes may play an important role in yellow pigment deposition in chicken skin, which included TLR2B, IYD, SMOC1, ALDH1A3, CYP11A1, FHL2, TECRL, ACACB, TYR, PMEL, and GPR143. In addition, we found that the expression and variations of the BCO2 gene, which is referred to as the yellow skin gene, cannot be used to estimate the skin yellowness value of chickens in this population. These data will help to further our understanding of chicken skin yellowness and might contribute to the selection of specific chicken strains with consistent skin coloration.

In Pursuit of the Muses. The Life and Work of Justus Lipsius

10.54179/2101 ◽  
2021 ◽  
Author(s):  
Jeanine De Landtsheer
Keyword(s):  
Sixteenth Century ◽  
English Translation ◽  
Valuable Insight ◽  
Reference Guide ◽  
First Time ◽  
Insight Into ◽  
Selection Of

Famed for his ground-breaking philological, philosophical, and antiquarian writings, the Brabant humanist Justus Lipsius (1547-1606) was one of the most renowned classical scholars of the sixteenth century. In this volume, Marijke Crab and Ide François bring together the seminal contributions to Lipsius’s life and scholarship by Jeanine De Landtsheer (1954-2021), who came to be known as one of the greatest Lipsius specialists of her generation. In Pursuit of the Muses considers Lipsius from two complementary angles. The first half presents De Landtsheer’s evocative life of the famous humanist, based on her unrivalled knowledge of his correspondence. Originally published in Dutch, it appears here in English translation for the first time. The second half presents a selection of eight articles by De Landtsheer that together chart a way through Lipsius’s scholarship. This twofold approach offers the reader a valuable insight into Lipsius’s life and work, creating an indispensable reference guide not only to Lipsius himself, but also to the wider humanist world of letters.

A Process Planning Method for Improving the Build Performance in Stereolithography

1999 ◽  
Author(s):  
Aaron P. West ◽  
David W. Rosen
Keyword(s):  
Process Planning ◽  
Planning Method ◽  
Analytical Models ◽  
Multi Objective Optimization ◽  
Process Variables ◽  
Build Time ◽  
Insight Into ◽  
Conflicting Goals ◽  
Selection Of

Abstract A process planning method is presented in this paper to aid stereolithography users in the selection of appropriate values of build process variables in order to achieve specific goals and characteristics that are desirable in the end prototype. To accomplish this, user-defined input in the form of goal preferences and feature tolerances are used to control how the prototype will be built by way of process planning. The user inputs will be used to drive the creation of the process plan so that a prototype is produced, which reflects the intent of the operator. The process planning method is adapted from multi-objective optimization and utilizes empirical data, analytical models, and heuristics to quantitatively relate build process variables to goals of surface finish, accuracy, and build time. The objective is to render decision support by handling tradeoffs among conflicting goals quantitatively and give the user some degree of insight into what quality of prototype may ultimately be produced. The process planning method is demonstrated on a part with non-trivial geometric features.

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