scholarly journals Correlation Between Erythrocyte Glutathione Levels and Severity of Melasma

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Izazi Hari Purwoko ◽  
Nopriyati Nopriyati ◽  
Theodorus Theodorus ◽  
Dwi Susanti ◽  
Hari Darmawan
Keyword(s):  
Negative Correlation ◽  
Case Series ◽  
Severity Index ◽  
Glutathione Level ◽  
Strong Negative Correlation ◽  
Female Patients ◽  
Case Series Study ◽  
The Face ◽  
Severe Group ◽  
Independent Variable

Background: Melasma is a common acquired disorder of hyperpigmentation, characterized classically by the presence of symmetrical, light-to-dark, muddy-brown macules with borders on the face, especially the forehead, cheeks, upper lip, chin, and nose. Knowledge of an increase in free radicals and decreased antioxidants in patients with melasma led to the belief that oxidative stress is involved in the pathogenesis of melasma. Glutathione (GSH) is an antioxidant that can be used as a parameter to assess the antioxidant-free radical activity in the pathogenesis of melasma. Objectives: The study aimed to determine the correlation between erythrocyte glutathione levels and the severity of melasma. Methods: A case series study was done from May to July 2018 in the Outpatient Clinic of Dermatology and Venereology Department, Dr. Mohammad Hoesin General Hospital Palembang. Thirty female patients met the inclusion criteria. The independent variable was the erythrocyte glutathione level, and the dependent variable was the melasma severity. The diagnosis was established based on clinical examinations, and the severity was determined by the modified Melasma Area Severity Index (mMASI) score. The correlation between variables was analyzed using Spearman Rho’s test (P < 0.05). The data analysis was done with SPSS version 20.0 (SPSS, Inc Chicago, Illinois). Results: Thirty female patients were diagnosed with melasma. The mean mMASI score was 8.72 ± 5.14 (2.0 to 16.9). Most of the participants had mild melasma (46.7%). The mild group had the highest mean erythrocyte glutathione level (4.05 ± 0.63 μmol/g) and the lowest mean erythrocyte glutathione level was in the severe group (1.79 ± 0.16 μmol/g). There was a very strong negative correlation between erythrocyte glutathione levels and melasma severity (r = -0.907; P = 0.000). Conclusions: There was a very strong negative correlation between erythrocyte glutathione levels and melasma severity.

scholarly journals Steroid-induced Rosacea- A Study From a Tertiary Care Hospital of Eastern Nepal

2021 ◽  
Vol 19 (1) ◽  
pp. 25-29
Author(s):  
Manoj Chaudhary ◽  
Sudha Agrawal
Keyword(s):  
Tertiary Care ◽  
Age Groups ◽  
Case Series ◽  
Sun Exposure ◽  
Care Hospital ◽  
Facial Erythema ◽  
Case Series Study ◽  
The Face ◽  
Triggering Factor ◽  
Study Population

Introduction: Topical corticosteroids (TC) are useful for treatment of various dermatological conditions in all age groups. Due to its cosmetic application TCs misuse is intertwined with fairness creams in our colour conscious society where people are obsessed with fair colour.   Aims and Objectives: To find the clinical presentations of steroid induced rosacea like-dermatitis on the face and to evaluate the purpose behind misusing TCs on the face.   Materials and methods: Descriptive prospective questionnaire-type case series study was approved by Institutional Ethical Committee of BPKIHS which involved 205 patients diagnosed as Steroid Induced Rosacea who consulted Dermatology OPD between March to June 2017.   Results: Among 205 patients enrolled, majority were from second to fourth decade (87.31%) of their life and maximum being females I.e. 91.2%. Around 97% of the study population were unaware of side effects of TCs. Most patients use Mometasone fuorate (58.04%) for melisma (88.29%). Friends acted as source of prescription (29.75%), followed by Pharmacist (24.88%) & Beauty centers (20%). Dermatologists prescribed TCs in only 6.34% cases. Sun exposure was identified as the triggering factor for steroid induced rosacea in 73.17% patients. Cheek was the commonest site involve in 92.19%, followed by forehead (65.36%), perioral area (46.83%), and chin (9.75%). Mixed type of lesions was the commonest lesion found in 52.20% patients, followed by diffuse facial erythema (36.09%), & telangiectasia (33.17%).   Conclusion: TCs misuse in the younger people for the sake of fairer skin with little or no knowledge about the adverse effects of this medication should be stopped.

The 90-day Readmission Rate after Single-Bundle ACL Reconstruction Plus LET: Analysis of 2,559 Consecutive Cases from a Single Institution

2020 ◽  
Author(s):  
Alberto Grassi ◽  
Giuseppe Gianluca Costa ◽  
Sergio Cialdella ◽  
Mirco Lo Presti ◽  
Maria Pia Neri ◽  
...  
Keyword(s):  
Acl Reconstruction ◽  
Readmission Rate ◽  
Significant Risk ◽  
Case Series ◽  
Single Bundle ◽  
Female Patients ◽  
Case Series Study ◽  
Increased Risk ◽  
Early Readmission ◽  
Over The Top

AbstractThe aim of the present study is to examine the readmission rate within 90 days of a cohort of patients, who underwent an arthroscopic anterior cruciate ligament (ACL) reconstruction with a lateral extraarticular tenodesis, from a single highly specialized sports traumatology department. From our institutional database, we identified 2,559 patients (78.5% males and 21.5% females, with a mean age at surgery of 30.9 ± 11.5 years) who underwent primary ACL reconstruction with the same “over-the-top” technique plus lateral extraarticular tenodesis (LET) from January 2010 to December 2017. From this count, we extracted all patients who were readmitted within 90 days and focused on causes of readmission and reoperation rate. Moreover, a multivariate logistic regression was performed to identify possible variables, such as gender, age, and concomitant meniscus surgery, which could predict the risk of early readmission. From the aforementioned cohort, 58 patients (2.27%) were readmitted within 90 days from surgery after a mean time of 31 ± 23 days. The most common cause of readmission was fever and knee swelling (0.78%), followed by superficial infection (0.63%), deep infection (0.55%), and joint stiffness (0.23%). The patients' age and meniscal lesions requiring concomitant arthroscopic treatment were found to be correlated to an increased risk of early readmission. Superficial infections were more common in female patients (odds ratio [OR] = 3.01), whereas the meniscal treatment was also a significant risk factor specifically for deep infections (OR = 3.56). In conclusion, this technique of arthroscopic ACL reconstruction with LET showed a low readmission rate within 90 days from surgery. However, patients and physicians should be aware of the risk of serious complications, such as deep and superficial infections, mostly in female patients and in cases of concurrent meniscal treatments. This is a Level IV, retrospective case series study.

Effect of Axial Length on Full-Field and Multifocal Electroretinogram

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Noura S Hamzawy ◽  
Tarek A El-Zarakany ◽  
Amany A El-Shazly ◽  
Sameh H Mohamed
Keyword(s):  
Visual Acuity ◽  
Negative Correlation ◽  
Axial Length ◽  
Multifocal Electroretinogram ◽  
Case Series ◽  
Length Measurement ◽  
Peripheral Retina ◽  
Full Field ◽  
Case Series Study ◽  
Four Quadrant

Abstract Background The Electroretinogram is a mass potential, which reflects the summed electrical activity of the retina. Full-field ERG measures the electrical signals from the whole retina in response to a light stimulus. The weakness of the full-field ERG is that it cannot provide topographical information regarding the functional integrity of the retina and cannot detect subtle functional defects. The response is dominated by the peripheral retina due to its predominance of retinal cells. Aim of the Work to investigate the effect of axial length on fullfield (ffERG)and multifocal ERG (mfERG). Subjects and Methods Forty-four eyes of 44 healthy subjects were included in this case series study which has been conducted at Ain shams university hospitals after the approval of the research ethical committee in the faculty of medicine, Ain Shams University between July 2018 and September 2019. Full ophthalmologic examination was performed for all participants, including visual acuity assessment (Best corrected visual acuity) using Snellen chart, calculation of spherical equivalent (SE), slit Lamp biomicroscopy examination with IOP measurement via Goldmann applanation tonometry (GAT), and fundus examination by indirect ophthalmoscope or via 90 D VOLK lens to assess macular area. Axial length measurement, ffERG & mf-ERG. Results; We found that in the absence of fundus changes, mfERG parameters showed decreased amplitudes with increase in axial length. The Six- Rings Response Densities showed negative correlation with AL while there is no significant correlation between Six- Rings Response Densities and SE. The Six- Rings P1 Amplitude showed negative correlation with AL while there is no significant correlation between P1 Amplitude and SE. The Six- Rings N1 Amplitude showed negative correlation with AL while there is no significant correlation between P1 Amplitude and SE. The four- quadrant Response Densities showed negative correlation with AL while there is no significant correlation between four- quadrant Response Densities and SE. The four- quadrant P1 Amplitude showed negative correlation with AL while there is no significant correlation between P1 Amplitude and SE. The four- quadrant N1 Amplitude showed negative correlation with AL while there is no significant correlation between P1 Amplitude and SE. There is no significant correlation between full-field clinical ERG parameters and both AL and SE. Conclusion In the absence of fundus changes, mfERG parameters showed decreased amplitudes with increase in axial length. For correct interpretation of ERG responses in clinical practice, we recommend consideration of axial length measurement when evaluating mfERG responses.

A Dense Corpus Study of Past Tense and Plural Overregularization in English

2004 ◽  
Vol 47 (6) ◽  
pp. 1319-1333 ◽  
Author(s):  
Robert J. C. Maslen ◽  
Anna L. Theakston ◽  
Elena V. M. Lieven ◽  
Michael Tomasello
Keyword(s):  
Negative Correlation ◽  
Initial Period ◽  
Past Tense ◽  
Strong Negative Correlation ◽  
Retrieval Failure ◽  
Corpus Study ◽  
Frequency Effects ◽  
Token Frequency ◽  
The Face ◽  
Child Speech

In the "blocking-and-retrieval-failure" account of overregularization (OR; G. F. Marcus, 1995; G. F. Marcus et al., 1992), the claim that a symbolic rule generates regular inflection is founded on pervasively low past tense OR rates and the lack of a substantive difference between past tense and plural OR rates. Evidence of extended periods of OR in the face of substantial correct input (M. Maratsos, 2000) and of an initial period in which nouns are more likely to be overregularized than verbs (V. A. Marchman, K. Plunkett, & J. Goodman, 1997) casts doubt on the blocking account and suggests instead an interplay between type and token frequency effects that is more consistent with usage-based approaches (e.g., J. Bybee, 1995; K. Köpcke, 1998; K. Plunkett & V. Marchman, 1993). However, previous naturalistic studies have been limited by data that account for only 1–2% of child speech. The current study reports analyses of verb and noun ORs in a dense naturalistic corpus (1 child, 2;00.12–3;11.06 [years;months.days]) that captures 8–10% of child speech and input. The data show (a) a marked difference in verb and noun OR rates; (b) evidence of a relationship between relative regular/irregular type frequencies and the onset and rate of past tense and plural ORs; (c) substantial OR periods for some verbs and nouns despite hundreds of correct tokens in child speech and input; and (d) a strong negative correlation between input token frequencies and OR rates for verbs and nouns. The implications of these findings for blocking and other accounts of OR are discussed.

scholarly journals Behaviour of urinary incontinence in the face of sacrocolpopexy

2017 ◽  
Vol 30 (1) ◽  
Author(s):  
Nuria L. Rodríguez-Mias ◽  
Jordi Sabadell-García ◽  
Elena Suárez-Salvador ◽  
Antonio Gil-Moreno ◽  
Jose Luis Poza-Barrasus
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
De Novo ◽  
Case Series ◽  
Genital Prolapse ◽  
Bladder Function ◽  
Urethral Hypermobility ◽  
Case Series Study ◽  
Increased Risk ◽  
The Face

The aim of this study was to determine whether an association exists between the performance of a sacrocolpopexy for genital prolapse and the bladder function. A case series study was performed that includes all patients who received sacrocolpopexy in a tertiary Spanish hospital. An analysis was performed to study the association of some variables and the occurrence or persistence of urinary incontinence after the surgery. Forty patients with indication of sacrocolpopexy were included. A year after sacrocolpopexy, the outcomes showed 97.3% of prolapse healing. 19.3% complained about de novo stress urinary incontinence, 33.3% recovered from it and another 66.7% remained the same. Only 10.8% asked for an anti-incontinence surgery after the sacrocolpopexy. The urethral hypermobility shows an increased risk of stress urinary incontinence after the sacrocolpopexy. Based on our results, we do not consider it necessary to perform a systematic antiincontinence procedure simultaneously with sacrocolpopexy unless a woman without urethral anti-incontinence surgical background shows a urethral hypermobility.

scholarly journals Hypoalbuminemia in Severe COVID-19 Post Recovery Patients

2020 ◽  
Author(s):  
Kameran Mohammed Ali ◽  
Ayad M. Ali ◽  
Hassan Mohammad Tawfeeq ◽  
Grazziela Figueredo ◽  
Hassan Muhammad Rostam
Keyword(s):  
Serum Albumin ◽  
Negative Correlation ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Strong Negative Correlation ◽  
Positive Correlation ◽  
Contagious Disease ◽  
Severe Group ◽  
Recovery Status

Abstract Pandemic Coronavirus disease 2019 (COVID-19) is a contagious disease affecting more than 200 countries, territories and regions. Thousands of studies have dealt with all aspects of the disease but little is known about post recovery status of the patients. Here, we examined ESR, CRP and serum albumin biomarkers in severe and mild-moderate COVID-19 post recovery patients. In severe group patients, serum albumin had a strong negative correlation with both ESR and CRP (R2= -0.861), (R2= -0.711) respectively. Also, there was a positive correlation between ESR and CRP (R2=0.85) in the same group. However, there was no correlation among mild-moderate group patients in those biomarkers. In addition, no correlation recorded between severe and mild-moderate groups. This finding concludes the sustained elevation of ESR and CRP with decreased serum albumin level in severe COVID-19 post recovery patients.

Two-Year Follow-up Study on Clinical and Radiological Outcomes of Polyurethane Meniscal Scaffolds

2012 ◽  
Vol 41 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Tineke De Coninck ◽  
Wouter Huysse ◽  
Laurent Willemot ◽  
René Verdonk ◽  
Koenraad Verstraete ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Negative Correlation ◽  
Radial Displacement ◽  
Case Series ◽  
International Knee Documentation Committee ◽  
Magnetic Resonance Images ◽  
Level Of Evidence ◽  
Strong Negative Correlation ◽  
Time Points ◽  
Outcome Scores

Background: Little is known about radial displacement (RD) of polyurethane (PU) scaffolds, intended for partial meniscus defect substitution; no data are available on whether rim thickness influences RD and whether RD correlates with clinical outcome scores. Hypotheses: The meniscus is not extruded preoperatively, but RD occurs after scaffold implantation. A thicker rim will limit RD, and there is no correlation between RD and clinical outcome. Study Design: Case series; Level of evidence, 4. Methods: Twenty-six patients were implanted with a PU scaffold (8 lateral, 18 medial). Radial displacement (mm) was evaluated on magnetic resonance images preoperatively and at 3 months, 1 year, and 2 years postoperatively. At each time point, it was determined whether a correlation existed between the rim and RD. Clinical outcome was determined using a visual analog scale (VAS) for pain as well as the Lysholm knee scoring scale, Knee Injury and Osteoarthritis Outcome Score (KOOS), and International Knee Documentation Committee (IKDC) score. Results: Radial displacement of lateral scaffolds was not significantly different ( P = .178) either preoperatively (mean ± SD, 3.42 ± 0.99 mm) or at 3 months (4.82 ± 0.59 mm), 1 year (4.55 ± 0.87 mm), or 2 years postoperatively (4.10 ± 0.93 mm). No correlation was observed between the rim and lateral RD at all time points. Medial scaffold RD increased significantly ( P < .001) from preoperative values (2.17 ± 0.84 mm) to those at 3 months (4.25 ± 0.89 mm), 1 year (4.43 ± 1.01 mm), and 2 years postoperatively (4.41 ± 0.96 mm). A strong negative correlation between medial RD and the rim was observed at all time points. There was no significant correlation between clinical outcome scores and RD, either preoperatively or postoperatively. Conclusion: This study demonstrated that limited medial meniscal RD was present preoperatively but increased by 2 mm after scaffold implantation. Lateral RD was also present preoperatively but did not increase after scaffold implantation. Importantly, a strong negative correlation was found between the rim and postoperative medial RD; a thicker rim limited RD. However, in the lateral compartment, rim thickness did not correlate with RD because RD was already strongly present preoperatively. Finally, no correlations were observed between scaffold RD and clinical outcome scores, either preoperatively or postoperatively.

Force Plate Analysis of Dogs with Bilateral Hip Dysplasia Treated with a Unilateral Triple Pelvic Osteotomy: A Long-term Review of Cases

1998 ◽  
Vol 11 (02) ◽  
pp. 85-93 ◽  
Author(s):  
Joanne R. Cockshutt ◽  
H. Dobson ◽  
C. W. Miller ◽  
D. L. Holmberg ◽  
Connie L. Taves ◽  
...  
Keyword(s):  
Gait Analysis ◽  
Hip Dysplasia ◽  
Weight Bearing ◽  
Force Plate ◽  
Case Series ◽  
Pelvic Osteotomy ◽  
Vertical Force ◽  
Long Term Outcome ◽  
Case Series Study

SummaryA retrospective case series study was done to determine the long-term outcome of operations upon dogs treated for canine hip dysplasia by means of a triple pelvic osteotomy (TPO). Twentyfour dogs with bilateral hip dysplasia, that received a unilateral TPO between January 1988 and June 1995, were re-examined at the Ontario Veterinary College. The assessment included physical, orthopedic and lameness examinations, standard blood work, pelvic radiographs and force plate gait analysis. They were compared to bilaterally dysplastic dogs that had not been treated, and also to normal dogs. Force plate data analysis demonstrated a significant increase in peak vertical force (PVF) and mean vertical force over stance (MVF) in the limb that underwent surgical correction by means of a TPO, when compared to the unoperated hip. It was determined that performing a unilateral TPO on a young dysplastic dog resulted in greater forces and weight bearing being projected through the TPO corrected limb when compared to the unoperated limb.Dogs with bilateral hip dysplasia treated with a unilateral triple pelvic osteotomy (TPO) were assessed by force plate gait analysis, radiographs and orthopedic examination. There was a significant increase in hip Norberg angles over time, although degenerative changes did progress. Limbs that had been operated upon had significantly greater peak and mean ground reaction forces than limbs that had not received an operation.

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