Unpacking Digital Material Mediation

2014 ◽  
Vol 18 (3) ◽  
pp. 154-182 ◽  
Author(s):  
Heather Wiltse ◽  

Digital technologies mediate engagement with the world by making activities visible. The automaticity and physicality of the ways in which they do this suggest that it could be productive to view them as responsive digital materials. This paper explores the structure and function of responsive materials in order to develop a conceptualization of responsive digital materials. It then begins to unpack the complexities of digital material mediation through both drawing on and extending existing postphenomenological theory.

2006 ◽  
Vol 5 (1) ◽  
pp. 49-75 ◽  
Author(s):  
Giorgio Sacerdoti

AbstractThe dispute settlement system of the World Trade Organization (the "WTO") presents a number of innovative features within the various models of international justice existing at the turn of the millennium. Ten years after its establishment, it is worthwhile to examine its key features in the light of a comparative analysis, exploring its strengths and weaknesses, and highlighting aspects of general interest and possible developments.


2021 ◽  
Vol 26 ◽  
pp. 372-382
Author(s):  
Farisani Thomas Nephawe ◽  
Matodzi Nancy Lambani

Competence in English pragmatics enhances the use of English in social contexts throughout the world. However, using English as a second language is always problematic particularly when it comes to the interpretation of speech act in English. The differences in structure and function between English and other languages such as Tshivenda are conspicuous. The current research explored Speech Act of English and Tshivenda representatives and directives among the Tshivenda-speaking people. The findings revealed that the Tshivenda-speaking people faced difficulties utilising English Speech Acts such as representatives, and directives. The research recommends frequent interaction between those proficient in English and Tshivenda-speaking people.


2021 ◽  
Author(s):  
Daniel L Moss ◽  
Jay Rappaport

The emergence of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the subsequent COVID-19 pandemic has significantly impacted the world not just with disease and death but also economic turmoil. The rapid development and deployment of extremely effective vaccines against SARS-CoV-2 has made the end of the pandemic a reality within reach. However, as the virus spreads it has acquired mutations; and thus, variants of concern have emerged that are more infectious and reduce the efficacy of existing vaccines. While promising efforts are underway to combat these variants, the evolutionary pressures leading to these variants are poorly understood. To that end, here we have studied the effects of three amino-acid substitutions on the structure and function of the SARS-CoV-2 spike glycoprotein receptor-binding domain found in several variants of concern such as B.1.1.7, B.1.351 and P.1 that are now circulating. We found that these substitutions alter the RBD structure and stability, as well as its ability to bind to ACE2, which may have opposing and compensatory effects. These findings provide new insights into how these Variants of Concern (VOC) may have been selected to optimize infectivity while maintaining the structure and stability of the receptor binding domain.


2021 ◽  
Author(s):  
Andri Frediansyah

The plant microbiome, like the plant, influences the processes that lead to plant development, health, and crop productivity. Cassava is a perennial herbaceous plant native to South America that has been cultivated for centuries as a staple food throughout the world. Not only is cassava a good source of carbohydrates, but it also has a high tolerance for a variety of phenotypic conditions, and the majority of cassava plants are susceptible to a variety of diseases. Thus, using cassava as a model, this chapter discusses the plant microbiome. We discuss the structure and function of the microbiome, as well as the technique for studying microbiomes. Additionally, we conducted a systematic review of references pertaining to the microbiome of the cassava plant using cultivation-dependent or cultivation-independent methods. Numerous significant genera of bacteria and fungi are found in cassava’s phyllosphere and rhizosphere, including groups of gram-negative bacteria, gram-positive Actinobacteria, and gram-positive non Actinobacteria. Additionally, we identified critical organisms in the phyllosphere and rhizosphere. Cassava endophytes also produce antifungal secondary metabolites such as pumilacidins and surfactin. The investigation of their phenotypes and interactions with the cassava plant will aid in increasing productivity.


2021 ◽  
Vol 8 ◽  
Author(s):  
Michael Levitt

Computer simulation is an important research tool in today’s scientific world. Computers allow us to perform computations that mimic the behavior of complex (biological) systems in ways that we could not otherwise achieve. You could think of these simulations as a computer game, in which a virtual world is created that works according to certain (e.g., physical) rules. While we play the game, we learn the rules governing this virtual world and its environment, and also the way that we affect this world as players. In this article, I will explain how we use computer simulations in the world of structural biology to study the structure and function of molecules. I will also describe how I think that we could use insights from the world of biology and computer simulations to advance the society that we live in.


2021 ◽  
Vol 5 (2) ◽  
pp. 110-123
Author(s):  
Topan Setiawan ◽  
Fitriana Ibrahim

The COVID-19 pandemic has forced major changes in the world of education. The application of social distancing to learning from home makes educators must be more creative in learning. The use of appropriate media in learning is very important to overcome these problems. One of the media used is android-based learning media. This research is continuation research of android application design in the subject of structure and function of amino acids and proteins. This research is limited to media validation. The instrument validation test stated that the instrument was valid with rcount greater than rtable at the number of N = 34 and a significance value of 5%. The reliability test of the validation instrument shows the rcount value of 0.880 and is greater than rtable 0.339 at the number of N = 34 and a significance value of 5%. The score of the questionnaire instrument was 3,196 obtained by averaging the scores from each category. It is in the range of 2.9-3.4 with a high category so that it can be interpreted that the application can be used as a learning media of the structure and function of the molecule.


2017 ◽  
Vol 33 (01) ◽  
Author(s):  
Ghadei K. ◽  
Rudd R. D. ◽  
Wade T. ◽  
Cathy S.

Virginia Cooperative extension is a part of US cooperative extension system operated through Virginia State University and Virginia tech with the support of federal, state and local governments. The structure and function of the Virginia extension has changed to serve the people in changing time, need and space. Unlike other countries, Virginia cooperative extension system is very unique as it provides complete package of extension services to the society guided by the Federal Government of USA. Through its multi-dimensional, multi-structured, and multi-leadership approach, it serves the society in many innovative ways. It provides almost all kinds of advisory services, training, demonstration and support with respect to crop and animal husbandry, industry, weather, safety and human health. In this manuscript, we made an attempt to bring these services before the world. It is based on a review of literature from books, papers, Virginia Cooperative Extension website, and personal discussions and observations. The paper reveals that Virginia tech is an important agent of Virginia extension system with a vast network to educate and train people of the society for sustainability of environment, agriculture and human health that have demonstrative utility for other countries of the world.


2016 ◽  
Vol 7 (3) ◽  
pp. 92-99
Author(s):  
Patricia Berg-Drazin

The rate of ankyloglossia (tongue-tie) appears to be on the rise in the United States and around the world. IBCLCs working with the families of babies with tongue-tie all too often are the first ones to notice the symptoms and suggest treatment. Even after the tongue has been released, these infants continue to struggle with breastfeeding. The tongue plays an integral role in breastfeeding, but it is also crucial to other oral functions such as speech, respiration, oral hygiene, swallowing, and chewing. The tongue is connected through the extrinsic muscles to bone both above and below the oral cavity. The restriction of the tongue results in associated strains in the body. We will follow the muscular connections and origins to understand the influences in the body. Craniosacral therapy (CST) has its origin in osteopathy, which teaches that structure and function are reciprocally interrelated. When structure is compromised, function will be as well. CST is a perfect complement to help these infants’ bodies release the tensions created as well as to aid in rebalancing structurally and somatically. A case study will illuminate the tremendous impact CST can have on children suffering from tongue-tie.


1985 ◽  
Vol 31 ◽  
pp. 2-30

Emmanuel Ciprian Amoroso, or ‘Amo’ as he was affectionately known to his thousands of friends and acquaintances around the world, is the only Trinidadian, indeed the only West Indian, to have been elected into the Fellowship of the Royal Society— a signal achievement. That he was able to overcome the prejudices of race and colour, so prevalent in British society particularly in the earlier decades of this century, is a tribute to his great personal charisma, his ability to speak in many tongues and so endear him self to people in nations and cultures very different from our own, and to the sheer force of his intellect. His studies on the formation, structure and function of the mammalian placenta and its role in the evolution of viviparity form the basis of his international scientific reputation. He will be remembered m ore for his ability to absorb a mass of factual information scattered throughout the world’s scientific literature over the last few centuries and to produce a concise, succinct summary of the present state of the art, than as an experimentalist. His skills lay more in observation and interpretation, in the correlation of structure with function, than in the design and execution of planned experiments. But it is as a speaker, indeed as an orator, and as a teacher that he will be best remembered throughout Europe, Australasia, Africa and the Americas. Listening to him deliver a lecture on a formal occasion, one had the distinct impression that if he had not succeeded as a scientist he would have becorme a great actor, or even an inspiring preacher; in a bygone age he would have been one of those great storytellers who could have held his audience enthralled. As Professor Courtenay Batholomew said of him , ‘He had a charisma and an aura about him w hereby when he walked into a gathering one had to enquire: “who is this man?” ’


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