scholarly journals Rhinoscleroma

2018 ◽  
Vol 142 (12) ◽  
pp. 1533-1536 ◽  
Author(s):  
Brandon Umphress ◽  
Kirtee Raparia
Keyword(s):  
Respiratory Tract ◽  
Surgical Debridement ◽  
Data Sources ◽  
Upper Respiratory Tract ◽  
Common Site ◽  
Recurrence Rates ◽  
Gram Negative ◽  
The Past ◽  
The Common ◽  
Upper Respiratory

Context.— Rhinoscleroma is a rare, chronic, infectious granulomatous process involving the upper respiratory tract caused by gram-negative bacilli, Klebsiella rhinoscleromatis. The site most commonly affected is the nasopharynx; however, lesions in various other locations have been described. Objective.— To review the literature for all the reported cases of rhinoscleroma in the past 5 years. Data Sources.— Published cases of rhinoscleroma from a PubMed (National Center for Biotechnology Information, Bethesda, Maryland) search were reviewed. Conclusions.— Rhinoscleroma in nonendemic regions is extremely rare; however, with increased travel, immigration, and globalization, it is imperative to recognize this entity because the symptoms can be devastating and in some cases fatal. Although nasopharynx is the common site of involvement, unusual sites such as the trachea can be involved in rare cases. Rhinoscleroma can be managed effectively with a combination of antibiotics and surgical debridement and repair; however, recurrence rates do remain high.

scholarly journals STUDIES IN THE COMMON COLD

1928 ◽  
Vol 47 (2) ◽  
pp. 193-206 ◽  
Author(s):  
Katherine C. Mills ◽  
G. S. Shibley ◽  
A. R. Dochez
Keyword(s):  
Respiratory Tract ◽  
Common Cold ◽  
General Character ◽  
Upper Respiratory Tract ◽  
Normal Flora ◽  
Gram Negative ◽  
The Common ◽  
Upper Respiratory

1. A study of the Gram-negative, filter-passing, anaerobic organisms, described by Olitsky and Gates, and Gates and McCartney, has been undertaken with a view to determining their general character and their possible rôle in the causation of the common cold. 2. These organisms seem to constitute part of the normal flora of the upper respiratory tract and would seem to bear no etiological relationship to the common cold.

scholarly journals Animal Coronaviruses and SARS-COV-2 in Animals, What Do We Actually Know?

Life ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 123
Author(s):  
Paolo Bonilauri ◽  
Gianluca Rugna
Keyword(s):  
Veterinary Medicine ◽  
Respiratory Tract ◽  
Common Cold ◽  
Domestic Animals ◽  
Respiratory Tract Diseases ◽  
Upper Respiratory Tract ◽  
The Common ◽  
Upper Respiratory

Coronaviruses (CoVs) are a well-known group of viruses in veterinary medicine. We currently know four genera of Coronavirus, alfa, beta, gamma, and delta. Wild, farmed, and pet animals are infected with CoVs belonging to all four genera. Seven human respiratory coronaviruses have still been identified, four of which cause upper-respiratory-tract diseases, specifically, the common cold, and the last three that have emerged cause severe acute respiratory syndromes, SARS-CoV-1, MERS-CoV, and SARS-CoV-2. In this review we briefly describe animal coronaviruses and what we actually know about SARS-CoV-2 infection in farm and domestic animals.

Respiratory viruses

2011 ◽  
pp. 208-211
Author(s):  
Dr Mark Harrison
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Common Cold ◽  
Respiratory Viruses ◽  
Upper Respiratory Tract Infections ◽  
Upper Respiratory Tract ◽  
The Common ◽  
Upper Respiratory ◽  
Syncytial Virus ◽  
Tract Infections

15.1 Rhinovirus, 209 15.2 Influenza, 210 15.3 Parainfluenza, 211 15.4 Respiratory syncytial virus (RSV), 211 • There are more than 100 different serotypes of rhinovirus. • Rhinovirus is chiefly limited to upper respiratory tract infections and is the major cause of the common cold....

scholarly journals Antibiotic Susceptibility Profiling of Gram-Negative Bacteria Causing Upper Respiratory Tract Infections in Hyderabad, Sindh

2020 ◽  
Vol 1 (1) ◽  
pp. 12-15
Author(s):  
Ghulam Maka ◽  
Samreen Shah ◽  
Shaista Bano ◽  
Sarfraz Ali Tunio
Keyword(s):  
Respiratory Tract ◽  
Antibiotic Susceptibility ◽  
Respiratory Tract Infections ◽  
Pathogenic Bacteria ◽  
Diffusion Method ◽  
Upper Respiratory Tract ◽  
Isolation And Identification ◽  
Gram Negative ◽  
Upper Respiratory ◽  
Tract Infections

Respiratory tract infections (RTIs) are important clinical problems and among the commonest infectious diseases throughout the world. Several factors including gender, age and season have been shown to influence the prevalence rates of RTIs. The current study aimed to isolate and identify bacteria causing of upper respiratory tract (URT) infections and to determine the antibiotic susceptibility patterns of the isolated bacteria. A total of 201 sputum and swab samples were collected from patients from August 2015 to March 2016 and investigated for Gram-negative pathogenic bacteria. The antibiotic sensitivity of isolated bacteria was performed using Kirby Bauer Disc diffusion method. Isolation and identification of the bacteria were carried out using conventional methods including microscopic, cultural and biochemical testing. Out of 201 samples, 29.85% (n=60) yielded bacterial growth in which 20.9% (n=42) belonged to male while 8.96% (n=18) were from female patients. Among the isolates, Pseudomonas aeruginosa was the most frequent bacteria accounting 48.33% (n=29), followed by Klebsiella pneumoniae 45% (n=27) and E. coli 6.67% (n=04). The data of antibiotic susceptibility profiling demonstrated that Cefoperazone sulbactam, Meropenem, Piperacillin Tazobactam and Amikacin were highly effective against all isolated bacteria. However, Ampicillin, Cephradine, Ofloxacin and Co-trimoxazole were found the least effective antibiotics against all isolated bacteria. In summary, an increasing trend in the resistance against antibiotics which are more frequently prescribed, such as Cephradine, Ampicillin and Co-trimoxazole was observed. Therefore, a continuous surveillance of antibiotic resistance trends of pathogens is needed to ensure appropriate recommendations for the treatment of the URTIs.

EFFECTS OF PENICILLIN AND BROAD-SPECTRUM ANTIBIOTICS ON THE EMERGENCE OF A GRAM-NEGATIVE BACILLARY FLORA IN THE UPPER RESPIRATORY TRACT OF INFANTS

PEDIATRICS ◽  
1952 ◽  
Vol 9 (5) ◽  
pp. 572-576
Author(s):  
ROBERT S. MCCURDY ◽  
ERWIN NETER
Keyword(s):  
Respiratory Tract ◽  
Broad Spectrum ◽  
Clinical Manifestations ◽  
Upper Respiratory Tract ◽  
Broad Spectrum Antibiotic ◽  
Gram Negative ◽  
E Coli ◽  
Broad Spectrum Antibiotics ◽  
Upper Respiratory ◽  
Aerobic Flora

A study was undertaken on 107 infants to determine the effect of penicillin and broad-spectrum antibiotics (aureomycin, chloromycetin and terramycin), alone and in combination, on the emergence of a predominant gram-negative, bacillary flora of the upper respiratory tract. The following data were obtained: 1. Such a change of the flora took place in 4 out of 12 patients treated with penicillin, 15 out of 22 treated with penicillin and a broad-spectrum antibiotic, and in only 4 out of 21 infants who received a broad-spectrum antibiotic exclusively. 2. Of the 32 cases whose flora had thus changed, members of the E. coli-A. aerogenes group were found in 30 instances, members of the genus Proteus in 3; Ps. aeruginosa in 2; Paracolobactrum in 1; and combinations thereof in four cases. 3. This change of the flora took place in 18 out of 71 infants suffering from respiratory infection and in 14 out of 36 children suffering from other diseases. 4. Reappearance of clinical manifestations was observed in 6 out of 19 patients whose respiratory tract flora changed following the use of penicillin and in none of the four individuals who were treated with a broad-spectrum antibiotic alone. In view of the small number of cases this observation requires confirmation. 5. It is concluded that in infants the use of penicillin used in conjunction with a broad-spectrum antibiotic is followed rather frequently by the emergence in the upper respiratory tract of a predominant gram-negative, bacillary, aerobic flora; such a change occurs less frequently after the use of a broad-spectrum antibiotic alone. The clinical significance of these data is discussed.

CLINICAL OBSERVATIONS OF CHANGES IN THE NASAL CAVITY MICROBIOME IN CHILDREN WITH MALIGNANT PARAMENINGEAL TUMORS DURING CHEMORADIATION THERAPY

2021 ◽  
Vol 100 (1) ◽  
pp. 144-153
Author(s):  
A.D. Rodina ◽  
◽  
T.V. Gorbunova ◽  
O.A. Merkulov ◽  
N.V. Ivanova ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Nasal Cavity ◽  
Malignant Tumors ◽  
Inflammatory Diseases ◽  
Nasopharyngeal Cancer ◽  
Growth Conditions ◽  
Upper Respiratory Tract ◽  
Gram Negative ◽  
Clinical Observations ◽  
Upper Respiratory

Malignant tumors of parameningeal localization are various morphological neoplasms located in the nasal cavity, nasopharynx, paranasal sinuses and middle ear. As a result of tumor growth, conditions are created for the development of chronic inflammation. Studies of the microbiome of the upper respiratory tract in children with malignant tumors were practically not conducted. Objective of the research: to identify changes in the microbiome of the nasal cavity in children with malignant tumors of parameningeal localization during chemoradiotherapy. Materials and methods: the study included 29 patients with parameningeal tumors, 2–17 years old. Among the included in the study there were 18 boys (62%) and 11 girls (37%). Morphologically, the following were verified: embryonic rhabdomyosarcoma (ERMS) – 17 (58%), alveolar rhabdomyosarcoma (arms) – 3 (10%), other sarcomas – 4 (13%), nasopharyngeal cancer – 5 (17%). All patients received induction chemotherapy. Simultaneous radiotherapy (LT) and chemotherapy (CT) – in 24 (82%) cases. After completing the chemoradiotherapy stage, consolidation therapy continued in 20 (70%) patients. Results: before the start of LT (after the induction stage of chemotherapy), a variety of microflora was observed in the nasal secretions, gram-positive and gram-negative bacteria were isolated in an equal ratio. The absence of growth of microorganisms was determined in 4 (13%) cases before the start of LT. Methicillin-resistant Staphylococcus epidermidis and Staphylococcus haemolyticus were more frequently detected after LT. Colonization of the nasal cavity of Candida albicans occurred before the start of LT in 4 (13%) and persisted after irradiation in 5 (17%) patients. In the delayed period, there was an increase in the percentage of patients who ridiculed gram-negative microorganisms – Pseudomonas aeruginosa in 4 (13%) cases. After 12 months, 3 (10%) patients showed a return of nosocomial flora (S. epidermidis MRSE and S. haemolyticus MRS), a decrease in colonization of P. aeruginosa and the preservation of C. albicans. Conclusion: at different stages of chemoradiotherapy, the nasal mucosa is colonized by various microorganisms that differ in their properties and pathogenicity. The continuation of this study will clarify the clinical significance of certain types of opportunistic microorganisms in the pathogenesis of inflammatory diseases of the upper respiratory tract in children with malignant tumors.

scholarly journals Upper Respiratory Tract Colonization by Gram-Negative Rods in Patients with Chronic Lymphocytic Leukemia: Analysis of Risk Factors

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Izabela Korona-Glowniak ◽  
Ewelina Grywalska ◽  
Beata Chudzik ◽  
Agnieszka Bojarska-Junak ◽  
Anna Malm ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Chronic Lymphocytic Leukemia ◽  
Respiratory Tract ◽  
Lymphocytic Leukemia ◽  
Upper Respiratory Tract ◽  
Stage Number ◽  
Gram Negative ◽  
Upper Respiratory ◽  
Respiratory Tract Colonization

The aim of the study was to assess the frequency and predisposing factors of colonization of upper respiratory tract by Gram-negative rods (GNRs) in chronic lymphocytic leukemia (CLL) patients. Antimicrobial susceptibility of the isolated strains was determined. A significantly higher frequency of GNR colonization in CLL patients was observed (36.7%) in comparison to healthy volunteers (8.3%). GNR isolates mainly belonged to the Enterobacteriaceae family. Three isolates of GNR demonstrating presence of AmpCβ-lactamases and one ESBL-producing strain were obtained from CLL patients. GNR colonization rate was higher among CLL patients with lower level of IgG in serum (P=0.017), with higher number of neutrophils (P=0.039) or higher number of lymphocytes in serum (P=0.053). The longer the time elapsed since diagnosis, the higher the frequency of GNR colonization observed. Multivariate analysis showed importance of the Rai stage, number, and type of infections as independent predictors of GNR colonization in CLL patients.

scholarly journals Upper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children

2012 ◽  
Vol 78 (17) ◽  
pp. 6262-6270 ◽  
Author(s):  
Melinda M. Pettigrew ◽  
Alison S. Laufer ◽  
Janneane F. Gent ◽  
Yong Kong ◽  
Kristopher P. Fennie ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Microbial Communities ◽  
Otitis Media ◽  
Acute Otitis Media ◽  
Antibiotic Use ◽  
Healthy Children ◽  
Upper Respiratory Tract ◽  
Content Type ◽  
The Past ◽  
Upper Respiratory

ABSTRACTThe composition of the upper respiratory tract microbial community may influence the risk for colonization by the acute otitis media (AOM) pathogensStreptococcus pneumoniae,Haemophilus influenzae, andMoraxella catarrhalis. We used culture-independent methods to describe upper respiratory tract microbial communities in healthy children and children with upper respiratory tract infection with and without concurrent AOM. Nasal swabs and data were collected in a cross-sectional study of 240 children between 6 months and 3 years of age. Swabs were cultured forS. pneumoniae, and real-time PCR was used to identifyS. pneumoniae,H. influenzae, andM. catarrhalis. The V1-V2 16S rRNA gene regions were sequenced using 454 pyrosequencing. Microbial communities were described using a taxon-based approach. Colonization byS. pneumoniae,H. influenzae, andM. catarrhaliswas associated with lower levels of diversity in upper respiratory tract flora. We identified commensal taxa that were negatively associated with colonization by each AOM bacterial pathogen and with AOM. The balance of these relationships differed according to the colonizing AOM pathogen and history of antibiotic use. Children with antibiotic use in the past 6 months and a greater abundance of taxa, includingLactococcusandPropionibacterium, were less likely to have AOM than healthy children (odds ratio [OR], 0.46; 95% confidence interval [CI], 0.25 to 0.85). Children with no antibiotic use in the past 6 months, a low abundance ofStreptococcusandHaemophilus, and a high abundance ofCorynebacteriumandDolosigranulumwere less likely to have AOM (OR, 0.51; 95% CI, 0.31 to 0.83). An increased understanding of polymicrobial interactions will facilitate the development of effective AOM prevention strategies.

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