scholarly journals Anti-inflammatory activity and a new compound isolated from aerial parts of Myrsine africana

2011 ◽  
Vol 10 (42) ◽  
pp. 8465-8470 ◽  
Author(s):  
Ahmad Bashir ◽  
Azam Sadiq ◽  
Bashir Shumaila ◽  
Adhikari Achyut ◽  
Hussain Farrukh
Keyword(s):  
Inflammatory Activity ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Myrsine Africana

In-vivo anti-inflammatory activity and safety assessment of the aqueous extract of Algerian Erica arborea L. (Ericaceae) aerial parts

2021 ◽  
Vol 271 ◽  
pp. 113881
Author(s):  
Djouher Amroun ◽  
Meriem Hamoudi ◽  
Seddik Khennouf ◽  
Sabrina Boutefnouchet ◽  
Daoud Harzallah ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Safety Assessment ◽  
Inflammatory Activity ◽  
Aerial Parts ◽  
Erica Arborea ◽  
Anti Inflammatory

scholarly journals Chemical Constituents from Farfugium Japonicum Var. formosanum

2012 ◽  
Vol 7 (4) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Sung-Fei Hsieh ◽  
Tain-Jye Hsieh ◽  
Mohamed El-Shazly ◽  
Ying-Chi Du ◽  
Chin-Chung Wu ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Cancer Cell Line ◽  
Inflammatory Activity ◽  
Human Neutrophils ◽  
Spectral Techniques ◽  
Methanolic Extracts ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Farfugium Japonicum ◽  
First Time

Two new eremophilenolides, 6β8β10β-trihydroxyeremophil-7(11)-en-12,8-olide (1) and 3βacetoxy-8α-hydroxy-6β-methoxyeremophila-7(11),9-dien-12,8-olide (2) along with twenty-nine other compounds were obtained from the methanolic extracts of the aerial parts and rhizomes of Farfugium japonicum (L.) Kitam. v ar. formosanum (Hayata) Kitam. (Compositae = Asteraceae). The structures of the isolated compounds were characterized and identified by spectral techniques. Compounds 5, 6, 10, 12-24, 29, and 30, were reported for the first time from this genus. Cytotoxicity and anti-inflammatory activity of the isolated compounds were evaluated. Compounds 3 and 16 possessed moderate cytotoxicity against human breast cancer cell line (MCF 7). Compounds 3, 16, 25 and 26 exhibited moderate cytotoxicity against hepatoma cells (Hep G2 and Hep 3B). With respect to the anti-inflammatory activity, compounds 15 and 16 (each 10 μg/mL) inhibited superoxide anion generation by human neutrophils in response to fMLP/CB by 92.0% and 87.3%, respectively.

scholarly journals ASSESMENT OF ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF FREEZE DRIED HYDROALCOHOLIC EXTRACT OF Bidens andicola ON ISOLATED NEUTROPHILS

2017 ◽  
Vol 10 (6) ◽  
pp. 160
Author(s):  
Vinueza D ◽  
LÓpez E ◽  
Acosta K ◽  
Abdo S
Keyword(s):  
Freeze Drying ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Hydroalcoholic Extract ◽  
Cytotoxicity Assays ◽  
Aerial Parts ◽  
Controlled Conditions ◽  
Freeze Dried ◽  
Anti Inflammatory

Objective: The aim of this study was to evaluate anti-inflammatory activity and cytotoxicity in vitro of hydroalcoholic extract of Bidens andicola.Methods: B. andicola hydroalcoholic extract was obtained from aerial parts of B. andicola, following a standardized methodology. Briefly, aerial parts of B. andicola were extracted with ethanol 70% v/v and defatted with n-hexane, hydroalcoholic fraction was concentrated under controlled conditions in a rotary evaporator, and finally the residue was freeze-drying to obtain the hydroalcoholic extract of B. andicola. Anti-inflammatory activity and cytotoxicity assays were carried out using in vitro isolated neutrophils model using stable water-soluble tetrazolium salts.Results and Conclusions: The in vitro anti-inflammatory assay on isolated neutrophils demonstrated that the hydroalcoholic extract showed antiinflammatoryactivity compared to aspirin, with inflammatory inhibition percent values of 80.138±0.729 to hydroalcoholic extract of B. andicola and 82.117±0.762 to aspirin, each tested in five replicates at the concentration of 200 ppm of hydroalcoholic extract or reference. 

Terpenoid and phenolic derivatives from the aerial parts of Elsholtzia rugulosa and their anti-inflammatory activity

2021 ◽  
Vol 181 ◽  
pp. 112543
Author(s):  
Fan Yang ◽  
Hang-Yi Pu ◽  
Aftab Yaseen ◽  
Bin Chen ◽  
Fu Li ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Aerial Parts ◽  
Phenolic Derivatives ◽  
Anti Inflammatory

scholarly journals Phytochemical Screening, Biological Studiesand GC-MS Analysis of Extract of Biden pilosa L

2019 ◽  
Vol 5 (1) ◽  
pp. 79-93
Author(s):  
Dharma Prasad Khanal ◽  
Rupa Rana ◽  
Bechan Raut ◽  
Rabindra Prasad Dhakal
Keyword(s):  
Ethyl Acetate ◽  
Aerial Part ◽  
Inflammatory Activity ◽  
Alcoholic Extract ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Bidens Pilosa ◽  
Aerial Parts ◽  
Ms Analysis ◽  
Anti Inflammatory

Objective: The aim of the research work was to carry out the extraction of areal parts of Biden pilosa L by hydroalcholic and Hexane, ethyl acetate and acetone mixture followed by qualitative phytochemical analysis, acute oral toxicity test, anti-inflammatory test and GC-MS analysis of the extracts. Method: The hydro-alcoholic and HEA(n-hexane, ethyl acetate and acetone) extraction was done from aerial parts using ethanol and water in the ratio 70:30 and n-hexane, ethyl acetate and acetone in the ratio of 1:1:1 (HEA extract)  respectively. Acute oral toxicity testwas performed OECD guidelines. The single spot in TLC was obtained using n-hexane as solvent for HEA fraction and finally phytocomponents were identified by GC-MS present in that spot.In vitro anti-inflammatory activity was performed by human RBC membrane stabilization method. Result: The phytochemical test results obtained indicate that hydro-alcoholic extract of aerial part of Bidens pilosa L. possess alkaloids, tannins, terpenoids and saponins whereas HEA extract possess alkaloids, flavonoids, tannins. Both hydro-alcoholic and HEA extracts were found to be safe up to the dose of 2000 mg/kg BW of the mice. Both extracts showed significant in vitro anti-inflammatory activity in a concentration dependent manner. The GC-MS analysis of HEA extract of aerial parts showed the presence of the sixteen different compounds from partially separated extract from TLC plates. Conclusion: Hydro-alcoholic extract of aerial part of Bidens pilosa L. possess alkaloids, tannins, terpenoids and saponins whereas HEA extract possess alkaloids, flavonoids, tannins. Both hydro-alcoholic and HEA extracts were found to be safe up to the dose of 2000 mg/kg BW of the mice. The GC-MS analysis of HEA extract of aerial parts showed the presence of the sixteen different compounds.

scholarly journals Evaluation of anti-inflammatory activity of derivatives from aerial parts ofBaccharis uncinella

2011 ◽  
Vol 49 (6) ◽  
pp. 602-607 ◽  
Author(s):  
Cynthia A. Zalewski ◽  
Luiz Felipe D. Passero ◽  
Alexis S.R.B. Melo ◽  
Carlos Eduardo P. Corbett ◽  
Márcia D. Laurenti ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Aerial Parts ◽  
Anti Inflammatory

scholarly journals Evaluation of anti-inflammatory activity of some Libyan medicinal plants in experimental animals

2012 ◽  
Vol 64 (3) ◽  
pp. 1059-1063 ◽  
Author(s):  
Jamal Elmezogi ◽  
Abdulmottaleb Zetrini ◽  
Ghazala Ben-Hussein ◽  
Masoud Anwair ◽  
Abdul Gbaj ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Significant Inhibition ◽  
Inflammatory Activity ◽  
Reduced Pressure ◽  
Aerial Parts ◽  
Potential Source ◽  
Salvia Fruticosa ◽  
Anti Inflammatory ◽  
Thapsia Garganica ◽  
First Time

Ballota pseudodictamnus (L.) Benth. (Lamiaceae), Salvia fruticosa Mill. (Lamiaceae) and Thapsia garganica L. (Apiaceae) are three well-known medicinal plants from the Libyan flora, which have long been used for the treatment of inflammations. The aim of the present study was to investigate, for the first time, the anti-inflammatory property of the methanol (MeOH) extracts of the aerial parts of these plants. Shade-dried and ground aerial parts of B. pseudodictamnus, S. fruticosa) and T. garganica were Soxhlet-extracted with MeOH. The extracts were concentrated by evaporation under reduced pressure at 40?C. The anti-inflammatory activity of the extracts was evaluated using the carrageenan-induced mice paw edema model. The administration of the extracts at a dose of 500 mg/kg body weight produced statistically significant inhibition (p < 0.05) of edema within 3 h of carrageenan administration. The results demonstrated significant anti-inflammatory properties of the test extracts. Among the extracts, the S. fruticosa extract exhibited the most significant inhibition of inflammation after 3 h (62.1%). Thus, S. fruticosa could be a potential source for the discovery and development of newer anti-inflammatory ?leads? for drug development. The anti-inflammatory activity of B. pseudodictamnus and S. fruticosa could be assumed to be related to high levels of phenolic compounds, e.g., flavonoids, present in these plants.

Chemical constituents and anti-inflammatory activity of the aerial parts of Curcuma longa

2016 ◽  
Vol 26 ◽  
pp. 485-493 ◽  
Author(s):  
Dae Wook Kim ◽  
Seon Min Lee ◽  
Hyun Sim Woo ◽  
Ji-Young Park ◽  
Byoung Seob Ko ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Curcuma Longa ◽  
Inflammatory Activity ◽  
Aerial Parts ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory effect of the methanol extract from Anthocephalus cadamba stem bark in animal models

2010 ◽  
Vol 1 (1) ◽  
pp. 6 ◽  
Author(s):  
Kodangala Subraya Chandrashekar ◽  
Kodangala Subraya Prasanna ◽  
Borthakur Abinash
Keyword(s):  
Methanol Extract ◽  
Stem Bark ◽  
Cellular Migration ◽  
Inflammatory Activity ◽  
Traditional Use ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Design And Methods ◽  
Anthocephalus Cadamba ◽  
Inflammatory Effect

Background:<em> Anthocephalus cadamba </em>(Rebox)Miq. (Rubiaceae) is widely distributed throughout the greater part of India, especially at low levels in wet place. Traditionally the bark is used as tonic, febrifuge and to reduce the pain and inflammation. The anti-inflammatory effect of methanol extract obtained from <span style="font-style: italic;"> Anthocephalus cadamba </span> aerial parts, MEAC, were investigated in this study. Design and methods: The effects of MEAC on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin) induced paw edema and cotton pallet-induced granuloma, respectively. The anti-edema effect of MEAC was compared with 10 mg/kg of indomethacin orally. Results: The results suggested that MEAC possess potent anti-inflammatory activity. The acute inflammatory model showed that all the doses of MEAC effectively suppressed the edema produced by histamine, so it may be suggested that its anti-inflammatory activity is possibly backed by its antihistaminic activity. In chronic inflammatory model the effect may be due to the cellular migration to injured sites and accumulation of collagen and mucopolysaccharide. Conclusions: On the basis of these findings, it may be inferred that <span style="font-style: italic;"> Anthocephalus cadamba </span> is an anti-inflammatory agent and the results are in agreement with its traditional use.

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