scholarly journals Correlation between oxidative stress parameters and left ventricular geometry in patients with chronic heart failure

2020 ◽  
Vol 37 (3) ◽  
pp. 241-251
Author(s):  
Sandra Šarić ◽  
Tatjana Cvetković ◽  
Dejan Petrović ◽  
Valentina Mitić ◽  
Sanja Stojanović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Chronic Heart Failure ◽  
Catalase Activity ◽  
Left Ventricular ◽  
Left Ventricular Geometry ◽  
Sh Groups ◽  
Oxidative Stress Parameters ◽  
Ventricular Geometry ◽  
Stress Parameters

Oxidative stress, as one of the pathophysiological mechanisms involved in the reduction of myocardial contractility, stimulates the proliferation of cardiac fibroblasts and the activation of matrix metalloproteinases, which leads to extracellular matrix remodeling. Left ventricular hypertrophy (LVH) is a well-known independent risk factor for cardiovascular events. The aim of this research was to determine the connection between the parameters of oxidative stress and left ventricular geometry indicators in patients with chronic heart failure. The study included 81 subjects diagnosed with heart failure and 68 subjects in the control group. Parameters of myocardial morphology and left ventricular function were measured by echocardiography. Thiobarbituric acid reactive substances (TBARS) content, advanced oxidation protein products (AOPP), total serum SH groups and catalase activity were performed in both groups. The results showed that there were significantly higher concentrations of TBARS, AOPP, and SH groups in patients compared to controls (p < 0.01) and higher concentration of TBARS in patients with concentric hypertrophy compared to patients with normal geometry (p < 0.05). Correlation analysis showed a strong positive correlation between geometry parameters and myocardial function and TBARS and negative correlation between the right ventricule diameter and catalase activity. The results of this study show that oxidative stress parameters are significantly elevated in patients with heart failure, and that concentrations of TBARS and AOPP - the markers of lipid and protein oxidation, strongly correlate with left ventricular geometry parameters.

scholarly journals Uric Acid, Oxidative Stress and Inflammation in Chronic Heart Failure with Reduced Ejection Fraction

2015 ◽  
Vol 23 (4) ◽  
pp. 397-406 ◽  
Author(s):  
Adriana Iliesiu ◽  
Alexandru Campeanu ◽  
Daciana Marta ◽  
Irina Parvu ◽  
Gabriela Gheorghe
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Uric Acid ◽  
Chronic Heart Failure ◽  
Ejection Fraction ◽  
Xanthine Oxidase ◽  
Left Ventricular ◽  
Paraoxonase 1 ◽  
Lv Function ◽  
The Relationship

Abstract Background. Oxidative stress (OS) and inflammation are major mechanisms involved in the progression of chronic heart failure (CHF). Serum uric acid (sUA) is related to CHF severity and could represent a marker of xanthine-oxidase activation. The relationship between sUA, oxidative stress (OS) and inflammation markers was assessed in patients with moderate-severe CHF and reduced left ventricular (LV) ejection fraction (EF). Methods. In 57 patients with stable CHF, functional NYHA class III, with EF<40%, the LV function was assessed by N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) levels and echocardiographically through the EF and E/e’ ratio, a marker of LV filling pressures. The relationship between LV function, sUA, malondialdehyde (MDA), myeloperoxidase (MPO), paraoxonase 1 (PON-1) as OS markers and high sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) as markers of systemic inflammation was evaluated. Results. The mean sUA level was 7.9 ± 2.2 mg/dl, and 61% of the CHF patients had hyperuricemia. CHF patients with elevated LV filling pressures (E/e’ ≥ 13) had higher sUA (8.6 ± 2.3 vs. 7.3 ± 1.4, p=0.08) and NT-proBNP levels (643±430 vs. 2531±709, p=0.003) and lower EF (29.8 ± 3.9 % vs. 36.3 ± 4.4 %, p=0.001). There was a significant correlation between sUA and IL-6 (r = 0.56, p<0.001), MDA (r= 0.49, p= 0.001), MPO (r=0.34, p=0.001) and PON-1 levels (r= −0.39, p= 0.003). Conclusion. In CHF, hyperuricemia is associated with disease severity. High sUA levels in CHF with normal renal function may reflect increased xanthine-oxidase activity linked with chronic inflammatory response.

scholarly journals Butein Inhibits Oxidative Stress Injury in Rats with Chronic Heart Failure via ERK/Nrf2 Signaling

2022 ◽  
Vol 2022 ◽  
pp. 1-10
Author(s):  
Peng Liu ◽  
Quanli Pan
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Chronic Heart Failure ◽  
Rat Model ◽  
Myocardial Dysfunction ◽  
Cardiac Injury ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Stress Injury ◽  
Oxidative Stress Injury

Background. Chronic heart failure (CHF) is a serious heart disease resulting from cardiac dysfunction. Oxidative stress is an important factor in aging and disease. Butein, however, has antioxidant properties. To determine the effect of butein on oxidative stress injury in rats, a CHF rat model was established. Methods. The CHF rat model was induced by abdominal aortic coarctation (AAC). Rats in CHF+butein and sham+butein group were given 100 mg/kg butein via gavage every day to detect the effect of butein on oxidative stress injury and myocardial dysfunction. The cardiac structural and functional parameters, including the left ventricular end-systolic dimension (LVESD), the left ventricular end-diastolic dimension (LVEDD), the left ventricular ejection fraction (LVEF), and the left ventricular fractional shortening (LVFS), were measured. Oxidative stress was measured through the production of reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA). Cardiac injury markers like creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) were evaluated. Hematoxylin and eosin (H&E) staining was used to observe the myocardial cell morphology. The effect of butein on the extracellular signal-regulated kinase (ERK)/nuclear factor-E2 p45-related factor (Nrf2) signaling was confirmed by Western blot analysis. Results. Butein had a significant effect on CHF in animal models. In detail, butein inhibited oxidative stress, relieved cardiac injury, and alleviated myocardial dysfunction. Importantly, butein activated the ERK1/2 pathway, which contributed to Nrf2 activation and subsequent heme oxygenase-1 (HO-1) and glutathione cysteine ligase regulatory subunit (GCLC) induction. Conclusions. In this study, butein inhibits oxidative stress injury in CHF rat model via ERK/Nrf2 signaling pathway.

scholarly journals Comparison of Oxidative Stress Parameters in Heart Failure Patients Depending on Ischaemic or Nonischaemic Aetiology

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Ewa Romuk ◽  
Celina Wojciechowska ◽  
Wojciech Jacheć ◽  
Jolanta Nowak ◽  
Jacek Niedziela ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Nyha Class ◽  
Maximal Oxygen Consumption ◽  
Stress Index ◽  
Oxidative Stress Parameters ◽  
Total Antioxidant ◽  
Mutual Relations ◽  
Protein Sulfhydryl Groups ◽  
Stress Parameters

Background. Abnormalities in the oxidative and antioxidant states causing oxidative stress were both found in heart failure (HF) of various aetiologies and atherosclerosis. Aim of Study. The goals of the study were as follows: comparison of oxidative stress parameters (OSP) in ischaemic cardiomyopathy (ICM) (n=479) and nonischaemic cardiomyopathy (nICM) (n=295) patients; assessment of the relationships of OSP with functional capacity (NYHA class), maximal oxygen consumption (max.O2), left ventricle ejection fraction (LVEF), and NT-proBNP concentration; and determination of the mutual relations of OSP in subgroups of patients with ICM and n-ICM. Methods. Serum concentrations of total antioxidant capacity (TAC), total oxidant status (TOS), uric acid (UA), bilirubin, albumin, protein sulfhydryl groups (PSH), and malondialdehyde (MDA) were measured. The oxidative stress index (OSI) and MDA/PSH ratio were calculated. Results. Higher concentrations of TAC (1.14 vs 1.11 mmol/l; p<0.001) and MDA (1.80 vs 1.70 μmol/l; p<0.05) and higher MDA/PSH ratios (0.435 vs 0.358; p<0,001) were observed in ICM than in nICM patients. Simultaneously, lower values of the OSI index (4.27 vs 4.6; p<0,05), PSH (4.10 vs 4.75 μmol/g of protein; p<0,001), and bilirubin (12.70 vs 15.40 μmol/l; p<0,001) concentrations were indicated in ICM patients. There were no differences in TOS, UA, and albumin between the examined groups. The NYHA class and VO2max correlate with MDA, bilirubin, and albumin in both groups, while with UA only in the ICM group. Correlations between the NYHA class, VO2max, and PSH were indicated in nICM. The association of LVEF with UA, bilirubin, and albumin has been demonstrated in the ICM group. The study showed negative correlations between TAC, MDA, and PSH and positive between TAC and MDA in both groups. In ICM patients, MDA positively correlated with UA. A negative correlation between PSH and concentrations of UA and bilirubin was expressed only in the nICM group. Conclusion. The obtained results confirm the relationship between the severity of HF and oxidative stress. The mechanisms of oxidative stress and antioxidant defence are partially different in the ICM and the nICM patients.

scholarly journals Oxidative Stress Markers in GnRH AgonistaAnd Antagonist Protocols in IVF

2017 ◽  
Vol 36 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Lidija Tulić ◽  
Snežana Vidaković ◽  
Ivan Tulić ◽  
Marijana Ćurčić ◽  
Jelena Stojnić ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gnrh Agonist ◽  
Ovarian Stimulation ◽  
Live Birth Rate ◽  
Serum Samples ◽  
Miscarriage Rate ◽  
Sh Groups ◽  
Oxidative Stress Parameters ◽  
Significant Difference ◽  
Stress Parameters

SummaryBackground: Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles.Methods: This prospective study included 82 patients who un der went IVF procedures. We determined SOD, MDA and SH groups in serum. Serum samples were obtained between the second and fourth day of the cycle and on the day of HCG administration during ovarian stimulation.Results: Patients were divided into two groups depending on the protocol of stimulation. The mean total and mature oocytes number and number of fertilized oocytes were higher in GnRH agonist group. There was no significant difference in biochemical pregnancy, miscarriage and live -birth rate in both groups. Mean serum SOD was significantly lower, while mean serum MDA and SH groups were significantly higher after ovarian stimulation. Delivery rate was higher in patients without OS while miscarriage rate was higher in patients with OS.Conclusions: Our study confirmed that there is a difference in the concentration of oxidative stress parameters before and after ovarian stimulation. IVF outcome is better in patients without OS after ovarian stimulation. However, the protocol of ovarian stimulation is neither associated with a change in oxidative stress parameters nor with the outcome of ART procedures.

Importance of Left Ventricular Geometry in the Occurrence of Isolated Diastolic Heart Failure in Patients

2005 ◽  
Vol 11 (9) ◽  
pp. S297
Author(s):  
Misato Otsuka ◽  
Mio Shuto ◽  
Shinji Nakao ◽  
Akiko Goda ◽  
Masao Yuba ◽  
...  
Keyword(s):  
Heart Failure ◽  
Diastolic Heart Failure ◽  
Left Ventricular ◽  
Left Ventricular Geometry ◽  
Ventricular Geometry
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