Microspheres-Novel Drug Delivery Carrier for Plant Extracts for Antibacterial Activity

In spite of advances in tuberculosis (TB) chemotherapy, TB is still airborne deadly disorder as a major issue of health concern worldwide today. Extensive researches have been focused to develop novel drug delivery systems to shorten the lengthy therapy approaches, prevention of relapses, reducing dose-related toxicities and to rectify technologically related drawbacks of anti-tubercular drugs. Moreover, the rapid emergence of drug resistance, poor patient compliance due to negative therapeutic outcomes and intracellular survival of Mycobacterium highlighted to develop carrier with optimum effectiveness of the anti-tubercular drugs. This could be achieved by targeting and concentrating the drug on the infection reservoir of Mycobacterium. In this article, we briefly compiled the general aspects of Mycobacterium pathogenesis, disease treatment along with progressive updates in novel drug delivery carrier system to enhance therapeutic effects of drug and the high level of patient compliance. Recently developed several vaccines might be shortly available as reported by WHO.

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Review on phytosomes: A novel drug delivery system

GSC Biological and Pharmaceutical Sciences ◽

10.30574/gscbps.2020.13.1.0345 ◽

2020 ◽

Vol 13 (1) ◽

pp. 203-211

Author(s):

Mahadev B. Khanzode ◽

Archana D. Kajale ◽

Madhuri A. Channawar ◽

Shilpa R. Gawande

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Plant Extracts ◽

Biological Membrane ◽

Molecular Complexes ◽

Water Soluble ◽

Face Stability ◽

Degenerative Disorders ◽

Novel Drug

The term “Phyto” means plant and “some” means cell It is also mentioned as herbosomes this is a new patented technology, where standardized plant extracts or water soluble phytoconstituents are complexed with phospholipids to produce lipid compatible molecular complexes, there by greatly increasing absorption and bioavailability. The recent development and conducted works of various researchers have been studied thoroughly to establish the transdermal route as a potential way to deliver phytoconstituents. Plant derived products or plant extracts are increasingly receiving attention as dietary supplements for the homeostatic management of inflammation, toxicities, cancers, weight loss and other chronic or acute degenerative disorders. But these products frequently face stability and bioavailability problems. Plant products after their isolation become prone to instability and are potentially unfit to cross the bio membrane as such. The phytosome technique reduces these tasks to reasonable extents. The phytosome or Herbosome technique increases the hydrophilicity of highly lipophilic drug there by making it suitable for drug delivery and increases the lipophilicity of hydrophilic phytoconstituents adequately to cross biological membrane. The topical application of phytosomes for cosmetic purpose has already been proven. This review also contains a comparative account of liposomes and phytosomes along with recent advancements in the field of phytosome technology with a special concern to transdermal drug delivery. The poor oral bioavailability of polyphenolic compound can be enhanced through the incorporation of them into phospholipid based self-assembled delivery system, i.e. popularly known as phytosome. There are number of products available in the market that contains phytosomal drug delivery system such as Ginkgo biloba, Silybum marianum, and Camellia sinensis.

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A Novel Drug Delivery of Microspheres

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v11i6.5059 ◽

2021 ◽

Vol 11 (6) ◽

pp. 257-264

Author(s):

Smily Walia ◽

J.S. Dua ◽

D.N. Prasad

Keyword(s):

Drug Delivery ◽

Medication Administration ◽

Magnetic Microspheres ◽

Target Tissue ◽

Polymeric Microspheres ◽

Target Drug Delivery ◽

Drug Delivery Carrier ◽

Target Drug ◽

Medication Delivery ◽

Novel Drug

Microspheres are multiparticulate drug delivery systems that distribute medications at a predetermined rate to a specific region. Microspheres are free-flowing powders manufactured from biodegradable proteins or synthetic polymers, with particle sizes ranging from 1 to 1000 micrometers. Benefits of using microspheres in medication delivery, bone tissue manufacture, and pollutant absorption and desorption by regeneration .The study demonstrates how microsphere parameters are planned and measured. Bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, and radioactive microspheres are only a few examples of complicated microspheres. Cosmetics, oral medication administration, target drug delivery, ocular drug delivery, gene delivery, and other industries covered in the paper could all benefit from microspheres. To ensure best therapeutic effectiveness, the agent must be delivered to target tissue at an optimal amount during the appropriate timeframe, with low toxicity and adverse effects. There are several methods for delivering the therapeutic substance to the target site in a controlled manner. The use of microspheres as medication carriers is one such technique. The value of microspheres as a novel drug delivery carrier to accomplish site-specific drug delivery was discussed in this article. Keywords: Microspheres, method of preparations, polymer bioadhesion, types of microspheres.

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RETRACTED: Novel drug delivery carrier from alginate-carrageenan and glycerol as plasticizer

Results in Physics ◽

10.1016/j.rinp.2017.08.014 ◽

2017 ◽

Vol 7 ◽

pp. 2979-2989 ◽

Cited By ~ 1

Author(s):

Handoko Darmokoesoemo ◽

Pratiwi Pudjiastuti ◽

Bagus Rahmatullah ◽

Heri Septya Kusuma

Keyword(s):

Drug Delivery ◽

Drug Delivery Carrier ◽

Novel Drug

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Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications

International Journal of Nanomedicine ◽

10.2147/ijn.s227805 ◽

2020 ◽

Vol Volume 15 ◽

pp. 2439-2483 ◽

Cited By ~ 2

Author(s):

Heshu Sulaiman Rahman ◽

Hemn Hassan Othman ◽

Nahidah Ibrahim Hammadi ◽

Swee Keong Yeap ◽

Kawa Mohammad Amin ◽

...

Keyword(s):

Drug Delivery ◽

Plant Extracts ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Natural Plant ◽

Novel Drug

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Albumin-Encapsulated Liposomes: A Novel Drug Delivery Carrier With Hydrophobic Drugs Encapsulated in the Inner Aqueous Core

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.08.003 ◽

2018 ◽

Vol 107 (1) ◽

pp. 436-445 ◽

Cited By ~ 17

Author(s):

Yuko Okamoto ◽

Kazuaki Taguchi ◽

Keishi Yamasaki ◽

Mina Sakuragi ◽

Shun'ichi Kuroda ◽

...

Keyword(s):

Drug Delivery ◽

Hydrophobic Drugs ◽

Drug Delivery Carrier ◽

Aqueous Core ◽

Novel Drug

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A Novel Drug Delivery Carrier Comprised of Nimodipine Drug Solution and a Nanoemulsion: Preparation, Characterization, in vitro, and in vivo Studies

International Journal of Nanomedicine ◽

10.2147/ijn.s226591 ◽

2020 ◽

Vol Volume 15 ◽

pp. 1161-1172 ◽

Cited By ~ 2

Author(s):

Saixu Huang ◽

Zhiyong Huang ◽

Zhiqin Fu ◽

Yamin Shi ◽

Qi Dai ◽

...

Keyword(s):

Drug Delivery ◽

In Vivo Studies ◽

Drug Delivery Carrier ◽

Novel Drug ◽

Drug Solution

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Prospects of Delivering Natural Compounds by Polymer-Drug Conjugates in Cancer Therapeutics

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520621666210419094623 ◽

2021 ◽

Vol 21 ◽

Author(s):

Nompumelelo P. Mthimkhulu ◽

Karabo S. Mosiane ◽

Ekene E. Nweke ◽

Mohammed Balogun ◽

Pascaline Fru

Keyword(s):

Drug Delivery ◽

Plant Extracts ◽

Drug Delivery Systems ◽

Cancer Therapeutics ◽

Natural Compounds ◽

Delivery Systems ◽

Drug Conjugates ◽

Medicinal Plant Extracts ◽

Novel Drug ◽

Polymer Drug Conjugates

: Synthetic chemotherapeutics have played a crucial role in minimizing mostly palliative symptoms associated with cancer; however, they have also created other problems such as system toxicity due to a lack of specificity. This has led to the development of polymer-drug conjugates amongst other novel drug delivery systems. Most of the formulations designed using delivery systems consist of synthetic drugs and face issues such as drug resistance, which has already rendered drugs such as antibiotics ineffective. This is further exacerbated by toxicity due to long term use. Given these problems and the fact that conjugation of synthetic compounds to polymers has been relatively slow with no formulation on the market after a decade of extensive studies, the focus has shifted to using this platform with medicinal plant extracts to improve solubility, specificity and increase drug release of medicinal and herbal bioactives. In recent years, various plant extracts such as flavonoids, tannins and terpenoids have been studied extensively using this approach. The success of formulations developed using novel drug-delivery systems is highly dependent on the tumour microenvironment especially on the enhanced permeability and retention effect. As a result, the compromised lymphatic network and ‘leaky’ vasculature exhibited by tumour cells act as a guiding principle in the delivering of these formulations. This review focuses on the state of the polymer-drug conjugates and their exploration with natural compounds, the progress and difficulties thus far, and future directions concerning cancer treatment.

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